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Evaluation of cultivars diversity and lipid composition properties of Idesia polycarpa var. vestita Diels

JOURNAL OF FOOD SCIENCE 2022年第9期87卷 3841-3855页

作者： Wen, Leyan Xiang, xuwen Wang, Zhirong Yang, Qingqing guo, Zehang Huang, Pimiao Mao, Jianmei An, Xiaofeng Kan, Jianquan Southwest Univ Coll Food Sci 2 Tiansheng Rd Chongqing 400715 Peoples R China Minist Agr & Rural Affairs Peoples Republ China Lab Qual & Safety Risk Assessment Agroprod Storag Chongqing Peoples R China Chinese Hungarian Cooperat Res Ctr Food Sci Chongqing Peoples R China Chongqing Key Lab Special Food Cobuilt Sichuan & Chongqing Peoples R China Chongqing Shanlinyuan Forestry Comprehens Dev Co Chongqing Peoples R China

Idesia polycarpa var. vestita Diels is a perennial deciduous tree widely distributed throughout China. Four I. polycarpa fruit of different cultivars with different fruit issues during the growth process were compared, which were on the basis of morphological characteristics and chemical compositions. The influencing factors of oil accumulation in I. polycarpa fruit and the correlation between different components were investigated, and the results revealed a negative correlation between oil content and total sugar (r = -0.930), ash (r = -0.606), and crude fiber (r = -0.952). Except for oil, none of the chemical components changed substantially during the growing phase, and most cultivars showed higher oil content in the pulp portion (14.14-43.99 g/100 g). Linoleic acid was the most abundant fatty acid in I. polycarpa oil (IPO), with values ranging from 52.18% to 66.65% (fruit), 55.44% to 65.15% (pulp), and 68.99% to 78.76% (seed). Principal component analysis revealed that Hubei varieties are more advantageous. Besides, the lipid composition of IPO was identified by ultrahigh-performance liquid chromatography coupled with electrospray ionization Q-Exactive Focus mass spectrometry. The glyceride components of IPO were mostly composed of 22 triacylglycerols, 30 diacylglycerols, and 8 monoacyglycerols. Meanwhile, linoleic acid was mainly distributed in sn-2 and sn-3 positions. Practical Application Morphologic characteristics, chemical compositions, oil fatty acid profiles, and oil correlation factors of I. polycarpa were analyzed. The comprehensive score of oil quality by PCA in Hb fruit was the highest. The glyceride components of I. polycarpa oil were mainly composed of 22 triacylglycerols, 30 diacylglycerols, and eight monoacyglycerols.

关键词： chemical properties fatty acid profile Idesia polycarpa var vestita Diels lipid composition principal component analysis

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XCO2 Super-Resolution Reconstruction Based on Spatial Extreme Random Trees

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ATMOSPHERE 2024年第4期15卷 440页

作者： Li, xuwen Jiang, Sheng Wang, Xiangyuan Wang, Tiantian Zhang, Su guo, Jinjin Jiao, Donglai Jiangsu Prov Environm Monitoring Ctr Nanjing 210019 Peoples R China Nanjing Univ Posts & Telecommun Sch Internet Things Nanjing 210023 Peoples R China

Carbon dioxide (CO2) is currently the most harmful greenhouse gas in the atmosphere. Obtaining long-term, high-resolution atmospheric column CO2 concentration (XCO2) datasets is of great practical significance for mitigating the greenhouse effect, identifying and controlling carbon emission sources, and achieving carbon cycle management. However, mainstream satellite observations provide XCO2 datasets with coarse spatial resolution, which is insufficient to support the needs of higher-precision research. To address this gap, in this study, we integrate spatial information with the extreme random trees model and develop a new machine learning model called spatial extreme random trees (SExtraTrees) to reconstruct a 1 km spatial resolution XCO2 dataset for China from 2016 to 2020. The results indicate that the predictive ability of spatial extreme random trees is more stable and has higher fitting accuracy compared to other methods. Overall, XCO2 in China shows an increasing trend year by year, with the spatial distribution revealing significantly higher XCO2 levels in eastern coastal regions compared to western inland areas. The contributions of this study are primarily in the following areas: (1) Considering the spatial heterogeneity of XCO2 and combining spatial features with the advantages of machine learning, we construct the spatial extreme random trees model, which is verified to have high predictive accuracy. (2) Using the spatial extreme random trees model, we reconstruct high-resolution XCO(2 )datasets for China from 2016 to 2020, providing data support for carbon emission reduction and related decision making. (3) Based on the generated dataset, we analyze the spatiotemporal distribution patterns of XCO2 in China, thereby improving emission reduction policies and sustainable development measures.

