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新生儿坏死性小肠结肠炎外周血和组织RIPK1、RIPK3的表达及其临床意义

江苏医药 2023年第5期49卷 491-495页

作者：王金虎杨福江赵绪稳杜晓斌戴春娟胡博天津市儿童医院新生儿外科 300074

目的分析新生儿坏死性小肠结肠炎(NEC)外周血和组织受体相互作用蛋白激酶1(RIPK1)和RIPK3表达及其临床意义。方法选取149例NEC患儿(NEC组,Ⅰ期107例,Ⅱ+Ⅲ期42例)和同期诊治80例非NEC患儿(对照组),应用实时荧光定量PCR检测患儿外周血单... 详细信息

目的分析新生儿坏死性小肠结肠炎(NEC)外周血和组织受体相互作用蛋白激酶1(RIPK1)和RIPK3表达及其临床意义。方法选取149例NEC患儿(NEC组,Ⅰ期107例,Ⅱ+Ⅲ期42例)和同期诊治80例非NEC患儿(对照组),应用实时荧光定量PCR检测患儿外周血单个核细胞中RIPK1和RIPK3mRNA的表达。选取5例接受肠造瘘术治疗的NEC患儿的NEC组织标本,同一患儿二期关瘘时部分正常回肠组织标本为对照,Western blot检测两组组织RIPK1和RIPK3蛋白表达。比较NEC患儿外周血RIPK1和RIPK3mRNA表达与疾病严重程度的关系。多因素logistic回归分析重度NEC发生的影响因素。ROC曲线分析单独或联合检测外周血RIPK1和RIPK3mRNA表达对重度NEC的诊断效能。结果NEC组外周血RIPK1和RIPK3mRNA表达高于对照组(P<0.05)。NEC组织RIPK1和RIPK3蛋白表达高于正常回肠组织(P<0.05)。重度NEC组气腹征、多器官功能障碍综合征(MODS)发生率和外周血RIPK1、RIPK3mRNA表达高于轻度NEC组(P<0.05)。多因素logistic回归分析显示,合并MODS和气腹征、外周血RIPK1和RIPK3mRNA表达升高是重度NEC发生的独立危险因素(P<0.05)。外周血RIPK1和RIPK3 mRNA联合检测诊断重度NEC的AUC大于单独检测(P<0.05)。结论NEC患儿外周血RIPK1和RIPK3mRNA表达升高,是重度NEC发生的独立影响因素,两者联合检测对重度NEC具有较高的诊断价值。

关键词：新生儿坏死性小肠结肠炎受体相互作用蛋白激酶

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Explicit Solutions to the n-dimensional Semi-stationary Compressible Stokes Problem

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INTERNATIONAL JOURNAL OF THEORETICAL PHYSICS 2025年第2期64卷 1-11页

作者： Zhang, Lijun zhao, Qiong Huo, xuwen Khalique, Chaudry Masood Zhejiang Univ Sci & Technol Hangzhou 310023 Zhejiang Peoples R China Shandong Univ Sci & Technol Coll Math & Syst Sci Qingdao 266590 Shandong Peoples R China Zhejiang Scitech Univ Hangzhou Sch Comp Sci & Technol Zhejiang 3100018 Peoples R China North West Univ Fac Nat & Agr Sci Mat Sci Innovat & Modelling Res Focus Area Mafikeng Campus ZA-2735 Mmabatho South Africa

The n-dimensional semi-stationary compressible Stokes equations, established to model the dynamics of vortices in the Ginzburg-Landau theories in superconductivity, is a simplification of the isentropic compressible Navier-Stokes equations. This model equation can also be derived from the equations for the flows in compressible porous media in petroleum engineering or in compressible tissues. In this work, we investigate the n-dimensional semi-stationary compressible Stokes equations and obtain a family of explicit solutions in which the density does not change with space variables but decays to zero with time increasing exponentially, while the velocity is a quadratic polynomial of the space variables. It is worth pointing out that our results not only include the known results for n=2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$n=2$$\end{document} and n=3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$n=3$$\end{document} in Xue and Dong (Int. J. Theor. Phys. 63(6), 151 (2024)), but also present the explicit solutions to the semi-stationary compressible Stokes equations in arbitrary higher dimensional space.

