Die vorliegende Erfindung betrifft eine Verfahren zum Herstellen eines Batteriemoduls (10), aufweisend die Verfahrensschritte: a) Bereitstellen wenigstens zweier Batteriezellen (12), wobei jede der Batteriezellen (12)...
标准号:
DE102016210839(A1)
Die vorliegende Erfindung betrifft eine Verfahren zum Herstellen eines Batteriemoduls (10), aufweisend die Verfahrensschritte: a) Bereitstellen wenigstens zweier Batteriezellen (12), wobei jede der Batteriezellen (12) zwei Zellanschlüsse (14) aufweist;b) Bereitstellen wenigstens eines Zellverbinders (16), wobei der Zellverbinder (16) biegbar ist;c) Verbinden des Zellverbinders (16) mit zwei Zellanschlüssen (14) unterschiedlicher Batteriezellen (12);und d) Biegen des Zellverbinders (16). Das vorbeschriebene Verfahren erlaubt eine einfache und dabei besonders flexible Herstellung von Batteriemodulen (10).
World’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (RF) cavities treated by medium-temperature furnace baking (mid-T bake) was developed, assembled and tested at IHEP for the Dal...
详细信息
Hyperlipidemia is one of the important risk factors of cardiovascular and cerebrovascular diseases. Monitoring of adverse reactions of hypolipidemic drugs is very crucial for clinical administration. In this study, in...
详细信息
ISBN:
(纸本)9781538667774
Hyperlipidemia is one of the important risk factors of cardiovascular and cerebrovascular diseases. Monitoring of adverse reactions of hypolipidemic drugs is very crucial for clinical administration. In this study, in order to explore the occurrence characteristics of ADRs for hypolipidemic drugs, we manually annotated and normalized the ADRs of hypolipidemic drugs from Chinese adverse event reports. Totally 579 records are involved in the study. Also we constructed a new dictionary of ADRs and a classification standard of the Severity of ADR to standardize the description of adverse drug reactions. Finally, we got a dictionary of ADR which have 171 terms, of 129 are from WHO-ART and 42 are self-defined. A new classification criteria for the severity of ADRs were built and each record were annotated by the criteria. Our annotated corpus, ADR dictionary and the classification standard can provide data source and dictionary resource to support future machine-learning-based ADR mining to better explore ADRs of hypolipidemic drugs.
The A1 subunit of cholera toxin (CTA1) retains the adjuvant function of CT, without its toxic side effects, making the molecule a promising mucosal adjuvant. However, the methods required to obtain a pure product are ...
详细信息
The A1 subunit of cholera toxin (CTA1) retains the adjuvant function of CT, without its toxic side effects, making the molecule a promising mucosal adjuvant. However, the methods required to obtain a pure product are both complicated and expensive, constricting its potential commercial applicability. Here, we fused the peptidoglycan binding domain (PA) to the C-terminus of CTA1, which enabled the fusion protein to be expressed by Bacillus subtilis, and secreted into the culture medium. CTA1 was then purified and displayed on GEM particles using a one step process, which resulted in the formation of CTA1-GEM complexes. Next, the CTA1-GEM complexes were used as an adjuvant to enhance the immune responses of mice to the influenza subunit vaccine. It was observed that the CTA1-GEM complexes enhanced specific systemic (IgG) and mucosal (IgA) immune responses against antigen, and induced cellular immune responses as well. The data presented here suggests that CTA1-GEM complexes can serve as a viable mucosal adjuvant. (C) 2017 Elsevier Inc. All rights reserved.
暂无评论