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Hormonal Influence in Stress Urinary Incontinence During Pregnancy and Postpartum

REPRODUCTIVE SCIENCES 2022年第8期29卷 2190-2199页

作者： Molinet Coll, Cristina Martinez Franco, Eva Altimira Queral, Laura cuadras, daniel Amat Tardiu, Lluis Pares, David Parc Sanitari St Joan de Deu Gynecol & Obstet Dept St Boi De Llobregat Spain Univ Barcelona UB C Antoni Pujadas 42 Barcelona 08830 Spain Parc Sanitari St Joan de Deu Chem Lab St Boi De Llobregat Spain Fundacio St Joan de Deu Stat Advising Serv Barcelona Spain Univ Barcelona UB Gynecol & Obstet Dept Hosp St Joan de Deu Barcelona Spain Univ Autonoma Barcelona Hosp Germans Trias & Pujol Sch Med Dept SurgColorectal Surg Unit Barcelona Spain

Hormonal changes have been proposed as an etiological factor of stress urinary incontinence (SUI) during pregnancy. Our main objective was to demonstrate the role of hormones in SUI development during pregnancy and postpartum. A prospective longitudinal study was designed. Primiparous women without previous urinary incontinence symptoms were included. Symptoms and Quality of Life (QoL) Questionnaires, physical examinations, and hormone concentration (progesterone, estradiol, and relaxin) were collected twice during pregnancy and three times during postpartum. Logistic regression models, with Wald's forward variable selection method, were used. Prevalence of SUI was 11% in the first trimester, 50% in the third trimester, and 16.4% at 6 months postpartum. The risk of developing SUI throughout pregnancy is higher in women with higher progesterone concentration in the first trimester (OR 1.38, 95% CI 1.06-1.81, p < 0.05) and it is lower in women with stronger pelvic floor muscles in the first trimester (OR 0.35, 95% CI 0.17-0.72, p < 0.05). When occurred during pregnancy, SUI has a 14-fold higher risk of persistence 6 months after birth. In addition, the severity of these symptoms is also an independent risk factor for SUI persistence at 6 months postpartum (OR 1.41, 95% CI 1.15-1.73, p < 0.05). Quality of Life was affected for pregnant women with SUI symptoms. SUI is a highly prevalent condition during pregnancy, affecting the QoL of women in many areas. Higher concentration of progesterone can play a role in SUI development during pregnancy. The presence and severity of SUI during pregnancy are risk factors for the persistence of symptoms 6 months postpartum. Sustaining an optimal pelvic floor muscle strength could prevent SUI during pregnancy.

关键词： Estradiol Pregnancy Progesterone Quality of life Relaxin Stress urinary incontinence

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Does the saltatory pattern on cardiotocograph (CTG) trace really exist? The ZigZag pattern as an alternative definition and its correlation with perinatal outcomes

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JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 2021年第21期34卷 3537-3545页

作者： Gracia-Perez-Bonfils, Anna Vigneswaran, Kugajeevan cuadras, daniel Chandraharan, Edwin Hosp Gen LHospitalet Gynaecol & Obstet Barcelona Spain NHS Trust Kings Coll Hosp London England St Joan de Deu Hosp Grp Stat Barcelona Spain St Georges Univ Hosp NHS Fdn Trust London England

Background: The saltatory pattern (SP) has been defined by guidelines as a uniformly increased bandwidth of >25 beats per min lasting for 30 min. However, previous research suggest that it is very unusual to observe such a "uniform" increase in the bandwidth persisting for >30 min. Baseline fetal heart rate variability (FHRV) on cardiotocography reflects the integrity of the central nervous system. During labor, in the presence of a gradually-evolving hypoxia associated with the onset of metabolic acidosis, FHRV may be reduced. However, if a fetus is exposed to rapidly-evolving hypoxia, it may not have sufficient time to release catecholamines and the perfusion of central organs can be impaired. In such cases, simultaneous increased activity of the sympathetic nervous system to obtain more oxygen as well as enhanced parasympathetic activity to reduce the myocardial workload can lead to autonomic instability. This exaggerated autonomic response can be seen frequently on the cardiotocograph as a rapid, irregular, abrupt "up and down" fluctuation across the baseline (amplitude >25 beats per min). The authors have termed this pattern as "ZigZag" when apparent for a minimum of 1 min. It differs from the SP in terms of duration and uniformity of the bandwidth. Objective: To determine the incidence of the SP during labor as well as a shorter and less uniform version of the SP newly called "ZigZag pattern" (ZZP). The intention was to correlate them with perinatal outcomes, taking into account the duration of the ZZP. Study design: A retrospective analysis of 500 consecutive cardiotocograph traces was performed to identify saltatory patterns and ZigZag patterns of 1 and 2 min of duration. Apgar scores, umbilical cord pH values and admission to the Neonatal Unit were evaluated and correlated with the cardiotocograph findings. Results: Not a single case of the SP was observed. A ZZP of 1 min of duration (ZZP1) was identified in 30.1% of the CTG during the last hour prior to de

