G protein-coupled receptor, family C, group 5, member A (GPRC5A) had received attentions for its role in carcinogenesis and prognostic values in several types of cancer. However, the functional roles of GPRC5A in gast...
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G protein-coupled receptor, family C, group 5, member A (GPRC5A) had received attentions for its role in carcinogenesis and prognostic values in several types of cancer. However, the functional roles of GPRC5A in gastric cancer (GC) had never been elucidated. The expression levels of GPRC5A were detected by real-time quantitative reverse transcription PCR and Western blot in GC tissues and adjacent non-tumor tissues. GPRC5A expression in tissue sections of 106 GC samples was evaluated using immunohistochemistry. The staining results were compared with clinicopathological factors and to the prognosis of GC patients. The mRNA and protein expression levels of GPRC5A in gastric cancer tissues were higher than those in adjacent non-tumor tissues. Positive GPRC5A expression was significantly correlated with larger size of primary tumor, diffuse type (Lauren's classification), deeper serosal invasion, and more lymph node metastasis. In addition, Kaplan-Meier curve analysis demonstrated that GC patients with positive GPRC5A expression had poor prognosis than those with negative GPRC5A expression. GPRC5A expression was identified as an independent factor of the overall survival in GC patients by multivariate Cox analysis. Further, the overall survival difference existed between patients with GPRC5A positive and negative groups in GC patients with lymph node metastasis. Our results suggested that elevated levels of GPRC5A played significant roles in GC progression. GPRC5A could serve as a prognostic biomarker of GC.
Background. Until now, there has been no ideal embolization agent for hemorrhage in interventional treatment. In this study, the thrombin was encapsulated in alginate calcium microsphere using electrostatic droplet te...
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Background. Until now, there has been no ideal embolization agent for hemorrhage in interventional treatment. In this study, the thrombin was encapsulated in alginate calcium microsphere using electrostatic droplet technique to produce new embolization agent: thrombin loaded alginate calcium microspheres (TACMs). Objectives. The present work was to evaluate the biocompatibility and hemostatic efficiency of TACMs. Methods. Cell cytotoxicity, hemolysis, and superselective embolization of dog liver arteries were performed to investigate the biocompatibility of TACMs. To clarify the embolic effect of TACMs mixed thrombus in vivo, hepatic artery injury animal model of 6 beagles was established and transcatheter artery embolization for bleeding was performed. Results. Coculture with VECs revealed the noncytotoxicity of TACMs, and the hemolysis experiment was negligible. Moreover, the histological study of TACMs in liver blood vessel showed signs of a slight inflammatory reaction. The results of transcatheter application of TACMs mixed thrombus for bleeding showed that the blood flow was shut down completely after the TACMs mixed thrombus was delivered and the postprocedural survival rate of animal models at 12 weeks was 100%. Conclusions. With their good biocompatibility and superior hemostatic efficiency, TACMs might be a promising new hemostatic agent with a wide range of potential applications.
A vertical cavity surface emitting laser (VCSEL) device, comprising: a bracket that has a hollow cavity (2) and a VCSEL chip (1) encapsulated in the hollow cavity (2), wherein the bracket comprises a base (3) and a di...
标准号:
WO2019/165769(A1)
A vertical cavity surface emitting laser (VCSEL) device, comprising: a bracket that has a hollow cavity (2) and a VCSEL chip (1) encapsulated in the hollow cavity (2), wherein the bracket comprises a base (3) and a diffusion sheet (4) used for sealing the base (3), the VCSEL chip (1) is encapsulated on the base (3), and the diffusion sheet (4) is disposed above a light emergent surface of the VCSEL chip (1), such that light emitted from the VCSEL chip (1) traverses the diffusion sheet (4) and is emitted to the outside;a cut-off film (5) is disposed on the diffusion sheet (4), a through hole (6) is opened on the cut-off film (5), and the through hole (6) is disposed above the light emergent surface of the VCSEL chip (1), such that the light emitted from the VCSEL chip (1) penetrates the through hole (6), and then traverses the diffusion sheet (4) and is emitted to the outside. The flexible adjustment of the light-emitting angle is achieved by means of combining the VCSEL chip (1) with the diffusion sheet (4). Additionally, by means of disposing the cut-off film (5) on the diffusion sheet (4), the light scattered on the cut-off film (5) is reflected back outside of the VCSEL device, thereby improving the light emergence effect.
The algorithm presented here is used on unmanned aerial vehicles system. In 2013,*** proposed a matching cost computation model(or function), This matching cost model combined three kinds of constraints, the cost func...
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The algorithm presented here is used on unmanned aerial vehicles system. In 2013,*** proposed a matching cost computation model(or function), This matching cost model combined three kinds of constraints, the cost function is formulated by combining three individual costs:a cost computed on an extended census transformation of the images, the absolute difference cost, taking into account information from colour channels, and a cost based on the principal image *** show that the cost function is excellent performance in similar *** it to the stereo matching of ancient buildings, it is favorable for practical. However, this experiment, in color mutated region, leaded to blurred ***, our proposed method added color space structural information, which based on HVS Weber's law, to the cost function. we use the differential excitation of WLD reflects the structure of color *** robust cost measures can reduce percent of bad pixels in mutated color region. The proposed method use color image, which is used after epipolar line rectification.
Disclosed is a method for purifying and concentrating a foot-and-mouth disease virus inactivated antigen, comprising the steps of: (1) adding an adaptor protein with the amino acid sequence as shown in SEQ ID NO: 2 in...
标准号:
WO2018137323(A1)
Disclosed is a method for purifying and concentrating a foot-and-mouth disease virus inactivated antigen, comprising the steps of: (1) adding an adaptor protein with the amino acid sequence as shown in SEQ ID NO: 2 into the foot-and-mouth disease virus inactivated antigen, mixing homogeneously, and incubating;(2) adding a purified carrier, mixing homogeneously, and incubating the mixture, wherein the purified carrier is the skeleton of Lactococcus lactis;and (3) centrifuging and obtaining a precipitate. The purifying and concentrating method can efficiently purify the foot-and-mouth disease virus inactivated antigen and efficiently remove impurities, and has a high antigen recovery efficiency, large concentration multiple, low equipment requirement, simple operation, and low cost.
In recent years, unmanned autonomous vehicle navigation technology or UAV research is a hot topic in the field of machine vision, and obstacle detection is the basis of autonomous navigation. In this thesis, the autho...
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In recent years, unmanned autonomous vehicle navigation technology or UAV research is a hot topic in the field of machine vision, and obstacle detection is the basis of autonomous navigation. In this thesis, the author analyzed the deficiency of stereoscopic vision and classified current monocular obstacle detection algorithms. According to the properties of algorithms, this paper elaborated the function of algorithms based on features, focal length and movements respectively. The author also discussed current situation and prospects for various types of algorithms, including feature extraction and matching, focusing and defocusing model, background subtraction, frame difference and optical flow. Finally, this paper summarized advantages and disadvantages of different autonomous navigation algorithm and discussed the prospect of the monocular obstacle detection technology.
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