In NSC KIPT, Kharkov, Ukraine a neutron source based on a subcritical assembly driven by a 100MeV/100kW electron linear accelerator will be constructed. This neutron source is an USA (ANL)- Ukraine (KIPT) Joint projec...
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ISBN:
(纸本)9783954501229
In NSC KIPT, Kharkov, Ukraine a neutron source based on a subcritical assembly driven by a 100MeV/100kW electron linear accelerator will be constructed. This neutron source is an USA (ANL)- Ukraine (KIPT) Joint project, and its accelerator will be designed and constructed by Institute of High Energy Physics (IHEP), China. The design and construction of such an accelerator with high average beam current and low beam power losses is a technical challenging task. In the paper, the main accelerator features and current status are under discussion.
The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well...
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The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well as establishing an immunosuppressive tumor microenvironment (TME). However, forcibly destroying the stroma barrier would break the balance of delicate signal transduction and dependence between tumor cells and matrix components. Uncontrollable growth and metastasis would occur, making PDAC more difficult to control. Hence, we design and construct an aptamer-decorated hypoxia-responsive nanoparticle s(DGL)(n)@Apt co-loading gemcitabine monophosphate and STAT3 inhibitor HJC0152. This nanoparticle can reverse its surficial charge in the TME, and reduce the size triggered by hypoxia. The released ultra-small DGL particles loading gemcitabine monophosphate exhibit excellent deep-tumor penetration, chemotherapy drugs endocytosis promotion, and autophagy induction ability. Meanwhile, HJC0152 inhibits overactivated STAT3 in both tumor cells and tumor stroma, softens the stroma barrier, and reeducates the TME into an immune-activated state. This smart code -livery strategy provides an inspiring opportunity in PDAC treatment.
Recently, heat treatment between 250 °C and 500 °C has been attempted to improve quality factor (Q) of superconducting radio-frequency cavities at FNAL and KEK. Experiments of such medium temperature (mid-T)...
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