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The dynamic of platelet count as a novel and valuable predictor for 90-day survival of hepatitis B virus-related acute-on-chronic liver failure patients

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CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY 2021年第2期45卷 101482-101482页

作者： Xu, xuwen Hou, Zhouhua Xu, Yuyuan Gu, Huimin Liang, Guangyu huang, Yukun Southern Med Univ Nanfang Hosp Dept Infect Dis 1838 North Guangzhou Ave Guangzhou 510515 Peoples R China Cent South Univ Xiangya Hosp Dept Infect Dis Changsha Peoples R China

Background: The prognosis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is extremely poor due to multiple organ dysfunction. Objectives: To investigate the prognostic risk factors and create a 90-day prognostic predictive model for the patients with HBV-ACLF. Methods: Demographic information, clinical examination, and laboratory test results of the enrolled patients were collected to study the prognostic risk factors. Univariate and multivariate analysis and stepwise Logistic regression were performed to develop the predictive model. External validation was performed to verify the model. Results: A total of 333 HBV-ACLF patients and 86 HBV-non-ACLF patients were included in this study. Age, alpha-fetoprotein (AFP), total bilirubin (TBIL), platelet (PLT), and international normalized ratio (INR) were found to be independent risk factors for poor outcomes of HBV-ACLF patients. The formula identified for the linear predictor (LP) of the prognosis of HBV-ACLF patients is thus: LPACLF = -5.04-0.056 x age-0.002 x AFP-0.010 x PLT + 0.002 x TBIL + 0.877 x INR. The area under curve (AUC) of the receiver operating characteristic curve (ROC) was 0.7835 (95% CI 0.7248-0.8423). Conclusions: A predictive model with good calibration and discrimination for 90-day survival ofHBVACLF patients, including 5 variables, namely age, AFP, PLT, TBIL, and INR was established. Platelet count was a sensitive and dynamic variable for the prognosis of HBV-ACLF. (c) 2020 Elsevier Masson SAS. All rights reserved.

关键词： Platelet Alpha-fetoprotein Acute-on-chronic liver failure Prognosis

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Two-terminal self-rectifying optoelectronic synaptic devices with largest-dynamic-range updates

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APPLIED MATERIALS TODAY 2023年 30卷

作者： huang, Wen Hang, Pengjie Xia, xuwen Li, Bin Li, Biao Kan, Chenxia Zhang, Huixing Zhu, Chen Wang, Chenhao Zhu, Xiaodong Yang, Deren Pi, Xiaodong Yu, Xuegong Li, Xing'ao Nanjing Univ Posts & Telecommun New Energy Technol Engn Lab Jiangsu Provence 9 Weiyuan Rd Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Sch Sci 9 Weiyuan Rd Nanjing 210023 Peoples R China Zhejiang Univ State Key Lab Silicon Mat Hangzhou 310027 Peoples R China Nanjing Univ Posts & Telecommun Coll Elect & Opt Engn Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Coll Microelect Nanjing 210023 Peoples R China Zhejiang Univ Sci & Technol Sch Sci Hangzhou 310027 Peoples R China

Two-terminal optoelectronic synaptic devices have attracted increasing attention owing to their simplicity of structures, which facilitate the device integration in neuromorphic computing systems. However, synaptic-weight updates and self-rectifying properties in two-terminal optoelectronic synaptic devices are inferior. Here, we fabricate two-terminal optoelectronic synaptic devices in accordance with the hybrid structure of optically active layers MAPbI(3) and electron transport layers (ETLs) SnO2 in an n-i-p planar system, where MAPbI3 and SnO2 are used for generating and trapping carriers, respectively. Synaptic functionalities such as excitatory post-synaptic current (EPSC), paired-pulse facilitation (PPF), spike-number dependent plasticity (SNDP), and spike-rate dependent plasticity (SRDP) are all successfully mimicked without external bias. These synaptic devices possess self-rectifying properties with a highest ratio of similar to 0.3 x 10(3) and their synaptic weight exhibits largest-dynamic-range updates of 14.3 within 14 seconds among the reported two-terminal optoelectronic synaptic devices. Furthermore, the spike-number tunability of EPSC in the synaptic devices leads to the realization of straight running of agrimotor driverless technology. Results dramatically promote the development of two-terminal optoelectronic synaptic devices in neuromorphic computing.

