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Expression of Protein SOX9 in Biliary Atresia

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 2022年第2期74卷 E21-E26页

作者： Arboleda-Bustan, Jenny E. Ribalta, Teresa Albert, Asteria cuadras, daniel Martin-Sole, Oriol Hosp Pediat Baca Ortiz Dept Pediat Surg Quito Ecuador Univ Barcelona Hosp Clin Hosp St Joan Deu Dept Pathol Barcelona Spain Inst Invest Biomed August Pi i Sunyer IDIBAPS Barcelona Spain Hosp St Joan Deu Dept Pediat Surg Barcelona Spain Hosp St Joan Deu Dept Stat Barcelona Spain

Objectives: Biliary atresia (BA) is still an enigmatic disease. Deeper knowledge of its pathophysiology could help develop better treatments. SOX9 regulates bile duct development, liver regeneration and fibrosis;therefore, it could be determinant in characterizing BA liver damage. Aim: To study if there is a SOX9 expression pattern in liver biopsies from BA patients. Methods: Liver biopsies from BA patients (group BA), from age-matched infants without primary hepatic disease (group Control), and from patients with other liver conditions (group OLC) were compared. Expression of SOX9 was checked for: amount, intensity of immunoreaction, localization within ductular structures, perifibrotic epithelial cells, and lobular cells. The scores were added to create a scale from 0 to 11 that allowed group comparison. SOX9 Scale and liver survival were also looked for a correlation. Results: All BA cases had a score >4, while all controls scored <4. OLC livers scored 1 to 8 (3.5 +/- 2.0) (P < 0.001 between all groups). A cut-off at 4 had 100% sensitivity and 88.24% specificity to differentiate BA from Controls and from OLC (area under receiver operating characteristic curve: 0.9989 (95% confidence interval: 0.9964-1.000). Strong expression of SOX9 was observed mainly in the nuclei of proliferated ductules of portal spaces and fibrotic bridges. SOX9 Scale score could not be related to liver survival in this study. Conclusion: In BA livers, SOX9 is mainly expressed in reactive ductular epithelium, following a pattern significantly different from that seen in non-BA patients;thus, SOX9 Scale may have a role in the diagnosis of BA.

关键词： biliary atresia immunohistochemistry liver biopsy SOX9

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Human papillomavirus-driven head and neck cancers in Japan during 2008-2009 and 2018-2019: The BROADEN study

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CANCER SCIENCE 2024年第8期115卷 2808-2818页

作者： Nibu, Ken-ichi Oridate, Nobuhiko Saito, Yuki Roset, Montserrat Maresma, Marta Fores cuadras, daniel Morais, Edith Roberts, Craig Chen, Ya-Ting Spitzer, Jacque Sato, Kayo Saito, Itori Tazaki, Ichiro Clavero, Omar Schroeder, Lea Alemany, Laia Mehanna, Hisham Mirghani, Haitham Giuliano, Anna R. Pavon, Miquel Angel Waterboer, Tim Kobe Univ Grad Sch Med Dept Otolaryngol Head & Neck Surg Kobe Hyogo Japan Yokohama City Univ Sch Med Dept Otorhinolaryngol Head & Neck Surg Yokohama Kanagawa Japan Univ Tokyo Dept Otolaryngol & Head & Neck Surg Tokyo Japan IQVIA Barcelona Spain MSD France Puteaux La Defense France Merck & Co Inc Rahway NJ USA MSD KK Tokyo Japan Catalan Inst Oncol IDIBELL Canc Epidemiol Res Program Barcelona Spain Inst Salud Carlos III Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER Madrid Spain German Canc Res Ctr Neuenheimer Feld 280 D-69120 Heidelberg Germany Univ Birmingham Inst Head & Neck Studies & Educ InHANSE Birmingham England Univ Paris Cite Hop Europeen Georges Pompidou APHP Dept Oto Rhino Laryngol & Head & Neck Surg Paris France H Lee Moffitt Canc Ctr & Res Inst Ctr Immunizat & Infect Res Canc Tampa FL USA

