检索结果-内蒙古大学图书馆

Identification of genetic loci associated with rough dwarf disease resistance in maize by integrating GWAS and linkage mapping

引用

PLANT SCIENCE 2022年 315卷 111100-111100页

作者： zhao, Meiai Liu, Shuangshuang Pei, Yuhe Jiang, xuwen Jaqueth, Jennifer S. Li, Bailin Han, Jing Jeffers, Daniel Wang, Jiabo Song, Xiyun Qingdao Agr Univ Coll Life Sci Key Lab Plant Biotechnol Univ Shandong Prov Qingdao 266109 Peoples R China Qingdao Agr Univ Coll Agron Key Lab Qingdao Major Crop Germplasm Resource Inn Qingdao 266109 Peoples R China Corteva Agrisci 7300 NW 62nd Ave Johnston IA 50131 USA Shandong Denghai Pioneer Jinan 254000 Shandong Peoples R China Yunnan Acad Agr Sci Yunnan Off Kunming 650205 Yunnan Peoples R China Southwest Minzu Univ Minist Educ Key Lab Qinghai Tibetan Plateau Anim Genet Resour Chengdu 160041 Sichuan Peoples R China

Maize rough dwarf disease (MRDD) is a viral disease that causes substantial yield loss, especially in China's summer planted maize area. Discovery of resistance genes would help in developing high-yielding resistant maize hybrids. Genome-wide association studies (GWASs) have advanced quickly and are now a powerful tool for dissecting complex genetic architectures. In this study, the disease severity index (DSI) of 292 maize inbred lines and an F6 linkage population were investigated across multiple environments for two years. Using the genotypes obtained from the Maize SNP 50K chip, a GWAS was performed with four analytical models. The results showed that 22 SNPs distributed on chromosomes 1, 3, 4, 6, 7 and 8 were significantly associated with resistance to MRDD (P<0.0001). The SNPs on chromosomes 3, 6 and 8 were consistent with the quantitative trait locus (QTL) regions from linkage mapping in an RIL population. Candidate genes identified by GWAS included an LRR receptor-like serine/threonine-protein kinase (GRMZM2G141288), and a DRE-binding protein (GRMZM2G006745). In addition, we performed an allele variation analysis of the SNP loci selected by GWAS and linkage mapping and found that the main alleles of the two SNP loci PZE_101170408 and PZE_106082685 on chromosome 1 differed in terms of disease-resistant materials and disease-susceptible materials. The identified SNPs and genes provide useful information for MRDD-related gene cloning and insights on the underlying disease resistance mechanisms, and they can be used in marker-assisted breeding to develop MRDD-resistant maize.

关键词： Maize MRDD GWAS Linkage mapping Candidate genes

来源：评论

学校读者我要写书评

暂无评论

Strongly prolonged hydroxyl radical production for Fenton-like reactions: The golden touch of Cu

引用

SEPARATION AND PURIFICATION TECHNOLOGY 2019年 213卷 500-506页

作者： Da, xuwen Ji, Hongwei zhao, Zhenwen Lan, Rongshan Li, Tuo Ma, Jiahai Univ Chinese Acad Sci Sch Chem Sci Beijing 100049 Peoples R China Chinese Acad Sci Inst Chem Key Lab Photochem Beijing 100190 Peoples R China Chinese Acad Sci Beijing Mass Spectrum Ctr Inst Chem Beijing 100190 Peoples R China

Hydroxyl radicals are believed as the most reactive species in the Fenton-like reactions and perform well at the beginning stage of the reaction due to very short lifetime. A reaction system with strongly prolonged hydroxyl radical lifetime is rarely reported. Adding Cu ions, an unreactive catalyst for hydrogen peroxide activation, the Fe/Cu/CDBQ/H2O2 system efficiently prolonged hydroxyl radical lifetime with two orders. This study found a strong, prolonged hydroxyl radical generation in a Fenton-like system using iron, copper ions and 2,5-dihydroxy-1,4-benzoquinone restricted in cyclodextrin (CDBQ). Meanwhile, rapid degradation and substantial mineralization of organics was achieved in this system. Further, the Cu ions could promote the efficiency of other Fenton-like system.