关键词： XCO2 spatial downscaling SExtraTrees high resolution spatial features

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UCNP@BSA@Ru nanoparticles with tumor-specific and NIR-triggered efficient PACT activity in vivo

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DALTON TRANSACTIONS 2021年第22期50卷 7715-7724页

作者： Zhang, Chao guo, Xusheng Da, xuwen Yao, Yishan Xiao, Haihua Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Beijing Inst Pharmacol & Toxicol Beijing 100850 Peoples R China Chinese Acad Sci Beijing Natl Lab Mol Sci Inst Chem State Key Lab Polymer Phys & Chem Beijing 100190 Peoples R China

Ru(ii)-based photoactivated chemotherapy (PACT) agents are promising;however, their short wavelength absorption (generally <550 nm) and poor tumor accumulation ability limit their in vivo applications. Herein, bovine serum albumin (BSA) coated lanthanide-doped upconversion nanoparticles (NaYF4:Yb:Tm@NaYF4 (UCNPs)) were loaded with a Ru(ii) PACT agent, i.e. [Ru(dip)(2)(spc)](+) (dip = 4,7-diphenyl-1,10-phenanthroline;spc = 2-sulfonic acid pyridine-3-carboxylic acid). The resultant UCNP@BSA@Ru can transfer [Ru(dip)(2)(spc)](+) to tumor cells in vitro as well as tumor tissues in vivo highly efficiently and selectively owing to the targeting ability of BSA and the enhanced permeability and retention effect of the nanoparticles. The subsequent near infrared (NIR) light irradiation at 980 nm or visible light irradiation at 470 nm can initiate dissociation of the spc ligand, and the released Ru(ii) aqua compounds ([Ru(dip)(2)(H2O)(2)](2+)) may exert a potent cytotoxicity towards a series of cancer cells but a much weaker effect on the normal IOSE80 cells. The in vivo (mouse) results showed that UCNP@BSA@Ru could inhibit tumor growth upon 980 nm irradiation more efficiently than in the dark and more efficiently than cisplatin (in the dark).

关键词： Tumors

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Solid electrochemiluminescence sensor by immobilization luminol in Zn-Co-ZIF CNFs for sensitive detection of procymidone in vegetables

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MICROCHIMICA ACTA 2024年第9期191卷 508-508页

作者： Lu, Juan guo, Yanjia Shan, Xiangyu Song, Yujia Li, Ruidan Tian, Li Li, xuwen Changchun Normal Univ Coll Chem Changchun 130032 Peoples R China Jilin Univ Coll Chem Changchun 130022 Peoples R China Technol Innovat Lab Res & Dev Econ Plants & Edible Changchun 130032 Jilin Peoples R China

A solid-state electrochemiluminescence (ECL) sensor was fabricated by immobilizing luminol, a classical luminescent reagent, on a Zn-Co-ZIF carbon fiber-modified electrode for the rapid and sensitive detection of procymidone (PCM) in vegetable samples. The sensor was created by sequentially modifying the glassy carbon electrode with Zn-Co-ZIF carbon fiber (Zn-Co-ZIF CNFs), Pt@Au NPs, and luminol. Zn-Co-ZIF CNFs, prepared through electrospinning and high-temperature pyrolysis, possessed a large specific surface area and porosity, making it suitable as carrier and electron transfer accelerator in the system. Pt@Au NPs demonstrated excellent catalytic activity, effectively enhancing the generation of active substances. The ECL signal was significantly amplified by the combination of Zn-Co-ZIF CNFs and Pt@Au NPs, which can subsequently be diminished by procymidone. The ECL intensity decreased proportionally with the addition of procymidone, displaying a linear relationship within the concentration range 1.0 x 10-13 to 1.0 x 10-6 mol L-1 (R2 = 0.993). The sensor exhibited a detection limit of 3.3 x 10-14 mol L-1 (S/N = 3) and demonstrated outstanding reproducibility and stability, making it well-suited for the detection of procymidone in vegetable samples.

