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Characterization of thermal neutron distribution of an Am-Be neutron source setup by CdZnTe detector

APPLIED RADIATION AND ISOTOPES 2023年 196卷 110778页

作者： Liang, xuwen zhao, Dong Jia, Wenbao Hei, Daqian Cheng, Can Nanjing Univ Aeronaut & Astronaut Dept Nucl Sci & Technol Nanjing Peoples R China Jiangsu Higher Educ Inst Collaborat Innovat Ctr Radiat Med Suzhou 215000 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China Nanjing Univ Aeronaut & Astronaut Coll Astronaut Nanjing 211106 Peoples R China

Owing to the developments in prompt gamma neutron activation analysis (PGNAA) and prompt gamma ray activation imaging (PGAI), it is necessary to develop an online thermal neutron distribution measurement method. The CdZnTe detector is considered as an alternative thermal neutron detector because of its high thermal neutron capture cross section. In this study, the thermal neutron field of an 241Am-Be neutron source was determined by CdZnTe detector. The intrinsic neutron detection efficiency of CdZnTe detector was calcu-lated by using indium foil activation, and the value was 3.65%. Then the characteristics of neutron source were conducted with the calibrated CdZnTe detector. The thermal neutron fluxes in front of beam port were measured at several distances ranging from 0 cm up to 28 cm. Thermal neutron field at distances of 1 cm and 5 cm were also measured. The experimental data were then compared with Monte Carlo simulation. The results demon-strated that the simulated data agree well with experimental measurements.

关键词： CdZnTe detector Monte Carlo simulation Am -Be neutron source Activation method Thermal neutron flux

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Intelligent rush repair of unmanned distribution network based on deep reinforcement learning 18

Intelligent rush repair of unmanned distribution network bas...

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18th IEEE International Conference on Mobility, Sensing and Networking (MSN)

作者： zhao, Yue Chuan, Yang Pu, Shi Han, xuwen Xia, Shiyu Xie, Yanqi Yangzhou Power Supply Branch State Grid Jiangsu E Yangzhou Jiangsu Peoples R China Xiamen Univ Technol Xiamen Peoples R China

ISBN: (纸本)9781665464574

With the continuous expansion of China's power grid scale and the increasing number of power users year by year, it is necessary to ensure the normal power supply of users. When a power failure occurs, it is particularly critical whether the emergency repair task can be completed quickly and scientifically. In this paper, an intelligent repair model of "unmanned" distribution network based on deep reinforcement learning is proposed, which adopts speech recognition technology and deep reinforcement learning algorithm to achieve the "unmanned" of the whole system. Users can transmit the emergency repair information to the voice recognition module of the power supply emergency repair center by voice, SMS and IMS, and the module will get the emergency repair position and the amount of emergency repair tasks. Then, the resource allocation module is used to learn the emergency repair resource allocation strategy online, and the intelligent control of emergency repair in distribution network is realized. To verify the proposed algorithm, it is compared with two typical allocation strategies under the same settings. The results of the experiments demonstrate that the method based on deep reinforcement learning performs better in terms of emergency repair delay and intelligent emergency repair of the power supply in distribution networks.

关键词： failure Speech recognition Emergency maintenance Neural network Deep reinforcement learning

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Optimal Clearing Model of Centralized Market Considering Path Constraints 1

Optimal Clearing Model of Centralized Market Considering Pat...

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International Symposium on Energy Environment and Green Development (EEGD)

作者： Zheng, zhao Chen, Kening Jiang, Yu Liu, xuwen State Grid Energy Res Inst Beijing Peoples R China State Grid JiangSu Elect Power Co Ltd Nanjing Jiangsu Peoples R China

China's electricity market is now still in the mode of "Unified market and two-tier operation" including provincial and inter-provincial market. The inter-provincial market is divided into the medium and long-term market and spot market. This study takes the inter provincial spot market as the research object, and proposes a unified optimization clearing algorithm for inter provincial spot market considering path constraints. The proposed method is able to handle AC-DC hybrid electricity network, and sort and determine the trading pairs using power flow tracing algorithm. The power market software PLEXOS and practical market data are used to simulate the proposed model, and the results show the accuracy and effectiveness.