There is limited understanding of epidemiology and time trends of human papilloma virus (HPV)-driven head and neck cancers (HNC) in Japan, especially outside of the oropharynx. To assess HPV-driven HNC, a non-interventional study (BROADEN) of HNC patients diagnosed in 2008-2009 and 2018-2019 was conducted in Japan. Adult patients with oropharyngeal, nasopharyngeal, laryngeal, hypopharyngeal or oral cavity cancers were included in this study. HPV was centrally tested using p16INK4a immunohistochemistry, HPV-DNA PCR and HPV E6*I mRNA. HPV attributability required positivity in at least two tests (p16INK4a immunohistochemistry, HPV-DNA PCR, HPV E6*I mRNA) in the oropharynx, and HPV-DNA and HPV E6*I mRNA positivity for non-oropharynx sites. Nineteen hospitals included a total of 1108 patients, of whom 981 had valid samples. Men accounted for 82% of HNC diagnoses. Patients in the earlier cohort were younger and included a higher percentage of smokers. There was an increasing trend of HPV-driven oropharyngeal cancer over the last decade, from 44.2% to 51.7%. HPV attribution in nasopharyngeal cancers was 3.2% in 2008-2009 and 7.5% in 2018-2019;and 4.4% and 0% for larynx respectively. In total, 95.2% of HPV-driven HNC were attributed to HPV genotypes included in the 9-valent HPV vaccine being HPV16 the most prominent genotype. These results suggest that an epidemiologic shift is happening in Japan, with a decrease in smoking and alcohol use and an increase in HPV-driven HNC. The increasing trend of HPV-driven HNC in Japan highlights the need for preventive strategies to mitigate the rise of HPV-driven HNC. The BROADEN study is one of the largest observational studies conducted in Japan assessing human papilloma virus (HPV) in head and neck cancer (HNC). The study includes 1108 patients diagnosed in 2008-2009 and 2018-2019 across 19 hospitals. Overall 981 HNC samples were tested by HPV-DNA PCR, p16INK4a, and HPV E6*I mRNA in a central laboratory using strict quality control

关键词： HPV attributability HPV genotype HPV-driven HNC HPV-driven vaccine oropharyngeal cancer

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CREST-UK: Real-world effectiveness, safety and outpatient delivery of CPX-351 for first-line treatment of newly diagnosed therapy-related AML and AML with myelodysplasia-related changes in the UK

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BRITISH JOURNAL OF HAEMATOLOGY 2024年第4期205卷 1326-1336页

作者： Mehta, Priyanka Campbell, Victoria Maddox, Jamie Floisand, Yngvar Kalakonda, Anita J. M. O'Nions, Jenny Coats, Thomas Nagumantry, Sateesh Hodgson, Katherine Whitmill, Richard Amott, Ian Flynn, Gillian Taussig, David Zhao, Rui Cunningham, Nicholas Roset, Montse cuadras, daniel Medalla, Greg Kuter, Hayley Park, Saemi Legg, Alex Khan, Anjum B. Univ Hosp Bristol & Weston NHS Fdn Trust Bristol England Western Gen Hosp Edinburgh Scotland South Tees Hosp NHS Fdn Trust Middlesbrough England Clatterbridge Canc Ctr NHS Fdn Trust Liverpool England NIHR CRN North West Coast Liverpool England Univ Coll London Hosp NHS Fdn Trust London England Royal Devon Univ Healthcare NHS Fdn Trust Exeter England Peterborough City Hosp Peterborough England Univ Hosp Leicester NHS Trust Leicester England Royal Wolverhampton NHS Fdn Trust Wolverhampton England NHS Fdn Trust Univ Hosp Derby & Burton Derby England Portsmouth Hosp NHS Trust Queen Alexandra Hosp Portsmouth England Royal Marsden Hosp Haematooncol Dept Marsden England Inst Canc Res London England Torbay & South Devon NHS Fdn Trust Torquay England Belfast City Hosp Belfast North Ireland IQVIA Real World Solut Barcelona Spain Jazz Pharmaceut Oxford England Leeds Teaching Hosp NHS Fdn Trust Leeds England