关键词： Hydroxyl radical Fenton reaction Copper ion

来源：评论

学校读者我要写书评

暂无评论

矿井水深度除氟的实验研究及经济技术分析

引用

绿色科技 2023年第16期25卷 154-160,165页

作者：项绪文赵伟贾新强沈军刘娟山东省环科院环境工程有限公司山东济南250100

为将矿井水的氟化物从6.2 mg/L降低到1 mg/L以下,对化学沉淀、羟基磷灰石吸附、离子交换等工艺进行了实验研究及工程经济技术分析。实验结果表明:复配除氟剂沉淀、羟基磷灰石吸附、树脂离子交换工艺能够将氟离子从6.2 mg/L降低到1 mg/L... 详细信息

为将矿井水的氟化物从6.2 mg/L降低到1 mg/L以下,对化学沉淀、羟基磷灰石吸附、离子交换等工艺进行了实验研究及工程经济技术分析。实验结果表明:复配除氟剂沉淀、羟基磷灰石吸附、树脂离子交换工艺能够将氟离子从6.2 mg/L降低到1 mg/L以下。但钙铝药剂难以稳定将氟离子降低到1 mg/L以下。复配除氟剂沉淀、羟基磷灰石吸附及树脂离子交换除氟工艺的处理成本分别为1.14、0.91、1.59元/t。3种工艺中,投资费用最高的是树脂离子交换工艺,最低的是化学沉淀工艺。

关键词：含氟废水化学沉淀吸附离子交换除氟剂

来源：评论

学校读者我要写书评

暂无评论

Erratum to“Probing the Interfacial Forces and Surface Interaction Mechanisms in Petroleum Production Processes”[Engineering 18(2022)49-61]

引用

Engineering 2023年第3期22卷 233-233页

作者： Diling Yang xuwen Peng Qiongyao Peng Tao Wang Chenyu Qiao Ziqian zhao Lu Gong Yueliang Liu Hao Zhang Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada College of Petroleum Engineering China University of PetroleumBeijing 102249China

In Ref.[1],Eq.(8)has a typo,the following replacement should be done.γ_(bb)/2rδ/δr(rδ(r,t)/δr=2γ_(bb)/R_(bb)-Þ(t,t)-Ⅱ[h[r,t)](bubble=drop-bubble=drop)The publisher regrets an error in the original–article,and the sentence that explained the equation“Eqs.(8)–(10)show the augmented Young–Laplace equation for the interactions of gas bubbles or liquid droplets in different configurations,where Rb is the bubble/drop radius,Rp is the particle radius,Rbp=(1/Rb+1/Rp)1.

关键词： bubble radius equation

来源：评论

学校读者我要写书评

暂无评论

A new nanobody-enzyme fusion protein-linked immunoassay for detecting antibodies against influenza A virus in different species

引用

JOURNAL OF BIOLOGICAL CHEMISTRY 2022年第12期298卷 102709页

作者： Ji, Pinpin Wang, Kun Zhang, Lu Yan, Zhenda Kong, Min Sun, xuwen Zhang, Qiang Zhou, Ning Liu, Baoyuan Zhou, En-Min Sun, Yani Wang, Xinjie zhao, Qin Northwest A&F Univ Dept Vet Prevent Med Coll Vet Med Yangling Shaanxi Peoples R China Chinese Acad Agr Sci Guangdong Lab Lingnan Modern Agr Agr Genom Inst Shenzhen Shenzhen BranchGenome Anal LabMinist Agr & Rura Shenzhen Peoples R China

