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武汉大学学报（工学版） 2021年第S02期54卷 21-25页

作者：申加胜张兰春安旭文魏亚庆郭礼鹏山东电力工程咨询院有限公司山东济南250013 武汉大学土木建筑工程学院湖北武汉430072 中国电力工程顾问集团华北电力设计院有限公司北京100120

为适应我国城市生活垃圾焚烧处理工程技术的发展需要,满足生活垃圾焚烧厂垃圾池结构设计的安全性和经济性要求,对垃圾池结构的荷载取值进行了研究。根据垃圾池结构的防腐要求,设计了垃圾池荷载的监测方案,在湖南某生活垃圾焚烧厂垃圾池... 详细信息

为适应我国城市生活垃圾焚烧处理工程技术的发展需要,满足生活垃圾焚烧厂垃圾池结构设计的安全性和经济性要求,对垃圾池结构的荷载取值进行了研究。根据垃圾池结构的防腐要求,设计了垃圾池荷载的监测方案,在湖南某生活垃圾焚烧厂垃圾池内布置测点进行监测,获得了垃圾池内底板竖向压力和池壁侧向压力的实测数据,并对不同垃圾堆高下垃圾池池底竖向压力、池壁侧向压力进行了统计分析,提出了垃圾焚烧厂垃圾池壁侧压力系数的取值建议方案。研究成果可为生活垃圾焚烧厂房垃圾池结构的设计提供基础资料和技术支持。

关键词：垃圾焚烧厂竖向压力侧向压力统计分析侧压力系数

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Smart hypoxia-responsive transformable and charge-reversible nanoparticles for the deep penetration and tumor microenvironment modulation of pancreatic cancer

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BIOMATERIALS 2022年第0期287卷 000-000页

作者： Chen, Hongyi guo, Qin Chu, Yongchao Li, Chao Zhang, Yiwen Liu, Peixin Zhao, Zhenhao Wang, Yu Luo, Yifan Zhou, Zheng Zhang, Tongyu Song, Haolin Li, xuwen Li, Chufeng Su, Boyu You, Haoyu Sun, Tao Jiang, Chen Fudan Univ Key Lab Smart Drug Delivery State Key Lab Med Neurobiol Dept PharmaceutSch PharmInst Brain SciMinist Ed Shanghai 201203 Peoples R China Fudan Univ Inst Brain Sci MOE Frontiers Ctr Brain Sci Sch PharmDept Pharmaceut Shanghai 201203 Peoples R China

The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well as establishing an immunosuppressive tumor microenvironment (TME). However, forcibly destroying the stroma barrier would break the balance of delicate signal transduction and dependence between tumor cells and matrix components. Uncontrollable growth and metastasis would occur, making PDAC more difficult to control. Hence, we design and construct an aptamer-decorated hypoxia-responsive nanoparticle s(DGL)(n)@Apt co-loading gemcitabine monophosphate and STAT3 inhibitor HJC0152. This nanoparticle can reverse its surficial charge in the TME, and reduce the size triggered by hypoxia. The released ultra-small DGL particles loading gemcitabine monophosphate exhibit excellent deep-tumor penetration, chemotherapy drugs endocytosis promotion, and autophagy induction ability. Meanwhile, HJC0152 inhibits overactivated STAT3 in both tumor cells and tumor stroma, softens the stroma barrier, and reeducates the TME into an immune-activated state. This smart code -livery strategy provides an inspiring opportunity in PDAC treatment.

