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SSRN 2025年

作者： Li, Jiejun Wang, Liang Ge, Caiyu zheng, zuwen Wang, Yijing Zhao, Pengcheng Xie, Yixi Fei, Junjie Key Laboratory of Environmentally Friendly Chemistry and Applications Ministry of Education Xiangtan University Xiangtan411105 China Key Laboratory for Green Organic Synthesis and Application of Hunan Province Xiangtan University Xiangtan411105 China Hunan Institute of Advanced Sensing and Information Technology Xiangtan University Xiangtan411105 China

As a natural flavonoid with diverse pharmacological activities and remarkable efficacy, Luteolin has shown attractive potential for use in various applications such as drug discovery, food preservation, and functional foods. However, excessive flavonoid intake may cause adverse effects, so be alert to potential side effects. Because of this, we have successfully developed an electrochemical sensing platform for luteolin using a facile synthetic strategy. The core of this platform lies in the composite of metal oxides/alloys and nitrogen-doped porous carbon obtained after pyrolysis, whose unique porous architecture and rich pyrrolic nitrogen structure provide efficient adsorption sites for luteolin, while the diverse active centers embedded in the composite significantly enhance its electrocatalytic efficacy. The carefully constructed FeCo-NC-800/GCE electrochemical sensing platform exhibits excellent performance in detecting luteolin, even in actual samples such as peanut shells, honeysuckle, and chrysanthemum, which verified the accuracy of the sensor and demonstrated its great potential in practical applications. © 2025, The Authors. All rights reserved.

关键词： Porous carbon

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腹腔镜下微创手术治疗胃穿孔的临床疗效及对胃肠动力恢复的影响

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当代医学 2022年第18期28卷 47-50页

作者：王勇郑祖文刘伟四川护理职业学院附属医院/四川省第三人民医院普外科四川成都610100

目的探讨腹腔镜下微创手术治疗胃穿孔的临床疗效及对胃肠动力恢复的影响。方法选取2018年12月至2020年12月本院收治的90例胃穿孔患者作为研究对象,随机分为两组,每组45例。对照组给予传统开放性修补手术,观察组给予腹腔镜下微创手术,... 详细信息

目的探讨腹腔镜下微创手术治疗胃穿孔的临床疗效及对胃肠动力恢复的影响。方法选取2018年12月至2020年12月本院收治的90例胃穿孔患者作为研究对象,随机分为两组,每组45例。对照组给予传统开放性修补手术,观察组给予腹腔镜下微创手术,比较两组围术期相关指标、术后胃肠动力指标、不同术后时期的血清胃泌素(GAS)水平、手术并发症发生率。结果观察组住院时间、引流管留置时间及下床活动时间均短于对照组,住院费用、术中出血量均少于对照组,手术时间长于对照组,差异有统计学意义(P<0.05)。观察组GAS水平、胃动素(MTL)水平、胃电幅及胃电主功率均明显高于对照组(P<0.05)。术后1、2、3 d,观察组血清GAS水平均高于对照组(P<0.05)。观察组手术并发症发生率低于对照组(P<0.05)。结论对胃穿孔患者采用腹腔镜微创手术可以有效明显改善患者的胃肠动力和病情,有利于患者康复且安全性高,值得临床推广应用。

关键词：胃穿孔腹腔镜微创手术治疗胃肠动力恢复

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NLR与CAR在大肠癌围术期感染患者中的表达及其检测价值

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分子诊断与治疗杂志 2023年第5期15卷 805-808,812页

作者：王勇何能刘佳刘伟郑祖文四川护理职业学院附属医院(四川省第三人民医院)普外科四川成都610000

目的探讨中性粒细胞与淋巴细胞比值(NLR)与C反应蛋白/白蛋白比值(CAR)在大肠癌围术期感染患者中的表达及其检测价值。方法选取2019年10月至2021年10月于四川护理职业学院附属医院诊治的102例大肠癌患者为观察组,另取同期体检健康者60名... 详细信息

目的探讨中性粒细胞与淋巴细胞比值(NLR)与C反应蛋白/白蛋白比值(CAR)在大肠癌围术期感染患者中的表达及其检测价值。方法选取2019年10月至2021年10月于四川护理职业学院附属医院诊治的102例大肠癌患者为观察组,另取同期体检健康者60名为对照组,比较两组的CAR和NLR水平;根据围术期是否发生感染将观察组分为感染组与未感染组,比较两组一般资料和CAR和NLR水平;随访12个月,根据患者是否死亡将感染患者分为死亡组和存活组,采用ROC曲线分析CAR、NLR及两者联合检测对大肠癌患者围术期感染和预后的诊断价值。结果观察组的CAR、NLR水平高于对照组,差异有统计学意义(P<0.05);感染组的C⁃反应蛋白(CRP)、白细胞(WBC)、中性粒细胞和淋巴细胞以及CAR、NLR水平均高于未感染组,白蛋白(Alb)水平低于未感染组,差异有统计学意义(P<0.05);死亡组的CAR和NLR水平均高于存活组,差异有统计学意义(P<0.05);CAR和NLR联合诊断大肠癌患者围术期感染的AUC为0.915(95%CI:0.843~0.961),且联合诊断的AUC高于单一诊断(P<0.05);CAR和NLR联合评估大肠癌围术期感染患者预后的AUC为0.900(95%CI:0.766~0.971),且联合评估的AUC高于单一评估(P<0.05)。结论NLR和CAR可有效诊断大肠癌围术期感染,并预测感染患者预后。