Circulation of influenza A virus (IAV), especially within poultry and pigs, continues to threaten public health. A simple and universal detecting method is important for monitoring IAV infection in different species. Recently, nanobodies, which show advantages of easy gene editing and low cost of production, are a promising novel diagnostic tool for the monitoring and control of global IAVs. In the present study, five nanobodies against the nucleoprotein of H9N2 IAV were screened from the immunized Bactrian camel by phage display and modified with horseradish peroxidase (HRP) tags. Out of which, we determined that H9N2-NP-Nb5-HRP can crossreact with different subtypes of IAVs, and this reaction is also blocked by positive sera for antibodies against different IAV subtypes. Epitope mapping showed that the nanobody-HRP fusion recognized a conserved conformational epitope in all subtypes of IAVs. Subsequently, we developed a nanobody-based competitive ELISA (cELISA) for detecting anti-IAV antibodies in different species. The optimized amount of coating antigen and dilutions of the fusion and testing sera were 100 ng/well, 1:4000, and 1:10, respectively. The time for operating the cELISA was approximately 35 min. The cELISA showed high sensitivity, specificity, reproducibility, and stability. In addition, we found that the cELISA and hemagglutination inhibition test showed a consistency of 100% and 87.91% for clinical and challenged chicken sera, respectively. Furthermore, the agreement rates were 90.4% and 85.7% between the cELISA and commercial IEDXX ELISA kit. Collectively, our developed nanobody-HRP fusion–based cELISA is an ideal method for monitoring IAV infection in different species.

关键词： influenza A virus antibodies against IAVs nucleoprotein nanobody nanobody-HRP fusion protein competitive ELISA

来源：评论

学校读者我要写书评

暂无评论

Network topology and machine learning analyses reveal microstructural white matter changes underlying Chinese medicine Dengzhan Shengmai treatment on patients with vascular cognitive impairment

引用

PHARMACOLOGICAL RESEARCH 2020年 156卷 104773-104773页

作者： Lu, Hui Zhang, Junying Liang, Ying Qiao, Yanan Yang, Caishui He, xuwen Wang, Wenxiao zhao, Shaokun Wei, Dongfeng Li, He Cheng, Weidong Zhang, Zhanjun Southern Med Univ Sch Tradit Chinese Med Guangzhou 510515 Guangdong Peoples R China China Acad Chinese Med Sci Inst Basic Res Clin Med Beijing 100700 Peoples R China Beijing Normal Univ State Key Lab Cognit Neurosci & Learning 19 Xinjiekouwai St Beijing 100875 Peoples R China Beijing Normal Univ IDG McGovern Inst Brain Res Beijing 100875 Peoples R China Capital Med Univ Sch Biomed Engn Beijing 100069 Peoples R China China Japan Friendship Hosp Beijing 100029 Peoples R China Beijing Normal Univ BABRI Ctr Beijing 100875 Peoples R China

With the increasing incidence of cerebrovascular diseases and dementia, considerable efforts have been made to develop effective treatments on vascular cognitive impairment (VCI), among which accumulating practice-based evidence has shown great potential of the traditional Chinese medicine (TCM). Current randomized double-blind controlled trial has been designed to evaluate the 6-month treatment effects of Dengzhan Shengmai (DZSM) capsules, one TCM herbal preparations on VCI, and to explore the underlying neural mechanisms with graph theory-based analysis and machine learning method based on diffusion tensor imaging (DTI) data. A total of 82 VCI patients were recruited and randomly assigned to drug (45 with DZSM) and placebo (37 with placebo) groups, and neuropsychological and neuroimaging data were acquired at baseline and after 6-month treatment. After treatment, compared to the placebo group, the drug groups showed significantly improved performance in Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-cog) score (p < 0.001) and the other cognitive domains. And with the reconstruction of white matter structural network, there were more streamlines connecting the left thalamus and right hippocampus in the drug groups (p < 0.001 uncorrected), with decreasing nodal efficiency of the right olfactory associated with slower decline in the general cognition (r = 0.364, p = 0.048). Moreover, support vector machine classification analyses revealed significant white matter network alterations after treatment in the drug groups (accuracy of baseline vs. 6-month later, 68.18 %). Taking together, the present study showed significant efficacy of DZSM treatment on VCI, which might result from white matter microstructure alterations and the topological changes in brain structural network.

