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Beyond transcription, aryl hydrocarbon receptor plays a protective role in periodontitis by interacting with CaMKII

JOURNAL OF PERIODONTOLOGY 2025年第1期96卷 67-81页

作者： zeng, xuwen Feng, Meiting Lu, Jiawei Wang, Ruiling Deng, Li Yang, Yanan Luo, Lijun Tongji Univ Stomatol Hosp Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dept Periodontol Shanghai Peoples R China Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dent Sch Shanghai Peoples R China Univ Porto Inst Res & Innovat Hlth i3S Inst Invest & Inovacao Saude Porto Portugal Univ Porto Inst Mol & Cell Biol IBMC Inst Biol Mol & Celular Porto Portugal

Background: The aryl hydrocarbon receptor (AhR) has been studied as an intracellular pattern recognition receptor that can identify bacterial pigments. To identify a potential therapeutic target for periodontitis, we investigated the expression of AhR in periodontitis and its role in the pathogenesis of periodontitis. Methods: First, we analyzed AhR expression in a single-cell dataset from human periodontal tissue. Quantitative polymerase chain reaction (qPCR), immunofluorescence, and immunohistochemistry were used to verify the AhR level. Later, we determined the phenotypes of ligature-induced periodontitis in myeloid-specific AhR-deficient mice (Lyz2-Cre(+/-) AhR(fx/fx)), after which RNA sequencing (RNA-seq), qPCR, Western blot, immunofluorescence, and immunohistochemistry were used to investigate the impacts of AhR on periodontitis and its mechanism. Finally, we determined the therapeutic effect of AhR agonist 6-Formylindolo[3,2-b]carbazole (FICZ) administration on murine periodontitis and verified the effects of FICZ on macrophage polarization in vitro. Results: AhR expression was enhanced in macrophages from periodontitis patients. Deletion of AhR from macrophages aggravated ligature-induced periodontitis and promoted the inflammatory response. Calcium/calmodulin-stimulated protein kinase II (CaMKII) phosphorylation was accelerated in AhR-deficient macrophages. Inhibiting CaMKII phosphorylation ameliorated periodontitis in Lyz2-Cre(+/-) AhR(fx/fx) mice. FICZ treatment blocked alveolar bone loss and relieved periodontal inflammation. FICZ diminished M1 macrophage polarization and promoted M2 macrophage polarization upon M1 macrophage induction. Conclusion: AhR played a protective role in the pathogenesis of periodontitis by orchestrating macrophage polarization via interacting with the CaMKII signaling pathway.

关键词： aryl hydrocarbon receptor CaMKII macrophage pattern recognition receptor periodontitis

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Overuse wrist injuries in adolescent platform and springboard divers

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RESEARCH IN SPORTS MEDICINE 2023年第3期31卷 273-284页

作者： Zhang, Cici Shen, Si Qiu, Lin Wang, Liqin zeng, xuwen Zhou, Quan Southern Med Univ Affiliated Hosp 3 Dept Radiol 183 West Zhongshan Ave Guangzhou Guangdong Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol Guangzhou Peoples R China Jinan Univ Med Imaging Ctr Affiliated Hosp 1 Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Ultrasound Guangzhou Peoples R China

To investigate overuse wrist injuries in adolescent divers using magnetic resonance imaging (MRI). The bilateral wrists (76 wrists) of 38 professional divers were examined by MRI;42 wrists with pain were placed in the symptomatic group, and 34 wrists without pain were placed in the asymptomatic group. Two experienced radiologists assessed the wrist injuries. Chi-square test was used to compare the difference in injuries between the two groups. Subchondral osteosclerosis was observed in 47.62% of symptomatic wrists and 52.94% of asymptomatic wrists. Distal radial epiphyseal plate injury was detected in 42.86% of symptomatic wrists and 11.76% of asymptomatic wrists. Triangular fibrocartilage complex injury was observed in 19.04% of symptomatic wrists and 8.82% of asymptomatic wrists. Bursae around the wrist were observed in 21.42% of symptomatic wrists and 17.64% of asymptomatic wrists. The incidence of distal radial epiphyseal plate injury was higher in the symptomatic group than in the asymptomatic group (P = 0.007), however, other injuries were not statistically different between the two groups (P > 0.05). This study demonstrated that adolescent divers had various wrist injuries, and distal radial epiphyseal plate injury was more common in the symptomatic wrist;these injuries show no specific clinical symptoms and are easily overlooked.

