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Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade

ISCIENCE 2020年第9期23卷 101446页

作者： Qiu, Yan Yang, Yuanyuan Wei, Yuda Liu, Xiaojian Feng, Zhuanghui Zeng, xuwen Chen, Yanhao Liu, Yan zhao, Yongxu Chen, Lanlan Luo, Lijun Ding, Qiurong Univ Chinese Acad Sci Chinese Acad Sci Shanghai Inst Nutr & Hlth Shanghai Inst Biol SciCAS Key Lab Nutr Metab & F Shanghai 200031 Peoples R China Tongji Univ Affiliated Stomatol Hosp 399 Yanchang Rd Shanghai 200072 Peoples R China Chinese Acad Sci Inst Stem Cell & Regenerat Beijing 100101 Peoples R China

Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity. Here we reported that, glyburide, one of the FDA-approved drugs currently used to treat type 2 diabetes, can significantly enhance UCP1 expression in both brown and white adipocytes. Glyburide-fed mice exhibited a clear resistance to high-fat diet-induced obesity, reduced blood triglyceride level, and increased UCP1 expression in brown adipose tissue. Moreover, in situ injection of glyburide to inguinal white adipose tissue remarkably enhanced UCP1 expression and increased thermogenesis. Further mechanistic studies indicated that the glyburide effect in UCP1 expression in adipocyteswas KATP channel independent but may involve the regulation of the Ca2+-Calcineurin-NFAT signal pathway. Overall, our findings revealed the significant effects of glyburide in regulating UCP1 expression and thermogenesis in adipocytes, which can be potentially repurposed to treat obesity.

关键词： Human Metabolism Molecular Biology

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Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke

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ADVANCED SCIENCE 2021年第20期8卷 e2101526页

作者： Li, Chao zhao, Zhenhao Luo, Yifan Ning, Tingting Liu, Peixin Chen, Qinjun Chu, Yongchao Guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, Zheng Wang, Yu Su, Boyu You, Haoyu Zhang, Tongyu Li, xuwen Song, Haolin Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept PharmaceutState Key Lab Med Neurobiol Key Lab Smart Drug DeliveryMinist EducInst Brai Shanghai 201203 Peoples R China Fudan Univ Sch Pharm Inst Brain Sci MOE Frontiers Ctr Brain SciDept Pharmaceut Shanghai 201203 Peoples R China

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective effects. Herein, a macrophage-disguised honeycomb manganese dioxide (MnO2) nanosphere loaded with fingolimod (FTY) is developed to salvage the ischemic penumbra. In particular, the biomimetic nanoparticles can accumulate actively in the damaged brain via macrophage-membrane protein-mediated recognition with cell adhesion molecules that are overexpressed on the damaged vascular endothelium. MnO2 nanosphere can consume excess hydrogen peroxide (H2O2) and convert it into desiderated oxygen (O-2), and can be decomposed in acidic lysosome for cargo release, so as to reduce oxidative stress and promote the transition of M1 microglia to M2 type, eventually reversing the proinflammatory microenvironment and reinforcing the survival of damaged neuron. This biomimetic nanomedicine raises new strategy for multitargeted combined treatment of ischemic stroke.

关键词： biomimetic nanoparticles inflammatory microenvironment microglia polarization neuroprotection O-2 generation reperfusion injury reactive oxygen species (ROS) consumption

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Code Conversion Method on Process-in-Memory Platform

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Journal of Physics: Conference Series 2020年第1期1670卷

作者： Jinhui Liu Chen zhao Fangzhou Du xuwen Liu Department of Computer Science and Technology Xidian University Xi'an Shaanxi 710126 China

Process-in-Memory (PIM) has become a favorable solution for data intensive applications with its advantages of placing processing units in or near memory, reducing the movement of data between memory and processing unit. However, most recent PIM platforms have relatively large limitations in terms of computing flexibility and types of computing, and programming is complicated, which cannot provide a unified programming framework. Therefore, it becomes a challenge to deploy the code to the hardware, which severely restricts the application development on the PIM platform. This paper presents a method of code conversion based on the PIM platform, which allows users to develop applications on the PIM platform with the high-level programming language, makes the PIM platform more accessible in the development of data intensive applications.

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High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

arXiv

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arXiv 2023年

作者： Zhai, Jiyuan Pan, Weimin He, Feisi Ge, Rui Mi, Zhenghui Sha, Peng Jin, Song Han, Ruixiong Wang, Qunyao Lin, Haiying Wang, Guangwei Li, Mei Sang, Minjing Sun, Liangrui Ye, Rui zhao, Tongxian Li, Shaopeng Zhu, Keyu Liu, Baiqi Wang, Xiaolong Yang, Xiangchen Bian, Xiaojuan Zhang, Xiangzhen Ma, Huizhou Dai, xuwen Zhang, Zhanjun Zhang, Liang zhao, Hui Guo, Runbin Mu, Zhihui Yang, Conglai Zheng, Xiaobing Dong, Chao Huang, Tongming Ma, Qiang Zheng, Hongjuan Liu, Ming Wang, Zihan Zhou, Wenzhong Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Key Laboratory of Particle Acceleration Physics & Technology Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Center for Superconducting RF and Cryogenics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China