关键词： Vascular cognitive impairment Traditional Chinese medicine Dengzhan Shengmai capsule Diffusion tensor imaging Structural brain network Graph theory analysis

来源：评论

学校读者我要写书评

暂无评论

Sequentially Triggered Bacterial Outer Membrane Vesicles for Macrophage Metabolism Modulation and Tumor Metastasis Suppression

引用

ACS NANO 2021年第8期15卷 13826-13838页

作者： Guo, Qin Li, xuwen Zhou, Wenxi Chu, Yongchao Chen, Qinjun Zhang, Yiwen Li, Chao Chen, Hongyi Liu, Peixin zhao, Zhenhao Wang, Yu Zhou, Zheng Luo, Yifan Li, Chufeng You, Haoyu Song, Haolin Su, Boyu Zhang, Tongyu Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryMinist EducState Key Shanghai 201203 Peoples R China

Metabolic interactions between different cell types in the tumor microenvironment (TME) often result in reprogramming of the metabolism to be totally different from their normal physiological processes in order to support tumor growth. Many studies have attempted to inhibit tumor growth and activate tumor immunity by regulating the metabolism of tumors and other cells in TME. However, metabolic inhibitors often suffer from the heterogeneity of tumors, since the favorable metabolic regulation of malignant cells and other cells in TME is often inconsistent with each other. Therefore, we reported the design of a pH-sensitive drug delivery system that targets different cells in TME successively. Outer membrane vesicles (OMVs) derived from Gram-negative bacteria were applied to coload paclitaxel (PTX) and regulated in development and DNA damage response 1 (Redd1)-siRNA and regulate tumor metabolism microenvironment and suppress tumor growth. Our siRNA@M-/PTX-CA-OMVs could first release PTX triggered by the tumor pH (pH 6.8). Then the rest of it would be taken in by M2 macrophages to increase their level of glycolysis. Great potential was observed in TAM repolarization, tumor suppression, tumor immune activation, and TME remolding in the triple-negative breast cancer model. The application of the OMV provided an insight for establishing a codelivery platform for chemical drugs and genetic medicines.

关键词： bacterial OMVs pH sensitive TAM polarization immune therapy cancer treatment

来源：评论

学校读者我要写书评

暂无评论

Ladderane records over the last century in the East China sea: Proxies for anammox and eutrophication changes

引用

WATER RESEARCH 2019年第Jun.1期156卷 297-304页

作者： zhao, Zongshan Cao, Yali Fan, Ying Yang, Haili Feng, xuwen Li, Li Zhang, Hailong Xing, Lei zhao, Meixun Ocean Univ China Inst Adv Ocean Study Minist Educ Key Lab Marine Chem Theory & Technol Qingdao 266100 Shandong Peoples R China Qingdao Natl Lab Marine Sci & Technol Lab Marine Ecol & Environm Sci Qingdao 266237 Shandong Peoples R China Chinese Acad Sci Qingdao Inst Bioenergy & Bioproc Technol CAS Key Lab Biobased Mat Qingdao 266101 Shandong Peoples R China Jiangxi Inst Anal & Test Nanchang 330029 Jiangxi Peoples R China State Ocean Adm Inst Oceanog 2 Hangzhou 310012 Zhejiang Peoples R China

