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湖泊科学 2022年第4期34卷 1384-1391页

作者：宋挺张军毅李旭文朱家民胡俊江苏省无锡环境监测中心无锡214121 江苏省环境监测中心南京210008 上海市青浦区环境监测站上海201799

随着全球气候变化和水体富营养化,在过去几十年中蓝藻水华改变了全球的淡水生态系统.蓝藻因独有的藻蓝蛋白而大多呈现蓝绿色,因此其水华也常称为蓝绿藻水华.然而随着蓝藻水华关注度的不断提升,尤其是监测和研究的不断深入,经常在水体中... 详细信息

随着全球气候变化和水体富营养化,在过去几十年中蓝藻水华改变了全球的淡水生态系统.蓝藻因独有的藻蓝蛋白而大多呈现蓝绿色,因此其水华也常称为蓝绿藻水华.然而随着蓝藻水华关注度的不断提升,尤其是监测和研究的不断深入,经常在水体中发现蓝藻水华出现黄化的现象.例如,太湖出现的黄色蓝藻水华,冬春季以长孢藻属(Dolichospermum)水华为主,夏秋季以微囊藻属(Microcystis)水华为主.即使外观看起来是蓝绿色的蓝藻水华,但仔细观察形成蓝藻水华的群体颗粒,也有部分呈现黄色,反之亦然.实际上,鉴于色素组成的差异性,也许水体中就没有两个颜色完全一致的蓝藻群体颗粒.目前对于黄色的蓝藻水华及其形成机理,国内外鲜有报道和研究.光照和氮限制被认为是最有可能的原因.在关注蓝藻水华黄化的同时,更应该关注和研究这些颜色变化给蓝藻水华及水环境所带来的风险和挑战,尤其是对水生态管理工作的启发和意义.

关键词：蓝藻水华黄色叶绿素类胡萝卜素藻胆蛋白

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Reconciling the Cooperative-Competitive Patterns among Tumor and Immune Cells for Triple-Negative Breast Cancer Treatment Using Multimodule Nanocomplexes

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ADVANCED MATERIALS 2024年第26期36卷 2312219-2312219页

作者： li, xuwen Guo, Qin Chen, Qinjun Chu, Yongchao Zhang, Yiwen Chen, Hongyi Zhao, Zhenhao Wang, Yu Luo, Yifan li, Chufeng You, Haoyu Song, Haolin Su, Boyu Jalili, Kiyumars Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryMinist EducState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Sahand Univ Technol Fac Polymer Engn POB 51317-11111 Tabriz Iran Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Targeting the competitive-cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune-dysfunction microenvironment to boost the immunotherapies for the triple-negative breast cancer treatment. Hence, a bacterial outer membrane vesicle-based nanocomplex is designed for specifically targeting malignant cells and immune cells to reconcile the relationships based on metabolic-immune crosstalk. By uniquely utilizing the property of charge-reversal polymers to realize function separation, the nanocomplexes could synergistically regulate tumor cells and immune cells. This approach could reshape the immunosuppressive competition-cooperation pattern into one that is immune-responsive, showcasing significant potential for inducing tumor remission in TNBC models. A multimodule nanocomplex dual targeting tumor-associated macrophages (TAMs) and tumor cells is devised to reconcile cooperative-competitive patterns among multiple cells through metabolic-immune regulation. The reversion of metabolic disequilibrium-immunosuppression tumor microenvironment is observed in TNBC models after treatment, contributing to the tumor remission. image

关键词： bacterial outer membrane CD24 l-arginine metabolic regulation T cell activation tumor-associated macrophages repolarization

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Gestational diabetes mellitus prediction model: A risk factors analysis of pregnant women with gestational diabetes mellitus but have normal oral glucose tolerance test results in the second trimester of pregnancy

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S57-S63页

作者： Lu, Jiayu Zhang, Song Jiang, Hongqing Yang, lin Hao, Dongmei Yang, Yimin li, xuwen Chen, Aiqing Shao, Jing liu, Xiaohong Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing 100124 Peoples R China Haidian Maternal & Children Hlth Hosp Beijing 100080 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Oral glucose tolerance test (OGTT) is a standard for the diagnosis of gestational diabetes mellitus (GDM). However, clinically, some cases with normal results were diagnosed as GDM in the third trimester. OBJECTIVE: To establish a risk model based on energy metabolism, epidemiology, and biochemistry that could predict the GDM pregnant women with normal OGTT results in the second trimester. METHODS: Qualitative and quantitative data were analyzed to find out the risk factors, and the binary logistic backward LR regression was used to establish the prediction model of each factor and comprehensive factor, respectively. RESULTS: The risk factors including the rest energy expenditure per kilogram of body weight, oxygen consumption per kilogram of body weight, if more than the weight gain criteria of the Institute of Medicine, the increase of body mass index between the second trimester and pre-pregnancy, and fasting blood glucose. By comparison, the comprehensive model had the best prediction performance, indicating that 85% of high-risk individuals were correctly classified. CONCLUSION: Energy metabolism, epidemiology, and biochemistry had better recognition ability for the GDM pregnant women with normal OGTT results in the second trimester. The addition of metabolic factors in the second trimester also improved the overall prediction performance.

