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中国农学通报 2018年第5期34卷 147-152页

作者：史磊磊范立民陈家长邴旭文赵志祥胡庚东吴伟南京农业大学无锡渔业学院江苏无锡214081 中国水产科学研究院淡水渔业研究中心/农业部长江下游渔业生态环境监测中心/农业部淡水鱼类遗传育种和养殖生物学重点开放实验室江苏无锡214081

旨在研究不同摄食状态罗非鱼养殖水体微生物群落功能多样性差异。利用Biolog技术对不同摄食状态下罗非鱼养殖水体微生物群落对六大类碳源利用情况及其微生物群落功能多样性与环境因子间的关系进行研究。结果显示:不同摄食状态罗非鱼养... 详细信息

旨在研究不同摄食状态罗非鱼养殖水体微生物群落功能多样性差异。利用Biolog技术对不同摄食状态下罗非鱼养殖水体微生物群落对六大类碳源利用情况及其微生物群落功能多样性与环境因子间的关系进行研究。结果显示:不同摄食状态罗非鱼养殖水体微生物对醇类和胺类的利用强度均存在显著性差异,对其他类碳源利用情况基本相同;RDA分析表明,NH_4^+-N、NO_2^--N、NO_3^--N是影响不同摄食状态罗非鱼养殖水体微生物群落功能多样性差异的主要因素。结果表明:不同摄食状态的罗非鱼养殖水体微生物群落功能多样性存在一定差异。

关键词：摄食状态微生物群落功能多样性 Biolog

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Gut microbiota analysis of juvenile genetically improved farmed tilapia (Oreochromis niloticus) by dietary supplementation of different resveratrol concentrations

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FISH & SHELLFISH IMMUNOLOGY 2018年 77卷 200-207页

作者： Zheng, Yao Wu, Wei Hu, Gengdong Qiu, Liping Meng, Shunlong Song, Chao Fan, Limin zhao, Zhixiang Bing, xuwen Chen, Jiazhang Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr 9 Shanshui East Rd Wuxi 214081 Jiangsu Peoples R China Minist Agr Fishery Ecoevironm Monitoring Ctr Lower Reaches Y Wuxi 214081 Jiangsu Peoples R China Minist Agr Lab Qual & Safety Risk Assessment Aquat Prod Envi Wuxi 214081 Jiangsu Peoples R China Nanjing Agr Univ Wuxi Fishery Coll Wuxi 214081 Jiangsu Peoples R China Minist Agr Key Lab Control Qual & Safety Aquat Prod Wuxi Jiangsu Peoples R China

The genetically improved farmed tilapia (GIFT, Oreochromis niloticus) is cultured widely for production of freshwater fish in China, while streptococcosis, likely related to pathogenic infections, occurs frequently in juvenile, mother, and operated GIFT. The gut microbiota plays an important role in nutrient digestibility in animals, and resveratrol (RES) has been used in feed for different freshwater fish species. Therefore, understanding changes in the tilapia gut microbiota across different concentrations of dietary RES supplementation is extremely important. The gut microbiota population in tilapia at 45 d after supplementation with different concentrations (0, 0.025, 0.05, 0.1 g/kg) of dietary RES was assessed by 16S rDNA gene sequencing. A total of 5445 operational taxonomic units were identified from all samples, and 14 phyla and 81 families were identified from all fecal samples. The bacteria of the phylum Firmicutes were significantly enriched in the 0.025 g/kg RES group when compared with the controls. Proteobacteria, Firmicutes and Cyanobacteria were the most dominant three phyla in all samples. With the increasing concentrations, the proportion of beneficial microbial taxa (Acetobacteraceae and Methylobacteriaceae) increased, whereas the proportion of harmful microbial taxa decreased, eg. Streptococcaceae except for 0.1 g/kg RES groups. RES did not affect the richness and diversity in tilapia gut microbiota. These findings provide information on the diversity and differences in GIFT gut microbiota database, and may contribute to developing strategies for management of diseases and long-term sustainability of O. niloticus culture.