关键词： Electrochemiluminescence Carbon nanofibers Modified glassy carbon electrode Procymidone Luminol

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Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4899-4913页

作者： Meng Wang Hekai Chen Tuan Zhang Zhikuan Zhang xuwen Xiang Meng Gao Yilan guo Shuangshuang Jiang Kejun Yin Mintao Chen Jian Huang Xincheng Zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin State Key Laboratory of Membrane Biology School of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesKey Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Graduate School of Pharmaceutical Sciences the University of TokyoTokyo 113-0033Japan Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100032China Toll Biotech Co. Ltd.(Beijing)Beijing 102209China

Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular *** them,TLR7,in particular,has been suggested to be a target for various inflammatory disorders and autoimmune diseases including systemic lupus erythematosus(SLE);but few small-molecule inhibitors with elaborated mechanism have been reported in ***,we reported a well-characterized human TLR7-specific small-molecule inhibitor,TH-407b,with promising potency and negligible cytotoxicity through a novel binding ***,TH-407b not only effectively inhibited TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrated potent inflammation suppressing activities in primary peripheral blood mononuclear cells(PBMCs)derived from SLE ***,TH-407b showed prominent efficacy in vivo,improved survival rate and ameliorated symptoms of SLE model *** obtain molecular insights into the TH-407b derivatives’inhibition mechanism,we performed the structural analysis of TLR7/TH-407b complex using cryogenic electron microscopy(cryo-EM)*** an atomistic resolution cryo-EM structure of the TLR family,it not only of value to facilitate structure-based drug design,but also shed light to methodology development of small proteins using ***,TH-407b has unveiled an inhibition strategy for TLR7 via stabilizing its resting/inactivated *** a resting state could be generally applicable to all TLRs,rendering a useful method for targeting this group of important immunological receptors.

关键词： TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

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Altered levels of circulating CD8⁺CXCR5⁺PD-1⁺T follicular cytotoxic cells in primary Sjogren's syndrome

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CLINICAL RHEUMATOLOGY 2022年第6期41卷 1697-1708页

作者： Zhai, xuwen Wang, Yanlin guo, Hui Liang, Zhaojun Feng, Min Wu, Yanyao Qin, Yan Zhao, Xiangcong Gao, Chong Luo, Jing Shanxi Med Univ Simulat Hosp Clin Skills Teaching Jinzhong 030600 Shanxi Peoples R China Shanxi Med Univ Dept Med Div Rheumatol Hosp 2 Taiyuan 030001 Shanxi Peoples R China Shanxi Med Univ Dept Med Div Nephrol Hosp 2 Taiyuan 030001 Shanxi Peoples R China Shenzhen Baoan Shiyan Peoples Hosp Dept Med Div Nephrol Shenzhen 518005 Guangdong Peoples R China Harvard Med Sch Brigham & Womens Hosp Dept Pathol Boston MA 02115 USA

Background Circulating CD8(+)T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) (CD8(+)CXCR5(+)T), a recently identified follicular cytotoxic T cell subset, are involved in antiviral immunity and autoimmunity, but their abundance and role in the pathogenesis of primary Sjogren syndrome (pSS) are unknown. Methods Circulating CD8(+)CXCR5(+)T cell and CD8(+) regulatory T cells (CD8(+)Treg) were evaluated in 49 pSS patients (19 patients with pulmonary involvement) and 24 age- and sex-matched healthy controls (HCs) by flow cytometry. Orthogonal partial least squares discriminant analysis (OPLS-DA) was performed, and receiver operating characteristic curves (ROC) were generated to identify characteristic cell subsets. Spearman's correlation analysis was conducted to examine the relationships between CD8(+)T cell subsets and clinical features. Results The proportions and numbers of CD8(+)CXCR5(+) , CD8(+)CXCR5(+) programmed death 1-positive (PD-1(+)), and CD8(+)CXCR5 PD-1(+)T cells were significantly higher, whereas those of CD8 +/- Treg were markedly lower, in pSS patients than HCs. The CD8(+)CXCR5(+)PD-1(+)T cell to CD8(+)Treg ratio had the greatest discriminatory power for pSS and HCs according to OPLS-DA and ROC analyses. The increased numbers of CD8(+)CXCR5(+)T cells and CD8(+)CXCR5(+)PD-1(+)T cells were strongly associated with those of CD4(+)CXCR5(+)T and B cells. The proportions and numbers of CD8(+)CXCR5(+)PD-1(+)T cells were increased in pSS patients with lung involvement. Conclusions We identified a new CD8(+)CXCR5(+)PD-1(+)T subset, which was increased in abundance in pSS patients, particularly those with lung involvement, compared with HCs. Also, the CD8(+)CXCR5(+)PD-1(+)T to CD8(+)Treg ratio may be useful for identifying pSS. Our findings suggest that targeting follicular CD8(+)T cell subsets has therapeutic potential for pSS.