World’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (RF) cavities treated by medium-temperature furnace baking (mid-T bake) was developed, assembled and tested at IHEP for the Dalian Advanced Light Source (DALS) and CEPC R&D. The 9-cell cavities in the cryomodule achieved an unprecedented highest average Q0 of 3.8 × 1010 at 16 MV/m and 3.6 × 1010 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total CW RF voltage greater than 191 MV, with an average cavity CW accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of CEPC, DALS and the other high repetition rate free electron laser facilities (LCLS-II, LCLS-II-HE, SHINE, S3FEL). There is evidence that the mid-T bake cavity may not require fast cool-down or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing. © 2023, CC BY.

关键词： Free electron lasers

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作物种业领域研究生课程思政教育探索与研究——以青岛农业大学《研究生Seminar》为例

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中国种业 2021年第6期 52-55页

作者：江绪文李贺勤赵延明张海艳张玉梅孙群王建华青岛农业大学青岛266109 中国农业大学北京100193

中国种业要做大做强,人才培养是关键,研究生阶段正处在学生的世界观、人生观、价值观形成关键时期,亟需开展思政教育。基于作物种业领域《研究生Seminar》课程教学思政必要性及可行性分析,结合课程教学特点,围绕新时代高教目标,从课程... 详细信息

中国种业要做大做强,人才培养是关键,研究生阶段正处在学生的世界观、人生观、价值观形成关键时期,亟需开展思政教育。基于作物种业领域《研究生Seminar》课程教学思政必要性及可行性分析,结合课程教学特点,围绕新时代高教目标,从课程内容、教学方法和手段、教学考核等方面探索了课程思政的有机融合,为作物种业领域研究生课程教学水平不断提升提出一些建设性策略。

关键词：作物种业研究生课程思政教育

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玉米果种皮对其种子萌发及生理特性的影响

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种子 2021年第9期40卷 40-47页

作者：刘京朱凯丽岳海旺李贺勤张海艳赵延明杨然兵尚书旗江绪文青岛农业大学玉米研究所山东青岛266109 河北省农林科学院旱作农业研究所河北衡水053000

以郑单958、先玉335、蠡玉16和迪卡007等4个玉米品种种子为材料,通过对果种皮特性、发芽能力、幼苗生长、种子化学成分、酶活性等进行测定,研究果种皮对种子萌发及生理特性的影响。结果表明,果种皮最大吸水量、覆胚果种皮(TCE)穿刺力和... 详细信息

以郑单958、先玉335、蠡玉16和迪卡007等4个玉米品种种子为材料,通过对果种皮特性、发芽能力、幼苗生长、种子化学成分、酶活性等进行测定,研究果种皮对种子萌发及生理特性的影响。结果表明,果种皮最大吸水量、覆胚果种皮(TCE)穿刺力和TCE厚度等3项指标在4个品种间均存在差异,其中郑单958的3项指标均最大,分别为1.02g·(50粒)^(-1)、1.81 N和53.33μm;移除TCE后,4个品种种子的发芽指数、芽(苗)长、主根长、芽(苗)鲜重、芽(苗)干重、根鲜重和根干重等7项指标与对照相比均明显上升。此外,25℃条件下萌发60 h, 4个品种种子胚根鞘破裂率均明显提高,且胚中部、胚根和胚根鞘组织内过氧化氢酶、过氧化物酶、超氧化物歧化酶的活性基本呈上升趋势;不同种子质量指标相关性分析表明,TCE穿刺力和TCE厚度之间呈极显著正相关,该2项指标与发芽势、平均发芽天数、种子总淀粉含量3项指标均呈正相关,但与芽(苗)长、主根长、芽(苗)鲜重、芽(苗)干重、根鲜重、根干重和种子粗脂肪含量等7项指标均呈负相关。研究表明,玉米果种皮特别是TCE相关生物力特性会影响种子萌发及生理特性,这可为进一步研究玉米种子萌发调控及高活力形成机理提供理论基础。

关键词：玉米种子萌发种子活力果种皮生物力

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Determination of common ginsenosides in Kang'ai injection by aqueous two-phase extraction with deep eutectic solvents and HPLC-UV/DAD

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MICROCHEMICAL JOURNAL 2018年 137卷 302-308页

作者： Li, Peng zhao, Pengyun Liu, Weijie Jiang, Yifu Wang, Wenjiao Bao, Longyue Jin, Yongri Li, xuwen Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

In this work, four kinds of deep eutectic solvents (DESs), composed of choline chloride (ChCl) and several alcohols, were synthesized and characterized by H-1 NMR and FT-IR spectra. Based on DES ( ChCl and 1,4-butanediol) and inorganic salt solution (dipotassium phosphate, K2HPO4), aqueous two-phase system (ATPS) coupled with high-performance liquid chromatography has been developed and applied. This method was used for the efficient extraction and determination of eight common ginsenosides (including ginsenoside Rg(1), Re, Rf, Rg(2), Rc, Rb-2 and Rd) in the traditional Chinese medicine injection named Kang'ai injection. To achieve optimum extraction performance, the experimental conditions were optimized, including type and amount of DES and salt, ultrasound time, temperature and pH value. In the dynamic linearity range, experimental results showed satisfactory recoveries of analytes ranging from 92.7-110.8% with the relative standard deviations (RSDs) ranging from 1.2-3.9%. It has been proved that DES-ATPS has great potential for determination of active ingredients in traditional Chinese medicine injection as well as samples in other analytical science field. (C) 2017 Elsevier B.V. All rights reserved.