关键词： Cardiotocograph CTG increased variability saltatory pattern ZigZag pattern

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RISK score for developing ventilator-associated pneumonia in children: The RISVAP study

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PEDIATRIC PULMONOLOGY 2022年第7期57卷 1635-1642页

作者： Girona-Alarcon, Monica Bobillo-Perez, Sara Sole-Ribalta, Anna cuadras, daniel Guitart, Carmina Balaguer, Monica Cambra, Francisco-Jose Jordan, Iolanda Univ Barcelona Hosp St Joan Deu Pediat Intens Care Unit Passeig St Joan Deu 2 Barcelona 08950 Spain Inst Recerca St Joan Deu Immunol & Resp Disorders Paediat Crit Patient Res Barcelona Spain Hosp St Joan Deu Paediat & Neonatal Emergency Transport Syst Barcelona Spain Hosp St Joan Deu Dept Stat Barcelona Spain Univ Barcelona Hosp St Joan Deu Pediat Intens Care Unit CIBERESP Barcelona Spain

Objectives Ventilator-associated pneumonia (VAP) is the second most common healthcare-associated infection in children. The aim of this study was to determine the risk factors for VAP in children and to create a risk score for developing VAP (RISVAP score). Study design It was a prospective observational study, including children who required mechanical ventilation (MV), registered in the multicentre ENVIN-HELICS database from 2014 to 2019. The regression coefficients of each independent risk factor for VAP were used to create the RISVAP score. Each factor scored 0 if it was absent, or, if it was present, an assigned value from 1 to 7, according to the regression coefficient. Results A total of 3798 patients were included, 97(2.5%) developing VAP. The independent risk factors for VAP were: female (odds ratio [OR]: 1.642, p = 0.024), MV > 4 days (OR: 26.79, p < 0.001), length in pediatric intensive care unit > 7 days (OR: 11.74, p < 0.001), and previous colonisation (OR: 4.18, p < 0.001). The RISVAP was calculated for each patient as the sum of all the independent risk factors. Three risk groups were obtained: low (0-5 points), intermediate (6-12 points), and high risk for VAP (13-16 points). The area under the curve for the final score was 0.905 (95%confidence interval: 0.888-0.923, p < 0.001). Conclusions The RISVAP is the first risk score for VAP in pediatric populations. Using this predictive score, might be helpful to detect vulnerable patients and therefore implement preventative strategies.

关键词： healthcare-associated infection intensive care pediatrics ventilator-associated pneumonia

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Monoamine neurotransmitters in early epileptic encephalopathies: New insights into pathophysiology and therapy

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DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 2022年第7期64卷 915-923页

作者： Julia-Palacios, Natalia Molina-Anguita, Cristina Sigatulina Bondarenko, Maria Cortes-Saladelafont, Elisenda Aparicio, Javier cuadras, daniel Horvath, Gabriella Fons, Carmen Artuch, Rafael Garcia-Cazorla, Angels Hosp St Joan Deu Inst Recerca Neurol Dept CIBERERNeurometab Unit Barcelona Spain Hosp St Joan Deu MetabERN Barcelona Spain Consorci Sanitari Terrasa Neurol Unit Dept Pediat Barcelona Spain Hosp Badalona Germans Trias & Pujol Dept Pediat Unit Inherited Metab Dis & Neuropediat Barcelona Spain Hosp St Joan Deu Inst Recerca Neurol Dept Epilepsy Unit Barcelona Spain Hosp St Joan Deu EpiCare Barcelona Spain Inst Recerca St Joan Deu Stat Dept Barcelona Spain Univ British Columbia Div Biochem Genet Dept Pediat Vancouver BC Canada Hosp St Joan Deu Inst Recerca Fetal Neonatal Neurol & Early Epilepsy Unit Neurol Dept Barcelona Spain Hosp St Joan Deu Barcelona IPR Dept Clin Biochem Barcelona Spain Hosp St Joan Deu Barcelona CIBERER ISCIII Barcelona Spain