关键词： Diver diving wrist adolescent injury

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High expression of aryl hydrocarbon receptor (AhR) plays an important role in the formation of fibrous epulis

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ORAL DISEASES 2022年第8期28卷 2258-2266页

作者： zeng, xuwen Xia, Siying Yan, Xiangzhen Hu, Congjiao An, Kangkang Luo, Lijun Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dept Periodont Sch Stomatol Shanghai Peoples R China

Objectives Epulis is considered to be a massive reactive lesion rather than a true neoplasia. AhR is thought to be associated with inflammation and development of neoplasms. Here, we aimed to observe the expression of AhR in fibrous epulis and explore its role and possible mechanism in the pathogenesis of epulis. Materials and Methods Epulis and normal gingival tissues were collected, and AhR expression was detected at the mRNA and protein levels by quantitative polymerase chain reaction (qPCR) and immunohistochemistry, respectively. The expression levels of proinflammatory cytokines and apoptosis-related factor genes in human periodontal ligament cells (hPDLCs) and human gingival fibroblasts (hGFs) transfected with AhR short interfering RNA (siRNA) or negative control siRNA, upon stimulation with lipopolysaccharide of Porphyromonas gingivalis (Pg-LPS), were then examined. Finally, the expression levels of the proinflammatory cytokines and apoptosis-related factor genes in the epulis tissues were observed by qPCR. Results AhR expression in fibrous epulis was significantly increased at both the mRNA and protein levels. The expression of proinflammatory cytokines and apoptosis-related factor genes in hPDLCs transfected with AhR siRNA was significantly decreased when stimulated with Pg-LPS. The same trends were observed for hGFs. The opposite trend was detected in the epulis tissues. Conclusion AhR may be a key factor in fibrous epulis pathogenesis that acts by regulating the expression of BCL2 family genes and inflammatory factor-related genes.

关键词： apoptosis aryl hydrocarbon receptor fibrous epulis P gingivalis

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Fatty Infiltration of Multifidus Muscles: An Easily Overlooked Risk Factor for the Severity of Osteoporotic Vertebral Fractures

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ORTHOPAEDIC SURGERY 2024年第3期16卷 585-593页

作者： Xu, Wuyan Liu, Xiaowen Wu, Li Liang, Shaohua Zhang, Ye Huang, Junbing zeng, xuwen Li, Siming Xu, Fan Xiong, Yuchao Jinan Univ Dept Radiol Guangzhou Red Cross Hosp Guangzhou Peoples R China Jinan Univ Dept Orthoped Guangzhou Red Cross Hosp Guangzhou Peoples R China Jinan Univ Clin Med Coll 2 Shenzhen Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol Guangzhou 510220 Peoples R China

ObjectivesOsteoporotic vertebral fractures (OVFs) are a critical public health concern requiring urgent attention, and severe OVFs impose substantial health and economic burdens on patients and society. Analysis of the risk factors for severe OVF is imperative to actively prevent the occurrence of this degenerative disorder. This study aimed to investigate the risk factors associated with the severity of OVF, with a specific focus on changes in the paraspinal *** total of 281 patients with a first-time single-level acute OVF between January 2016 and January 2023 were enrolled in the study. Clinical and radiological data were collected and analyzed. The cross-sectional area (CSA) and degree of fatty infiltration (FI) of the paraspinal muscles, including the multifidus muscles (MFMs), erector spinae muscles (ESMs), and psoas major muscles (PSMs), were measured by magnetic resonance imaging (MRI) of the L4/5 intervertebral discs. According to the classification system of osteoporotic fractures (OF classification) and recommended treatment plan, OVFs were divided into a low-grade OF group and a high-grade OF group. Univariate and multivariate logistic regression analyse s were performed to identify risk factors associated with the severity of ***-eight patients were included in the low-grade OF group, and 183 patients were included in the high-grade OF group. Univariate analysis revealed a significantly higher incidence of a high degree of FI of MFMs (OR = 1.71, p = 0.002) and ESMs (OR = 1.56, p = 0.021) in the high-grade OF group. Further multivariate logistic regression analysis demonstrated that a high degree of FI of the MFMs (OR = 1.71, p = 0.002) is an independent risk factor for the severity of *** high degree of FI of the MFMs was identified as an independent risk factor for the severity of OVF. Decreasing the degree of FI in the MFMs might lower the incidence of the severity of OVF, potentially reducing the necessity for s