关键词： Power markets

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Multifunctional ORF3 protein of hepatitis E virus

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JOURNAL OF MEDICAL VIROLOGY 2024年第6期96卷 e29691-e29691页

作者： Li, Xiaoxuan Sun, xuwen Pinpin, Ji zhao, Qin Sun, Yani Northwest Agr & Forestry Univ Coll Vet Med Dept Prevent Vet Med Yangling Shaanxi Peoples R China

Hepatitis E virus (HEV) is an emerging zoonotic pathogen that is transmitted primarily through the fecal-oral route and can cause acute hepatitis in humans. Since HEV was identified as a zoonotic pathogen, different species of HEV strains have been globally identified from various hosts, leading to an expanding range of hosts. The HEV genome consists of a 5' noncoding region, three open reading frames (ORFs), and a 3' noncoding region. The ORF3 protein is the smallest but has many functions in HEV release and pathogenesis. In this review, we systematically summarize recent progress in understanding the functions of the HEV ORF3 protein in virion release, biogenesis of quasi-enveloped viruses, antigenicity, and host environmental regulation. This review will help us to understand HEV replication and pathogenesis mechanisms better.

关键词： hepatitis E innate immunity ORF3 protein quasi-enveloped virion

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Design of Intelligent Logistics System Based on JIT Material Distribution Plan

Design of Intelligent Logistics System Based on JIT Material...

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The 2018 International Conference on Transportation & Logistics,Information & Communication,Smart City(TLICSC 2018)

作者： Yunrui Wang Zhengli Wu xuwen zhao School of Mechanical Engineering Xi'an University of Science and Technology

ISBN: (纸本)9781510876996

With increasingly high demands of personalized requirements and delivery time of customers,material distribution must be on time with guaranteeing the *** became one of the most critical technologies for companies to achieve the intelligent *** at the issues which is large batch size and serious accumulation in the material distribution of a specific enterprise,PCBA board was chosen as the research object in this *** analyzing the process of material distribution,the economic distribution batch model and the distribution kanban model were set ***,the ANDON system has been designed and a just-in-time distribution system for materials was eventually *** system greatly reduces material distribution personals and time,which saves distribution expenditures and combines this system with the currently used MES system by the company to achieve the cooperative control of plan and materials,thus providing guarantee for intelligent logistics *** present,this system has been used in enterprises,making good advancement.

关键词： Intelligent logistics JIT material distribution economic distribution batch distribution Kanban ANDON system

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A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells and Support to the Immune Cells by Epigenetic Regulation

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ADVANCED SCIENCE 2025年第15期12卷 e2415207页

作者： Su, Boyu Chen, Qinjun Li, xuwen Fang, Mingzhu Wang, Yu Song, Haolin You, Haoyu Zhou, Zheng Wu, Yuxing zhao, Zhenhao Chen, Yun Fan, Hongrui Li, Chufeng Jiang, Chen Sun, Tao Fudan Univ State Key Lab Med Neurobiol Sch Pharm Dept PharmaceutKey Lab Smart Drug DeliveryMinist Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution and abnormal epigenetic processes, and resulting in a protumor immune microenvironment. Tumors require a steady supply of methionine for maintaining epigenetic flexibility, which is the only exogenous precursor of methyl donor S-adenosylmethionine for methylation, crucial for their resistance to therapies and survival in a nutrient-deficient microenvironment. Thus, tumor cells upregulate the Lat4 transporter to compete and deprive methionine in the microenvironment, sustaining their malignant phenotypes and also impairing immune cell functions. Addressing this methionine addiction is the key to overcoming drug resistance and improving immune response. Despite the challenge of lacking specific Lat4 inhibitors, an oxaliplatin prodrug crosslinked fluorinated polycation/anti-Lat4 small interfering RNA complex nanoregulator (AS-F-NP) has been designed and developed here. This nanoregulator restricted the greedy methionine uptake of tumor cells by knocking down Lat4, which in turn inhibited the malignant evolution of the tumor while restoring the viability and function of tumor-infiltrating immune cells.