Aim To study neurotransmitter status in children with early epileptic and developmental and epileptic encephalopathy (DEE) and to explore the clinical response to dopaminergic and serotoninergic therapies in a group of patients. Method Two hundred and five patients (111 males [54.1.%] and 94 females [45.9%], mean age 10 months at the onset of epilepsy [SD 1 year 1 month], range 0-3 year) with epileptic encephalopathy/DEE were recruited, including those with West syndrome, Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, myoclonic encephalopathy in non-progressive disorders, infantile spasms, Doose syndrome, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, and those unclassified. Cerebrospinal fluid (CSF) neurotransmitter studies and patients' medical records were reviewed. Additionally, we present clinical data of 10 patients with low CSF neurotransmitter levels who received dopaminergic/serotoninergic treatments. Results Abnormal neurotransmitter values were identified in 68 (33%) patients. 5-Hydroxyindoleacetic acid (5-HIAA) deficit was the most prevalent alteration (91%). Low CSF 5-HIAA levels were significantly higher in 1- to 3-year-old children. A negative significant correlation was found between 5-HIAA levels and epilepsy duration before CSF study (Spearman's rho=-0.191, p=0.007). Abnormalities in deep grey matter were associated with low levels of CSF homovanillic acid and 5-HIAA. Ten patients with low CSF neurotransmitter levels received dopamine and/or serotonin therapies. Six of them showed initial decrease of seizure frequency and severity and maintained improvement in some neurodevelopmental skills. Interpretation A considerable number of patients showed neurotransmitter abnormalities. Age at seizure onset and duration of epilepsy before CSF study were the principal factors related to neurotransmitter depletion. Early monoamine supplementation would seem advisable as a neuroprotective strategy. Wha

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CREST-UK: CPX-351 Real-World Effectiveness and Safety Study for the Treatment of Newly Diagnosed Therapy-Related AML and AML with Myelodysplasia-Related Changes in the UK

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BLOOD 2022年 140卷 6152-6154页

作者： Mehta, Priyanka Khan, Anjum Maddox, Jamie Floisand, Yngvar Whitmill, Richard cuadras, daniel Pedros, Montse Park, Saemi Medalla, Greg Legg, Alex Campbell, Victoria Louise Univ Hosp Bristol & Weston NHS Fdn Trust Bristol Avon England Leeds Teaching Hosp NHS Trust St Jamess Inst Oncol Leeds W Yorkshire England South Tees Hosp NHS Fdn Trust Middlesbrough Cleveland England NHS Fdn Trust Clatterbridge Canc Ctr Liverpool Merseyside England Royal Wolverhampton NHS Fdn Trust Wolverhampton England IQVIA Real World Solut Barcelona Spain Jazz Pharmaceut Oxford England Western Gen Hosp Edinburgh Midlothian Scotland

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Clinical Genetics Assessment Triangle (CGAT): A simple tool to identify patients with genetic conditions

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EUROPEAN JOURNAL OF MEDICAL GENETICS 2023年第11期66卷 104858-104858页

作者： Ferri-Rufete, David Lopez-Gonzalez, Aitor Casas-Alba, Didac cuadras, daniel Palau, Francesc Martinez-Monseny, Antonio Hosp St Joan de Deu Dept Pediat Esplugas de Llobregat 08950 Spain Hosp St Joan de Deu Dept Genet Med Pediat Inst Rare Dis IPER Passeig de St Joan de Deu 2 Esplugas de Llobregat 08950 Spain Fundacio St Joan de Deu Stat Dept Esplugas de Llobregat 08950 Spain Inst Salud Carlos III Ctr Invest Biomed Red Enfermedades Raras CIBERER Madrid 28029 Spain

