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The Akt Pathway Is Involved in Rapid Ischemic Tolerance in Focal Ischemia in Rats

TRANSLATIONAL STROKE RESEARCH 2010年第3期1卷 202-209页

作者： Gao, xuwen Zhang, Hanfeng Steinberg, Gary zhao, Heng Stanford Univ Sch Med Dept Neurosurg Stanford CA 94305 USA Stanford Univ Sch Med Stanford Stroke Ctr Stanford CA 94305 USA

Although the protective mechanisms of delayed ischemic preconditioning have received extensive studies, few have addressed the mechanisms associated with rapid ischemic preconditioning. We investigated whether ischemic tolerance induced by rapid preconditioning is regulated by the Akt survival signaling pathway. Stroke was generated by permanent occlusion of the left distal middle cerebral artery plus 30 min or 1 h occlusion of the bilateral common carotid artery (CCA) in male rats. Rapid preconditioning performed 1 h before stroke onset reduced infarct size by 69% in rats with 30 min CCA occlusion, but by only 19% with 1 h occlusion. After control ischemia with 30 min CCA occlusion, Western blot showed that P-Akt was transiently increased while Akt kinase assay showed that Akt activity was decreased. Although preconditioning did not change P-Akt levels at 1 and 5 h compared with control ischemia, it attenuated reduction in Akt activity at 5 h in the penumbra. However, preconditioning did not change the levels of P-PDK1, P-PTEN, and P-GSK3 beta in the Akt pathway, all of which were decreased after stroke. At last, the PI3K kinase inhibitor, LY294002, completely reversed the protection from ischemic preconditioning. In conclusion, Akt contributes to the protection of rapid preconditioning against stroke.

关键词： Rapid preconditioning Ischemic tolerance Cerebral ischemia Focal ischemia Neuroprotection Akt

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活瓣式小肠造瘘术在新生儿腹部外科疾病中的应用分析

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临床小儿外科杂志 2020年第1期19卷 36-39页

作者：王金虎赵绪稳杜晓斌戴春娟胡博包国强天津市儿童医院新生儿外科

目的探讨活瓣式小肠造瘘术在降低新生儿及婴儿小肠造瘘术后并发症中的临床应用价值。方法根据治疗方案的不同将入选的患儿分为活瓣式肠造瘘术组(13例)以及常规肠造瘘术组(10例),其中活瓣式肠造瘘术组采用袢式造瘘的方法,先将肠管浆肌层... 详细信息

目的探讨活瓣式小肠造瘘术在降低新生儿及婴儿小肠造瘘术后并发症中的临床应用价值。方法根据治疗方案的不同将入选的患儿分为活瓣式肠造瘘术组(13例)以及常规肠造瘘术组(10例),其中活瓣式肠造瘘术组采用袢式造瘘的方法,先将肠管浆肌层与腹膜及腹壁肌层缝合固定,在与该缝合层面约一个肠管直径距离处将肠管浆肌层与皮肤、皮下、腹壁肌肉一并缝合固定,使处于腹壁内的肠段形成类似回盲部的“瓣样”皱襞结构。对比活瓣式小肠造瘘术组与常规肠造瘘组术后水电失衡情况,皮肤糜烂、肠管脱出的发生率及排便情况。结果与常规造瘘术组相比,活瓣式造瘘术组患儿每日每百毫升进奶量对应的排便质量显著降低[(25.95±3.39)g vs.(22.23±2.49)g,P<0.05],每日每千克体质量对应的排便质量显著降低[(27.05±3.31)g vs.(23.23±2.64)g,P<0.05],每周体质量增长量显著提高[(136.42±20.23)g vs.(154.27±16.74)g,P<0.05];同时可以有效预防肠管脱出,并减轻瘘口周围皮肤糜烂程度。结论活瓣式小肠造瘘术可以减少肠造瘘口排便内容物中的水分含量,降低新生儿及婴儿小肠造瘘术后并发症的发生率,减轻护理负担,显著改善预后。

关键词：肠造口术婴儿,新生治疗结果

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Stereo matching algorithm of Color Image Based on Weber's law and Census 10

Stereo matching algorithm of Color Image Based on Weber's la...