关键词： cancer therapy epigenetic immune methionine oxaliplatin siRNA

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A general method for instantaneous undeformed chip thickness calculation in five-axis milling based on Boolean operations

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INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY 2021年第7-8期116卷 2325-2334页

作者： Li, Guochao Liu, Yunlong zhao, Donghao Dai, Lei Zhou, Honggen Jing, xuwen Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Jiangsu Univ Sci & Technol Jiangsu Prov Key Lab Adv Mfg Marine Mech Equipmen Zhenjiang 212003 Jiangsu Peoples R China

Instantaneous undeformed chip thickness (IUCT) plays a critical role in optimizing and monitoring of five-axis milling processes, as it determines machining precision and tool life by affecting cutting forces. Analytical and numerical methods have been widely used for IUCT calculation. However, these methods have some deficiencies, such as solving the unsolvable transcendental equations, modeling the complex cutting edge trajectory, and poor adaptability for five-axis milling. Therefore, a Boolean method which consists of subtraction and intersection operations is developed. First, the blank for the current cutting edge is obtained by the Boolean subtraction operation between the workpiece and the swept volume that produced by the front cutting edges. Second, the Boolean intersection operation is executed between the blank and the auxiliary edge entity (AEE) that corresponding to the tool edge. Then, the IUCT of each cutting edge or each cutting point can be deduced based on the Boolean result with the known blank geometry, tool geometry, tool path, and machining parameters. The method is verified by milling force experiments. It is an efficient, accurate, and general method because it does not need to establish complex mathematical or numerical models. The calculated IUCT will promote the optimizing and monitoring of five-axis milling processes.

关键词： Chip thickness Boolean operation Five-axis milling Milling force

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Probing the Interfacial Forces and Surface Interaction Mechanisms in Petroleum Production Processes

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Engineering 2022年第11期18卷 49-61页

作者： Diling Yang xuwen Peng Qiongyao Peng Tao Wang Chenyu Qiao Ziqian zhao Lu Gong Yueliang Liu Hao Zhang Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 1H9Canada College of Petroleum Engineering China University of PetroleumBeijing 102249China

Despite the advances that have been made in renewable energy over the past decade,crude oil or petroleum remains one of the most important energy resources to the *** production presents many challenging issues,such as the destabilization of complex oil-water emulsions,fouling phenomena on pipelines and other facilities,and water *** problems are influenced by the molecular forces at the oil/water/solid/gas interfaces involved in relevant ***,we present an overview of recent advances on probing the interfacial forces in several petroleum production processes(e.g.,bitumen extraction,emulsion stabilization and destabilization,fouling and antifouling phenomena,and water treatment)by applying nanomechanical measurement technologies such as a surface forces apparatus(SFA)and an atomic force microscope(AFM).The interaction forces between bitumen and mineral solids or air bubbles in the surrounding fluid media determine the bitumen liberation and flotation efficiency in oil sands *** stability of complex oil/water emulsions is governed by the forces between emulsion drops and particularly between interface-active species(e.g.,asphaltenes).Various oil components(e.g.,asphaltenes)and emulsion drops interact with different substrate surfaces(e.g.,pipelines or membranes),influencing fouling phenomena,oil-water separation,and wastewater *** these intermolecular and interfacial forces has advanced the mechanistic understanding of these interfacial interactions,facilitating the development of advanced materials and technologies to solve relevant challenging issues and improve petroleum production *** challenges and suggestions on future research directions in the field are also presented.