Objective: The objective of this study was to develop a simple tool for general physicians to promptly identify and refer pediatric patients with a higher probability of having a genetic condition. Study design: This retrospective, descriptive study was conducted at a tertiary pediatric hospital's Clinical Genetics Unit from June 2019 to January 2020. We included patients under 18 years of age who visited the unit, excluding those without genetic testing. Epidemiological, clinical, and genetic variables were collected from electronic medical records. The primary outcome was the diagnosis of a genetic condition based on genetic testing. Results: Among 445 patients, 304 were included;163 (53.6%) were male, and mean age was 7.4 years (SD 5.1 years). A genetic condition was diagnosed in 139 patients (45.7%). Using a multiple logistic regression model, five variables significantly contributed to reaching a diagnosis: suspected diagnosis at referral (OR 3.45, P < 0.001), short stature (OR 3.11, P < 0.001), global developmental delay/intellectual disability (OR 2.65, P < 0.001), dysmorphic craniofacial features (OR 1.99, P = 0.035), and multiple congenital anomalies (OR 2.54, P = 0.033). The association strength (OR) increased when these variables were paired with each other. The study's findings are presented in the form of a triangle, known as the Clinical Genetics Assessment Triangle (CGAT), which summarizes the results. A decision tree model is applied to guide clinical department referrals based on the affected sides of the triangle. Conclusions: The CGAT has the potential to enable general physicians to promptly identify pediatric patients with an increased probability of having a genetic condition.

关键词： Pediatric patients Genetic testing Clinical genetics Dysmorphology Referral criteria Pediatric patients Genetic testing Clinical genetics Dysmorphology Referral criteria

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Transperineal anal sphincter complex evaluation after obstetric anal sphincter injuries: With or without tomographic ultrasound imaging technique?

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EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 2021年 257卷 70-75页

作者： Franco, Eva Martinez Ros, Cristina Santoro, Giulio Aniello Garriga, Jordi Cassado Tardiu, Lluis Amat cuadras, daniel Espuna, Montserrat Parc Sanitari St Joan de Deu Obstet & Gynecol Barcelona Spain Univ Barcelona Hosp Clin Barcelona ICGON Pelv Floor Unit Barcelona Spain Treviso Reg Hosp Dept Surg Pelv Floor Unit Treviso Italy Univ Hosp Mutua Terrassa Obstet & Gynecol Barcelona Spain Hosp St Joan de Deu Obstet & Gynecol Barcelona Spain Fundacio St Joan de Deu Stat Advising Serv Barcelona Spain

Objectives: "Significant" obstetric anal sphincter injuries (OASIS) have been defined as visible defects of at least 30 degrees in at least 4/6 slices using tomographic ultrasound imaging (TUI) with transperineal ultrasound (TPUS). The objective of this study was to assess if TUI is mandatory for the evaluation of OASIS. Methods: Patients with a history of OASIS were evaluated by performing 3D-endoanal ultrasound (EAUS) and 3D-TPUS with and without TUI. Any damage to the internal (LAS) or external (EAS) anal sphincters was recorded and scored using the Starck's and the Norderval's systems. Intraobserver and intertechniques correlations were calculated. Results: From September 2012 to May 2015, 63 women, mean age 32.5 +/- 4.6 years, with OASIS (3a: 26 pts., 41.3 %;3b: 26 pts., 41.3 %;3c: 6 pts., 9.5 %, 4: 4 pts., 6.3 %, "button hole" tear: 1 pt., 1.6 %). Inter-technique and intraobserver correlations were excellent (TUI: k = 0.9;sweeping technique: k = 0.85;EAUS: k = 0.9) in determining OASIS. Using the Starck's Score, excellent correlation was found for both TPUS modalities (TUI: k = 0.86;sweeping technique: k = 0.89). However, for the different individual parameters, the correlation was moderate for EAS depth (TUI: k = 0.44;sweeping technique: k = 0.5) and good for LAS depth (TUI: k = 0.7;sweeping technique: k = 0.78). Similar results were found using the Norderval's classification. Conclusions: OASIS can be assessed by TPUS without TUI technique, dragging the rendered box and following the anal canal from the anal verge to the anorectal junction in the longitudinal plane and describing findings. (C) 2020 Elsevier B.V. All rights reserved.