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10th International Conference on Intelligent Information Hiding and Multimedia Signal Processing (IIH-MSP)

作者： Wu, Qiang zhao, Xiangnan Li, xuwen Beijing Univ Technol Coll Elect Informat & Control Engn Beijing Peoples R China Beijing Univ Technol Coll Life Sci & Bioengn Beijing Peoples R China

ISBN: (纸本)9781479953905

The algorithm presented here is used on unmanned aerial vehicles system. In 2013,*** proposed a matching cost computation model(or function), This matching cost model combined three kinds of constraints, the cost function is formulated by combining three individual costs: a cost computed on an extended census transformation of the images;the absolute difference cost, taking into account information from colour channels;and a cost based on the principal image derivatives. Experiments show that the cost function is excellent performance in similar estimates. Apply it to the stereo matching of ancient buildings, it is favorable for practical. However, this experiment, in color mutated region, leaded to blurred border. Therefore, our proposed method added color space structural information, which based on HVS Weber's law, to the cost function. we use the differential excitation of WLD reflects the structure of color space. This robust cost measures can reduce percent of bad pixels in mutated color region. The proposed method use color image, which is used after epipolar line rectification.

关键词： The stereo matching of color image Census Weber's law

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基于蒸汽相法合成的ZIF-8前驱体制备铈掺杂ZnO

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宁波工程学院学报 2019年第1期31卷 12-18页

作者：吴昌松李佳欣孙青许盛皓赵徐雯李秋平贾志舰宁波工程学院浙江宁波315211

ZnO半导体因为具有独特的光催化降解有机污染物的能力,已经成为当前化学研究的热点。本文采用蒸汽相法合成金属—有机框架化合物ZIF-8作为锌源前驱体,将其高温热解制备ZnO纳米粒子;在合成ZIF-8的过程中,引入稀土Ce进行原位掺杂,在此基... 详细信息

ZnO半导体因为具有独特的光催化降解有机污染物的能力,已经成为当前化学研究的热点。本文采用蒸汽相法合成金属—有机框架化合物ZIF-8作为锌源前驱体,将其高温热解制备ZnO纳米粒子;在合成ZIF-8的过程中,引入稀土Ce进行原位掺杂,在此基础上得到了一系列Ce掺杂的ZnO纳米粒子(Ce/ZnO)。通过XRD、SEM、EDX、 FT-IR等手段对所得材料的结构、形貌等物理化学性能进行表征分析;以罗丹明B为降解对象,考察了所得ZnO半导体的光催化性能。结果表明:通过在ZIF-8锌源中掺入Ce元素,可调控终产物ZnO纳米粒子的形貌,适量的Ce元素掺杂,可改善ZnO半导体的催化性能,且该法制备的Ce/ZnO能保持较高的循环催化活性与再生催化活性。

关键词：光催化半导体掺杂氧化锌铈

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Mechanistic investigations into synergistically enhanced radiative-charge-transfer in Au-Ag bimetallic nanoclusters (vol 56, pg 5665, 2020)

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CHEMICAL COMMUNICATIONS 2020年第48期56卷 6594-6594页

作者： Liu, Jianbo zhao, Rusong Wang, Xia Gao, xuwen Zou, Guizheng Qilu Univ Technol Key Lab Appl Technol Sophisticated Analyt Instrum Shandong Acad Sci Shandong Anal & Test Ctr Jinan 250353 Peoples R China Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

Synergetic effects in Au-Ag bimetallic nanoclusters (BNCs) more favorably enhanced electrochemical redox induced electrochemiluminescence (ECL) over photoexcitation induced photoluminescence (PL); this not only led to Au-Ag BNCs with enhanced bandgap-engineered ECL compared to Au NCs, but it also generated surface-defect related ECL to enhance the total ECL intensity.