Anaerobic ammonium oxidation (anammox), an important process for converting fixed nitrogen to N-2, plays an important role in the present-day marine nitrogen cycle. However, little is known about anammox activities in the past, especially in regions that were strongly affected by human activities, evidenced by eutrophication and hypoxia, which promote anammox bacteria growth. In this study, ladderanes have been measured in a sediment core and suspended particulate matter (SPM) in the East China Sea (ECS), to reconstruct the anammox record and to evaluate its responses to eutrophication and hypoxia. The detection and distribution of different ladderane lipids in SPM provide additional evidence that ladderanes were mostly produced in the water column and could reflect anammox activities. Summed ladderane content from the core varied between 11 and 300 ng/g dry weight (dw) sediment, with C20-[5]-ladderane fatty acid methyl esters (FAME) as the predominant compound (5-150 ng/g dw), followed by C20-[3]-ladderane FAME (1-110 ng/g dw), C18-[3]-ladderane FAME (1-32 ng/g dw) and 08 -[5]-ladderane FAME (3-11 ng/g dw). The detection of ladderanes over the last century indicate the existence of anammox in the past. The rapidly increasing trend of ladderanes since the 1960s correlates with an increase in phytoplankton biomarkers (2 Sigma(B + D + A), brassicasterol (B), dinosterol (D) and C-37 alkenones (A)), indicating that eutrophication exacerbated anammox growth. The co-variation between our ladderane record and published records of low-oxygen tolerant foraminiferal microfossils and hypoxia events over the past 60 years suggested that sediment ladderanes are a useful indicator for past changes of oxygen depletion or hypoxia in the ECS. (C) 2019 Elsevier Ltd. All rights reserved.

关键词： Anammox Ladderanes Nitrogen cycle Phytoplankton Hypoxia

来源：评论

学校读者我要写书评

暂无评论

化工园区污水处理提标改造设计案例

引用

云南化工 2024年第8期51卷 160-163页

作者：项绪文袁志明沈军李体康赵伟李星山东省环科院环境工程有限公司山东济南250013

某化工园区污水处理厂工程建设规模为1.5万m^(3)/d,要求出水水质的COD及氨氮从《城镇污水处理厂污染物排放标准》(GB18918—2002)的一级A标准提标至《地表水环境质量标准》(GB3838-2002)IV类水。经改造后,污水处理厂的处理工艺为“缓冲... 详细信息

某化工园区污水处理厂工程建设规模为1.5万m^(3)/d,要求出水水质的COD及氨氮从《城镇污水处理厂污染物排放标准》(GB18918—2002)的一级A标准提标至《地表水环境质量标准》(GB3838-2002)IV类水。经改造后,污水处理厂的处理工艺为“缓冲水池+调节池+初沉池+臭氧氧化+厌氧水解+A/O+A/O+二沉池+絮凝沉淀池+分配池+臭氧催化氧化+活性焦吸附+紫外线消毒”。废水经过预处理及生化改造,解决了有机物去除及脱氮难的问题,通过臭氧催化氧化和活性焦的深度处理,保证了COD的指标,使水质达到新的排放标准。

关键词：化工园区废水处理提标改造臭氧催化氧化活性焦

来源：评论

学校读者我要写书评

暂无评论

硅烷偶联剂改性的短切玄武岩纤维增强三元乙丙橡胶复合材料的研究

引用

化工新型材料 2024年第S01期52卷 199-204,211页

作者：李辉张卜方赵春霞向东王斌程金波黄浩然张旭文武元鹏西南石油大学新能源与材料学院成都610500

将玄武岩纤维(BF)用硅烷偶联剂KH570改性后,制备了玄武岩纤维增强三元乙丙橡胶(E-BF7)复合材料,研究了玄武岩纤维用量对复合材料力学性能、热稳定性、动态热力学性能、耐水性能以及耐化学液体性能的影响。结果表明:与未加纤维的三元乙... 详细信息

将玄武岩纤维(BF)用硅烷偶联剂KH570改性后,制备了玄武岩纤维增强三元乙丙橡胶(E-BF7)复合材料,研究了玄武岩纤维用量对复合材料力学性能、热稳定性、动态热力学性能、耐水性能以及耐化学液体性能的影响。结果表明:与未加纤维的三元乙丙橡胶相比,添加15份KH570改性的玄武岩纤维BF7得到的三元乙丙橡胶复合材料E-BF7-15,拥有更好的综合性能。其拉伸强度从12.49MPa提高到14.50MPa,提高了16.1%,撕裂强度从41.47MPa提高到51.67MPa,提高了24.6%,其耐水性和耐化学液体性能也得到明显提升。

关键词：三元乙丙橡胶玄武岩纤维复合材料纤维改性硅烷偶联剂

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：