关键词： Hypoxia-responsive Sizereduction Chargereversal Deeppenetration TMEmodulation

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Phytoplankton community changes in a coastal upwelling system during the last century

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Global and Planetary Change 2023年 224卷

作者： Peng, Peng Bi, Rong Sachs, Julian P. Shi, Jie Luo, Yifei Chen, Weifang Huh, Chih-An Yu, Meng Cao, Yali Wang, Yaoyao Cao, Zhong Bao, Xiaohan guo, Xinyu Li, Huijuan Feng, xuwen Li, Hongchun Zhao, Meixun Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Qingdao266100 China Laoshan Laboratory Qingdao266237 China School of Oceanography University of Washington Box 355351 SeattleWA98195 United States Key laboratory of Marine Environment and Ecology Ministry of Education Ocean University of China Qingdao266100 China State Key Laboratory of Marine Environmental Science and College of Ocean and Earth Sciences Xiamen University Xiamen361102 China Institute of Earth Sciences Academia Sinica Taipei11529 Taiwan Yantai Maritime Safety Administration Yantai264000 China Jinan250014 China Second Institute of Oceanography Ministry of Natural Resources of People's Republic of China Hangzhou310012 China Department of Geosciences National Taiwan University Taipei10617 Taiwan

Phytoplankton communities in coastal upwelling systems are influenced by the interplay between human-induced and natural climate forcing that vary regionally and the two factors have not been well quantified. Combining lipid biomarker analyses in 23 sediment cores from the Zhejiang coast of the East China Sea and a physical-ecological model, we found that during the 1960s–2000s there was a 42 ± 4% increase in diatom proportions and a 17 ± 8% decrease in dinoflagellate proportions within the core upwelling area that is attributed to changes in Kuroshio Current transport and coastal upwelling. During the 1950s–2000s there was a 16 ± 8% increase in dinoflagellate proportions and 12 ± 4% decrease in diatom proportions outside the core upwelling area which is attributed to anthropogenic nutrient inputs and climate warming. Our results provide a novel approach to quantify mechanisms of past and future changes in marine phytoplankton communities. © 2023 Elsevier B.V.

关键词： Ocean currents

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Investigation of energetic ion losses induced by long-lived saturated internal mode with energetic particle diagnostics in the HL-2A tokamak

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NUCLEAR FUSION 2023年第8期63卷 086014-086014页

作者： Zhang, Jie Zhang, Yipo Chen, Wei Cheng, Shikui Ogawa, Kunihiro He, Xiaofei Wang, Yongqin Liu, Yi Xu, Min Isobe, Mitsutaka Zhu, Yuxuan Zhan, xuwen Zhou, Jianhang Zhang, Jinglong Liu, Liang He, Xiaoxue Li, Dong Li, Yonggao guo, Wenping Yu, Liming Hao, Guangzhou Li, Bo Shi, Zhongbing Ji, Xiaoquan Zhong, Wulv Southwestern Inst Phys POB 432 Chengdu 610041 Peoples R China Natl Inst Fus Sci Natl Inst Nat Sci Toki Japan SOKENDAI Grad Univ Adv Studies Toki Japan Chengdu Univ Technol Coll Nucl Technol & Automation Engn Chengdu 610059 Peoples R China

Several sets of energetic particle diagnostics, including a set of neutron flux monitoring systems, a solid-state neutral particle analyzer and a fast ion loss probe (FILP), have been used to investigate the energetic ion losses induced by the long-lived saturated internal mode (LLM) in the HL-2A tokamak. Clear experimental evidence for different levels of energetic ion losses induced by LLM, sawtooth and minor disruption has been observed. A numerical calculation for the evolution of neutron emissions was carried out with the FBURN code, and it shows that the neutron emission drop rate linearly increases with the LLM amplitude and no threshold perturbation amplitude exists, illustrating that the loss mechanism for LLM induced energetic ion loss is dominantly convective. In addition, measurement results of the FILP demonstrate that LLM tends to expel energetic ions with relatively low energy (E < 27 keV) and high pitch angle (? > 60(?)), and can suppress the prompt loss of energetic ions with high energy and low pitch angle to a certain degree. Furthermore, the physical process for LLM induced energetic ion loss can be explained by orbit calculations, which show that LLM induced lost energetic ions will transport from center to peripheral region first, and then get lost out of plasma. The experimental observations are successfully reproduced by calculations using the ORBIT code combined with both the NUBEAM code and the MARS-K code. The paper clearly describes the whole physical process of LLM induced energetic ion loss for the first time in the HL-2A tokamak.

