Network reconfiguration and demand response can both reduce the loss and improve the security of the distribution networks (DNs). In this paper, we describe a day-ahead DN reconfiguration schedule model considering de...
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ISBN:
(纸本)9781538656860
Network reconfiguration and demand response can both reduce the loss and improve the security of the distribution networks (DNs). In this paper, we describe a day-ahead DN reconfiguration schedule model considering demand response, in which network reconfiguration is conducted by distribution system operator (DSO) while the demand response strategies are realized by customer aggregators. To preserve information privacy and reduce computational burden, a two-level decomposition & coordination algorithm is proposed to solve this model, which is based on a log-barrier cost function. In the upper level, the DSO optimizes the network reconfiguration schedule, calculates the barrier cost of every load bus and then sends it to the corresponding customer aggregator. In the lower level, every customer aggregator exploits available controllable demands like heat pump (HP), electric vehicle (EV) to minimize the nodal daily cost based on the barrier cost calculated in DSO. Numerical tests verify the promising convergence of this decomposition algorithm and show a reduction of the total cost in DN.
Camptothecin (CPT) has been shown to block disassembly of the topoisomerase I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability, and severe toxicity of CPTs have limited their...
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Camptothecin (CPT) has been shown to block disassembly of the topoisomerase I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability, and severe toxicity of CPTs have limited their clinical applications. Herein, we report the design and synthesis of H2O-soluble and orally bioavailable hexacyclic CPT derivatives. By analysis of a virtual chemical library and cytotoxicity screening in vitro, 9 and 11 were identified as potential prodrugs and chosen for further characterization in vivo. Both compounds exhibited remarkable anticancer and anti-inflammation efficacies in animals and improved drug-like profiles.
As part of ongoing environmental investigations of U mining impacts, forty-two sediment samples of a nearly-half-meter-long sediment core retrieved from a natural reservoir near an active uranium (U) mining site, Sout...
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As part of ongoing environmental investigations of U mining impacts, forty-two sediment samples of a nearly-half-meter-long sediment core retrieved from a natural reservoir near an active uranium (U) mining site, South China were analyzed to quantify the extent of U release and identify U release mechanism within the riverine catchment. Enrichment levels of U was dispersed not only in the surface sediments but also in deep sediments across the depth profile. Further analysis by SEM-EDS and XRD indicated that U partitioning in the depth profile was possibly controlled by complicated interplay of leaching and precipitation cycles of U-bearing minerals. Even with the relative complexity of U dispersal processes within the catchment, the Pb isotopic fingerprinting techniques allowed quantification of source inputs of the sediments by using a binary mixing model. The results revealed that along the depth profile, only 6%-50% of the sediment material is anthropogenically derived from the U ore tailing, with the other predominant proportions originated from geogenically natural weathering of granitic bedrocks. This study highlights the use of Pb isotopes as a powerful tool for quantitatively fingerprinting the sources of U dispersal in the sediment core, and natural-occurring U contamination that may become a hidden geoenvironmental health hazard in this area. (C) 2017 Elsevier Ltd. All rights reserved.
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