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Beyond transcription, aryl hydrocarbon receptor plays a protective role in periodontitis by interacting with CaMKII

JOURNAL OF PERIODONTOLOGY 2025年第1期96卷 67-81页

作者： zeng, xuwen Feng, Meiting Lu, Jiawei Wang, Ruiling Deng, Li Yang, Yanan Luo, Lijun Tongji Univ Stomatol Hosp Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dept Periodontol Shanghai Peoples R China Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dent Sch Shanghai Peoples R China Univ Porto Inst Res & Innovat Hlth i3S Inst Invest & Inovacao Saude Porto Portugal Univ Porto Inst Mol & Cell Biol IBMC Inst Biol Mol & Celular Porto Portugal

Background: The aryl hydrocarbon receptor (AhR) has been studied as an intracellular pattern recognition receptor that can identify bacterial pigments. To identify a potential therapeutic target for periodontitis, we investigated the expression of AhR in periodontitis and its role in the pathogenesis of periodontitis. Methods: First, we analyzed AhR expression in a single-cell dataset from human periodontal tissue. Quantitative polymerase chain reaction (qPCR), immunofluorescence, and immunohistochemistry were used to verify the AhR level. Later, we determined the phenotypes of ligature-induced periodontitis in myeloid-specific AhR-deficient mice (Lyz2-Cre(+/-) AhR(fx/fx)), after which RNA sequencing (RNA-seq), qPCR, Western blot, immunofluorescence, and immunohistochemistry were used to investigate the impacts of AhR on periodontitis and its mechanism. Finally, we determined the therapeutic effect of AhR agonist 6-Formylindolo[3,2-b]carbazole (FICZ) administration on murine periodontitis and verified the effects of FICZ on macrophage polarization in vitro. Results: AhR expression was enhanced in macrophages from periodontitis patients. Deletion of AhR from macrophages aggravated ligature-induced periodontitis and promoted the inflammatory response. Calcium/calmodulin-stimulated protein kinase II (CaMKII) phosphorylation was accelerated in AhR-deficient macrophages. Inhibiting CaMKII phosphorylation ameliorated periodontitis in Lyz2-Cre(+/-) AhR(fx/fx) mice. FICZ treatment blocked alveolar bone loss and relieved periodontal inflammation. FICZ diminished M1 macrophage polarization and promoted M2 macrophage polarization upon M1 macrophage induction. Conclusion: AhR played a protective role in the pathogenesis of periodontitis by orchestrating macrophage polarization via interacting with the CaMKII signaling pathway.

关键词： aryl hydrocarbon receptor CaMKII macrophage pattern recognition receptor periodontitis

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Nomogram to screen older adult patients attending the radiology department for sarcopenia

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BMC GERIATRICS 2025年第1期25卷 1-9页

作者： Yuan, Guiying Ye, Guoxi Hu, Jianguang Hu, Huimin Shi, Chanmei Zhang, Ye Huang, Junbing Li, Zhiqiong zeng, xuwen Tan, Rongshao Xiong, Yuchao Jinan Univ Guangzhou Red Cross Hosp Dept Resp Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol 396 Tongfu Rd Guangzhou Guangzhou 510220 Guangdong Provi Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Nephrol Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Inst Dis Oriented Nutr Res Dept Clin Nutr Guangzhou Peoples R China

BackgroundSarcopenia is an age-related syndrome that can impact the physical and mental health of older adults. However, it is often overlooked in clinical practice. Therefore, we aim to construct a nomogram based on simplified discriminant parameters for screening older adult patients for sarcopenia *** cross-sectional study included 654 patients aged >= 60 years who underwent an examination in the radiology department between October 2023 and June 2024. Patients were diagnosed with sarcopenia according to the method and cutoff value criteria proposed the Asian Working Group on Sarcopenia (AWGS) 2019 criteria. Calf circumference (CC), SARC-F score, mid-upper arm circumference (MUAC), and SARC-CalF score were used as simplified discriminant parameters for sarcopenia. The discriminative ability of these parameters for sarcopenia was assessed using receiver operating characteristic analysis. Additionally, we included each screening parameter and evaluated it's important for screening for the presence of sarcopenia via univariate and multivariate logistic regression analysis to develop a new screening nomogram model. The performance of the nomogram was evaluated using receiver operating characteristic curves, and the performance of the nomogram model was compared to that of CC, SARC-F, MUAC, and the SARC-CalF using the Delong *** the 654 subjects, 120 (18.3%) were diagnosed with sarcopenia, and the areas under the curve (AUCs) of the CC, SARC-F, MUAC, and SARC-CalF were 0.73, 0.61, 0.66, and 0.70, respectively. The multivariate analysis results revealed that older age, male sex, low CC, low MUAC, and low strength were related to sarcopenia. A nomogram model constructed with these five variables had an AUC of 0.84. The DeLong test showed that the diagnostic efficacy of the joint model was significantly higher than that of CC, SARC-F, MUAC, and *** simple nomogram based on simplified discriminant parameters offers personalized