关键词： Compressible fluids Semi-stationary compressible Stokes problem Explicit solutions

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Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

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NATURE COMMUNICATIONS 2021年第1期12卷 308页

作者： Yan, Zhengzheng Luo, Haihua Xie, Bingyao Tian, Tian Li, Shan Chen, Zhixia Liu, Jinghua zhao, xuwen Zhang, Liyong Deng, Yongqiang Billiar, Timothy R. Jiang, Yong Southern Med Univ State Key Lab Organ Failure Res Guangdong Prov Key Lab Prote Sch Basic Med SciDept Pathophysiol Guangzhou 510515 Peoples R China Univ Pittsburgh Sch Med Dept Surg Pittsburgh PA 15213 USA Southern Med Univ Nanfang Hosp Dept Anesthesiol Guangzhou 510515 Peoples R China

Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. Here, we identify SLP76 as a binding partner for the cytosolic tail of RAGE both in vitro and in vivo and demonstrate that SLP76 binds RAGE through its sterile alpha motif (SAM) to mediate downstream signaling. Genetic deficiency of RAGE or SLP76 reduces AGE-induced phosphorylation of p38 MAPK, ERK1/2 and IKK alpha/beta, as well as cytokine release. Delivery of the SAM domain into macrophages via the TAT cell-penetrating peptide blocks proinflammatory cytokine production. Furthermore, administration of TAT-SAM attenuates inflammatory cytokine release and tissue damage in mice subjected to cecal ligation and puncture (CLP) and protects these mice from the lethality of sepsis. These findings reveal an important function for SLP76 in RAGE-mediated pro-inflammatory signaling and shed light on the development of SLP76-targeted therapeutics for sepsis.

关键词： Bacterial infection Cell signalling Monocytes and macrophages

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血清I-FABP和CBG对新生儿坏死性小肠结肠炎需要选择手术治疗的预测价值

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江苏医药 2024年第6期50卷 577-581页

作者：杨福江胡博戴春娟马林赵绪稳王金虎杜晓斌天津市儿童医院(天津大学儿童医院)新生儿外科天津300074

目的探讨血清肠型脂肪酸结合蛋白(I-FABP)和β葡萄糖苷酶(CBG)对新生儿坏死性小肠结肠炎(NEC)需要选择手术治疗的预测价值。方法93例确诊为NEC的新生儿,根据患儿住院后是否进行手术治疗分为手术组(27例)和非手术组(66例)。比较两组患儿... 详细信息

目的探讨血清肠型脂肪酸结合蛋白(I-FABP)和β葡萄糖苷酶(CBG)对新生儿坏死性小肠结肠炎(NEC)需要选择手术治疗的预测价值。方法93例确诊为NEC的新生儿,根据患儿住院后是否进行手术治疗分为手术组(27例)和非手术组(66例)。比较两组患儿一般资料及确诊NEC时血清I-FABP、CBG水平。采用多因素logistic回归分析NEC患儿选择手术治疗的独立影响因素。分析血清I-FABP和CBG单独及联合检测对NEC患儿行手术治疗的预测价值。结果手术组血清I-FABP及CBG水平高于非手术组(P<0.05)。多因素logistic回归分析结果显示,确诊NEC时血清I-FABP及CBG水平升高是NEC患儿行手术治疗的独立危险因素(P<0.05)。血清I-FABP联合CBG检测预测NEC患儿行手术治疗的AUC为0.941[95%CI(0.888~0.993),P<0.01],相应的预测灵敏度和特异度分别为85.0%和94.0%。结论确诊NEC时的血清I-FABP和CBG水平有助于早期预测需行手术治疗的NEC患儿。

关键词：新生儿坏死性小肠结肠炎肠型脂肪酸结合蛋白 β葡萄糖苷酶

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HPV vaccination strategy for 14-year-old females and economic returns for cervical cancer prevention in Wuxi City, China: a cost effectiveness analysis

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COST EFFECTIVENESS AND RESOURCE ALLOCATION 2024年第1期22卷 1页