关键词： Anal sphincter OASIS Transperineal ultrasound Tomographic ultrasound imaging

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Clinical Characterization, Transmissibility, and Seroconversion of SARS-CoV-2 Infection in Children (before the Start of Vaccination) in the Barcelona Metropolitan Region (Spain)

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JOURNAL OF PEDIATRIC INFECTIOUS DISEASES 2024年第5期19卷 251-259页

作者： Pons-Tomas, Gemma Hernandez-Garcia, Maria Mele-Casas, Maria de-Sevilla, Mariona F. Launes, Cristian Girona-Alarcon, Monica Barnes, Maria Rios Bassat, Quique Ajanovic, Sara Cubells, Marta Claverol, Joana Penela-Sanchez, daniel Jou, Cristina Monsonis, Manuel Esteva, Cristina Fassanella, Assumpta cuadras, daniel Munoz-Almagro, Carmen Jordan, Iolanda Fortuny, Claudia Garcia-Garcia, Juan Jose Fumado, Victoria Univ Barcelona Hosp St Joan Deu Dept Pediat Barcelona Spain Inst Recerca St Joan Deu IRSJD Infect Dis & Microbiome Barcelona Spain Univ Barcelona Inst Recerca St Joan Deu Barcelona Spain Consorcio Invest Biomed Red Epidemiol & Salud Publ Madrid Spain Univ Barcelona Hosp St Joan Deu Pediat Intens Care Unit Barcelona Spain Hosp St Joan deu Dept Infect Dis Barcelona Spain Univ Barcelona Hosp Clin ISGlobal Barcelona Spain Ctr Invest Saude Manhica CISM Maputo Mozambique Inst Catalana Recerca & Estudis Avancats ICREA Barcelona Spain Hosp St Joan Deu Dept Pathol & Biobank Barcelona Spain Inst Salud Carlos III Ctr Invest Biomed Red Enfermedades Raras CIBERER Barcelona Spain Hosp St Joan Deu Dept Microbiol Barcelona Spain Hosp St Joan de Deu Dept Mol Microbiol Barcelona Spain Fundacio St Joan Deu Stat Dept Barcelona Spain Univ Int Catalunya Dept Med Barcelona Spain Univ Barcelona Fac Med & Hlth Sci Dept Surg & Med Surg Specialties Barcelona Spain

Objective Analyzing the clinical and microbiological characteristics of coronavirus disease 2019 (COVID-19) infection in children seems essential to determine their role in the etiopathogenesis of the disease. Methods A prospective, longitudinal, and observational study, including children with severe acute respiratory syndrome coronavirus-2 infection, in the Barcelona Metropolitan Region (Spain), was performed. The recruitment pathways were: (1) children who attended a summer school and were included in an active surveillance study and (2) children who were visited in the Emergency Department of Hospital Sant Joan de Deu with symptoms. Close contacts with positive polymerase chain reaction (PCR) results were also included. The children recruited were followed up for 5 weeks. Evaluation of participants included a questionnaire for COVID-19 symptoms, nasopharyngeal swabbing for real-time PCR at 0, 7, and 14 days (weekly repeated up to week 5 if it resulted positive at 14 days), and serology testing at the recruitment and at the fifth week of follow-up. Results A total of 90 children were recruited, of which 32% were asymptomatic. Transmission was studied in 70/90 children, and in 12 cases (17%), transmission to other children or adults was observed. No clinical or epidemiological differences were found between children who transmitted and those who did not. At the end of the follow-up, 11% of nasopharyngeal PCR remained positive. The serological response was studied in 73/90 children, and 80.82% of children seroconverted. Conclusion No differences in epidemiological characteristics were found between children who transmitted and those who did not. PCR can be persistently positive for more than 5 weeks. The majority of patients who suffer from the disease produce antibodies against it.

关键词： SARS-CoV-2 children RNA persistence serological response antibodies infectivity

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Do the clinical criteria used to diagnose periodontitis affect the association with prematurity?