Favourable outcomes with CPX-351 versus conventional 7 + 3 were demonstrated in the pivotal phase III trial in adults aged 60-75 years with newly diagnosed, highrisk/secondary acute myeloid leukaemia (AML). As a complement to the clinical trial and to address important data gaps, the CPX-351 Real-World Effectiveness and SafeTy (CREST-UK;NCT05169307) study evaluated the use of CPX-351 in routine clinical practice in the UK, in 147 patients with newly diagnosed therapy-related AML or AML with myelodysplasia-related changes. Best response of complete remission or complete remission with incomplete platelet or neutrophil recovery was achieved by 53% of evaluable patients. Kaplan-Meier median overall survival (OS) was 12.8 months (95% confidence interval 9.2-15.3). Fifty (34%) patients proceeded to haematopoietic cell transplantation (HCT);median OS landmarked from the HCT date was not reached. There were no new safety concerns with CPX-351 identified in CREST-UK. Patients treated with CPX-351 in the outpatient setting spent an average of 24.4, 16.7, 28.2, and 27.7 fewer days on the ward compared with inpatients during first induction, second induction, first consolidation, and second consolidation, respectively. The results from CREST-UK provide valuable insights into the effectiveness, safety, and outpatient delivery of CPX-351 in routine clinical practice in the UK.

关键词： acute myeloid leukaemia chemotherapy clinical observations CPX-351 real-world

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Pediatric SMA patients with complex spinal anatomy: Implementation and evaluation of a decision-tree algorithm for administration of nusinersen

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EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY 2021年 31卷 92-101页

作者： Carrera-Garcia, Laura Muchart, Jordi Lazaro, Juan Jose Exposito-Escudero, Jessica cuadras, daniel Medina, Julita de Basea, Magda Bosch Colomer, Jaume Jimenez-Mallebrera, Cecilia Ortez, Carlos Natera-de Benito, daniel Nascimento, Andres Hosp St Joan de Deu Neuromuscular Unit Neuropediat Dept Inst Recerca Pediat Hosp Barcelona Spain ISCIII Ctr Biomed Res Rare Dis CIBERER Barcelona Spain Hosp St Joan de Deu Dept Radiol Barcelona Spain Hosp St Joan de Deu Dept Anesthesiol Barcelona Spain Hosp St Joan de Deu Dept Stat Barcelona Spain Hosp St Joan de Deu Dept Rehabil Barcelona Spain Global Hlth Inst Barcelona ISGlobal Barcelona Spain Univ Pompeu Fabra UPF Dept Expt & Hlth Sci Barcelona Spain CIBER Epidemiol & Publ Hlth CIBERESP Madrid Spain

The approval of nusinersen for the treatment of spinal muscular atrophy (SMA) has significantly changed the natural history of the disease. Nevertheless, scoliosis secondary to axial muscle weakness occurs at some point in most of patients with SMA and a conventional posterior interlaminar approach for intrathecal administration of nusinersen can be particularly challenging to perform in patients with severe scoliosis and/or previous spine fusion surgeries. We developed a protocol for the administration of nusinersen in pediatric patients, which includes a decision-tree algorithm that categorizes patients according to the estimated technical difficulty for the intrathecal administration. Complex spine patients were defined as those with a Cobb angle greater than 50 degrees and/or a history of spinal surgery, while the rest of patients were considered non-complex. Nusinersen was successfully administered through a conventional non-CT-guided lumbar puncture in all 14 non-complex spine patients (110 out of 110 procedures;100%). The feasibility of the intrathecal injection in the 15 complex spine patients was assessed by 3D CT. Administration was considered unfeasible in 7 out of these 15 patients according to imaging. In the 8 complex spine patients in whom the administration was considered feasible, conventional non-CT-guided lumbar punctures were successful only in 19 out of 53 procedures (36%). The remaining 34 procedures (64%) were guided by CT scan, all successful. Our work demonstrates that a cutoff point of 50 degrees in Cobb angle and history of spinal surgery can reliably be used to anticipate the need for CT guidance in nusinersen administration. (C) 2021 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

关键词： Computer tomography Intrathecal administration Nusinersen Scoliosis Spinal muscular atrophy Spondylodesis

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Burden of Illness of Type 2 Diabetes Mellitus in the Kingdom of Saudi Arabia: A Five-Year Longitudinal Study

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ADVANCES IN THERAPY 2024年第3期41卷 1120-1150页