关键词： Prediction model gestational diabetes mellitus rest energy metabolism

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A novel calcium phosphate-based nanocomposite for the augmentation of cement-injectable cannulated pedicle screws fixation: A cadaver and biomechanical study

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JOURNAL OF ORTHOPAEDIC TRANSLATION 2020年 20卷 56-66页

作者： Sun, Haolin liu, Chun li, xuwen liu, Huiling Zhang, Weiguang Yang, Huilin li, Chunde Yang, Lei Peking Univ Dept Orthoped Hosp 1 8 Xishiku St Beijing 100034 Peoples R China Soochow Univ Inst Orthoped Dept Orthoped Suzhou Peoples R China Peking Univ Sch Basic Med Sci Dept Human Anat 38 Xueyuan Rd Beijing 100191 Peoples R China Hebei Univ Technol Ctr Hlth Sci & Engn Sch Mat Sci & Engn Tianjin Key Lab Mat Laminating Fabricat & Interfa Tianjin Peoples R China

Background/objective: Both polymethylmethacrylate (PMMA) and traditional calcium phosphate-based cements have some deficiencies as augmentation materials for pedicle screw fixation. Here, a novel calcium phosphate-based nanocomposite (CPN) for the augmentation of pedicle screw fixation was developed based on previous study, and the handling properties, biomechanical performance, and biodegradation behaviour of CPN were evaluated and compared with clinical PMMA by means of a cadaver study and animal tests. Methods: Bone mineral density of the lumbar vertebrae was tested. Pedicle screws were placed into the lumbar vertebrae under the guidance of three dimensionally printed templates;each of which was designed based on computed tomography (CT) reconstruction of each vertebrae and augmented with either PMMA or CPN. X-ray and CT scan were used to evaluate the accuracy of screw placement and dispersion as well as interdigitation of bone cement. The axial pull-out strength and maximum torque were tested using a mechanical testing machine. Degradation behaviour of CPN was evaluated by in vitro immersion tests for 8 weeks and in vivo rabbit femur defect model for up to 6 months, respectively. Results: Standard mechanical tests revealed that PMMA was much stronger than CPN after setting (compressive strength 95 vs. 49 MPa, respectively, p < 0.001). Results of the projection area and volume distribution of cement along the distal end of the screws revealed that CPN exhibited unique dispersing and interdigitation abilities compared with PMMA. Specifically, CPN dispersed uniformly and symmetrically along the screw, while PMMA was limited to the proximal part of the screw. Axial pull-out test results showed that the axial pull-out strengths of CPN- and PMMA-augmented pedicle screws were similar (1199 +/- 225 N vs 1337 +/- 483 N, respectively) and not significantly different (p = 0.47), although CPN was an intrinsically weaker material than PMMA. Similarly, CPN showed average torq

关键词： Calcium phosphate-based cement Injectable Osteoporosis Pedicle screw PMMA

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CA125结合人附睾分泌蛋白4检验诊断卵巢癌的价值

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系统医学 2023年第1期8卷 10-14页

作者：邵大祥李绪文扬州市江都人民医院检验科江苏扬州225200

目的研究分析糖类抗原125(CA125)结合人附睾分泌蛋白4(HE4)检验诊断卵巢癌的价值。方法选取2019年1月—2022年3月在扬州市江都人民医院治疗的60例卵巢癌患者设为研究组,选取同期收治的60例卵巢良性肿瘤患者设为对照组。对两组患者CA125... 详细信息