关键词： Two-terminal optoelectronic synaptic devices SnO2 MAPbI(3) Self-rectifying Synaptic-weight updates

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Geographic differences in pharmacotherapy patterns and outcomes of acute ischemic stroke in China

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BMC NEUROLOGY 2024年第1期24卷 64页

作者： Li, Ying Ou, Qianhua Lu, Yuxuan Shen, Zhiyuan Li, Jieyu Zhang, Zhuangzhuang Tai, Liwen Li, Guozhong Chen, Huisheng Zhang, Guiru Zhang, Lei Sun, xuwen Qiu, Jinhua Wei, Yan Zhu, Sainan Wang, Zhaoxia Sun, Weiping huang, Yining Peking Univ First Hosp Dept Neurol 8 Xishiku St Beijing 100034 Peoples R China Beijing Key Lab Neurovasc Dis Discovery Beijing Peoples R China Techpool Biopharm Co Ltd Dept Med Affairs Guangzhou Peoples R China Hebei Med Univ Hosp 2 Dept Neurol Shijiazhuang Peoples R China Harbin Med Univ Affiliated Hosp 1 Dept Neurol Harbin Peoples R China Gen Hosp Shenyang Mil Command Dept Neurol Shenyang Peoples R China Penglai Peoples Hosp Dept Neurol Penglai Peoples R China Sun Yat Sen Univ Affiliated Hosp 5 Dept Neurol Zhuhai Peoples R China Qindao Univ Affiliated Yantai Yuhuangding Hosp Med Coll Dept Neurol Yantai Peoples R China Huizhou First Hosp Dept Neurol Huizhou Peoples R China Harrison Int Peace Hosp Dept Neurol Hengshui Peoples R China Peking Univ First Hosp Dept Biostat Beijing Peoples R China

Background: Vast economic and healthcare status discrepancies exist among regions in China, contributing to different treatment patterns. This study was aimed to investigate the current status of pharmacotherapy for acute ischemic stroke (AIS) and outcomes in China and explore the geographic variation in stroke care. Methods: This study was a multicenter prospective registry study, which collected the data of patients with AIS from 80 hospitals in 46 cities in 2015-2017 across China. Poor functional outcome defined as a modified Rankin Scale score of 3-6 was assessed at 3 and 12 months. Multivariate logistic regression was used. Results: Among 9973 eligible patients, the number of receiving intravenous thrombolysis (IVT), antiplatelet agents, anticoagulants, statin and human urinary kallidinogenase was 429 (4.3%), 9363 (93.9%), 1063 (10.7%), 6828 (74.7%) and 5112 (51.2%), respectively. Multivariable analysis showed IVT use in northeastern was significantly more frequent than in eastern region (OR = 3.17, 95% CI, 2.53-3.99), while the antiplatelets agents use were less frequent (OR = 0.46, 95%CI: 0.38-0.57). The proportions of poor outcomes at 3 and 12 months were 20.7% and 15.8%, respectively. Multivariate analysis showed AIS patients from northeastern and central region had significantly lower risk of poor outcome at month 3 and 12 than those from eastern region (all P < 0.05). Conclusions: There was a low IVT use and a high antiplatelet agent and statin use for AIS in China. The pharmacotherapy and prognosis of AIS had variation by geographic region.

