检索结果-内蒙古大学图书馆

Biomimetic Dendrimer-Peptide Conjugates for Early Multi-Target Therapy of Alzheimer's Disease by Inflammatory Microenvironment Modulation

引用

ADVANCED MATERIALS 2021年第26期33卷 2100746-2100746页

作者： Liu, Peixin Zhang, Tongyu Chen, Qinjun Li, Chao Chu, Yongchao Guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, Zheng Wang, Yu zhao, Zhenhao Luo, Yifan Li, xuwen Song, Haolin Su, Boyu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Key Lab Smart Drug Delivery Minist Educ State Key Lab Med Neurobiol Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Dept Pharmaceut Sch Pharm Shanghai 201203 Peoples R China

Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on beta-amyloid (A beta) targeting. However, such therapeutic strategies have limited clinical outcomes due to the chronic and irreversible impairment of the nervous system in the late stage of AD. Recently, inflammatory responses, manifested in oxidative stress and glial cell activation, have been reported as hallmarks in the early stages of AD. Based on the crosstalk between inflammatory response and brain cells, a reactive oxygen species (ROS)-responsive dendrimer-peptide conjugate (APBP) is devised to target the AD microenvironment and inhibit inflammatory responses at an early stage. With the modification of the targeting peptide, this nanoconjugate can efficiently deliver peptides to the infected regions and restore the antioxidant ability of neurons by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway. Moreover, this multi-target strategy exhibits a synergistic function of ROS scavenging, promoting A beta phagocytosis, and normalizing the glial cell phenotype. As a result, the nanoconjugate can reduce ROS level, decrease A beta burden, alleviate glial cell activation, and eventually enhance cognitive functions in APPswe/PSEN1dE9 model mice. These results indicate that APBP can be a promising candidate for the multi-target treatment of AD.

关键词： Alzheimer&apos s disease antioxidant ability glial cell activation inflammatory responses multi‐ target treatments synergistic function

来源：评论

学校读者我要写书评

暂无评论

An aramid nanofibers-based gel polymer electrolyte with high mechanical and heat endurance for all-solid-state NIR electrochromic devices

引用

SOLAR ENERGY MATERIALS AND SOLAR CELLS 2019年 200卷 109952-000页

作者： Yang, xuwen Cong, Shan Li, Juan Chen, Jian Jin, Feng zhao, Zhigang Univ Sci & Technol China Sch Nano Technol & Nano Bion Hefei 230026 Anhui Peoples R China Chinese Acad Sci Key Lab Nanodevices & Applicat Suzhou Inst Nanotech & Nanobion Suzhou 215123 Peoples R China Chinese Acad Sci Key Lab Multifunct Nanomat & Smart Syst Suzhou 215123 Peoples R China Chinese Acad Sci Div Nanomat Suzhou Inst Nanotech & Nanobion Nanchang 330200 Jiangxi Peoples R China

A new type of gel polymer electrolyte composed of free-standing aramid nanofibers was used to fabricate allsolid-state near-infrared (NIR) electrochromic devices for NIR sheltering applications. This new type of gel polymer electrolyte showed excellent mechanical and heat endurance compared with currently available gel polymer electrolytes. The good film-forming ability of the aramid nanofibers makes assembling the electrochromic devices more convenient. The as-fabricated device showed an optical modulation of about 40% at 980 nm and achieved a coloration efficiency of 79.5 cm(2)C(-1), values that are larger than those previously reported for other electrochromic devices with similar structures. It is expected that aramid nanofibers-LiCIO4-based electrolyte films with high mechanical and heat endurance will have potential applications in spacecraft thermal control, optical communication, and biomedical analysis.

关键词： Near-infrared Aramid nanofibers Gel polymer electrolyte Thermal stability Electrochromic devices

来源：评论

学校读者我要写书评

暂无评论

基于关键特征的船用柴油机机身工艺可靠性评价系统开发

引用

机床与液压 2021年第19期49卷 72-76,84页

作者：杨威斌景旭文肖志建周宏根赵晨华孙丽李国超江苏科技大学机械工程学院江苏镇江212003 广船国际有限公司广东广州510000 陕西柴油机重工有限公司陕西咸阳713100

船用柴油机机身加工工艺复杂,为实现对机身工艺可靠性的评估,开发基于关键特征的船用柴油机机身工艺可靠性评价系统。该系统实现了对机身加工工艺信息的管理、关键特征的筛选,进而实现了对船用柴油机机身工艺可靠性的评估,为快速评价加... 详细信息