关键词： Resveratrol GIFT Gut microbiota 16S rDNA Disease defense

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Medium-temperature furnace bake of superconducting radio-frequency cavities at ihep

arXiv

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arXiv 2020年

作者： He, Feisi Pan, Weimin Sha, Peng Zhai, Jiyuan Mi, Zhenghui Dai, xuwen Jin, Song Zhang, Zhanjun Dong, Chao Liu, Baiqi zhao, Hui Ge, Rui zhao, Jianbing Mu, Zhihui Du, Lei Sun, Liangrui Zhang, Liang Yang, Conglai Zheng, Xiaobing Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Key Laboratory of Particle Acceleration Physics & Technology Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Center for Superconducting RF and Cryogenics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China

Recently, heat treatment between 250 °C and 500 °C has been attempted to improve quality factor (Q) of superconducting radio-frequency cavities at FNAL and KEK. Experiments of such medium temperature (mid-T) bake with furnaces have also been carried out at IHEP. Firstly, over ten 1.3 GHz 1-cell cavities were treated with different temperatures at a small furnace, which all demonstrated improvement of Q and anti-Q-slope phenomenon. The average quality factor has reached 3.6×1010 when the gradient is 16 MV/m，while the highest Q is 4.9×1010@16MV/m;the maximum gradients of these 1-cell cavities are between 25.1 and 36.9 MV/m. Then, the recipe of mid-T furnace bake at 300 °C for 3 hours has been applied to six 1.3 GHz 9-cell cavities at a new big furnace, which have all shown higher Q and anti-Q-slope at medium field (16~24 MV/m). The average quality factor has reached 3.8×1010 when the gradient is 16 MV/m. The maximum gradients of the 9-cell cavities are between 22.7 and 26.5 MV/m. © 2020, CC0.

关键词： Radio waves

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Analysis of heart rate variation and foetal quiet sleep cycle correlation for normal and suspicious foetuses

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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 2018年第4期32卷 988-992页

作者： Li, Guangfei Zhang, Song Yang, Lin Li, Shufang Wang, Yan zhao, Yangyu Yang, Yimin Hao, Dongmei Li, xuwen Zhang, Lei Xu, Mingzhou Beijing Univ Technol Coll Life Sci & Bioengn Beijing Peoples R China Peking Univ Hosp 3 Obstet & Gynecol Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China Beijing Aerosp Changfeng Co Ltd Beijing Peoples R China

Cardiotocography (CTG) is the basic method of monitoring foetal condition in the perinatal period. However, due to the limited insight into the CTG generation mechanism, some CTG recordings can be mistreated as a predictor of neonatal asphyxia, leading to a wrong assessment of the foetal status and improper obstetric intervention. Therefore, in case of suspicious CTG indications, a reliable verification of the true foetal status is vital for reducing the clinical diagnosis false-positive rate and avoiding the unnecessary obstetrician intervention. The paper presents the results obtained for 44 foetuses on the shares of three heart rate variation (HRV) ranges and quiet sleep cycles. This approach uses the parameters of the HRV range shares and quiet sleep cycles to analyse different types of foetuses. The results obtained show that most parameters reveal significant differences between normal and suspicious groups. This is quite lucrative for defining a set of coefficients, whose incorporation into a classifier will improve the accuracy of distinguishing the normal foetuses from suspicious ones.

关键词： Foetal heart rate foetal quiet sleep HRV range share

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Improved Local Maximal Occurrence Feature Representation for Person Re-Identification

Improved Local Maximal Occurrence Feature Representation for...

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IEEE International Conference on Software Engineering and Service Sciences (ICSESS)

作者： Yuanxin Zhu zhao Yang xuwen Yao Sai zhao Shaohu Peng School of Mechanical and Electric Engineering Guangzhou University Guangzhou Guangdong P.R. China

ISBN: (纸本)9781538665664;9781538665657

Person re-identification is a technique to automatically search the same people in different camera views. It is a challenging task because of the huge variations caused by different illuminations and views in images. There is an effective method tackling the problem, which learns a useful feature representation for the pedestrian images. In recent research, a feature representation named Local Maximal Occurrence (LOMO)achieves outstanding performance, but LOMO has a disadvantage that its robustness to illumination is not excellent. In this paper, we propose an improved LOMO representation to further reduce the impact of light. The improved LOMO feature combines Color Name feature with LOMO, because Color Name feature has strong robustness to illumination. However, Color Narne feature has the weakness that it loses graphical details. Therefore, the feature is unsuitable for traditional pooling method. To overcome the disadvantage, a specific pooling method called global Gaussian pooling for Color Name feature is designed, which is based on Gaussian distribution and can weigh the different regions of an image. The important regions gain more attention in matching images. The experimental results on two public available datasets demonstrate the effectiveness of our proposed approach.