关键词： Sarcopenia Nomogram Calf circumference SARC-F SARC-CalF

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Covalent organic framework materials with advanced topologies for efficient methane adsorption

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Science China Materials 2025年第4期68卷 1298-1299页

作者： xuwen Peng Hao Zhang Hongbo zeng Department of Chemical and Materials Engineering Tsinghua UniversityBeijing 100084Chin a 2 Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G IH9Canada

Methane,as the main component of natural gas,is a key transitional fuel resource due to its abundance and relatively low carbon emissions,aligning with global carbon neutrality objectives[1].Traditional natural gas storage methods,such as liquefied and compressed natural gas,require costly infrastructure and high-pressure ***,adsorbed natural gas offers a safer,more cost-effective,and environmentally friendly solution by enhancing storage capacity at reduced pressures through the use of methane adsorbents[2].

关键词： natural gas carbon neutrality natural gasis covalent organic frameworks transitional fuel resource liquefied compressed natural gasrequire enhancing storage capacity reduced pressures methane adsorption

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High expression of aryl hydrocarbon receptor (AhR) plays an important role in the formation of fibrous epulis

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ORAL DISEASES 2022年第8期28卷 2258-2266页

作者： zeng, xuwen Xia, Siying Yan, Xiangzhen Hu, Congjiao An, Kangkang Luo, Lijun Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dept Periodont Sch Stomatol Shanghai Peoples R China

Objectives Epulis is considered to be a massive reactive lesion rather than a true neoplasia. AhR is thought to be associated with inflammation and development of neoplasms. Here, we aimed to observe the expression of AhR in fibrous epulis and explore its role and possible mechanism in the pathogenesis of epulis. Materials and Methods Epulis and normal gingival tissues were collected, and AhR expression was detected at the mRNA and protein levels by quantitative polymerase chain reaction (qPCR) and immunohistochemistry, respectively. The expression levels of proinflammatory cytokines and apoptosis-related factor genes in human periodontal ligament cells (hPDLCs) and human gingival fibroblasts (hGFs) transfected with AhR short interfering RNA (siRNA) or negative control siRNA, upon stimulation with lipopolysaccharide of Porphyromonas gingivalis (Pg-LPS), were then examined. Finally, the expression levels of the proinflammatory cytokines and apoptosis-related factor genes in the epulis tissues were observed by qPCR. Results AhR expression in fibrous epulis was significantly increased at both the mRNA and protein levels. The expression of proinflammatory cytokines and apoptosis-related factor genes in hPDLCs transfected with AhR siRNA was significantly decreased when stimulated with Pg-LPS. The same trends were observed for hGFs. The opposite trend was detected in the epulis tissues. Conclusion AhR may be a key factor in fibrous epulis pathogenesis that acts by regulating the expression of BCL2 family genes and inflammatory factor-related genes.