作者： Jiang, Jingfeng zhao, Fanqi Hong, Xiang Wang, xuwen Nanjing Med Univ Wuxi Ctr Dis Control & Prevent Affiliated Wuxi Ctr Dis Control & Prevent Wuxi 214023 Peoples R China Southeast Univ Minist Educ Sch Publ Hlth Dept Epidemiol & Hlth StatKey Lab Environm Med & Nanjing Peoples R China

Background Since December 2021, Wuxi, China has offered a two-dose human papillomavirus (HPV) vaccination to 14-year-old females for free. This study evaluated the costs and benefits of this vaccination scheduled in the Expanded Program on Immunization in Wuxi from the perspective of the cities' demographic characteristics, economic development, and policy support. Methods The model-based economic evaluation used TreeAge Pro software to construct a decision tree-Markov model for the vaccination strategy in which 100,000 14-year-old females received two doses of bivalent HPV vaccine or no vaccination. Costs and effects of the strategy were assessed from a societal perspective through literature research and data obtained from the Wuxi Centre for Disease Control and Prevention. Univariate, multivariate, and probabilistic sensitivity analyses assessed the stability of the findings. Results The cost of the bivalent HPV vaccine in Wuxi is 711.3 CNY. The two-dose of bivalent HPV vaccine for 100,000 14-year-old females would cost an additional 658,016 CNY compared to no vaccination, but would result in 1,960 Quality Adjustment Years of Life (QALYs). Using the per capita gross domestic product of 187,415 CNY in 2021 in Wuxi as the willingness-to-pay threshold, the vaccination strategy costs 3,357.37 CNY per QALY gained, which is much lower than the threshold, suggesting that it is a very cost-effective strategy. In addition, the vaccine strategy reduced the incidence of cervical cancer by 300 cases and cervical cancer deaths by 181 cases, representing a benefit-cost ratio of 2.86 (> 1) when health output outcomes were measured in monetary terms. These results suggested that the vaccination strategy was advantageous. Sensitivity analyses showed that changes in the parameters did not affect the conclusions and that the findings were robust. Conclusions Compared to no vaccination, the delivery of two doses of bivalent HPV vaccine for 14-year-old females was a more highly cost-

关键词： Cost-effectiveness HPV Cervical cancer Vaccination

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Manganese-based virus-mimicking nanomedicine with triple immunomodulatory functions inhibits breast cancer brain metastasis

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BIOMATERIALS 2025年 320卷 123262-123262页

作者： zhao, Zhenhao Zhou, Jingyi Li, xuwen Zhang, Tongyu Tian, Zonghua Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Minist EducKey Lab Smart Drug DeliveryState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Hindered by the challenges of blood-brain barrier (BBB) hindrance, tumor heterogeneity and immunosuppressive microenvironment, patients with breast cancer brain metastasis have yet to benefit from current clinical treatments, experiencing instead a decline in quality of life due to radiochemotherapy. While virus-mimicking nanosystems (VMN) mimicking viral infection processes show promise in treating peripheral tumors, the inability to modulate the immunosuppressive microenvironment limits the efficacy against brain metastasis. Accordingly, a VMN-based triple immunomodulatory strategy is initially proposed, aiming to activate innate and adaptive immune responses and reverse the immunosuppressive microenvironment. Here, manganese-based virus-mimicking nanomedicine (Vir-HD@HM) with intratumoral drug enrichment is engineered. Vir-HD@HM can induce the immune response through the activation of cGAS-STING by mimicking the in vivo infection process of herpesviruses. Meanwhile, DNAzyme mimicking the genome can rescue the epigenetic silencing of PTEN with the assistance of Mn2+, thus ameliorating the immunosuppressive metastatic microenvironment and achieving synergistic sensitizing therapeutic efficacy. In vivo experiments substantiate the efficacy of VirHD@HM in recruiting NK cells and CD8+ T cells to metastatic foci, inhibiting Treg cells infiltration, and prolonging murine survival without adjunctive radiochemotherapy. This study demonstrates that Vir-HD@HM with triple immunomodulation offers an encouraging therapeutic option for patients with brain metastasis.