关键词： NLR CAR 大肠癌感染

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Ultrasensitive electrochemical sensor for luteolin based on MOFs-derived metal oxide/alloy-doped nitrogen-containing porous carbon composites

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Talanta 2025年 296卷 128359页

作者： Jiejun Li Liang Wang Caiyu Ge zuwen zheng Yijing Wang Pengcheng Zhao Junjie Fei Yixi Xie Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education Xiangtan University Xiangtan 411105 People's Republic of China. Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education Xiangtan University Xiangtan 411105 People's Republic of China Hunan Institute of Advanced Sensing and Information Technology Xiangtan University Xiangtan 411105 People's Republic of China. Hunan Institute of Advanced Sensing and Information Technology Xiangtan University Xiangtan 411105 People's Republic of China. Electronic address: fei_junjie@***. Key Laboratory for Green Organic Synthesis and Application of Hunan Province Xiangtan University Xiangtan 411105 People's Republic of China. Electronic address: xieyixige@***.

As a natural flavonoid with diverse pharmacological activities, luteolin has shown attractive potential in various applications such as drug discovery, food preservation, health care products, and cosmetics. The precise quantification of luteolin is not only crucial for optimizing its therapeutic efficacy, but also for ensuring compliance with safety standards, as its biological activity largely depends on concentration thresholds and excessive intake may lead to adverse reactions. Here, we have successfully developed an electrochemical sensing platform for luteolin using a simple synthesis strategy. The core of this platform lies in the composite of metal oxides/alloys and nitrogen-doped porous carbon obtained after pyrolysis, whose unique porous architecture and rich pyrrolic nitrogen structure provide efficient adsorption sites for luteolin, while the diverse active centers embedded in the composite significantly enhance its electrocatalytic efficacy. The carefully constructed FeCo-NC-800/GCE electrochemical sensing platform exhibits excellent performance in detecting luteolin. More importantly, we have successfully applied this sensing platform to the detection of luteolin in actual samples such as peanut shells, honeysuckle, and chrysanthemum, which verified the accurate identification of luteolin by FeCo-NC-800/GCE in complex environmental backgrounds and demonstrated its great potential in practical applications.

关键词： Bimetallic Electrochemical sensor Food analysis Luteolin

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A convergence analysis for projected fast iterative soft-thresholding algorithm under radial sampling MRI

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JOURNAL OF MAGNETIC RESONANCE 2023年第1期351卷 107425页

作者： Qu, Biao Zhang, zuwen Chen, Yewei Qian, Chen Kang, Taishan Lin, Jianzhong Chen, Lihua Wu, Zhigang Wang, Jiazheng zheng, Gaofeng Qu, Xiaobo Xiamen Univ Dept Instrumental & Elect Engn Xiamen Peoples R China Xiamen Univ Biomed Intelligent Cloud R&D Ctr Dept Elect Sci Fujian Prov Key Lab Plasma & Magnet Resonance Xiamen Peoples R China Xiamen Univ Zhongshan Hosp Sch Med Dept Radiol Xiamen Peoples R China Chongqing Univ Canc Hosp Sch Med Dept Radiol Chongqing Peoples R China Philips Beijing Peoples R China

Radial sampling is a fast magnetic resonance imaging technique. Further imaging acceleration can be achieved with undersampling but how to reconstruct a clear image with fast algorithm is still challeng-ing. Previous work has shown the advantage of removing undersampling image artifacts using the tight -frame sparse reconstruction model. This model was further solved with a projected fast iterative soft-thresholding algorithm (pFISTA). However, the convergence of this algorithm under radial sampling has not been clearly set up. In this work, the authors derived a theoretical convergence condition for this algorithm. This condition was approximated by estimating the maximal eigenvalue of reconstruction operators through the power iteration. Based on the condition, an optimal step size was further suggested to allow the fastest convergence. Verifications were made on the prospective in vivo data of static brain imaging and dynamic contrast-enhanced liver imaging, demonstrating that the recommended parameter allowed fast convergence in radial *** 2023 Elsevier Inc. All rights reserved.