关键词： Acute ischemic stroke Geographic variation Outcome Pharmacotherapy

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Observation of Dirac nodal line states in topological semimetal candidate PrSbTe

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Physical Review B 2024年第4期109卷 045113-045113页

作者： Dengpeng Yuan Dajian huang Xin Ma Xu Chen Huifen Ren Yun Zhang Wei Feng Xiegang Zhu Bo Wang xuwen He Jian Wu Shiyong Tan Qunqing Hao Qiang Zhang Yi Liu Qin Liu Zhengtai Liu Chao Cao Qiuyun Chen Xinchun Lai Science and Technology on Surface Physics and Chemistry Laboratory Mianyang 621907 China Center for Correlated Matter and School of Physics Zhejiang University Hangzhou 310058 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201210 China

The interplay among topology, crystal symmetry, magnetic order, and strong electron correlation can give rise to a plethora of exotic physical phenomena. The ZrSiS family is known as typical topological Dirac semimetals, among them LnSbTe (Ln denotes lanthanide) compounds exhibit intriguing characteristics due to the presence of Ln 4f electrons, resulting in quantum states and unique properties. In this paper, the topological electronic structure of PrSbTe is systematically studied by angle-resolved photoemission spectroscopy (ARPES), combined with magnetic, specific heat measurements, and band structure calculations. The detailed three-dimensional electronic structure of PrSbTe has been obtained, and a diamond-shaped Fermi surface and multiple Dirac nodal lines have been observed, which are in remarkable agreement with theoretical calculations. Moreover, the 4f electrons in PrSbTe are rather localized, which can be revealed by on-resonant ARPES data and further confirmed by the rather small Sommerfeld coefficient of γ=2.6231mJ/molK2. Our results provide more detailed information about the LnSbTe family, which gives a deeper understanding of the interaction between Ln 4f electrons and the topological states.

关键词： Electronic structure Fermi surface Topological materials Dirac semimetal Node-line semimetals Angle-resolved photoemission spectroscopy Magnetic techniques Specific heat measurements

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伪狂犬活/灭活病毒接种小鼠诱导免疫效力及差异因子比较

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南京农业大学学报 2023年第1期46卷 106-111页

作者：章晨昕于晓明侯立婷张元鹏乔绪稳侯继波黄克和郑其升陈瑾南京农业大学动物医学院江苏南京210095 江苏省农业科学院动物免疫工程研究所/国家兽用生物制品工程技术研究中心江苏南京210014 江苏省食品质量安全重点实验室-省部共建国家重点实验室培育基地江苏南京210014

[目的]本研究旨在比较活/灭活病毒进入体内后对免疫系统活化的差异,为免疫增强剂的筛选和评价建立高效动物模型。[方法]本试验利用伪狂犬病毒(PRV)Bartha-K61株建立小鼠伪狂犬人工感染模型,筛选活/灭活病毒接种小鼠后免疫相关差异因子。... 详细信息

[目的]本研究旨在比较活/灭活病毒进入体内后对免疫系统活化的差异,为免疫增强剂的筛选和评价建立高效动物模型。[方法]本试验利用伪狂犬病毒(PRV)Bartha-K61株建立小鼠伪狂犬人工感染模型,筛选活/灭活病毒接种小鼠后免疫相关差异因子。将PRV Bartha-K61活毒以不同剂量、不同方式感染小鼠,通过计算小鼠存活率确定最佳感染剂量与感染方式;将筛选的最佳剂量的伪狂犬病毒活毒与相同剂量下灭活病毒按照前述筛选的最佳感染方式接种小鼠,利用ELISA试剂盒检测免疫7 d后小鼠血清中TNF-α、IL-1β、IFN-β和IL-6水平;利用PRV gB ELISA检测免疫7 d后小鼠血清PRV特异性gB抗体水平;利用灭活PRV作为特异性抗原进行淋巴细胞增殖试验并计算各组淋巴细胞刺激指数(SI)。[结果]在保证小鼠存活的前提下,6~8周龄小鼠的PRV的安全感染剂量为5×104TCID50;同等剂量下,相比于肌肉和腹腔注射,皮下注射为最安全的感染方式;同等剂量的活毒和灭活病毒接种小鼠后,与灭活病毒组相比,活病毒感染7 d后小鼠血清中TNF-α、IL-1β和IFN-β水平显著升高(P<0.001,P<0.01),与灭活病毒组相比,活病毒组小鼠血清PRV gB特异性抗体IgG水平和SI也显著升高(P<0.05,P<0.001);不同灭活方式间各细胞因子和SI差异不显著(P>0.05)。[结论]成功建立小鼠伪狂犬人工感染模型,明确活/灭活伪狂犬病毒接种小鼠后,机体早期存在与免疫相关差异因子,为后续免疫增强剂的评价筛选提供依据。