关键词： Breast cancer brain metastasis Virus-mimicking nanosystem Immune activation Immunosuppressive microenvironment regulation PTEN cGAS-STING

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新生儿坏死性小肠结肠炎伴发肠穿孔的危险因素研究

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临床小儿外科杂志 2021年第11期20卷 1042-1047页

作者：赵绪稳胡博戴春娟杨福江杜晓斌王金虎天津市儿童医院(天津大学儿童医院)新生儿外科天津市300074

目的探讨新生儿坏死性小肠结肠炎(necrotizing enterocolitis,NEC)伴发肠穿孔的危险因素,为临床诊治提供参考。方法收集天津市儿童医院2016年9月至2019年12月确诊为NEC伴发肠穿孔且符合纳入标准的32例患者,作为病例组;选取同期收治的NE... 详细信息

目的探讨新生儿坏死性小肠结肠炎(necrotizing enterocolitis,NEC)伴发肠穿孔的危险因素,为临床诊治提供参考。方法收集天津市儿童医院2016年9月至2019年12月确诊为NEC伴发肠穿孔且符合纳入标准的32例患者,作为病例组;选取同期收治的NEC未伴发肠穿孔患者96例,作为对照组。对比分析两组患者的一般资料(胎龄、出生体重、性别、起病日龄、起病至肠穿孔病程)、围产期资料(母亲孕龄、宫内窘迫、胎膜早破、分娩方式、孕期合并糖尿病情况、妊娠高血压情况、孕期感染情况)、NEC诊断后并发症(呼吸衰竭、休克、败血症、凝血功能障碍、低钙血症、肝肾功能损害、低钾和高钾血症)、起病时化验结果(白细胞、血小板、血红蛋白、PCT、CRP及血清白蛋白)等临床资料,采用单因素分析和多因素Logistic回归分析,总结NEC伴发肠穿孔的危险因素。结果单因素分析结果显示:NEC是否伴发肠穿孔与出生体重、胎龄、母亲孕龄、孕期感染、呼吸衰竭、休克、败血症、凝血功能障碍、肾功能损害、低钙血症、低钾血症、白细胞、血小板、血红蛋白、PCT、CRP及血清白蛋白水平相关(P<0.05)。多因素Logistic回归分析结果显示,凝血功能障碍(OR=7.125,95%CI:2.095~24.230)、低钾血症(OR=6.627,95%CI:1.557~28.205)是NEC伴发肠穿孔的独立危险因素,而高血清白蛋白(OR=0.792,95%CI:0.694~0.905)及白细胞数偏高(OR=0.917,95%CI:0.844~0.995)是其保护因素。结论凝血功能障碍、低钾血症、低白细胞数及低血清白蛋白是NEC伴发肠穿孔的独立危险因素。对于新生儿NEC,临床上应早期识别其危险因素,并及时干预,以避免肠穿孔。

关键词：坏死性小肠结肠炎肠穿孔危险因素婴儿,新生

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CoFe2O4@Ti3C2 MXene nanocomposite-based broad-spectrum degradation of biotoxins

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APPLIED CATALYSIS B-ENVIRONMENT AND ENERGY 2024年 350卷

作者： Chen, xuwen Sallach, J. Brett Ling, Wanting zhao, Xuqiang Borch, Thomas Gao, Yanzheng Nanjing Agr Univ Inst Organ Contaminant Control & Soil Remediat Coll Resources & Environm Sci Nanjing 210095 Peoples R China Univ York Dept Environm & Geog York YO10 5NG England Colorado State Univ Dept Soil & Crop Sci Ft Collins CO 80523 USA Colorado State Univ Dept Chem Ft Collins CO 80523 USA Weigang Rd 1 Nanjing 210095 Peoples R China

A significant research priority is developing a treatment method to effectively remove biotoxins commonly found in food production and the environment. A novel CoFe2O4@Ti3C2 MXene nanocomposite was fabricated by growing ferrite on MXene, and used nanocomposite to develop an oxidation-based treatment system with persulfate (PS). The ability of this system to broad-spectrum degrade mycotoxins and plant toxins was evaluated, and the catalytic and oxidation mechanisms were characterized. Co and Fe sites provide activation efficiency towards PS with adsorption energies of -21.15 and -19.63 eV, Ti site promote activation by inducing the reduction of Co and Fe. The production of reactive oxygen species via electron transfer contributed to the degradation of fourteen biotoxins with removal rates above 88%, and the frontier molecular orbital energy explained the difference in degradation extent. Electron-rich sites were predicted to help explain the degradation mechanism. The products were harmless to the ecology and human. The observations clearly indicate that Ferrite-MXene nanocomposites are viable options for broad-spectrum degradation of a wide variety of biotoxins.