关键词： Radial sampling Fast algorithm Image reconstruction Compressed sensing MRI

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Automatic screening of patients with atrial fibrillation from 24-h Holter recording using deep learning

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EUROPEAN HEART JOURNAL - DIGITAL HEALTH 2023年第3期4卷 216-224页

作者： Zhang, Peng Lin, Fan Ma, Fei Chen, Yuting Fang, Siyi zheng, Haiyan Xiang, zuwen Yang, Xiaoyun Li, Qiang Huazhong Univ Sci & Technol Britton Chance Ctr Biomed Photon Wuhan Natl Lab Optoelect 1037 Luoyu Rd Wuhan 430074 Hubei Peoples R China Huazhong Univ Sci & Technol Collaborat Innovat Ctr Biomed Engn Sch Engn Sci MoE Key Lab Biomed Photon 1037 Luoyu Rd Wuhan 430034 Hubei Peoples R China Huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Dept Internal Med 1095 Jiefang Ave Wuhan 430030 Hubei Peoples R China Huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Div CardiolDept Internal Med 1095 Jiefang Ave Wuhan 430030 Hubei Peoples R China Zigui Cty Peoples Hosp Dept Rehabil Tradit Chinese Med 10 Changning Ave Yichang 443600 Hubei Peoples R China

AimsAs the demand for atrial fibrillation (AF) screening increases, clinicians spend a significant amount of time identifying AF signals from massive amounts of data obtained during long-term dynamic electrocardiogram (ECG) monitoring. The identification of AF signals is subjective and depends on the experience of clinicians. However, experienced cardiologists are scarce. This study aimed to apply a deep learning-based algorithm to fully automate primary screening of patients with AF using 24-h Holter *** and resultsA deep learning model was developed to automatically detect AF episodes using RR intervals and was trained and evaluated on 23 621 (2297 AF and 21 324 non-AF) 24-h Holter recordings from 23 452 patients. Based on the AF episode detection results, patients with AF were automatically identified using the criterion of at least one AF episode lasting 6 min or longer. Performance was assessed on an independent real-world hospital-scenario test set (19 227 recordings) and a community-scenario test set (1299 recordings). For the two test sets, the model obtained high performance for the identification of patients with AF (sensitivity: 0.995 and 1.000;specificity: 0.985 and 0.997, respectively). Moreover, it obtained good and consistent performance (sensitivity: 1.000;specificity: 0.972) for an external public data *** the criterion of at least one AF episode of 6 min or longer, the deep learning model can fully automatically screen patients for AF with high accuracy from long-term Holter monitoring data. This method may serve as a powerful and cost-effective tool for primary screening for AF. Graphical AbstractA deep learning algorithm uses RR interval data to automatically detect AF episodes and identify patients with AF. AF, atrial fibrillation;PAF, paroxysmal AF;WAF, whole-course AF;NAF, non-AF;AUC, area under the ROC curve;CI, confidence interval.

关键词： Deep learning Atrial fibrillation Electrocardiogram Holter monitoring Real-world clinical data

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Control strategy without phase-locked loop based on power estimation and natural frame for single-phase cascaded H-bridge converter

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INTERNATIONAL JOURNAL OF CIRCUIT THEORY AND APPLICATIONS 2022年第12期50卷 4517-4538页

作者： Zhang, Zhao Chen, Yanming Yang, Daliang Kong, Fannie Liu, Jinbao Shao, Dashuai Peng, zuwen Li, zheng Zeng, Sencai Zhao, Mingkai Guangxi Univ Coll Elect Engn Nanning 530004 Peoples R China

Based on a single-phase cascaded H-bridge (CHB) multilevel converter, this paper investigates a control strategy combining power estimation and natural frame control (NFC) with the omission of grid voltage sensors. Besides, this control method, without phase-locked loop (PLL), can meet the continuous operation of the system and also eliminates grid voltage feedforward. First, natural frame control is introduced to derive the implementation process of control strategy without PLL, and the calculation formula of AC reference currents is given. Furthermore, the separate control of active and reactive currents is achieved. Second, the principle of proposed control algorithm is presented, and the sinusoidal voltage unit vector for synchronization can be accurately estimated. Next, considering the errors, the article corrects the method through parameter compensation. In addition, the balanced control method stabilized the DC side voltage of the converter. Finally, the effectiveness of this method is verified by computer simulation and experimental prototype.