关键词： CD8(+)CXCR5(+) follicular cytotoxic T subsets CD8(+) regulatory T cells Lung involvement OPLS-DA Primary Sjogren's syndrome

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Enhancing gas production and CO2 sequestration from marine hydrate reservoirs through optimized CO2 hydrate cap

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ENERGY 2024年 303卷

作者： guo, Yang Li, Shuxia Sun, Hao Wu, Didi Liu, Lu Zhang, Ningtao Qin, xuwen Lu, Cheng China Univ Petr East China State Key Lab Deep Oil & Gas Qingdao 266580 Peoples R China China Univ Petr East China Sch Petr Engn Qingdao 266580 Peoples R China East China Bur Sinopec Explorat & Dev Res Inst Nanjing 210019 Peoples R China China Geol Survey China Aero Geophys Survey & Remote Sensing Ctr Nat Beijing 100083 Peoples R China China Geol Survey Minist Nat Resources Oil & Gas Resources Survey Beijing 100083 Peoples R China

The invasion of formation water during marine hydrate production gravely affects gas productivity. CO2 hydrate caps effectively inhibit water invasion while sequestering CO2, which is considered an excellent prospective application. However, forming field -scale artificial CO2 hydrate caps remains a global challenge. This study proposed an innovative method for forming an artificial CO2 hydrate cap. The fracture length, injection time, production pressure, and production well distance, which are all factors that affect sealing capacity and production enhancement, were optimized. Results indicated that the sealing capacity exhibited a trend of initially increasing and subsequently decreasing with fracture length. The injection time was positively correlated with the sealing capacity and was sufficient to seal both vertically and horizontally once it reached 4 years. In addition to sequestering CO2, the CO2 hydrate cap enhanced gas production by 146.56 % and reduced water production by 37.47 % compared to direct depressurization. CO2 invasion occurred when the well spacing was too close, while being distant was not favorable for pressure propagation and heat utilization by the CO2 hydrate cap. This method simultaneously achieves multiple goals for energy and environmental, providing essential implications for the future commercial application of marine hydrates.

关键词： Gas hydrate CO2 hydrate cap Enhanced gas production CO2 sequestration Numerical simulation

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Controlled Anodic Decomposition Pathway of Supramolecular Lithium Borate for Rationally Tuned Interphase Chemistry

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2025年第19期64卷 e202500425页

作者： Zhou, Haiyu Hou, Wenhui Zhu, Da Zhou, Pan Peng, xuwen Liu, Zhi Yan, Shuaishuai Lu, Yang Ou, Yu Liu, Fengxiang Xia, Yingchun Liu, Hao Cao, Qingbin Song, Xuan guo, Decai Xu, Hong Liu, Kai Tsinghua Univ Dept Chem Engn State Key Lab Chem Engn Beijing 100084 Peoples R China Tsinghua Univ Inst Nucl & New Energy Technol Beijing 100084 Peoples R China SINOPEC Dalian Res Inst Petr & Petrochem 96 Nankai RdTieshan St Dalian 116045 Liaoning Peoples R China

The rational tailoring and molecular-level engineering of stable cathode-electrolyte interphases (CEIs) is paramount to advancing the performance of next-generation high-energy, layered nickel-rich oxide-based lithium metal batteries. However, developing well-tailored electrolyte additives with rationally controlled interfacial chemistry remains highly challenging. Here, two lithium borates: lithium (2-methoxy-15-crown-5)trifluoroborate (C-LiMCFB) and lithium (15-methoxy-2,5,8,11,14-pentaoxahexadecan)trifluoroborate (L-LiMCFB), incorporating cyclic 15-crown-5 (15C5) and linear pentaethylene glycol monomethyl ether (PEGME) as respective host groups tethered to the boron center are designed and synthesized. In C-LiMCFB, the supramolecular polydentate chelation/de-chelation of the 15C5 with Li+ can sequentially deactivate/activate the anodic decomposition of the C & horbar;O bonds, therefore leading to the controlled cleavage pathway of B & horbar;O and C & horbar;O bonds. The controlled interfacial chemistry leads to the formation of a uniform CEI layer, rich in lithium boron-oxygen clusters interwoven with LiF, on the NCM811 surface. This novel CEI configuration demonstrates an exceptional balance of mechanical robustness, adhesiveness, and toughness, providing highly desirable protection for the NCM811 cathode. The discovery of these novel supramolecular boron-based lithium salts not only unlocks supramolecular chemistry for rational electrolyte tuning but also provides a deeper understanding of the CEI formation mechanism in high-energy lithium metal batteries.