船用柴油机机身加工工艺复杂,为实现对机身工艺可靠性的评估,开发基于关键特征的船用柴油机机身工艺可靠性评价系统。该系统实现了对机身加工工艺信息的管理、关键特征的筛选,进而实现了对船用柴油机机身工艺可靠性的评估,为快速评价加工策略的优劣提供了可视化操作平台和决策支持。研究结果为机身实际生产加工提供了参考。

关键词：加工工艺工艺可靠性评价系统关键特征数据库

来源：评论

学校读者我要写书评

暂无评论

重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用对深Ⅱ度烧伤的影响

引用

中国美容整形外科杂志 2022年第7期33卷 413-416,434页

作者：李亮王旭文何丽彩李双蔺利剑赵龙刚李雯河北中石油中心医院整形手外烧伤科河北廊坊065000 廊坊永清康定精神病医院河北廊坊065600

目的观察重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用对深Ⅱ度烧伤患者的影响。方法选取2019年6月至2020年5月河北中石油中心医院整形手外烧伤科治疗的120例深Ⅱ度烧伤患者为研究对象,采用随机数字表法对患者分组:对照组1... 详细信息

目的观察重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用对深Ⅱ度烧伤患者的影响。方法选取2019年6月至2020年5月河北中石油中心医院整形手外烧伤科治疗的120例深Ⅱ度烧伤患者为研究对象,采用随机数字表法对患者分组:对照组1、对照组2、观察组,每组40例患者。对照组1采用削痂术联合重组人酸性成纤维细胞生长因子治疗,对照组2采用削痂术联合夫西地酸乳膏治疗,观察组采用削痂术联合重组人酸性成纤维细胞生长因子和夫西地酸乳膏治疗,3组患者均连续治疗至创面愈合。治疗前、治疗第20天测量白细胞介素-2(interleukin-2, IL-2)、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素-10(Interleukin-10, IL-10)、白细胞介素-6(interleukin-6, IL-6)、血管内皮生长因子(vascular endothelial growth factor, VEGF)、表皮细胞生长因子(epidermal cell growth factor, EGF)、金属蛋白酶组织抑制因子1(tissue inhibitor of metalloproteinase 1, TIMP-1)、转化生长因子β1(transforming growth factor β1, TGF-β1)水平,观察患者创面愈合时间,采用温哥华瘢痕量表(vancouver scar scale, VSS)评价3组患者瘢痕增生程度,记录患者不良反应情况。结果观察组TNF-α、IL-6水平低于对照组1和对照组2(P<0.05),观察组IL-2、IL-10水平高于对照组1和对照组2(P<0.05),观察组VEGF、EGF、TIMP-1、TGF-β1水平高于对照组1和对照组2(P<0.05),治疗第10、15、20天,3组创面愈合率升高(P<0.05),观察组创面愈合率高于对照组1和对照组2(P<0.05),观察组创面愈合平均时间低于对照组1和对照组2(P<0.05),观察组瘢痕血管分布、颜色、厚度和柔软度评分低于对照组1和对照组2(P<0.05),3组均无明显不良反应发生。结论重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用治疗深Ⅱ度烧伤患者,可降低促炎因子TNF-α、IL-6水平,提升抑炎因子IL-2、IL-10水平,抑制炎症,提升VEGF、EGF、TIMP-1、TGF-β1水平,提升创面愈合率,降低瘢痕增生,安全性较高。

关键词：重组人酸性成纤维细胞生长因子夫西地酸乳膏深Ⅱ度烧伤创面愈合瘢痕增生

来源：评论

学校读者我要写书评

暂无评论

糯玉米自交系籽粒淀粉理化特性的相关和聚类分析

引用

扬州大学学报（农业与生命科学版） 2021年第3期42卷 97-103页

作者：徐广海张成冉孙鹏赵延明江绪文孙晴晴张海艳青岛农业大学农学院/山东省旱作农业重点实验室山东青岛266109

以54个糯玉米自交系为材料,对其籽粒淀粉物质组成和理化特性进行相关和聚类分析。结果表明:供试材料淀粉理化特性在自交系间差异显著,淀粉理化特性与淀粉物质组成含量密切相关。淀粉糊化特性参数之间显著相关。蛋白质含量、脂肪含量、... 详细信息