关键词： energetic ion loss long-lived saturated internal mode neutron flux measurement neutral particle analyzer fast ion loss probe

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新常态下河南省休闲农业可持续发展能力评价及对策研究

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中国农业资源与区划 2016年第9期37卷 34-39页

作者：郭旭文河南科技学院

在中央制定4项新政策大力扶持休闲农业的新常态下,休闲农业迎来了新的发展机遇。文章以河南省为研究对象,阐述河南省休闲农业的发展现状,在评价原则及指标体系构建的基础上,以发展基础条件、协调能力和可持续发展能力为3个系统层,选取4... 详细信息

在中央制定4项新政策大力扶持休闲农业的新常态下,休闲农业迎来了新的发展机遇。文章以河南省为研究对象,阐述河南省休闲农业的发展现状,在评价原则及指标体系构建的基础上,以发展基础条件、协调能力和可持续发展能力为3个系统层,选取41个指标,采用AHP方法对河南省159地区(县、区、市)的休闲农业可持续发展能力进行评价并划分等级,并对2007~2015年该省休闲农业可持续发展能力综合指数进行评价,评价结果显示:河南省休闲农业可持续发展能力将呈现良好的增长势头,其中,洛阳市洛龙区休闲农业可持续发展能力位列该省第一,而新乡县则位列末位。并从创新意识、政府扶持、法律法规的完善、融资渠道、人才培训等方面提出提高河南省休闲农业可持续发展能力的政策建议。

关键词：休闲农业新常态可持续发展能力河南省对策

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翼状胬肉切除术联合角膜缘干细胞移植术对原发性翼状胬肉患者视力恢复的影响及安全性

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中外医疗 2025年第8期44卷 57-60页

作者：张诚陈旭文郭美珍福清东南眼科医院眼科

目的研究翼状胬肉切除术（excision of pterygium, EOP）联合角膜缘干细胞移植（corneal limbal stem cell transplantation, CLSCT）术对原发性翼状胬肉患者视力恢复的影响及安全性。方法随机选取2023年2月—2024年2月经福清东南眼... 详细信息

目的研究翼状胬肉切除术（excision of pterygium, EOP）联合角膜缘干细胞移植（corneal limbal stem cell transplantation, CLSCT）术对原发性翼状胬肉患者视力恢复的影响及安全性。方法随机选取2023年2月—2024年2月经福清东南眼科医院确诊为原发性翼状胬肉的110例患者作为研究对象，依据不同手术方法分为对照组和观察组，各55例。对照组仅接受EOP治疗，观察组接受EOP联合CLSCT术治疗，比较两组的手术疗效、视力状况、泪膜功能以及手术安全性。结果观察组手术总有效率为94.55%（52/55），高于对照组的81.82%（45/55），差异有统计学意义（χ2=4.274,P=0.038）。术后3个月，观察组角膜屈光度小于对照组，裸眼视力高于对照组，差异均有统计学意义（P均<0.05）。术后3个月，观察组泪膜功能指标优于对照组，差异有统计学意义（P<0.05）。两组手术并发症总发生率对比，差异无统计学意义（P>0.05）。结论对原发性翼状胬肉患者施以EOP联合CLSCT术式治疗有确切效果，有利于泪膜功能及视力状况的恢复，并且手术的安全性良好。

关键词：原发性翼状胬肉翼状胬肉切除术角膜缘干细胞移植术视力恢复安全性

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Serum metabolomics reveals the intervention mechanism and compatible regularity of Chaihu Shu Gan San on chronic unpredictable mild stress-induced depression rat model

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JOURNAL OF PHARMACY AND PHARMACOLOGY 2020年第8期72卷 1133-1143页