目的研究分析糖类抗原125(CA125)结合人附睾分泌蛋白4(HE4)检验诊断卵巢癌的价值。方法选取2019年1月—2022年3月在扬州市江都人民医院治疗的60例卵巢癌患者设为研究组,选取同期收治的60例卵巢良性肿瘤患者设为对照组。对两组患者CA125、HE4水平进行检测,统计对比检测结果。结果研究组患者CA125、HE4水平均高于对照组患者,差异有统计学意义(P<0.05)。在研究组中,Ⅲ~Ⅳ期患者CA125、HE4水平均高于Ⅰ~Ⅱ期患者,差异有统计学意义(P<0.05)。在研究组中,有淋巴转移患者CA125、HE4水平分别为(412.03±86.59)kU/L、(372.36±86.75)pmol/L,均高于无淋巴转移患者,差异有统计学意义(t=15.046、7.636,P<0.05)。CA125结合HE4诊断卵巢癌的特异度、灵敏度、准确度、阴性预测值、阳性预测值均高于CA125与HE4单项诊断,差异有统计学意义(P<0.05)。结论在卵巢癌诊断中,CA125结合HE4检验的临床价值更高,能够精准判定患者病情,为患者治疗提供指导依据。

关键词：卵巢癌糖类抗原125 人附睾分泌蛋白4 诊断价值

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仿刺参中两种新海参烷型皂苷

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高等学校化学学报 2023年第4期44卷 27-34页

作者：孙志恒刘桂英王冰姿陈义夫冯月竹金永日李绪文吉林大学化学学院长春130012 辽宁省海洋水产科学研究院大连116023

从仿刺参(Apostichopus japonicus Selenka)乙醇提取物中分离得到2个新的海参烷型皂苷类化合物,通过波谱数据分析并结合理化性质鉴定其分别为3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃喹诺糖]-4-O-[... 详细信息

从仿刺参(Apostichopus japonicus Selenka)乙醇提取物中分离得到2个新的海参烷型皂苷类化合物,通过波谱数据分析并结合理化性质鉴定其分别为3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃喹诺糖]-4-O-[β-D-吡喃葡萄糖]-β-D-吡喃木糖}-海参烷-7(8),25(26)-二烯-16-酮(化合物1,命名为Holotoxin E1)和3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃葡萄糖]-4-O-[β-D-吡喃葡萄糖-(1→3)-β-D-吡喃葡萄糖]-β-D-吡喃木糖}-海参烷-7(8),25(26)-二烯-16-酮(化合物2,命名为Holotoxin E2).采用CCK-8法考察了包含上述2个新成分在内的共6个海参烷型皂苷对乳腺癌MDA-MB-231细胞和肝癌HepG2细胞的细胞毒活性.结果表明,除Holotoxin E2外,其余5种化合物对MDA-MB-231(IC50=2.386~4.686μmol/L)和HepG2(IC50=5.909~18.860μmol/L)均具有较好的抑制作用.

关键词：仿刺参海参烷型皂苷分离结构鉴定细胞毒活性

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“双减”政策背景下学校体育“家校社”协同育人的问题检视与实践超越

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体育科技文献通报 2023年第2期31卷 157-159,163页

作者：李旭雯刘辉陈凯长沙市雅礼实验中学湖南长沙410000

“双减”政策颁布的目的旨在从根本上释放学生学习压力,并将学校体育“家校社”协同育人发展推至新阶段。如何最大化发挥家庭体育、学校体育、社会体育的各自特色,实现1+1+1>3的育人效果,亟需深思。本文运用文献综述法、逻辑分析法... 详细信息

“双减”政策颁布的目的旨在从根本上释放学生学习压力,并将学校体育“家校社”协同育人发展推至新阶段。如何最大化发挥家庭体育、学校体育、社会体育的各自特色,实现1+1+1>3的育人效果,亟需深思。本文运用文献综述法、逻辑分析法等研究方法,探析“双减”政策背景下学校体育“家校社”协同育人实践问题,提出相应改进策略建议。研究认为,问题检视:“家校社”体育认知程度浅显;“家校社”体育资源供给乏力;“家校社”合作机制条件欠缺。建议:觉醒认知意识,更新学校体育“家校社”三方教育观念;凝聚体质合力,整合学校体育“家校社”三方优势资源;融合信息技术,塑造学校体育“家校社”三方交流平台。

关键词： “双减”政策家校社协同育人学校体育

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FETAL TYPE CLASSIFICATION BASED ON FETAL ELECTROCARDIOGRAPH IN NON-STRESS TESTS

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JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2021年第9期21卷 2140052-2140052页

作者： liu, Jianli Yang, Yimin Zhang, Song li, xuwen Yang, lin Hao, Dongmei Beijing Univ Technol Fac Environm & Life Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100024 Peoples R China