作者： Alharbi, Mohammed Othman, Abdullah Nahari, Ahmed Ali Al-Jedai, Ahmed Hamdan cuadras, daniel Almalky, Faisal Alazmi, Fayez Almudaiheem, Hajer Yousef Alshubrumi, Hamad Alswat, Hameed Alsahafi, Homaid Sindi, Kamelia Basaikh, Khadija Alqahtani, Majed Lamotte, Mark Yahia, Moataz Hassan, Mohamed El-Khedr Almutlaq, Mohammed Alroaly, Mohammed Alzelaye, Somaya Alghamdi, Zein Minist Hlth Therapeut Serv Riyadh Saudi Arabia Aseer Cent Hosp Aseer Diabet Ctr Abha Saudi Arabia King Fahad Cent Hosp Jazan Saudi Arabia IQVIA Barcelona 08025 Spain Al Noor Specialist Hosp Diabetol Ctr Mecca Saudi Arabia Al Qurayyat Gen Hosp Endocrine & Diabet Specialized Ctr Qurayyat Saudi Arabia King Fahad Specialist Hosp Buraidah Diabet Ctr Dammam Saudi Arabia King Abdulaziz Specialized Hosp Taif Saudi Arabia Hera Gen Hosp Diabet & Endocrinol Ctr Mecca Saudi Arabia Dammam Med Complex Dammam Saudi Arabia King Abdulaziz Hosp Endocrine & Diabet Ctr Jeddah Saudi Arabia King Fahad Specialized Hosp Diabet Ctr Tabuk Saudi Arabia IQVIA Global HEOR Zaventem Belgium Novo Nordisk Riyadh Saudi Arabia King Saud Hosp Diabet Ctr Unaizah Saudi Arabia King Abdulaziz Specialist Hosp Endocrine & Diabet Ctr Jouf Saudi Arabia Al Qunfudah Gen Hosp Ctr Endocrinol & Diabet Mellitus Al Qunfudah Makkah Saudi Arabia King Fahad Hosp Diabet Ctr Madina Saudi Arabia

IntroductionType 2 diabetes mellitus (T2DM) is associated with huge clinical and economic burden in the Kingdom of Saudi Arabia (KSA) which can be curtailed by efficacious treatment. In order to achieve this, current treatment pathways for T2DM and associated costs need to be *** longitudinal cohort review was conducted to collect country-specific and patient-specific clinical data, over a minimum observation period of 5 years in the KSA. Patient demographics, clinical characteristics and treatment patterns were recorded. The IQVIA Core Diabetes Model (CDM) version 9.5 Plus was used to assess the burden of illness, which included long-term projections of clinical (life expectancy [LE], quality-adjusted life-years [QALYs], event rates of diabetes-related complications) and direct medical cost (per-patient annual or lifelong [50 years]) outcomes of the most commonly used first-line (1st-line) regimens for T2DM from a payer perspective in the *** were collected from a subpopulation of 638 patients from 15 participating centres. There was an equal gender representation with a majority of the patients belonging to Arabian/Saudi ethnicity (71.0%). Biguanides (81.5%), sulfonylureas (51.6%), dipeptidyl peptidase 4 (DPP4) inhibitors (26.2%) and fast-acting insulins (17.2%) were the most prescribed 1st-line agents. The most frequently used 1st-line regimens resulted in an estimated LE of 25-28 years, QALYs of 18-21 years and lifelong total cost of illness of 201,377-437,371 Saudi Arabian riyal (53,700-116,632 US dollars).ConclusionOur study addresses gaps in the current research by providing a complete landscape of baseline demographic, clinical characteristics and treatment patterns from a heterogeneous group of patients with T2DM in the KSA. Additionally, the burden of illness analysis using CDM showed substantially higher cost of T2DM care from a payer perspective in the KSA.