关键词： Surface defects

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血清I-FABP和CBG对新生儿坏死性小肠结肠炎需要选择手术治疗的预测价值

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江苏医药 2024年第6期50卷 577-581页

作者：杨福江胡博戴春娟马林赵绪稳王金虎杜晓斌天津市儿童医院(天津大学儿童医院)新生儿外科天津300074

目的探讨血清肠型脂肪酸结合蛋白(I-FABP)和β葡萄糖苷酶(CBG)对新生儿坏死性小肠结肠炎(NEC)需要选择手术治疗的预测价值。方法93例确诊为NEC的新生儿,根据患儿住院后是否进行手术治疗分为手术组(27例)和非手术组(66例)。比较两组患儿... 详细信息

目的探讨血清肠型脂肪酸结合蛋白(I-FABP)和β葡萄糖苷酶(CBG)对新生儿坏死性小肠结肠炎(NEC)需要选择手术治疗的预测价值。方法93例确诊为NEC的新生儿,根据患儿住院后是否进行手术治疗分为手术组(27例)和非手术组(66例)。比较两组患儿一般资料及确诊NEC时血清I-FABP、CBG水平。采用多因素logistic回归分析NEC患儿选择手术治疗的独立影响因素。分析血清I-FABP和CBG单独及联合检测对NEC患儿行手术治疗的预测价值。结果手术组血清I-FABP及CBG水平高于非手术组(P<0.05)。多因素logistic回归分析结果显示,确诊NEC时血清I-FABP及CBG水平升高是NEC患儿行手术治疗的独立危险因素(P<0.05)。血清I-FABP联合CBG检测预测NEC患儿行手术治疗的AUC为0.941[95%CI(0.888~0.993),P<0.01],相应的预测灵敏度和特异度分别为85.0%和94.0%。结论确诊NEC时的血清I-FABP和CBG水平有助于早期预测需行手术治疗的NEC患儿。

关键词：新生儿坏死性小肠结肠炎肠型脂肪酸结合蛋白 β葡萄糖苷酶

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Optimal Clearing Model of Centralized Market Considering Path Constraints 1

Optimal Clearing Model of Centralized Market Considering Pat...

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International Symposium on Energy Environment and Green Development (EEGD)

作者： Zheng, zhao Chen, Kening Jiang, Yu Liu, xuwen State Grid Energy Res Inst Beijing Peoples R China State Grid JiangSu Elect Power Co Ltd Nanjing Jiangsu Peoples R China

China's electricity market is now still in the mode of "Unified market and two-tier operation" including provincial and inter-provincial market. The inter-provincial market is divided into the medium and long-term market and spot market. This study takes the inter provincial spot market as the research object, and proposes a unified optimization clearing algorithm for inter provincial spot market considering path constraints. The proposed method is able to handle AC-DC hybrid electricity network, and sort and determine the trading pairs using power flow tracing algorithm. The power market software PLEXOS and practical market data are used to simulate the proposed model, and the results show the accuracy and effectiveness.

关键词： Power markets

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The antiallergic activity of flavonoids extracted from Citri Reticulatae Pericarpium

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JOURNAL OF FOOD PROCESSING AND PRESERVATION 2018年第4期42卷 e13588-e13588页

作者： Shi, Xiaolei Niu, Liyan zhao, Lina Wang, Bo Jin, Yongri Li, xuwen Jilin Univ Dept Food Qual & Safety Coll Food Sci & Engn Changchun 130062 Jilin Peoples R China Jilin Univ Dept Analyt Chem Coll Chem Changchun 130012 Jilin Peoples R China