关键词：伪狂犬病毒小鼠模型免疫效力差异因子

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Experimental Study on Noncoaxial Characteristics of Saturated Remolded Loess

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ADVANCES IN CIVIL ENGINEERING 2020年第1期2020卷

作者： Jiang, Xuemeng Niu, Haoshuang huang, Wenpeng Shang, xuwen Wang, Deng Changan Univ Key Lab Special Area Highway Engn Minist Educ Xian 710064 Peoples R China

In practical engineering, if the influence of noncoaxial stress and strain is not considered, part of soil deformation will be ignored, resulting in the structural design which is not safe enough. A series of undrained tests was performed on remolded loess specimens using a hollow cylinder apparatus to examine the coupling between principal stress magnitude and direction in these specimens. First, the elastic parameters of remolded loess were obtained, and these parameters were used as the basis for investigating the noncoaxiality of the soil body under principal stress axis rotation (PSAR). The effects of elastic strain, intermediate principal stress coefficient, and magnitude of the deviatoric stress on the noncoaxiality of remolded loess were also investigated. The results of these experiments show that remolded loess exhibits significant noncoaxial behavior during PSAR. The noncoaxiality angle of remolded loess cyclically fluctuates with increases in the principal stress angle. It was also observed that the noncoaxiality angle will be overestimated if the effects of elastic strain are overlooked. Reversals in the direction of PSAR cause dramatic changes in the noncoaxiality angle. Increases in the intermediate principal stress coefficient are accompanied by increases in the noncoaxiality angle, up to a certain degree;however, these changes do not affect the development of the noncoaxiality angle. In coupled rotational tests with a range of deviatoric stress amplitudes, it was observed that changes in the deviatoric stress amplitude will affect the development of the noncoaxiality angle;increases in the deviatoric stress amplitude cause the noncoaxiality angle versus principle stress angle plot to shift to the left gradually, thus accelerating the trends of the noncoaxiality angle. Increases in the cycle number also increase the noncoaxiality of remolded loess.

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硅烷偶联剂改性的短切玄武岩纤维增强三元乙丙橡胶复合材料的研究

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化工新型材料 2024年第S01期52卷 199-204,211页

作者：李辉张卜方赵春霞向东王斌程金波黄浩然张旭文武元鹏西南石油大学新能源与材料学院成都610500

将玄武岩纤维(BF)用硅烷偶联剂KH570改性后,制备了玄武岩纤维增强三元乙丙橡胶(E-BF7)复合材料,研究了玄武岩纤维用量对复合材料力学性能、热稳定性、动态热力学性能、耐水性能以及耐化学液体性能的影响。结果表明:与未加纤维的三元乙... 详细信息

将玄武岩纤维(BF)用硅烷偶联剂KH570改性后,制备了玄武岩纤维增强三元乙丙橡胶(E-BF7)复合材料,研究了玄武岩纤维用量对复合材料力学性能、热稳定性、动态热力学性能、耐水性能以及耐化学液体性能的影响。结果表明:与未加纤维的三元乙丙橡胶相比,添加15份KH570改性的玄武岩纤维BF7得到的三元乙丙橡胶复合材料E-BF7-15,拥有更好的综合性能。其拉伸强度从12.49MPa提高到14.50MPa,提高了16.1%,撕裂强度从41.47MPa提高到51.67MPa,提高了24.6%,其耐水性和耐化学液体性能也得到明显提升。