以54个糯玉米自交系为材料,对其籽粒淀粉物质组成和理化特性进行相关和聚类分析。结果表明:供试材料淀粉理化特性在自交系间差异显著,淀粉理化特性与淀粉物质组成含量密切相关。淀粉糊化特性参数之间显著相关。蛋白质含量、脂肪含量、直链淀粉含量与膨胀势、峰值黏度、低谷黏度、崩解值、最终黏度呈显著负相关,与蓝值(蛋白质含量除外)、糊化温度呈显著正相关;直链淀粉含量与碘结合力呈极显著正相关,与回复值呈极显著负相关。根据糊化特性可将54个糯玉米自交系聚为3类,3类自交系的个数分别为29、17、8。各类之间的差异主要反映为其黏度值的大小,第Ⅰ类黏度值大,类内变异系数小;第Ⅲ类黏度值小,类内变异系数大;第Ⅱ类介于两者之间。因此,类群Ⅰ中的自交系材料具有黏度高、易糊化等优良特性且表现稳定,可作为骨干亲本用于糯玉米淀粉品质的改良。

关键词：糯玉米淀粉理化特性相关分析聚类分析

来源：评论

学校读者我要写书评

暂无评论

基于模糊PID控制的船用胎架高度联控方法研究

引用

江苏科技大学学报（自然科学版） 2021年第1期35卷 58-65页

作者：刘金锋王镇景旭文唐明明曹旭武董建伟赵晨华江苏科技大学机械工程学院镇江212100 陕西柴油机重工有限公司兴平713100

胎架作为船舶分段建造变形控制的重要工装,但不具有联合调控与自适应控制能力,无法快速响应分段建造质量问题,为此本文提出基于模糊PID控制的船用胎架高度联控方法.首先,基于船舶分段拟合曲面建立胎架高度补偿模型,为胎架的自适应调控... 详细信息

胎架作为船舶分段建造变形控制的重要工装,但不具有联合调控与自适应控制能力,无法快速响应分段建造质量问题,为此本文提出基于模糊PID控制的船用胎架高度联控方法.首先,基于船舶分段拟合曲面建立胎架高度补偿模型,为胎架的自适应调控提供依据;其次,基于分段变形范围和受压载荷构建胎架间关联机制,达到胎架系统的动态联调;然后,利用模糊PID控制算法实现胎架高度的自适应调控,达到抑制分段外板变形的目的;最后,通过智能胎架系统对本方法进行验证分析,并与常规PID对比分析,表明本文方法具有较好的稳定性.

关键词：船舶分段建造智能胎架高度调控模糊PID

来源：评论

学校读者我要写书评

暂无评论

Enantioselective Reductive (Hetero)Arylation of CyclicN-Sulfonyl Imines by Cobalt Catalysis

引用

Angewandte Chemie 2023年第19期135卷

作者： Jieshuai Xiao Prof. Dr. Minyan Wang xuwen Yin Shuo Yang Pei Gu Xueli Lv Dr. Yue zhao Prof. Dr. Zhuangzhi Shi State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center (ChemBIC) School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China College of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225002 China School of Chemistry and Chemical Engineering Henan Normal University Xinxiang Henan 453007 China

Transition-metal-catalyzed enantioselective addition of aryl organometallic reagents to imines has emerged as one of the most powerful tools for the formation of optically active diarylmethylamines. Here, we report the first asymmetric reductive (hetero)arylations of imines using aryl and heteroaryl halides enabled by a chiral cobalt-bisphosphine catalyst. This approach shows good functional group compatibility and complements the reported strategy without use of organometallic reagents. Mechanistic investigations supported that aryl-cobalt, instead of an arylzinc reagent, was formed in situ in this reductive aryl-addition event.

关键词： Addition Arylation Cobalt Enantioselectivity Imines

来源：评论

学校读者我要写书评

暂无评论

A Dopant Replacement-Driven Molten Salt Method toward the Synthesis of Sub-5-nm-Sized Ultrathin Nanowires

引用

SMALL 2020年第23期16卷 2001098-2001098页

作者： Mao, Yihua Yang, xuwen Gong, Wenbin Zhang, Jing Pan, Ting Sun, Hongzhao Chen, Zhigang Wang, Zhen Zhu, Junfa Hu, Jun Cong, Shan Geng, Fengxia zhao, Zhigang Chinese Acad Sci Key Lab Nanodevices & Applicat Suzhou Inst Nanotech & Nanobion Suzhou 215123 Peoples R China Xuzhou Univ Technol Sch Phys & Energy Xuzhou 221018 Jiangsu Peoples R China Univ Sci & Technol China Natl Synchrotron Radiat Lab Hefei 230029 Peoples R China Chinese Acad Sci Key Lab Multifunct Nanomat & Smart Syst Suzhou 215123 Peoples R China Soochow Univ Coll Energy Suzhou 215123 Peoples R China Chinese Acad Sci Suzhou Inst Nanotech & Nanobion Div Nanomat Nanchang 330200 Jiangxi Peoples R China