关键词： Fatty Infiltration Osteoporosis Multifidus Muscles Osteoporotic Vertebral Fracture

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Prediction of Subsequent Vertebral Fracture After Acute Osteoporotic Fractures from Clinical and Paraspinal Muscle Features

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CALCIFIED TISSUE INTERNATIONAL 2024年第6期114卷 614-624页

作者： Xiong, Yuchao Zhang, Cici Chen, Xiaopei Wu, Li Liang, Shaohua Zhang, Ye Huang, Junbing Guo, Wei zeng, xuwen Xu, Fan Jinan Univ Guangzhou Red Cross Hosp Dept Radiol Guangzhou Peoples R China

To construct a nomogram based on clinical factors and paraspinal muscle features to predict vertebral fractures occurring after acute osteoporotic vertebral compression fracture (OVCF). We retrospectively enrolled 307 patients with acute OVCF between January 2013 and August 2022, and performed magnetic resonance imaging of the L3/4 and L4/5 intervertebral discs (IVDs) to estimate the cross-sectional area (CSA) and degree of fatty infiltration (FI) of the paraspinal muscles. We also collected clinical and radiographic data. We used univariable and multivariable Cox proportional hazards models to identify factors that should be included in the predictive nomogram. Post-OVCF vertebral fracture occurred within 3, 12, and 24 months in 33, 69, and 98 out of the 307 patients (10.8%, 22.5%, and 31.9%, respectively). Multivariate analysis revealed that this event was associated with percutaneous vertebroplasty treatment, higher FI at the L3/4 IVD levels of the psoas muscle, and lower relative CSA of functional muscle at the L4/5 IVD levels of the multifidus muscle. Area under the curve values for subsequent vertebral fracture at 3, 12, and 24 months were 0.711, 0.724, and 0.737, respectively, indicating remarkable accuracy of the nomogram. We developed a model for predicting post-OVCF vertebral fracture from diagnostic information about prescribed treatment, FI at the L3/4 IVD levels of the psoas muscle, and relative CSA of functional muscle at the L4/5 IVD levels of the multifidus muscle. This model could facilitate personalized predictions and preventive strategies.

关键词： Osteoporosis Compression fracture Paraspinal muscles Fat infiltration Nomograms

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Nomogram to screen older adult patients attending the radiology department for sarcopenia

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BMC GERIATRICS 2025年第1期25卷 1-9页

作者： Yuan, Guiying Ye, Guoxi Hu, Jianguang Hu, Huimin Shi, Chanmei Zhang, Ye Huang, Junbing Li, Zhiqiong zeng, xuwen Tan, Rongshao Xiong, Yuchao Jinan Univ Guangzhou Red Cross Hosp Dept Resp Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol 396 Tongfu Rd Guangzhou Guangzhou 510220 Guangdong Provi Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Nephrol Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Inst Dis Oriented Nutr Res Dept Clin Nutr Guangzhou Peoples R China