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ODONTOLOGY 2021年第2期109卷 455-463页

作者： Moncunill-Mira, Jordi Brunet-Llobet, Lluis cuadras, daniel Lorente-Colome, Nuria Pascal, Rosalia Rovira, Carlota Nadal, Alfons Miranda-Rius, Jaume Univ Barcelona Hosp St Joan Deu Dept Dent Barcelona Spain Inst Recerca St Joan Deu IRSJD Clin Orthodont & Periodonta Med Res Grp HDCORPEMr Hosp Dent Barcelona Spain Fundacio St Joan Deu FSJD Stat Unit Barcelona Spain Univ Barcelona Hosp St Joan Deu BCNatal Barcelona Ctr Maternal Fetal & Neonatal Barcelona Spain Univ Barcelona Hosp St Joan Deu Dept Pathol Barcelona Spain Univ Barcelona Agust Pi & Sunyer Biomed Res Inst IDIBAPS Dept Pathol Hosp Clin Barcelona Spain Univ Barcelona Fac Med & Hlth Sci Dept Odontostomatol Feixa Llarga S-N Barcelona 08907 Spain

In recent years, several studies have examined the possible relationship between periodontal disease in pregnant women and preterm birth. One of the difficulties facing these studies is the heterogeneity of the clinical criteria used to define periodontitis. The aim of this cross-sectional study was to determine the degree of association between maternal periodontitis and preterm birth according to different consensus definitions of periodontal disease. In a study of 146 mothers (60 with preterm births and 86 with term deliveries) at the Sant Joan de Deu Maternal and Children's Hospital in Barcelona, a periodontal examination was carried out within 2 days of birth and the presence of periodontal disease was evaluated using the main clinical classifications published in the literature. The prevalence of periodontitis ranged from 25.4 to 52.1%, depending on the criteria used for its definition. Using the most restrictive criteria, pregnant women with periodontitis had a higher risk of preterm birth (OR: 7.49;p < 0.001) and premature rupture of membranes (OR: 2.49;p = 0.017). Premature infants born to mothers with periodontitis presented a tendency toward low weight, adjusted for gestational age (OR: 3.32;p = 0.065). Our findings suggest that the association between periodontitis and preterm birth is influenced by the definitions of periodontitis used.

关键词： Clinical diagnosis Periodontitis Gingivitis Epidemiology Premature birth

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Prenatal selection of cord blood donors according to the estimated fetal weight percentile and new approaches;results of a prospective cohort study

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TRANSFUSION 2021年第4期61卷 1215-1221页

作者： Lin Xinxin Crovetto, Francesca Gonzalez, Alba cuadras, daniel Sanchez, Mar Azqueta, Carmen Farssac, Elisenda Torrabadella, Marta Querol, Sergio Gomez-Roig, Maria Dolores Univ Barcelona BCNatal Barcelona Ctr Maternal Fetal & Neonatal Hosp Sant Joan Deu Barcelona Spain Univ Barcelona Hosp Clin IDIBAPS Barcelona Spain Sant Joan Deu Fdn Stat Dept Barcelona Spain Programa Concordia Banc Sang & Teixits Barcelona Spain Inst Recerca Sant Joan Deu IR SJD Barcelona Spain Maternal & Child Hlth Ans Dev Network SAMID Baracaldo Spain

Background Umbilical cord blood (UCB) donation is becoming inefficient and we recently proposed the estimated fetal weight percentile (EFWp) >= 60th as a predictor for a prenatal selection of donors. The aim of this study is to prospectively validate this and to identify new potential prenatal predictive parameters. Study Design and Methods Prospective cohort study of low-risk pregnancies undergoing third trimester ultrasound, whose UCB was collected at delivery (2016-2018) and compared with a historical cohort (2013-2016, N = 869). Several ultrasound parameters (EFWp, amniotic fluid, Doppler evaluation, placental thickness) were assessed ultrasound and perinatal data were collected. The association with standard of high quality of UCB was assessed by logistic regression analysis. Results Among 297 cases, 161 (54%) were selected according to the EFWp >= 60th for UCB units' collection. Cellular criteria for banking was achieved in 27 cases (16.8%), with an average increase of 1.7 times compared to the historical cohort (9.8%, P = .009). Selecting donors according to the 60th EFWp resulted in a higher probability of collecting clinical suitable UCB (P = .025). Among prenatal and perinatal parameters, EFWp, amniotic fluid, umbilical vein (UV) velocity, newborn weight and percentile and placental weight were significantly associated with a higher cellular content. At logistic regression analysis, significant contributors of UCB collection, were EFWp at 37-38 weeks ultrasound (OR 1.04;95% CI: 1-1.08;P = .042) and UV velocity (OR 1.14;95% CI: 1-1.29;P = .037). Conclusion The evaluation of the EFWp equal or above 60 and the increased UV velocity can result in higher efficiency of public UCB donation programs.

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