The high-temperature molten-salt method is an important inorganic synthetic route to a wide variety of morphological phenotypes. However, its utility is limited by the fact that it is typically incapable of producing ultrathin (<5 nm diameter) nanowires, which have a crucial role in novel nanotechnology applications. Herein, a rapid molten salt-based synthesis of sub-5-nm-sized nanowires of hexagonal tungsten oxide (h-WO3) that is critically dependent on a substantial proportion of molybdenum (Mo) dopant is described. This dopant-driven morphological transition in tungsten oxide (WO3) may be attributable to the collapse of layered structure, followed by nanocluster aggregation, coalescence, and recrystallization to form ultrathin nanowires. Interestingly, due to the structural properties of h-WO3, the thus-formed ultrathin nanowires are demonstrated to be excellent photocatalysts for the production of ammonia (NH3) from nitrogen (N-2) and water. The ultrathin nanowires exhibit a high photocatalytic NH3-production activity with a rate of 370 mu mol g(-1) h(-1) and an apparent quantum efficiency of 0.84% at 420 nm, which is more than twice that obtained from the best-performing Mo-doped W18O49 nanowire catalysts. It is envisaged that the dopant replacement-driven synthetic protocol will allow for rapid access to a series of ultrathin nanostructures with intriguing properties and increase potential applications.

关键词： dopant replacement hexagonal structures molten-salt synthesis tungsten oxide ultrathin nanostructures

来源：评论

学校读者我要写书评

暂无评论

虎杖对水质和微生物群落结构及功能的影响

引用

环境科学与技术 2020年第5期43卷 25-32页

作者：陈家长赵志祥施羽露史磊磊郑尧邴旭文中国水产科学研究院淡水渔业研究中心农业部长江下游渔业生态环境监测中心农业部水产品质量安全环境因子风险评估实验室(无锡)江苏无锡214081 南京农业大学无锡渔业学院江苏无锡214081

为研究虎杖种植后池塘水质变化和水体微生物群落碳源利用能力,该研究于室外构建了吉富罗非鱼养殖池塘5%虎杖生态浮床,2017年6-9月持续测定水质,利用Biolog技术分析池塘水体微生物群落结构及功能特征。结果表明6-7月生长期间虎杖种植能... 详细信息

为研究虎杖种植后池塘水质变化和水体微生物群落碳源利用能力,该研究于室外构建了吉富罗非鱼养殖池塘5%虎杖生态浮床,2017年6-9月持续测定水质,利用Biolog技术分析池塘水体微生物群落结构及功能特征。结果表明6-7月生长期间虎杖种植能有效削减池塘水体中TN、TP、Chl.a浓度,在温度较高的8、9月虎杖种植塘TP显著降低(P<0.05);7-9月虎杖种植塘水体微生物AWCD值显著增加(P<0.05),多样性McIntosh和Richness(除9月)指数均显著提高(P<0.05),且水体微生物对聚合糖类、氨基酸类、醇类的代谢能力显著提高(P<0.05)。在吉富罗非鱼养殖池塘种植虎杖,可在改善水质的基础上提高水体微生物群落多样性指数及对碳源的利用能力。

关键词：罗非鱼虎杖浮床微生物群落多样性碳源利用

来源：评论

学校读者我要写书评

暂无评论

Parasitic modes suppression in CW cold tests of 1.3 GHz 9-cell high Q cavities at IHEP

arXiv

引用

arXiv 2021年

作者： Mi, Zhenghui He, Feisi Pan, Weimin Sha, Peng Zhai, Jiyuan Dai, xuwen Jin, Song Zhang, Zhanjun Dong, Chao Liu, Baiqi zhao, Hui Ge, Rui zhao, Jianbing Mu, Zhihui Du, Lei Sun, Liangrui Zhang, Liang Yang, Conglai Zheng, Xiaobing Lin, Haiying Wang, Guangwei He, Xiangcong Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Key Laboratory of Particle Acceleration Physics & Technology Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Center for Superconducting RF and Cryogenics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China

The CW RF test of 1.3 GHz 9-cell cavity in liquid helium bath at 2 K is a very important key point in the cavity procurement. Some problems can be found through the test, according which to optimized and improve the process of cavity. Recently, Medium temperature (mid-T) furnace bake of 1.3 GHz 9-cell cavities have been carried out at IHEP. Through the proceed of mid-T bake, the quality factor of cavity has been greatly improved. While the excitation of the parasitic modes in the high Q cavities CW cold test has been encountered, which implies an error source for the cavity gradient and quality factor determination. In order to ensure the testing accuracy of superconducting cavity, we have improved the testing system. Finally, the parasitic mode is completely suppressed and the CW RF cold test of high Q cavity is guaranteed. © 2021, CC BY.

关键词： Superfluid helium

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：