BackgroundSarcopenia is an age-related syndrome that can impact the physical and mental health of older adults. However, it is often overlooked in clinical practice. Therefore, we aim to construct a nomogram based on simplified discriminant parameters for screening older adult patients for sarcopenia *** cross-sectional study included 654 patients aged >= 60 years who underwent an examination in the radiology department between October 2023 and June 2024. Patients were diagnosed with sarcopenia according to the method and cutoff value criteria proposed the Asian Working Group on Sarcopenia (AWGS) 2019 criteria. Calf circumference (CC), SARC-F score, mid-upper arm circumference (MUAC), and SARC-CalF score were used as simplified discriminant parameters for sarcopenia. The discriminative ability of these parameters for sarcopenia was assessed using receiver operating characteristic analysis. Additionally, we included each screening parameter and evaluated it's important for screening for the presence of sarcopenia via univariate and multivariate logistic regression analysis to develop a new screening nomogram model. The performance of the nomogram was evaluated using receiver operating characteristic curves, and the performance of the nomogram model was compared to that of CC, SARC-F, MUAC, and the SARC-CalF using the Delong *** the 654 subjects, 120 (18.3%) were diagnosed with sarcopenia, and the areas under the curve (AUCs) of the CC, SARC-F, MUAC, and SARC-CalF were 0.73, 0.61, 0.66, and 0.70, respectively. The multivariate analysis results revealed that older age, male sex, low CC, low MUAC, and low strength were related to sarcopenia. A nomogram model constructed with these five variables had an AUC of 0.84. The DeLong test showed that the diagnostic efficacy of the joint model was significantly higher than that of CC, SARC-F, MUAC, and *** simple nomogram based on simplified discriminant parameters offers personalized

关键词： Sarcopenia Nomogram Calf circumference SARC-F SARC-CalF

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Comparison of whole-body 18F-FDG PET/CT and PET/MRI for distant metastases in patients with malignant tumors: a meta-analysis

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BMC CANCER 2023年第1期23卷 37-37页

作者： Zhang, Cici Liang, Zhishan Liu, Wei zeng, xuwen Mo, Yuzhen Guangzhou Red Cross Hosp Dept Radiol Guangzhou Peoples R China Peoples Hosp Guangxi Zhuang Autonomous Reg Dept Cardiol Nanning Peoples R China Guangzhou Red Cross Hosp Dept Breast Guangzhou Peoples R China 396 TongFu Rd HaiZhu Dist Guangzhou Guangdong Peoples R China

Background As a first-line imaging modality, whole-body fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) and 18F-FDG PET/magnetic resonance imaging (MRI) had been widely applied in clinical practice. However, 18F-FDG PET/MRI may be superior to PET/CT for the diagnosis of distant metastases in patients with advanced-stage. Therefore, it is timely and important to systematically determine the diagnostic accuracy of 18F-FDG PET/MRI compared with that of 18F-FDG PET/CT for the diagnosis of distant *** This study aimed to compare the diagnostic accuracy of 18F-FDG PET/CT and PET/MRI for the diagnosis of distant metastases in patients with malignant tumors. Relevant studies using both 18F-FDG PET/CT and PET/MRI for assessment of distant metastases in patients with malignant tumors were searched in PubMed, Embase, The Cochrane Library, and Scopus from January 2010 to November 2023. Two reviewers independently selected studies according to the inclusion and exclusion criteria. A reviewer extracted relevant data and assessed the quality of the eligible studies. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and area under the summary receiver operating characteristic curve (AUC) for 18F-FDG PET/CT and PET/MRI were analyzed. Subgroup analysis was *** Across 14 studies (1042 patients), 18F-FDG PET/MRI had a higher sensitivity (0.87 versus 0.81), AUC value (0.98 versus 0.95), and similar specificity (0.97 versus 0.97), than PET/CT for detecting distant metastases. In 3 studies of breast cancer (182 patients), 18F-FDG PET/MRI had a higher sensitivity (0.95 versus 0.87) and specificity (0.96 versus 0.94) than PET/CT. In 5 studies of lung cancer (429 patients), 18F-FDG PET/CT had a higher sensitivity (0.87 versus 0.84) and a lower specificity (0.95 versus 0.96) to PET/*** 18F-FDG PET/MRI and PET/CT both performed well as detectors of distant meta

关键词： Tumor Distant metastases Positron emission tomography magnetic resonance imaging computed tomography

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Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment

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MATERIALS RESEARCH EXPRESS 2023年第11期10卷 115404-115404页