关键词： CoFe2O4@Ti(3)C(2)MXene nanocomposite Biotoxins Hydrothermal synthesis Broad-spectrum degradation Persulfate

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Exchange bias effect in epitaxial La0.35Sr0.65MnO3/La0.7Sr0.3MnO3 bilayers: Impact of antiferromagnet growth conditions

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VACUUM 2020年 175卷 109280-109280页

作者： zhao, xuwen Wong, Hon Fai Liu, Yu Kuai Ng, Sheung Mei Cheng, Wang Fai Mak, Chee Leung Leung, Chi Wah Hong Kong Polytech Univ Dept Appl Phys Hung Hom Hong Kong Peoples R China

Antiferromagnets have shown great potential for replacing ferromagnets in spintronics applications in recent years. In this work, antiferromagnetic La0.35Sr0.65MnO3 (AFM-LSMO) thin films were grown on ultrathin ferromagnetic La0.7Sr0.3MnO3 (FM-LSMO) layer over a wide temperature range. The different AFM-LSMO growth temperatures introduced variation of strain states in the AFM-LSMO layer, changing the AFM-LSMO magnetic properties. Considering the thermally activated switching model of antiferromagnetic grains, the behaviour of AFM-LSMO growth temperature-dependent exchange bias effect are explained. This work demonstrates the modulation of exchange bias effect through the control of AFM-LSMO growth conditions, suggesting possibility to control and probe oxide antiferromagnets via exchange bias coupling.

关键词： Pulsed laser deposition Perovskite oxide thin films Exchange bias effect

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新生儿骶尾部畸胎瘤手术后肛门直肠功能的相关因素分析

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临床小儿外科杂志 2021年第1期20卷 39-43页

作者：杜晓斌胡博戴春娟赵绪稳王金虎杨福江天津市儿童医院新生儿外科天津市300000

目的评估新生儿骶尾部畸胎瘤手术后远期肛门直肠功能,并探讨其影响因素。方法选取2013年8月至2018年2月天津市儿童医院新生儿外科收治的97例新生儿骶尾部畸胎瘤患者,记录患者临床特征及肛门直肠功能障碍发生情况,对患者肛门直肠功能障... 详细信息

目的评估新生儿骶尾部畸胎瘤手术后远期肛门直肠功能,并探讨其影响因素。方法选取2013年8月至2018年2月天津市儿童医院新生儿外科收治的97例新生儿骶尾部畸胎瘤患者,记录患者临床特征及肛门直肠功能障碍发生情况,对患者肛门直肠功能障碍的发生率及其危险因素进行分析。结果新生儿骶尾部畸胎瘤的Altman分型、肿瘤体积和术中残余肿瘤体积与术后肛门直肠功能的恢复相关(P<0.05),而性别、血清AFP水平、肿瘤性状和病理类型与肛门直肠功能障碍不相关(P>0.05);在Altman分型Ⅱ型和Ⅲ型的新生儿中,术后出现肛门直肠功能障碍和未发现肛门直肠功能障碍者比较,畸胎瘤大小差异具有统计学意义(P<0.05),而Ⅰ型新生儿中上述指标差异没有统计学意义(P>0.05)。结论肛门直肠功能的恢复与多种因素有关,术前对Altman分类、肿瘤体积和肿瘤位置关系的准确预判,可有效避免肿瘤生长、瘤体对盆底、肛门直肠周围组织及神经的压迫和侵犯,也可避免术中对重要组织脏器的损伤,并预防终末器官损害,改善患者的远期预后。

关键词：骶尾部/畸形畸胎瘤/诊断畸胎瘤/外科学治疗结果功能恢复婴儿,新生

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