关键词： apoptosis aryl hydrocarbon receptor fibrous epulis P gingivalis

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Overuse wrist injuries in adolescent platform and springboard divers

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RESEARCH IN SPORTS MEDICINE 2023年第3期31卷 273-284页

作者： Zhang, Cici Shen, Si Qiu, Lin Wang, Liqin zeng, xuwen Zhou, Quan Southern Med Univ Affiliated Hosp 3 Dept Radiol 183 West Zhongshan Ave Guangzhou Guangdong Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol Guangzhou Peoples R China Jinan Univ Med Imaging Ctr Affiliated Hosp 1 Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Ultrasound Guangzhou Peoples R China

To investigate overuse wrist injuries in adolescent divers using magnetic resonance imaging (MRI). The bilateral wrists (76 wrists) of 38 professional divers were examined by MRI;42 wrists with pain were placed in the symptomatic group, and 34 wrists without pain were placed in the asymptomatic group. Two experienced radiologists assessed the wrist injuries. Chi-square test was used to compare the difference in injuries between the two groups. Subchondral osteosclerosis was observed in 47.62% of symptomatic wrists and 52.94% of asymptomatic wrists. Distal radial epiphyseal plate injury was detected in 42.86% of symptomatic wrists and 11.76% of asymptomatic wrists. Triangular fibrocartilage complex injury was observed in 19.04% of symptomatic wrists and 8.82% of asymptomatic wrists. Bursae around the wrist were observed in 21.42% of symptomatic wrists and 17.64% of asymptomatic wrists. The incidence of distal radial epiphyseal plate injury was higher in the symptomatic group than in the asymptomatic group (P = 0.007), however, other injuries were not statistically different between the two groups (P > 0.05). This study demonstrated that adolescent divers had various wrist injuries, and distal radial epiphyseal plate injury was more common in the symptomatic wrist;these injuries show no specific clinical symptoms and are easily overlooked.

关键词： Diver diving wrist adolescent injury

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MRI and histologic analysis of collagen type II sponge on repairing the cartilage defects of rabbit knee joints

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 2011年第2期96B卷 267-275页

作者： Chen, Honghui Yang, Xiaohong Liao, Yingyang zeng, xuwen Liang, Peihong Kang, Ning Tan, Jianrong Liang, Zhiping Jinan Univ Coll Med Affiliated Hosp 4 Guangzhou Inst Traumat Surg Guangzhou 510220 Guangdong Peoples R China Jinan Univ Coll Med Affiliated Hosp 4 Dept Radiol Guangzhou 510220 Guangdong Peoples R China

There are limited treatment options for cartilage defects in clinical practice because of the lack of suitable biomaterials. Here, we evaluated the effects of collagen type II sponge on the articular cartilage repairing process using a cartilage injury of a rabbit knee joint model. We showed that the home-made collagen type II sponges appeared to have a suitable pore size of 93.26 +/- 38.4 mu m for chondrocyte growth. MRI with H&E staining results demonstrated that the effusion absorption in the collagen type II sponge treated group was quicker than that of the control group. Moreover, sporadic cartilage signals first appeared at 6 weeks in the collagen type II sponge treated group. Safranin O staining and immunohistochemical analysis confirmed that the newly formed cartilage expresses glycosaminoglycan and type II collagen matrix. Using Sirius red polarized light staining, we showed that the newly formed cartilage-like areas from the collagen type II treated group are significantly greater than those of the control group. Taken together, our data demonstrated that the home-made collagen type II sponge is able to promote cartilage repair in the cartilage injury of a rabbit knee joint model. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 96B: 267-275, 2011.

关键词： collagen type II magnetic resonance imaging histopathology cartilage defect repair Sirius red polarized light staining

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Fatty Infiltration of Multifidus Muscles: An Easily Overlooked Risk Factor for the Severity of Osteoporotic Vertebral Fractures

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ORTHOPAEDIC SURGERY 2024年第3期16卷 585-593页

作者： Xu, Wuyan Liu, Xiaowen Wu, Li Liang, Shaohua Zhang, Ye Huang, Junbing zeng, xuwen Li, Siming Xu, Fan Xiong, Yuchao Jinan Univ Dept Radiol Guangzhou Red Cross Hosp Guangzhou Peoples R China Jinan Univ Dept Orthoped Guangzhou Red Cross Hosp Guangzhou Peoples R China Jinan Univ Clin Med Coll 2 Shenzhen Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol Guangzhou 510220 Peoples R China