关键词： Burden of illness Core diabetes model Kingdom of Saudi Arabia Real-world Saudi Arabia Type 2 diabetes mellitus

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The Phenotype and Genotype of Congenital Myopathies Based on a Large Pediatric Cohort

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PEDIATRIC NEUROLOGY 2021年 115卷 50-65页

作者： Natera-de Benito, daniel Ortez, Carlos Jou, Cristina Jimenez-Mallebrera, Cecilia Codina, Anna Carrera-Garcia, Laura Exposito-Escudero, Jessica Cesar, Sergi Martorell, Loreto Gallano, Pia Gonzalez-Quereda, Lidia cuadras, daniel Colomer, Jaume Yubero, Delia Palau, Francesc Nascimento, Andres Inst Recerca Neuromuscular Unit Neuropediat Dept Passeig St Joan de Deu 2 Barcelona Spain Hosp St Joan de Deu Passeig St Joan de Deu 2 Barcelona Spain ISCIII Ctr Biomed Res Rare Dis CIBERER Madrid Spain Hosp St Joan de Deu Dept Pathol Barcelona Spain Hosp St Joan de Deu Barcelona Dept Cardiol Barcelona Spain Hosp St Joan de Deu Dept Genet & Mol Med Barcelona Spain IIB St Pau Dept Genet Hosp St Pau Barcelona Spain Fundacio St Joan de Deu Stat Dept Barcelona Spain Inst Recerca St Joan de Deu Lab Neurogenet & Mol Med Barcelona Spain Univ Barcelona Hosp Clin Inst Med & Dermatol Sch Med Barcelona Spain Univ Barcelona Sch Med Div Pediat Barcelona Spain

Background: Congenital myopathies (CMs) are a clinically and genetically heterogeneous group of hereditary muscular disorders. The distribution of genetic and histologic subtypes has been addressed in only a few cohorts, and the relationship between phenotypes and genotypes is only partially understood. Methods: This is a retrospective cross-sectional data collection study conducted at a single center. The clinical, histopathological, and molecular characterization of 104 patients with CM is reported. Results: The most common histopathological subtype was core myopathy (42%). Patients with severe endomysial fibrosis were more commonly unable to walk than patients with only a mild-grade endomysial fibrosis (56% vs 16%). Inability to walk was also more prevalent in patients with severe fatty replacement (44% vs 19%). The genetic etiology was more frequently identified among those patients with "specific" histologic findings (74% vs 62%). A definite molecular diagnosis was reached in 65 of 104 patients (62%), with RYR1 (24/104) and ITN (8/104) being the most frequent causative genes. Neonatal onset occurred in 56%. Independent ambulation was achieved by 74%. Patients who walked late were more likely to become wheelchair-dependent. Respiratory support was needed in one of three patients. Gastrostomy placement was required in 15%. Cardiac involvement was observed in 3%, scoliosis in 43%, and intellectual disability in 6%. Conclusions: This study provides an updated picture of the clinical, histopathological, and molecular landscape of CMs. Independently of the causative gene, fibrosis and fatty replacement in muscle biopsy specimens are associated with clinical severity. Mutations in TTN are responsible for a higher proportion of cases than previously thought. (C) 2020 Elsevier Inc. All rights reserved.

关键词： Congenital myopathy Molecular genetics Muscle biopsy Natural history Next-generation sequencing

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SARS-CoV-2 transmission in teenagers and young adults in Futbol Club Barcelona's Multidisciplinary Sports Training Academy

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EUROPEAN JOURNAL OF PEDIATRICS 2023年第5期182卷 2421-2432页