关键词： Image color analysis Lighting Histograms Feature extraction Measurement Gaussian distribution Training

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Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

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JOURNAL OF MEDICINAL CHEMISTRY 2018年第19期61卷 8613-8624页

作者： Pang, Peichen Chen, Jiean Li, Xijian Li, Miyang Yu, Huidong zhao, Jean J. Ni, Jing Wang, xuwen Sun, Huiyong Tian, Sheng Zhu, Feng Liu, Feng Huang, Yong Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Peking Univ State Key Lab Chem Oncogen Key Lab Chem Genom Shenzhen Grad Sch Shenzhen 518055 Guangdong Peoples R China Rongene Pharma Co Ltd Guangzhou 510663 Guandong Peoples R China Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Dept Biol Chem & Mol Pharmacol Boston MA 02215 USA Soochow Univ Coll Pharmaceut Sci Suzhou 215123 Jiangsu Peoples R China

Camptothecin (CPT) has been shown to block disassembly of the topoisomerase I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability, and severe toxicity of CPTs have limited their clinical applications. Herein, we report the design and synthesis of H2O-soluble and orally bioavailable hexacyclic CPT derivatives. By analysis of a virtual chemical library and cytotoxicity screening in vitro, 9 and 11 were identified as potential prodrugs and chosen for further characterization in vivo. Both compounds exhibited remarkable anticancer and anti-inflammation efficacies in animals and improved drug-like profiles.

关键词： Mixtures Rodent models Solubility Genetics Toxicity

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Effect of stamping deformation on microstructure and properties evolution of an Al-Mg-Si-Cu alloy for automotive panels

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JOURNAL OF MATERIALS SCIENCE 2017年第10期52卷 5569-5581页

作者： Yang, Mingjun Liu, Siliang He, xuwen Wang, Jiong Kong, Yi zhao, Pizhi Li, Kai Du, Yong Cent S Univ State Key Lab Powder Met Changsha 410083 Peoples R China Suzhou Res Inst Nonferrous Met Dept Fabricat Proc & Technol Aluminum Alloys Suzhou 215026 Peoples R China CHINALCO Res Inst Sci & Technol Dept Fabricat Proc & Technol Aluminum Alloys Beijing 100082 Peoples R China Cent S Univ Inst Mat Microstruct Changsha 410083 Peoples R China

The effect of 5 % tensile deformation, which simulates the stamping process of Al-Mg-Si-Cu automotive outer panels, on the microstructural evolution during age strengthening, has been investigated. In addition, its benefit on key mechanical properties including hardness, yield strength, ductility, and corrosion resistance has been linked to the microstructural features. It was found that the aging precipitation sequence, SSSS -> clusters and G.P. zones -> beta aEuro(3) -> beta' + Q' -> Q, was not influenced by the dislocations introduced through the stamping deformation prior to aging. On the other hand, stamping deformation could promote the formation of precipitates and refine the precipitates because of the enhanced heterogeneous nucleation and the accelerated precipitation kinetics, leading to superior strength of the alloy at the early stage. Meanwhile, the larger amount of Cu incorporated into nanoprecipitates leads to better intergranular corrosion resistance of the stamped alloy compared with the unstamped one. Due to the reduction in free Si amount at grain boundaries, the formation of fine subgrain structures and the increase of dislocation accumulation, the ductility of the stamped alloy was increased.

关键词： ALUMINUM-magnesium-silicon alloys DEFORMATIONS (Mechanics) METAL microstructure TENSILE strength DISLOCATIONS in crystals

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Effects of dietary resveratrol supplementation on hepatic and serum pro-/anti-inflammatory activity in juvenile GIFT tilapia, Oreochromis niloticus

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DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2017年 73卷 220-228页

作者： Zheng, Yao zhao, Zhixiang Wu, Wei Song, Chao Meng, Shunlong Fan, Limin Bing, xuwen Chen, Jiazhang Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Minist Agr Sci Observing & Expt Stn Fishery Resources & Envi Wuxi 214081 Jiangsu Peoples R China Nanjing Agr Univ Wuxi Fishery Coll Wuxi 214081 Jiangsu Peoples R China