Electronic fetal heart rate (FHR) monitoring is a technical means to evaluate the state of the fetus in the uterus by monitoring FHR. The main purpose is to detect intrauterine hypoxia and take corresponding medical measures timely. Because the fetus sleeps quietly for up to 1 hour sometimes, ultrasound Doppler is not easy to continuously detect for a long time. The electronic fetal monitor obtains the fetal heart rate, which not only improves the accuracy and comfort, but also the convenient implementation of long-term monitoring. It is beneficial to reduce perinatal fetal morbidity and mortality. This study used maternal-fetal Holter monitor which is based on the technology of fetal electrocardiograph (FECG) to collect the FHR, and then design algorithm to extract the baseline FHR, acceleration, variation, sleep-wake cycle and nonlinear parameters. There were significant differences in the 22 parameters between the normal and the suspicious group. Using the 22 characteristic parameters, the support vector machine was used to classify the normal and the suspected group of fetuses. 80% of the data was used to train a classification model. The remaining 20% of the data was used as a test set and its accuracy reached 93.75%.

关键词： Fetal Holter monitor fetal heart rate support vector machine

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Highly sensitive detection of rabbit IgG by electron spin resonance using CuS nanoparticles as probe

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SENSORS AND ACTUATORS B-CHEMICAL 2021年 338卷 129835-129835页

作者： Tian, Sizhu li, xuwen Jiang, Jia Tang, li Zhang, Hanqi Yu, Yong Zhang, Ziwei Jilin Univ Coll Chem Qianjin St 2699 Changchun 130012 Peoples R China Jilin Univ Coll Instrumentat & Elect Engn West Minzhu St 938 Changchun 130061 Peoples R China

Water soluble copper sulfide (CuS) nanoparticles were synthesized using L-cysteine as the ligand. Multiple biotins were conjugated to the antibody of rabbit IgG, and the streptavidin was attached to the CuS nanoparticles. The Cu2+ ions enclosed in the nanoparticles were used as the electron spin resonance (ESR) probes and detected with ESR spectrometer. The immunoassay reaction was resulted in the formation of the coating antibody attached to the microplate well, the detecting antibody labeled with the biotins, and the streptavidin attached to the CuS nanoparticles. After the immunoassay reaction was performed, large amount of Cu2+/Cu+ ions inside the nanoparticles were released with the help of diethyldithiocarbamate (DDC) and the Cu2+-DDC complex formed. The Cu2+-DDC complex was extracted into n-butanol, which was used as the analytical sample. Both ESR and UV?vis signals were collected for the analytical sample. The double logarithm standard curve was well simulated with a linear regression equation. The limits of detection of the rabbit IgG were 1.76 pg/mL and 2.36 pg/mL by ESR and UV?vis method, respectively. The detection range using ESR as the detector was from 8.8 pg/mL to 500 ng/mL, covering almost 5 magnitude orders of the rabbit IgG concentrations. The rabbit serum was analyzed and the rabbit IgG concentration was found to be 7.76 mg/mL. The reproducibility of the present method was good enough with the intra-assay error within 3.4 % and the inter-assay error within 11.2 %. The spiked serum samples were analyzed and the experimental results indicated that the recoveries were from 108.2 to 113.7%.

关键词： CuS nanoparticles Electron spin resonance Immunoassay Cu2+-DDC complex Rabbit IgG

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Establishment of a personalized fetal growth curve model

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S311-S317页

作者： Bao, Xinyu Wang, Yan Zhang, Song Yang, lin liu, Guoli Yang, Yimin li, xuwen Hao, Dongmei Chen, Aiqing liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Fetal weight is one of the important indicators for judging whether fetal growth and development are normal. Fetal weight exceeding the normal range may lead to poor delivery outcomes. OBJECTIVE: We aimed to establish a personalized fetal growth curve in order to effectively monitor fetal growth during pregnancy. Fetal weight can be monitored while fetal growth and development are assessed. METHODS: This study retrospectively analyzed the birth weight and ultrasound database of 3,093 newborns delivered at normal term. The personalized fetal growth curve model was generated based on the birth weight formula established by Gardosi combined with the proportional weight equation. RESULTS: (1) The average birth weight of the single fetus at normal term was 3,457g. (2) According to the regression results of the proportion of fetal weight in full-term pregnancy and gestational week, the proportional weight equation is Weight% = 500.9 + 51.60GA + 1.727GA(2) 0.01718GA(3) (GA is gestational week), R-2 is 98%, P < 0.001. CONCLUSIONS: In this study, the normal birth weight of newborns and normal range of fetal weight can be estimated by using the personalized fetal growth curve model.

关键词： Fetal weight fetal growth curve birth weight proportional weight equation normal range

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