The fruits of Citrus are popular all over the world. It was reported that the extracts of fruits possessed antiallergic activities. In China, Citri Reticulatae Pericarpium (CRP) is a production of peels. In this study, flavonoids were extracted by solvent method, and enriched by polyamide. Then antiallergic activity of flavonoids was investigated in vivo and in vitro. Under optimal parameters, most abundant compounds of extracts were hesperidin and narirutin, their contents were 232.0325 and 98.7946 mg/g, respectively. In vitro, RBL-2H3 cell line was used to investigate the antiallergic activity. As the results shown, -hexosaminidase release of antigen-induced degranulation was decreased by flavonoids. An ovalbumin-induced allergic asthmatic model was used to test the activity of the flavonoids in vivo. After treated with different concentrations of flavonoids, the levels of IgE, IL-4, and IL-13 decreased significantly. These findings provide evidence that flavonoids extracted from CRP have potential using in antiallergic therapeutic area. Practical applicationsOranges are popular all over the world as fruit, besides a little percent of peels are applied as traditional medicine in China, the others are thrown away as rubbish. To explore the new way to extend the application of peels, we extracted the total flavonoids from Citri Reticulatae Pericarpium (CRP) and evaluated the antiallergic activity of it. Fortunately, the total flavonoids have antiallergic activity in vitro and vivo. The findings provide evidence that extracts from CRP have potential using in antiallergic therapeutic area. It can also afford a theoretical basis for the new application of orange peel.

关键词： Citrus fruits

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Improved Local Maximal Occurrence Feature Representation for Person Re-identification 9

Improved Local Maximal Occurrence Feature Representation for...

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9th IEEE International Conference on Software Engineering and Service Science (ICSESS)

作者： Zhu, Yuanxin Yang, zhao Yao, xuwen zhao, Sai Peng, Shaohu Guangzhou Univ Sch Mech & Elect Engn Guangzhou 510006 Guangdong Peoples R China

ISBN: (纸本)9781538665657

Person re-identification is a technique to automatically search the same people in diffe..ent camera views. It is a challenging task because of the huge variations caused by different illuminations and views in images. There is an effective method tackling the problem, which learns a useful feature representation for the pedestrian images, In recent research, a featu..e rep..esentation named Local Maximal Occurrence (LOMO) achieves outstanding performance, but LOMO has a disadvantage that its robustness to illumination is not excellent. In this pape.., we propose an imp..oved LOMO representation to further reduce the impact of light. The improved LOMO feature combines Color Name feature with LOMO, because Color Name feature has strong robustness to illumination. However, Color Name feature has the weakness that it loses graphical details. The..efore, the feature is unsuitable for traditional pooling method. To overcome the disadvantage, a specific pooling method called global Gaussian pooling for Color Name feature is designed, which is based on Gaussian distribution and can weigh the different regions of an image. The important regions gain mo..e attention in matching images. The experimental results on two public available datasets demonstrate the effectiveness of our proposed approach.

关键词： component Person re-identification feature representation

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A general method for instantaneous undeformed chip thickness calculation in five-axis milling based on Boolean operations

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INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY 2021年第7-8期116卷 2325-2334页

作者： Li, Guochao Liu, Yunlong zhao, Donghao Dai, Lei Zhou, Honggen Jing, xuwen Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Jiangsu Univ Sci & Technol Jiangsu Prov Key Lab Adv Mfg Marine Mech Equipmen Zhenjiang 212003 Jiangsu Peoples R China

Instantaneous undeformed chip thickness (IUCT) plays a critical role in optimizing and monitoring of five-axis milling processes, as it determines machining precision and tool life by affecting cutting forces. Analytical and numerical methods have been widely used for IUCT calculation. However, these methods have some deficiencies, such as solving the unsolvable transcendental equations, modeling the complex cutting edge trajectory, and poor adaptability for five-axis milling. Therefore, a Boolean method which consists of subtraction and intersection operations is developed. First, the blank for the current cutting edge is obtained by the Boolean subtraction operation between the workpiece and the swept volume that produced by the front cutting edges. Second, the Boolean intersection operation is executed between the blank and the auxiliary edge entity (AEE) that corresponding to the tool edge. Then, the IUCT of each cutting edge or each cutting point can be deduced based on the Boolean result with the known blank geometry, tool geometry, tool path, and machining parameters. The method is verified by milling force experiments. It is an efficient, accurate, and general method because it does not need to establish complex mathematical or numerical models. The calculated IUCT will promote the optimizing and monitoring of five-axis milling processes.

关键词： Chip thickness Boolean operation Five-axis milling Milling force

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