关键词： Aqueous two-phase system Ginsenosides High-performance liquid chromatography Kang'ai injection

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三氟拉嗪与八肋游仆虫中心蛋白N端半分子的结合及对蛋白功能的影响

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高等学校化学学报 2019年第11期40卷 2257-2264页

作者：叶旭文张文龙王志军赵亚琴杨斌盛山西大学分子科学研究所化学生物学与分子工程教育部重点实验室

采用荧光光谱、圆二色光谱(CD)、等温滴定量热分析(ITC)、电泳及分子对接等分析技术,研究了三氟拉嗪(TFP)与八肋游仆虫中心蛋白N端半分子(apoN-EoCen)的结合,考察了TFP对apoN-EoCen性质的影响.结果表明,在室温下10 mmol/L Hepes缓冲溶液... 详细信息

采用荧光光谱、圆二色光谱(CD)、等温滴定量热分析(ITC)、电泳及分子对接等分析技术,研究了三氟拉嗪(TFP)与八肋游仆虫中心蛋白N端半分子(apoN-EoCen)的结合,考察了TFP对apoN-EoCen性质的影响.结果表明,在室温下10 mmol/L Hepes缓冲溶液(pH=7.4)中,TFP与apoN-EoCen以摩尔比1∶1结合于apoN-EoCen的第二个EF-手的E,F螺旋之间,条件结合常数约为10^3L/mol;TFP的结合导致蛋白质二级结构发生改变,α螺旋含量减小,Tb^3+敏化荧光强度降低83%,apoN-EoCen切割DNA的类核酸酶活性明显受到抑制;Tb^3+仍可占据复合物apoN-EoCen-TFP中蛋白质的2个金属离子结合位置,条件结合常数约为7.0×10^5L/mol,TFP的结合不抑制金属离子诱导的蛋白质聚集.

关键词： apoN-EoCen 三氟拉嗪 Tb^3+离子光谱分析

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早熟棉花品种——金垦1565

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中国棉花 2021年第11期48卷 27-28,F0003页

作者：孔宪辉余渝王旭文司爱君刘文豪赵福相刘丽新疆农垦科学院棉花研究所/农业农村部西北内陆区棉花生物学与遗传育种重点实验室新疆石河子832000

金垦1565于2021年8月通过新疆维吾尔自治区农作物品种审定委员会审定,在北疆早熟棉区的生育期为123 d左右,株型紧凑,植株呈筒形,Ⅰ~Ⅱ式果枝,吐絮畅,含絮好,易摘拾;高抗枯萎病,耐黄萎病。2016―2017年新疆早熟棉组区域试验中,金垦1565... 详细信息

金垦1565于2021年8月通过新疆维吾尔自治区农作物品种审定委员会审定,在北疆早熟棉区的生育期为123 d左右,株型紧凑,植株呈筒形,Ⅰ~Ⅱ式果枝,吐絮畅,含絮好,易摘拾;高抗枯萎病,耐黄萎病。2016―2017年新疆早熟棉组区域试验中,金垦1565平均籽棉、皮棉产量分别为4778.3 kg·hm^(-2)、1954.5 kg·hm^(-2)。本文简要介绍了金垦1565的选育过程、特征特性、产量表现、纤维品质、抗病性及栽培技术。

关键词：早熟棉花品种金垦1565 高产优质抗病性纤维品质栽培技术

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Correction: Mechanistic investigations into synergistically enhanced radiative-charge-transfer in Au-Ag bimetallic nanoclusters

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Chemical communications (Cambridge, England) 2020年第48期56卷 6594页

作者： Jianbo Liu Rusong zhao Xia Wang xuwen Gao Guizheng Zou Qilu University of Technology (Shandong Academy of Sciences) Shandong Analysis and Test Center Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province Jinan 250353 China. wangxia20200323@*** and Shandong University School of Chemistry and Chemical Engineering Jinan 250100 China. zouguizheng@***. Qilu University of Technology (Shandong Academy of Sciences) Shandong Analysis and Test Center Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province Jinan 250353 China. wangxia20200323@***. Shandong University School of Chemistry and Chemical Engineering Jinan 250100 China. zouguizheng@***.

Correction for 'Mechanistic investigations into synergistically enhanced radiative-charge-transfer in Au-Ag bimetallic nanoclusters' by Jianbo Liu et al., Chem. Commun., 2020, 56, 5665-5668, DOI: 10.1039/D0CC0...

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