作者： Li, Zhuoran Yang, Huikang Xu, Fan zeng, xuwen Huang, Haowei Jiang, Xinqing Jinan Univ Dept Radiol Guangzhou Red Cross Hosp Guangzhou Guangdong Peoples R China South China Univ Technol Guangzhou Peoples Hosp 1 Sch Med Dept Radiol Guangzhou Guangdong Peoples R China Jinan Univ Dept Radiotherapy Guangzhou Red Cross Hosp Guangzhou Guangdong Peoples R China Jinan Univ Guangzhou Peoples Hosp 1 Dept Radiol Guangzhou Guangdong Peoples R China

Vitamin E Poly(ethylene glycol) monoplatinum ester (TPGS) nanoparticles have attracted much attention in recent years for overcome multidrug resistance. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked polymer (FA-SS-TPGS) was synthesized. These polymer nanoparticles were utilized as theranostic agents for tumor-targeted magnetic resonance imaging (MRI) and chemotherapy. By loading doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) particles into TPGS nanoparticles, FA-SS-TPGS@DOX/SPIO nanoparticles are obtained. In vitro drug release studies revealed that under a reducing environment in the presence of glutathione (GSH), approximately 100% of the doxorubicin (DOX) was released from the disulfide bond-linked theranostic nanoparticles within 24 h. DOX and SPIO were efficiently delivered into HepG2-ADM cells due to the folate receptor-mediated endocytosis process of the nanoparticles. Additionally, the presence of glutathione (GSH) triggered the cleaving of the disulfide bonds, further facilitating the delivery of DOX and SPIO into the cells. Furthermore, the FA-SS-TPGS @DOX-SPIO nanoparticles exhibited strong MRI contrast enhancement properties. In conclusion, FA-SS-TPGS@DOX/SPIO are potential nanoparticles for tumor-targeted MRI and chemotherapy, which can also overcome multidrug resistance.

关键词： multidrug resistance TPGS tumor-targeted disulfide bond theranostic nanoparticles

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考虑灵活性需求的园区综合能源系统协同优化配置

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电力自动化设备 2022年第9期42卷 9-17页

作者：林顺富曾旭文沈运帷李东东上海电力大学电气工程学院上海200090

为了进一步考虑灵活性需求对综合能源系统(IES)资源配置的影响,在IES规划过程中,提出一种计及灵活性需求及新能源不确定性的园区IES协同优化配置方法。基于价格弹性理论建立综合需求响应(IDR)柔性负荷模型,采用Z-number方法描述IDR认知... 详细信息

为了进一步考虑灵活性需求对综合能源系统(IES)资源配置的影响,在IES规划过程中,提出一种计及灵活性需求及新能源不确定性的园区IES协同优化配置方法。基于价格弹性理论建立综合需求响应(IDR)柔性负荷模型,采用Z-number方法描述IDR认知过程与结果的不确定性;考虑新能源的随机性和相关性,利用非参数估计法与Frank-Copula函数改进风光出力联合概率模型,得到典型日风光出力曲线;以IES运营商年化总成本最低为目标,构建上层优化设备型号与台数、下层优化机组运行的IES双层协同配置模型。算例结果表明相较于未考虑IDR及新能源不确定性的场景,所提配置模型减少了成本,进一步提高了经济性,同时配置方案充分考虑源荷双侧不确定性给系统带来的运行风险问题,从而实现了IES规划经济性与运行安全性的平衡。

关键词：园区综合能源系统灵活性需求综合需求响应配置规划不确定性

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Covalent organic framework materials with advanced topologies for efficient methane adsorption

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Science China Materials 2025年第4期68卷 1298-1299页

作者： xuwen Peng Hao Zhang Hongbo zeng Department of Chemical and Materials Engineering Tsinghua UniversityBeijing 100084Chin a 2 Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G IH9Canada

Methane,as the main component of natural gas,is a key transitional fuel resource due to its abundance and relatively low carbon emissions,aligning with global carbon neutrality objectives[1].Traditional natural gas storage methods,such as liquefied and compressed natural gas,require costly infrastructure and high-pressure ***,adsorbed natural gas offers a safer,more cost-effective,and environmentally friendly solution by enhancing storage capacity at reduced pressures through the use of methane adsorbents[2].

关键词： natural gas carbon neutrality natural gasis covalent organic frameworks transitional fuel resource liquefied compressed natural gasrequire enhancing storage capacity reduced pressures methane adsorption

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