作者： Zhang, Hongye Huang, Huimin Song, Hui Chin, Bonnie Zheng, Hua Ruan, Junxiang Wu, Fang Cheng, Bang Wu, Jinxia Liu, xuwen Liang, Yonghong Song, Fangming Chen, Zhaoni Tang, Chaoling Lu, Shiyin guo, Hongwei Zou, Zhongmei Su, Zhiheng Guangxi Med Univ Pharmaceut Coll Nanning 530021 Peoples R China Shenyang Pharmaceut Univ Dept Clin Pharm Shenyang Peoples R China Guangxi Med Univ Med Sci Res Ctr Nanning Peoples R China Guangxi Med Univ Chinese Minist Educ Key Lab Longev & Aging Related Dis Nanning Peoples R China Guangxi Med Univ Ctr Translat Med Nanning Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China

Objectives To provide a comprehensive study of the intervention mechanism and compatible regularity of Chaihu Shu Gan San (CSGS) in a chronic unpredictable mild stress (CUMS)-induced depression model. Methods Ethological study and ELISA assay were applied to measure the phenotypes of depression after CUMS stimulate and assess the antidepressant activity of fluoxetine, CSGS and its compatibilities. The serum metabolic profile changes were revealed by untargeted Q/TOF MS-based metabolomics followed by multivariate statistical analysis. Key findings CSGS exhibits an significant intervention effect on CUMS-induced depression. After the multivariate statistical analysis, 17 potential serum biomarkers were identified and 16 of them could be regulated by CSGS. The intervention of CSGS on CUMS-induced depression involved five key pathways. Moreover, each functional unit (monarch, minister, assistant and guide medicine) in CSGS regulates different metabolites and metabolic pathways to achieve different effects on antidepressant;however, their intervention efficacies are inferior to the holistic formula, which may be due to the synergism of bioactive ingredients in the seven herbs of CSGS. Conclusions CSGS produced an obvious antidepressant activity. The comprehensive and holistic metabolomics approach could be a powerful tool to study the intervention mechanism and the compatibility rule of traditional Chinese medicine.

关键词： antidepression Chaihu Shu Gan San chronic unpredictable mild stress-induced depression compatibility serum metabolomics ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry

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妊娠期糖尿病围手术期血糖水平与产后出血量及新生儿血糖关系

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广州医科大学学报 2022年第2期50卷 35-39页

作者：郭蓝蓝张学真狄小丹汤栩文邓雯锋广州市妇女儿童医疗中心广东广州510623

目的:探讨妊娠期糖尿病孕妇围手术期血糖水平与产后出血量及新生儿血糖的关系。方法:前瞻性收集2020年4月⁃2021年4月在广州市妇女儿童医疗中心行剖宫产妊娠期糖尿病孕妇175例,按照孕期血糖控制状况分为控制良好的研究A组和控制不佳的研... 详细信息

目的:探讨妊娠期糖尿病孕妇围手术期血糖水平与产后出血量及新生儿血糖的关系。方法:前瞻性收集2020年4月⁃2021年4月在广州市妇女儿童医疗中心行剖宫产妊娠期糖尿病孕妇175例,按照孕期血糖控制状况分为控制良好的研究A组和控制不佳的研究B组;将同时期剖宫产的非糖尿病孕妇设为对照C组,分析3组孕妇围手术期血糖与产后出血量及新生儿血糖关系。结果:3组的术后2 h血糖、术后24 h出血量、新生儿血糖均有统计学差异(P<0.05),术后2 h血糖为A组(5.1±1.0)mmol/L,B组(5.7±1.3)mmol/L,C组(5.5±1.0)mmol/L;24 h出血量为A组440(410,500)mL,B组480(404,578)mL,C组420(370,506)mL;新生儿血糖为A组(3.1±0.8)mmol/L,B组(2.8±0.8)mmol/L,C组(3.7±0.9)mmol/L。术后24 h出血量与术后2 h血糖相关(P<0.05)。通过曲线拟合分析得出妊娠期糖尿病术后血糖的理想范围为4.4~6.7 mmol/L。结论:做好妊娠糖尿病孕妇孕期及围手术期血糖的科学管理,可能减少产后出血量及降低新生儿低血糖发生率。