Dietary resveratrol (RES) supplementation may have some pharmacological effects including anti inflammation. Previous studies have shown that Kupffer cell activation and apoptosis induction increases the transcription of pro- and anti-inflammatory cytokines. The main purpose of this study was to investigate the pro- and anti-inflammatory activities of 0.1 or 0.3 g/kg RES as a dietary supplement in juvenile freshwater tilapia (Oreochromis niloticus). The results showed that hepatic and serum immunoglobulin M (IgM) significantly decreased and increased while anti- and pro-inflammatory cytokines significantly increased and decreased, respectively, in the RES-treated groups. The expression of serum and hepatic IgM and anti-inflammatory cytokines [interleukin (IL)-10] and its inverse inhibitor interferon (IFN)-gamma significantly increased while pro-inflammatory cytokine transcription significantly decreased. Hematoxylin-eosin staining and scanning electron microscopy revealed intestinal deformation, irregular goblet cells, and apoptotic cells in the 03 g/kg RES groups. RES (0.3 g/kg) also induced necrosis, apoptosis, reduction in Kupffer cell number, compressed sinusoids, and deformation of epidermal cells in the liver of the treated groups. In conclusion, the results of the present study show that high doses of RES were absorbed in the gut and then damaged the liver and intestinal tissue. (C) 2017 Published by Elsevier Ltd.

关键词： Resveratrol Inflammatory cytokine Gene expression Apoptosis GIFT tilapia

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Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines

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ORGANIC LETTERS 2017年第1期19卷 58-61页

作者： Ren, xuwen Li, Guangxun Huang, Jin Wang, Weidong Zhang, Yongpo Xing, Guomin Gao, Chunyan zhao, Gang zhao, Jinzhong Tang, Zhuo Shanxi Agr Univ Taigu Coll Art & Sci Jinzhong 030800 Shanxi Peoples R China Chinese Acad Sci Chengdu Inst Biol Nat Prod Res Ctr Chengdu 610041 Sichuan Peoples R China Sichuan Univ Coll Chem Engn Chengdu 610041 Sichuan Peoples R China

A novel Povarov-type reaction for straightforward synthesis of novel spiro bi-tetrahydroquinolines with readily available 1,2-DHQs (1,2-dihydroquinolines) and aromatic imines was developed. The reaction could be selectively stopped at the first stage under a Bronsted acid catalyst to afford the corresponding functionalized 1,2-DHQs conveniently.

关键词： QUINOLINE synthesis CHEMICAL reactions CHEMICAL precursors DIENOPHILES SPIRO compounds synthesis

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宁夏地区45例新型冠状病毒肺炎各型临床分析及治疗要点

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宁夏医科大学学报 2020年第3期42卷 297-300页

作者：田军赵晗姚辰飞刘超顾春娥高建宁叶巧玲杨旭文周攀胡锐张伟徐麟赵桂霞宁夏第四人民医院银川750000

目的了解宁夏新型冠状病毒肺炎(COVID-19)的临床分型及治疗要点。方法回顾宁夏第四人民医院2020年1月24日至2020年2月8日45例COVID-19患者的临床症状、实验室检查及影像学资料,总结分析COVID-19各型的特点及治疗方案。结果COVID-19分为... 详细信息

目的了解宁夏新型冠状病毒肺炎(COVID-19)的临床分型及治疗要点。方法回顾宁夏第四人民医院2020年1月24日至2020年2月8日45例COVID-19患者的临床症状、实验室检查及影像学资料,总结分析COVID-19各型的特点及治疗方案。结果COVID-19分为轻型、普通型、重型、危重型。各型临床症状、实验室检查、胸部CT表现有各自特点。轻型患者仅表现为低热、轻微乏力等,无肺炎表现;普通病例的病程约为2周;重症病例在病程的第1周病情较重,通过治疗在第2周症状及肺部病变有所减轻。儿童病例症状相对较轻。治疗以中西医结合抗病毒方案为主。结论宁夏地区45例COVID-19患者的临床分型、治疗周期与病情不同,中西医结合治疗有效。

关键词：新型冠状病毒肺炎临床症状实验室检查胸部CT

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