ObjectivesOsteoporotic vertebral fractures (OVFs) are a critical public health concern requiring urgent attention, and severe OVFs impose substantial health and economic burdens on patients and society. Analysis of the risk factors for severe OVF is imperative to actively prevent the occurrence of this degenerative disorder. This study aimed to investigate the risk factors associated with the severity of OVF, with a specific focus on changes in the paraspinal *** total of 281 patients with a first-time single-level acute OVF between January 2016 and January 2023 were enrolled in the study. Clinical and radiological data were collected and analyzed. The cross-sectional area (CSA) and degree of fatty infiltration (FI) of the paraspinal muscles, including the multifidus muscles (MFMs), erector spinae muscles (ESMs), and psoas major muscles (PSMs), were measured by magnetic resonance imaging (MRI) of the L4/5 intervertebral discs. According to the classification system of osteoporotic fractures (OF classification) and recommended treatment plan, OVFs were divided into a low-grade OF group and a high-grade OF group. Univariate and multivariate logistic regression analyse s were performed to identify risk factors associated with the severity of ***-eight patients were included in the low-grade OF group, and 183 patients were included in the high-grade OF group. Univariate analysis revealed a significantly higher incidence of a high degree of FI of MFMs (OR = 1.71, p = 0.002) and ESMs (OR = 1.56, p = 0.021) in the high-grade OF group. Further multivariate logistic regression analysis demonstrated that a high degree of FI of the MFMs (OR = 1.71, p = 0.002) is an independent risk factor for the severity of *** high degree of FI of the MFMs was identified as an independent risk factor for the severity of OVF. Decreasing the degree of FI in the MFMs might lower the incidence of the severity of OVF, potentially reducing the necessity for s

关键词： Fatty Infiltration Osteoporosis Multifidus Muscles Osteoporotic Vertebral Fracture

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Prediction of Subsequent Vertebral Fracture After Acute Osteoporotic Fractures from Clinical and Paraspinal Muscle Features

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CALCIFIED TISSUE INTERNATIONAL 2024年第6期114卷 614-624页

作者： Xiong, Yuchao Zhang, Cici Chen, Xiaopei Wu, Li Liang, Shaohua Zhang, Ye Huang, Junbing Guo, Wei zeng, xuwen Xu, Fan Jinan Univ Guangzhou Red Cross Hosp Dept Radiol Guangzhou Peoples R China

To construct a nomogram based on clinical factors and paraspinal muscle features to predict vertebral fractures occurring after acute osteoporotic vertebral compression fracture (OVCF). We retrospectively enrolled 307 patients with acute OVCF between January 2013 and August 2022, and performed magnetic resonance imaging of the L3/4 and L4/5 intervertebral discs (IVDs) to estimate the cross-sectional area (CSA) and degree of fatty infiltration (FI) of the paraspinal muscles. We also collected clinical and radiographic data. We used univariable and multivariable Cox proportional hazards models to identify factors that should be included in the predictive nomogram. Post-OVCF vertebral fracture occurred within 3, 12, and 24 months in 33, 69, and 98 out of the 307 patients (10.8%, 22.5%, and 31.9%, respectively). Multivariate analysis revealed that this event was associated with percutaneous vertebroplasty treatment, higher FI at the L3/4 IVD levels of the psoas muscle, and lower relative CSA of functional muscle at the L4/5 IVD levels of the multifidus muscle. Area under the curve values for subsequent vertebral fracture at 3, 12, and 24 months were 0.711, 0.724, and 0.737, respectively, indicating remarkable accuracy of the nomogram. We developed a model for predicting post-OVCF vertebral fracture from diagnostic information about prescribed treatment, FI at the L3/4 IVD levels of the psoas muscle, and relative CSA of functional muscle at the L4/5 IVD levels of the multifidus muscle. This model could facilitate personalized predictions and preventive strategies.

关键词： Osteoporosis Compression fracture Paraspinal muscles Fat infiltration Nomograms

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Assessing the impact of marketization on energy poverty

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ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY 2025年第4期27卷 9257-9286页

作者： Shi, Xinjie zeng, Pei Cui, Liu Gao, xuwen Qiu, Tongwei Jiang, Qiang Fu, Linlin China Acad Rural Dev Zhejiang Univ Sch Publ Affairs Hangzhou Peoples R China Zhejiang Univ Res Ctr Common Prosper Innovat Ctr Yangtze River Delta Future Reg Dev Lab Jiaxing Peoples R China Zhejiang Univ & Huzhou City Ctr Common Prosper Huzhou Peoples R China Zhejiang Univ Inst Common Prosper & Dev Hangzhou Peoples R China Nanjing Agr Univ Coll Econ & Management Nanjing Peoples R China Guangxi Univ Sci & Technol Sch Econ & Management Liuzhou Peoples R China Zhejiang Acad Agr Sci Inst Rural Dev Hangzhou Peoples R China