关键词：妊娠糖尿病围手术期血糖产后出血量新生儿血糖

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A Micro-Environment Regulator for Filling the Clinical Treatment Gap after a Glioblastoma Operation

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ADVANCED HEALTHCARE MATERIALS 2022年第3期11卷 2101578-2101578页

作者： Zhang, Yiwen You, Haoyu Wang, Yaoben Chen, Qinjun guo, Qin Chu, Yongchao Li, Chao Zhou, Wenxi Chen, Hongyi Liu, Peixin Wang, Yu Zhao, Zhenhao Zhou, Zheng Luo, Yifan Li, xuwen Zhang, Tongyu Song, Haolin Li, Chufeng Su, Boyu Sun, Tao Bi, Yunke Yu, Lin Jiang, Chen Fudan Univ Sch Pharm Dept PharmaceutState Key Lab Med Neurobiol & MOE Inst Brain SciMinist EducKey Lab Smart Drug Del Shanghai 201203 Peoples R China Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China Shanghai Jiao Tong Univ Sch Med Shanghai Gen Hosp Dept Neurosurg Shanghai 201203 Peoples R China

The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate and effective postoperative treatment. Herein, an immediate and mild postoperative local treatment strategy is developed that regulates the postoperative microenvironment and delays GBM recurrence. Briefly, an injectable hydrogel system (imGEL) loaded with Zn(II)(2)-AMD3100 (AMD-Zn) and CpG oligonucleotide nanoparticles (CpG NPs) is injected into the operation cavity, with long-term function to block the recruitment of microglia/ macrophages and activate cytotoxic T cells. The finding indicated that the imGEL can regulate the immune microenvironment, inhibit GBM recurrence, and gain valuable time for subsequent adjuvant clinical chemotherapy.

关键词： drug delivery glioblastoma injectable hydrogels microenvironments post-operative therapy

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Biomimetic Dendrimer-Peptide Conjugates for Early Multi-Target Therapy of Alzheimer's Disease by Inflammatory Microenvironment Modulation

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ADVANCED MATERIALS 2021年第26期33卷 2100746-2100746页

作者： Liu, Peixin Zhang, Tongyu Chen, Qinjun Li, Chao Chu, Yongchao guo, Qin Zhang, Yiwen Zhou, Wenxi Chen, Hongyi Zhou, Zheng Wang, Yu Zhao, Zhenhao Luo, Yifan Li, xuwen Song, Haolin Su, Boyu Li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Key Lab Smart Drug Delivery Minist Educ State Key Lab Med Neurobiol Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Dept Pharmaceut Sch Pharm Shanghai 201203 Peoples R China

Current therapeutic strategies for Alzheimer's disease (AD) treatments mainly focus on beta-amyloid (A beta) targeting. However, such therapeutic strategies have limited clinical outcomes due to the chronic and irreversible impairment of the nervous system in the late stage of AD. Recently, inflammatory responses, manifested in oxidative stress and glial cell activation, have been reported as hallmarks in the early stages of AD. Based on the crosstalk between inflammatory response and brain cells, a reactive oxygen species (ROS)-responsive dendrimer-peptide conjugate (APBP) is devised to target the AD microenvironment and inhibit inflammatory responses at an early stage. With the modification of the targeting peptide, this nanoconjugate can efficiently deliver peptides to the infected regions and restore the antioxidant ability of neurons by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway. Moreover, this multi-target strategy exhibits a synergistic function of ROS scavenging, promoting A beta phagocytosis, and normalizing the glial cell phenotype. As a result, the nanoconjugate can reduce ROS level, decrease A beta burden, alleviate glial cell activation, and eventually enhance cognitive functions in APPswe/PSEN1dE9 model mice. These results indicate that APBP can be a promising candidate for the multi-target treatment of AD.

关键词： Alzheimer&apos s disease antioxidant ability glial cell activation inflammatory responses multi‐ target treatments synergistic function

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