关键词： Intermolecular and surface forces Interface Emulsion Colloids Fouling and antifouling Water treatment

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Nanomaterials with dual immunomodulatory functions for synergistic therapy of breast cancer brain metastases

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Bioactive Materials 2023年第9期27卷 474-487页

作者： Zhenhao zhao Chufeng Li Yiwen Zhang Chao Li Yongchao Chu xuwen Li Peixin Liu Hongyi Chen Yu Wang Boyu Su Qinjun Chen Tao Sun Chen Jiang Department of Pharmaceutics School of PharmacyFudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceShanghai201203China

A long-standing paucity of effective therapies results in the poor outcomes of triple-negative breast cancer brain *** has made progress in the treatment of tumors,but limited by the non-immunogenicity of tumors and strong immunosuppressive environment,patients with TNBC brain metastases have not yet benefited from *** immunoregulatory strategies with enhanced immune activation and reversal of the immunosuppressive microenvironment provide new therapeutic options for ***,we propose a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and construct reduction-sensitive immune microenvironment regulation nanomaterials(SIL@T).SIL@T modified with targeting peptide penetrates the BBB and is subsequently internalized into metastatic breast cancer cells,releasing silybin and oxaliplatin responsively in the ***@T preferentially accumulates at the metastatic site and can significantly prolong the survival period of model *** studies have shown that SIL@T can effectively induce immunogenic cell death of metastatic cells,activate immune responses and increase infiltration of CD8+T ***,the activation of STAT3 in the metastatic foci is attenuated and the immunosuppressive microenvironment is *** study demonstrates that SIL@T with dual immunomodulatory functions provides a promising immune synergistic therapy strategy for breast cancer brain metastases.

关键词： Breast cancer brain metastases Drug delivery Immunogenic cell death Microenvironmental regulation STAT3

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Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss

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JOURNAL OF PSYCHIATRIC RESEARCH 2023年第1期162卷 11-20页

作者： Li, Guangfei Li, Yashuang Zhang, zhao Chen, Yu Li, Bao Hao, Dongmei Yang, Lin Yang, Yimin Li, xuwen Li, Chiang-Shan R. Beijing Univ Technol Fac Environm & Life Dept Biomed Engn Beijing Peoples R China Beijing Int Sci & Technol Cooperat Base Intelligen Beijing Peoples R China Beijing Inst Technol Sch Life Sci Dept Biomed Engn Beijing Peoples R China Yale Univ Sch Med Dept Psychiat New Haven CT USA Yale Univ Sch Med Dept Neurosci New Haven CT USA Yale Univ Sch Med Interdept Neurosci Program New Haven CT USA Yale Univ Wu Tsai Inst New Haven CT USA Beijing Univ Technol 220 Life Sci Bldg 100 Pingleyuan Beijing 100124 Peoples R China Connecticut Mental Hlth Ctr S112 34 Pk St New Haven CT 06519 USA

Ventral striatum (VS) processes rewarding and punishing stimuli. Women and men vary in externalizing and internalizing traits, which may influence neural responses to reward and punishment. To investigate sex dif-ferences in how individual traits influence VS responses to reward and punishment, we curated the data of the Human Connectome Project and identified 981 (473 men) subjects evaluated by the Achenbach Adult Self-Report Syndrome Scales. We processed the imaging data with published routines and extracted VS response (beta) to win and to loss vs. baseline in a gambling task for correlation with externalizing and internalizing symptom severity. Men vs. women showed more severe externalizing symptoms and higher VS response to monetary losses (VS-loss beta) but not to wins. Men but not women showed a significant, positive correlation between VS-loss beta and externalizing traits, and the sex difference was confirmed by a slope test. The correlations of VS-loss vs. exter-nalizing and of VS-win vs. externalizing and those of VS-loss vs. externalizing and of VS-loss vs. internalizing traits both differed significantly in slope, confirming its specificity, in men. Further, the sex-specific relationship between VS-loss beta and externalizing trait did not extend to activities during exposure to negative emotion in the face matching task. To conclude, VS responses to loss but not to win and their correlation with externalizing rather than internalizing symptom severity showed sex differences in young adults. The findings highlight the relationship of externalizing traits and VS response to monetary loss and may have implications for psychological models of externalizing behaviors in men.

关键词： Externalizing VS Punishment Sex differences fMRI

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