关键词： cascaded H-bridge (CHB) natural frame control (NFC) grid voltage sensors phase-locked loop (PLL) power estimation

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Voltage-Sensorless Natural Frame Control for Single-Phase CHB Converter under Distorted Grid Conditions

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ENERGIES 2022年第3期15卷 769页

作者： Shao, Dashuai Liu, Jinbao Yang, Daliang Peng, zuwen Li, zheng Guangxi Univ Guangxi Key Lab Power Syst Optimizat & Energy Tec Nanning 530004 Peoples R China Guangxi Univ Coll Elect Engn Nanning 530004 Peoples R China

In this paper, a control scheme combining grid voltage sensorless control and natural frame control (NFC) has been proposed for single-phase cascaded H-bridge converter (CHB) under distorted grid conditions. Firstly, the virtual flux (VF) signal is estimated by a modified virtual flux estimator (VFE). Then the VF-based NFC is derived, using the estimated sinusoidal VF signal to generate the unit vectors for synchronization, which enables the omitting of the coordinate transformation, current quadrature signal generation, and phase-locked loop (PLL). Aiming at the problem that grid harmonic interference is not well considered in the conventional NFC and conventional voltage sensorless control, a current controller with enhanced harmonic-rejection ability is proposed in this paper. As a result, better steady-state performance and rapid transient response are achieved. The effectiveness of the proposed method has been verified on a prototype of the single-phase 3-cell CHB converter.

关键词： cascaded H-bridge distorted grid conditions natural frame control voltage sensorless control virtual flux

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腹腔镜辅助结直肠癌根治术治疗结直肠癌的疗效及对患者营养水平、机体免疫状态的影响

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癌症进展 2019年第5期17卷 595-598页

作者：王勇余应筠郑祖文刘伟成都市航天医院普外科成都6101000 成都市航天医院科教处成都6101000

目的观察腹腔镜辅助结直肠癌根治术对结直肠癌患者的临床疗效,分析结直肠癌患者手术前后营养水平与机体免疫状态的变化情况。方法回顾性分析92例结直肠癌患者的临床资料,根据手术方法的不同将患者分为研究组与对照组,每组46例。研究组... 详细信息

目的观察腹腔镜辅助结直肠癌根治术对结直肠癌患者的临床疗效,分析结直肠癌患者手术前后营养水平与机体免疫状态的变化情况。方法回顾性分析92例结直肠癌患者的临床资料,根据手术方法的不同将患者分为研究组与对照组,每组46例。研究组患者行腹腔镜辅助结直肠癌根治术,对照组患者行常规开腹手术。观察两组患者的围手术期指标(手术时间、术中出血量、术后排气时间、术后住院时间),采用免疫混悬计检测法检测两组患者的术后机体免疫指标[自然杀伤(NK)细胞、C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]和营养指标[白蛋白(ALB)、血红蛋白(Hb)、转铁蛋白(TRF)、前白蛋白(PRE)、视黄醇结合蛋白(RBP)]。结果研究组患者的术中出血量明显低于对照组患者,术后排气时间和术后住院时间均明显短于对照组患者,手术时间明显长于对照组患者(P﹤0.01)。术后7天,对照组患者的ALB、Hb、TRF、PRE、RBP水平均低于研究组患者(P﹤0.05)。术后7天,研究组患者的CRP、IL-6和TNF-α水平均明显低于对照组患者,NK细胞水平明显高于对照组患者(P﹤0.01)。结论临床中对结直肠癌患者实施腹腔镜手术治疗是可行的,腹腔镜手术对患者机体免疫力的影响较小,且能够促进患者术后机体的恢复,改善患者术后的营养水平,值得临床推广应用。

关键词：结直肠癌腹腔镜营养水平免疫状态

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Indirect Current Control Method Based on Reference Current Compensation of an LCL-Type Grid-Connected Inverter

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ENERGIES 2022年第3期15卷 965页

作者： Li, zheng Yang, Linhang Yang, Daliang Peng, zuwen Shao, Dashuai Liu, Jinbao Guangxi Univ Guangxi Key Lab Power Syst Optimizat & Energy Tec Nanning 530004 Peoples R China Guangxi Univ Coll Elect Engn Nanning 530004 Peoples R China

NPC (neutral point clamped converter) is widely used in medium- and high-voltage grid connection because of its small power devices, simple overall structure, and easy control. This paper presents an improved indirect current control strategy for an LCL-type NPC. Firstly, the reference current is compensated to suppress the resonant peak of the LCL filter and improve the tracking accuracy of the output current. Then, with the relationship between state variables, the control structure is optimized by introducing the non-PLL control method, so that the sensors are reduced to only two sets. Finally, the traditional differential operator is improved to compensate the calculation delay in digital control. The experimental results show that the amplitude of thee grid-connected current is consistent with the reference value, the phase deviation is reduced from 7 degrees to about 1 degrees, and the transient response time is shortened to 1/3 of that of the traditional method.

关键词： LCL filter three-phase grid-connected inverter indirect current control reference current compensation calculation delay

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