This paper introduces the performance metric of DSP parallel processing system and presents a model of coarse-grained speedup of DSP parallel processing structure. Quantitative research is done according to the system...
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Acanthopanacis Cortex (AC) is a Chinese herbal medicine (Wu-Jia-Pi in PinYin) which is recognized with therapeutic effect of "strengthening bone and sinew", yet its regulating biological network is still obs...
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ISBN:
(纸本)9781509040940
Acanthopanacis Cortex (AC) is a Chinese herbal medicine (Wu-Jia-Pi in PinYin) which is recognized with therapeutic effect of "strengthening bone and sinew", yet its regulating biological network is still obscure. In this study, started from AC's chemical compounds, their direct target proteins were filtered out. Then these targeted proteins were annotated with biological processes under the framework of Gene Ontology (GO) terms' hierarchical networks which were overrepresented and enriched with them with statistic significant p-value set to 0.05. In the biological process hierarchy networks, ossification formed a big one with bone formation associated biological processes. Further protein-protein interaction analysis with these targeted proteins and bone expressed ones formed a clear and concise protein-regulation network for ossification which should be responsible for the therapeutic effect of "strengthening bone and sinew". This study proposed a new approach of analyzing biological functions of a specified Chinese herbal medicine targeting certain therapeutic effect.
With the appearance of different manufacturers and types of 1553B bus devices, the problem of the lack of real-time analysis and evaluation of effective tools for bus test method becomes severe. So a set of general co...
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ISBN:
(纸本)9780769551203
With the appearance of different manufacturers and types of 1553B bus devices, the problem of the lack of real-time analysis and evaluation of effective tools for bus test method becomes severe. So a set of general configurable and flexible testing and simulating verification system for 1553B bus. In this thesis, a set of real-time hardware and software systems solution is proposed, a novel mechanism of inject fault testing and detect fault is adopted. Besides, the proposed system could receive good performance in practical applications.
研究不同时间点(1、2、4、8、16 d)及修复期(26 d)、不同浓度(0、0.06、0.3、1.5 mg/L)二溴海因(DBDMH)对雄性吉富罗非鱼血浆中抗氧化酶基因的基因毒性,筛选稳定的生物标志物。实时荧光定量PCR方法检测DBDMH对超氧化物歧化酶(sod)、谷胱甘肽-S-转移酶(gst)、谷胱甘肽还原酶(gr)、谷胱甘肽过氧化物酶1(gpx1)、过氧化氢酶(cat)基因表达的影响。中浓度组雄性吉富罗非鱼血浆抗氧化酶基因(除gr)表达受DBDMH胁迫诱导显著上调;各DBDMH浓度组1 d(sod,gst,gpx1),2 d(gst,gr)抗氧化基因表达呈现浓度依赖性下降,4 d sod,gpx1基因表达呈现浓度依赖性上升;8 d中浓度DBDMH处理组基因表达(gst,gr,gpx1)显著低于低浓度组;恢复试验阶段,中、高浓度DBDMH组各抗氧化酶基因表达均不能恢复到正常水平。0.3 mg/L DBDMH显著增强雄性吉富罗非鱼血浆所测抗氧化酶基因的表达(除1 d gpx1、cat,8和16 d gr),此浓度下抗氧化酶基因作为标志物较合适。
Syndrome wind-cold-dampness in traditional Chinese medicine (TCM) can be referred to diseases of osteoarthritis, rheumatoid arthritis, cervical spondylitis, and spondylitis and so on. Over thousand years TCM clinical ...
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ISBN:
(纸本)9781509040940
Syndrome wind-cold-dampness in traditional Chinese medicine (TCM) can be referred to diseases of osteoarthritis, rheumatoid arthritis, cervical spondylitis, and spondylitis and so on. Over thousand years TCM clinical explorations, this syndrome can be treated with a group of herbal medicines in TCM. However, their molecular level biological functions are still not clear. In this study, a set of algorithms e.g., hypergeometric distribution, Jaccard index, and recursive programming for hierarchy network were deployed in the context gene/protein functional similarity and enrichment analysis. The analysis was mainly focused on the associated herbal medicines, their chemical compounds, target proteins' similarity, and gene ontology terms' hierarchical network overrepresentation through the enrichment analysis of hypergeometric distribution with P-value set to 0.05. As a result, these associated herbs share low level (
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
标准号:
EP3246317(A4)
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
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