In conjunction with economic growth, improving the quality of life for its citizens is a central concern for the Chinese government. Energy poverty, a topic closely linked to people's quality of life, has garnered global attention. This study examines the relationship between marketization and energy poverty by constructing provincial-level panel data using the fixed effect model. To address endogeneity, the instrumental variable method is further employed. The study obtains two major findings. First, the study reveals a significant upward trend in marketization in China in recent years, with a concomitant decrease in energy poverty. Here, the causal (and negative) effects of marketization on energy poverty are identified. Second, the mechanism analysis shows that this effect operates through (i) improvements in the quantity of energy supply (rather than energy supply efficiency), (ii) the accumulation of human capital that promotes the use of clean energy, and (iii) an increase in people's income. This study makes three key contributions. First, it empirically analyzes the impact of marketization on energy poverty from a macro-perspective. Second, it systematically discusses the pathways through which marketization operates. Third, drawing on several theories, it provides a deeper understanding of the theoretical connection between marketization and energy poverty.

关键词： Energy poverty Marketization Instrumental variable China

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A Novel and High-Efficiency Approach to Improve the Sustainability of Agitation Leaching Technology to Refractory Copper Oxide Ore Using the Self-Pressurizing Technology

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JOURNAL OF SUSTAINABLE METALLURGY 2025年 1-17页

作者： Wang, Jian zeng, Xin Liu, xuwen Xu, Wenlong Pan, Yue Li, Jinhui Wang, Ruixiang Xiao, Yanfei Xu, Zhifeng Jiangxi Prov Key Lab Green & Low Carbon Met Strate Ganzhou 341000 Peoples R China Jiangxi Univ Sci & Technol Sch Met Engn 86 Hongqi Ave Ganzhou 341000 Peoples R China Ganzhou Engn Technol Res Ctr Green Met & Proc Inte Ganzhou 341000 Peoples R China Nanchang Univ Sch Phys & Mat Sci Nanchang 330031 Peoples R China Tibet Yulong Copper Co Ltd 22 West City Rd Chengdu 854000 Peoples R China Jiangxi Coll Appl Technol 9 Wenfeng Rd Ganzhou 341000 Peoples R China Minist Nat Resources Key Lab Ion Rare Earth Resources & Environm Ganzhou 341000 Peoples R China

Considering economics and environmental protection, the agitation leaching technology using sulfuric acid is considered a preferred alternative to recover copper oxide ores in the copper industry. However, this process is still extremely difficult to extract copper from some complex polymetallic and refractory oxide ores, such as copper oxide ores with high alkalinity gangues (HAG) and high binding rates (HBR), respectively. In this paper, a novel and high-efficiency extraction process involving agitation leaching with self-pressurizing technology at low temperatures is proposed to improve copper extraction of the refractory HAG and HBR copper oxide ores from Tibet. Under the self-pressurizing agitation leaching process, the effects of leaching parameters are investigated on copper extraction and other elements dissolution including aluminum, arsenic, and iron, respectively. The results show that the self-pressurizing leaching technology of complex copper oxide ores has some advantages, including relatively simple to apply, environmentally friendly, energy-saving, and high efficiency, especially the higher copper extraction (more than 98.0%) over the conventional agitation leaching process in the sulfuric acid media. Under optimum experimental conditions of mass ratio of copper oxide ores of 5:5, agitation speed of 400 rpm, initial sulfuric acid concentration of 4.0 mol/L, and leaching time of 60 min at 80 degrees C, the copper extraction reached 98.9%, while the maximum average pressure reached 1.31 MPa in the closed reaction vessel. The self-pressurizing leaching technology can significantly improve the adaptability of the conventional agitation leaching technology to the refractory copper oxide ore without adding the other reagent.

关键词： Self-driven pressurization Agitation leaching Copper oxide ores Low temperature

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