作者： Hernandez-Garcia, Maria Bassat, Quique Fumado, Victoria Rodas, Gil Pi, Ramon Miranda-Garcia, Maite Girona-Alarcon, Monica Catala, Marti Alonso, Sergio Alvarez-Lacalle, Enrique Lopez, daniel Mele-Casas, Maria Pons-Tomas, Gemma F. de Sevilla, Mariona Bonet-Carne, Elisenda Fortuny, Claudia Garcia-Miquel, Aleix Jou, Cristina Adroher, Cristina Claverol, Joana Cubells, Marta Codina, Anna cuadras, daniel Gratacos, Eduard Brotons, Pedro Munoz-Almagro, Carmen Prats, Clara Garcia-Garcia, Juan Jose Jordan, Iolanda Hosp St Joan Deu Barcelona Paediat Dept Passeig St Joan Deu 2 Esplugas de Llobregat 08950 Barcelona Spain ISGlobal Barcelona Inst Global Hlth Barcelona Spain Inst Salud Carlos III Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE Madrid Spain Ctr Invest Saude Manh CISM Maputo Mozambique ICREA Catalan Inst Res & Adv Studies Barcelona Spain Hosp St Joan Deu Barcelona Infect Dis Dept Barcelona Spain Inst Recerca St Joan Deu IRSJD Infect Dis & Microbiome Barcelona Spain Univ Barcelona Fac Med & Hlth Sci Barcelona Spain Hosp Clin Barcelona Sports Med Unit Barcelona Spain Hosp Sant Joan Deu Barcelona Barcelona Spain Futbol Club Barcelona Barca Innovat Hub Med Dept Barcelona Spain Fundacio St Joan Deu Barcelona Spain Hosp St Joan Deu Barcelona Paediat Intens Care Unit Barcelona Spain Univ Oxford Nuffield Dept Orthopaed Rheumatol & Musculoskelet Oxford England Univ Politecn Cataluna Dept Phys Computat Biol & Complex Syst BIOCOM SC Castelldefels Spain Hosp Clin Barcelona BCNatal Fetal Med Res Ctr Barcelona Spain Inst Invest Biomed August Pi I Sunyer IDIBAPS Barcelona Spain Univ Politecn Catalunya Barcelona Tech Barcelona Spain Hosp St Joan Deu Barcelona Dept Pathol & Biobank Barcelona Spain Inst Salud Carlos III Ctr Invest Biomed Red Enfermedades Raras CIBER ER Madrid Spain Hosp St Joan Deu Barcelona Strateg Planning & Management Control Barcelona Spain Fundacio St Joan Deu Stat Dept Barcelona Spain Univ Int Catalunya Dept Med Barcelona Spain Hosp Sant Joan Deu Barcelona RDI Microbiol Dept Barcelona Spain

Most studies, aimed at determining the incidence and transmission of SARS-CoV-2 in children and teenagers, have been developed in school settings. Our study conducted surveillance and inferred attack rates focusing on the practice of sports. Prospective and observational study of those attending the sports facilities of Futbol Club Barcelona (FCB), in Barcelona, Spain, throughout the 2020-2021 season. Participants were young players (from five different sports) and adult workers, who belonged to stable teams (shared routines and were involved in same quarantine rules). Biweekly health questionnaires and SARS-CoV-2 screening were conducted. From the 234 participants included, 70 (30%) both lived and trained in the FCB facilities (Recruitment Pathway 1;RP1) and 164 (70%) lived at their own household and just came to the facilities to train (RP2). During the study, 38 positive cases were identified;none had severe symptoms or needed hospitalization. The overall weekly incidence in the cohorts did not differ compared to the one expected in the community, except for 2 weeks when an outbreak occurred. The attack rate (AR) was three times higher for the participants from RP1, in comparison to those from RP2 (p < 0.01). A Basketball team showed a significant higher ***: Physical activities in stable teams are not related to an increased risk of transmission of SARS-CoV-2, since there were the same observed cases than expected in the community. The risk is higher in indoor sports (Basketball vs. Football), and in closed cohort living settings (RP1 vs. RP2). The fulfilment of preventive measures is essential.

关键词： COVID-19 SARS-CoV-2 Adolescent Transmission Sports Youth sports

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Corrigendum to "Pediatric SMA patients with complex spinal anatomy: Implementation and evaluation of a decision-tree algorithm for administration of nusinersen"[ Eur. J. Paediatr. Neurol. (2021) 92-101]

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European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2022年 37卷 167-168页

作者： Laura Carrera-García Jordi Muchart Juan José Lazaro Jessica Expósito-Escudero daniel cuadras Julita Medina Magda Bosch de Basea Jaume Colomer Cecilia Jimenez-Mallebrera Carlos Ortez daniel Natera-de Benito Andrés Nascimento Neuromuscular Unit Neuropediatric Department Institut de Recerca Pediàtrica Hospital Sant Joan de Déu Center for the Biomedical Research on Rare Diseases (CIBERER) Center for the Biomedical Research on Rare Diseases (CIBERER) ISCIII Barcelona Spain. Electronic address: lcarrerag@***. Department of Radiology Hospital Sant Joan de Déu Barcelona Spain. Department of Anesthesiology Hospital Sant Joan de Déu Barcelona Spain. Neuromuscular Unit Neuropediatric Department Institut de Recerca Pediàtrica Hospital Sant Joan de Déu Center for the Biomedical Research on Rare Diseases (CIBERER) Center for the Biomedical Research on Rare Diseases (CIBERER) ISCIII Barcelona Spain. Department of Statistics Fundació Sant Joan de Déu Barcelona Spain. Department of Rehabilitation Hospital Sant Joan de Déu Barcelona Spain. Global Health Institute Barcelona (ISGlobal) Barcelona Spain Department of Experimental and Health Sciences Universitat Pompeu Fabra (UPF) Barcelona Spain CIBER Epidemiology and Public Health (CIBERESP) Madrid Spain.