关键词： Battery electrolytes Energy storage Lithium metal batteries Supramolecular chemistry

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Effect of multiple-frequency ultrasound-assisted transglutaminase dual modification on the structural, functional characteristics and application of Qingke protein

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ULTRASONICS SONOCHEMISTRY 2023年 94卷 106317页

作者： Li, Aijun guo, Zehang Wang, Zhirong Yang, Qingqing Wen, Leyan Xiang, xuwen Kan, Jianquan Southwest Univ Coll Food Sci 2 Tiansheng Rd Chongqing 400715 Peoples R China Yangzhou Univ Coll Food Sci & Engn Yangzhou 225127 Jiangsu Peoples R China Chinese Hungarian Cooperat Res Ctr Food Sci Chongqing 400715 Peoples R China Minist Agr & Rural Affairs Peoples Republ China Lab Qual & Safety Risk Assessment Agriprod Storage Chongqing 400715 Peoples R China Chongqing Key Lab Special Food Co Built Sichuan & Chongqing 400715 Peoples R China 2 Tiansheng Rd Chongqing 400715 Peoples R China

Qingke protein rich in restricted amino acids such as lysine, while the uncoordination of ratio of glutenin and gliadin in Qingke protein has a negative impact on its processing properties. In this study, the effect of multiple-frequency ultrasound combined with transglutaminase treatment on the functional and structural properties of Qingke protein and its application in noodle manufacture were investigated. The results showed that compared with the control, ultrasound-assisted transglutaminase dual modification significantly increased the water and oil holding capacity, apparent viscosity, foaming ability, and emulsifying activity index of Qingke protein, which exhibited a higher storage modulus G' (P < 0.05). Meanwhile, ultrasound combined with transglutaminase treatment enhanced the cross-linking degree of Qingke protein (P < 0.05), as shown by decreased free amino group and free sulfhydryl group contents, and increased disulfide bond content. Moreover, after the ultrasound-assisted transglutaminase dual modification treatment, the fluorescence intensity, the contents of alpha-helix and random coil in the secondary structure of Qingke protein significantly decreased, while the beta-sheet content increased (P < 0.05) compared with control. SDS-PAGE results showed that the bands of Qingke protein treated by ultrasound combined with transglutaminase became unclear. Furthermore, the quality of Qingke noodles made with Qingke powder (140 g/kg dual modified Qingke protein mixed with 860 g/kg extracted Qingke starch) and wheat gluten 60-70 g/kg was similar to that of wheat noodles. In summary, multiple-frequency ultrasound combined with transglutaminase dual modification can significantly improve the physicochemical properties of Qingke protein and the modified Qingke proteins can be used as novel ingredients for Qingke noodles.

关键词： Qingke protein Modification Functional properties Application Qingke noodles

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Enhanced gas production from low-permeability hydrate reservoirs based on embedded discrete fracture models: Influence of branch parameters

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ENERGY 2023年第1期282卷

作者： guo, Yang Li, Shuxia Qin, xuwen Lu, Cheng Wu, Didi Liu, Lu Zhang, Ningtao China Univ Petr East China Key Lab Unconvent Oil & Gas Dev Minist Educ Qingdao 266580 Peoples R China China Univ Petr East China Sch Petr Engn Qingdao 266580 Peoples R China Minist Nat Resources China Geol Survey Beijing 100037 Peoples R China Minist Nat Resources China Geol Survey Oil & Gas Resources Survey Beijing 100083 Peoples R China East China Bur Sinopec Explorat & Dev Res Inst Nanjing 210019 Peoples R China

The low permeability of marine hydrate reservoirs makes it difficult for trail results to meet the demand for exploitation. Hydraulic fracturing and multi-branch wells are the primary methods for enhancing productivity. This study proposed a new production enhancement method of multi-branch wells combined with multi-stage fracturing (MWMF) based on the embedded discrete fracture model (EDFM). By simulation of the Shenhu area, the multi-physical field evolution of the MWMF production process was first revealed, followed by the systematic analysis of the MWMF production enhancement effect with branch parameters. Results indicated that the cumulative gas production of MWMF increased by 327% compared with only horizontal wells. The production of four-branch wells exhibited a 7% reduction compared to horizontal wells using the MWMF method, suggesting increased branch numbers inhibit production. Increasing branch length was positively correlated with enhanced production. Notably, the influence of branch length on gas production became more pronounced as the number of branches increased. The interface of the three-phase layer (TPL) and hydrate-bearing layer (HBL) was the most suitable location for branch well placement. This novel study provides valuable insights into new applications of the MWMF method in developing low-permeability hydrate reservoirs.

关键词： Natural gas hydrate Multi-branch well Multi-stage fracture Embedded discrete fracture model Enhanced gas production

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