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A pilot 1-year follow-up randomised controlled trial comparing metacognitive training to psychoeducation in schizophrenia: effects on insight

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SCHIZOPHRENIA 2023年第1期9卷 1-13页

作者： Lopez-Morinigo, Javier-David Martinez, Adela Sanchez-Escribano Barrigon, Maria Luisa Escobedo-Aedo, Paula-Jhoana Ruiz-Ruano, Veronica Gonzalez Sanchez-Alonso, Sergio Mata-Iturralde, Laura Munoz-Lorenzo, Laura cuadras, daniel Ochoa, Susana Baca-Garcia, Enrique David, Anthony S. Univ Autonoma Madrid Dept Psiquiatria Madrid Spain IIS Fdn Jimenez Diaz Dept Psiquiatria Madrid Spain CIBERSAM Ctr Invest Biomed Red Salud Mental Madrid Spain Univ Complutense Hosp Gen Univ Gregorio Maranon Inst Psychiat & Mental Hlth Sch Med Madrid Spain Univ Hosp Virgen Rocio Dept Psychiat Seville Spain Inst Recerca St Joan Deu Etiopatogenia & Tratamiento Trastornos Mentales Gr Barcelona Spain Parc Sanit Sant Joan Deu Barcelona Spain Univ Catol Maule Talca Chile Ctr Hospitalier Univ Ni^mes Dept Psychiat Nimes France UCL London England

Poor insight in schizophrenia spectrum disorders (SSD) is linked with negative outcomes. This single-centre, assessor-blind, parallel-group 1-year follow-up randomised controlled trial (RCT) tested whether metacognitive training (MCT) (compared to psychoeducation) may improve insight and outcomes in outpatients with SSD assessed: at baseline (T0);after treatment (T1) and at 1-year follow-up (T2). Insight (primary outcome) was measured with (i) the Schedule for Assessment of Insight-Expanded version- (SAI-E), including illness recognition (IR), symptom relabelling (SR), treatment compliance (TC) and total insight scores (TIS);and (ii) the Beck Cognitive Insight Scale (BCIS). Between-group comparisons were nonsignificant, while within the MCT group (but not within controls) there was a significant medium effect size for improved TIS at T2 (d = 0.67, P = 0.02). Secondary outcomes included cognitive measures: Jumping to Conclusions (JTC), Theory of Mind (ToM), plus symptom severity and functioning. Compared to psychoeducation, MCT improved the PANSS excitement (d = 1.21, P = 0.01) and depressed (d = 0.76, P = 0.05) factors at T2;and a JTC task both at T1 (P = 0.016) and at T2 (P = 0.031). Participants in this RCT receiving MCT showed improved insight at 1-year follow-up, which was associated with better mood and reduced JTC cognitive bias. In this pilot study, no significant benefits on insight of MCT over psychoeducation were detected, which may have been due to insufficient power.

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Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Children in Summer Schools Applying Stringent Control Measures in Barcelona, Spain

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CLINICAL INFECTIOUS DISEASES 2022年第1期74卷 66-73页

作者： Jordan, Iolanda Fernandez de Sevilla, Mariona Fumado, Victoria Bassat, Quique Bonet-Carne, Elisenda Fortuny, Claudia Garcia-Miquel, Aleix Jou, Cristina Adroher, Cristina Mele Casas, Maria Girona-Alarcon, Monica Hernandez Garcia, Maria Pons Tomas, Gemma Ajanovic, Sara Arias, Sara Balanza, Nuria Baro, Barbara Millat-Martinez, Pere Varo, Rosauro Alonso, Sergio Alvarez-Lacalle, Enric Lopez, daniel Claverol, Joana Cubells, Marta Brotons, Pedro Codina, Anna cuadras, daniel Bruijning-Verhagen, Patricia Faust, Saul Munro, Alasdair Munoz-Almagro, Carmen Catala, Marti Prats, Clara Jose Garcia-Garcia, Juan Gratacos, Eduard Univ Barcelona Paediat Intens Care Unit Hosp St Joan de Deu Barcelona Spain Univ Barcelona Inst Recerca St Joan de Deu Barcelona Spain Consorcio Invest Biomed Red Epidemiol & Salud Pub Madrid Spain Univ Barcelona Pediat Serv Hosp St Joan de Deu Barcelona Spain Hosp St Joan de Deu Infect Dis Dept Barcelona Spain Univ Barcelona ISGlobal Hosp Clin Barcelona Spain Ctr Invest Saude Manhica Maputo Mozambique Inst Catalana Recerca & Estudis Avancats Barcelona Spain Univ Barcelona BCNatal Fetal Med Res Ctr Hosp Clin Barcelona Spain Univ Barcelona Hosp St Joan de Deu Barcelona Spain Inst Invest Biomed August Pi & Sunyer Barcelona Spain Univ Politecn Cataluna BarcelonaTech Barcelona Spain Dept Pathol Barcelona Spain Biobank Hosp St Joan de Deu Ctr Invest Biomed Red Enfermedades Raras Barcelona Spain Inst Salud Carlos III Ctr Invest Biomed Red Enfermedades Raras Barcelona Spain Hosp St Joan de Deu Strateg Planning & Management Control Barcelona Spain Univ Barcelona Barcelona Inst Global Hlth Hosp Clin Barcelona Spain Univ Politecn Cataluna Dept Phys Computat Biol & Complex Syst Castelldefels Spain Fundacio St Joan de Deu Barcelona Spain Univ Int Catalunya Dept Med Barcelona Spain Fundacio St Joan de Deu Stat Dept Barcelona Spain Univ Med Ctr Utrecht Julius Ctr Hlth Sci Dept Infect Dis Epidemiol Utrecht Netherlands Univ Southampton Natl Inst Hlth Res Southampton Clin Res Facil Southampton Hants England Univ Southampton Southampton Biomed Res Ctr Univ Hosp Natl Hlth Serv Fdn Trust Southampton Hants England Univ Southampton Fac Med Southampton Hants England Univ Southampton Inst Life Sci Southampton Hants England Germans Trias & Pujol Res Inst Comparat Med & Bioimage Ctr Catalonia Badalona Spain Ctr Biomed Res Rare Dis Madrid Spain

Background Understanding the role of children in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is critical to guide decision-making for schools in the pandemic. We aimed to describe the transmission of SARS-CoV-2 among children and adult staff in summer schools. Methods During July 2020, we prospectively recruited children and adult staff attending summer schools in Barcelona who had SARS-CoV-2 infection. Primary SARS-CoV-2 infections were identified through (1) a surveillance program in 22 summer schools of 1905 participants, involving weekly saliva sampling for SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) during 2-5 weeks;and (2) cases identified through the Catalonian Health Surveillance System of children diagnosed with SARS-CoV-2 infection by nasopharyngeal RT-PCR. All centers followed prevention protocols: bubble groups, handwashing, face masks, and conducting activities mostly outdoors. Contacts of a primary case within the same bubble were evaluated by nasopharyngeal RT-PCR. Secondary attack rates and the effective reproduction number in summer schools (Re*) were calculated. Results Among the >2000 repeatedly screened participants, 30 children and 9 adults were identified as primary cases. A total of 253 close contacts of these primary cases were studied (median, 9 [interquartile range, 5-10] for each primary case), among which 12 new cases (4.7%) were positive for SARS-CoV-2. The Re* was 0.3, whereas the contemporary rate in the general population from the same areas in Barcelona was 1.9. Conclusions The transmission rate of SARS-CoV-2 infection among children attending school-like facilities under strict prevention measures was lower than that reported for the general population. This suggests that under preventive measures schools are unlikely amplifiers of SARS-CoV-2 transmission, supporting current recommendations for school opening. Transmission rates among children and adults in summer school settings

关键词： SARS-CoV-2 COVID-19 transmission children

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