关键词：三元乙丙橡胶玄武岩纤维复合材料纤维改性硅烷偶联剂

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绿色建造评价框架体系

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绿色建造与智能建筑 2022年第11期 7-11页

作者：肖绪文李翠萍于震平黄宁刘星中国建筑股份有限公司同济大学建筑工程系中国建筑业协会绿色建造与智能建筑分会中国建筑土木建设有限公司

绿色建造方式有利于建筑领域的可持续发展。绿色建造包含了工程立项、设计、施工各阶段,并强调建造全过程的协同管理。绿色建造示范工程已在我国开展了试点工作。为了定量判断绿色建造工程实践工作的水平,亟需出台有关的评价标准。本文... 详细信息

绿色建造方式有利于建筑领域的可持续发展。绿色建造包含了工程立项、设计、施工各阶段,并强调建造全过程的协同管理。绿色建造示范工程已在我国开展了试点工作。为了定量判断绿色建造工程实践工作的水平,亟需出台有关的评价标准。本文简述了绿色建造主要内容,提出了主要评价指标,据此构建了评价框架体系,为绿色建造评价标准的编制提供参考。

关键词：绿色建造评价指标评价框架

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浙江知识产权公共服务数字化集成平台设计与研究

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中国科技纵横 2024年第6期 26-29页

作者：张潞璐曹杭平黄健民朱明陈旭文傅潇杭国家市场监管技术创新中心(市场监管数字化研究与应用) 浙江杭州 310000 浙江省标准化研究院浙江杭州 310000

建设知识产权公共服务数字化集成平台是深化知识产权服务事项改革的重要方式,为进一步提升浙江知识产权公共服务数字化集成水平,以"知识产权在线"为例,充分运用"互联网+知识产权"、大数据和信息化技术,分析建设背... 详细信息

建设知识产权公共服务数字化集成平台是深化知识产权服务事项改革的重要方式,为进一步提升浙江知识产权公共服务数字化集成水平,以"知识产权在线"为例,充分运用"互联网+知识产权"、大数据和信息化技术,分析建设背景与实际需求,提出浙江融合优化知识产权各类资源和服务的知识产权平台设计与建设方式,为全国类似平台的功能设计以及服务能力和效率的提升提供经验借鉴.

关键词：知识产权集成公共服务数字化

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Association of rs1059004 polymorphism in the OLIG2 locus with functional brain network in first-episode negative schizophrenia

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PSYCHIATRY RESEARCH-NEUROIMAGING 2020年 303卷 111130-111130页

作者： Lv, Yahui Wu, Sijia Lin, Yanyan Wang, xuwen Wang, Jijun Cai, Suping huang, Liyu Xidian Univ Sch Life Sci & Technol Xian 710071 Shaanxi Peoples R China Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Shanghai 200030 Peoples R China

Schizophrenia has often been viewed as a disorder of connectivity. The single nucleotide polymorphism rs1059004 in the oligodendrocyte lineage transcription factor 2 gene locus has been reported to be associated with schizophrenia. We measured the functional connectivity and functional brain network topology properties in 49 schizophrenic patients and 47 healthy controls. We compared the strength and diversity of the functional connectivity and topological properties of functional networks between different genotypes. The correlations among functional connectivity, topological properties and behavioral performances were also investigated in this study. We found that the connectivity strength of schizophrenic patients carrying the risk A allele was generally decreased whereas connectivity diversity was increased. Regarding topological properties, all groups showed small-world properties, the nodal efficiency showed significant differences in the right precuneus and left middle temporal pole between different genotypes in schizophrenic patients. Moreover, the nodal efficiency in the left middle temporal pole was positively correlated with the neuropsychological assessment battery results of the schizophrenic patients who were homozygous for the C allele. Our results elucidate the contribution of rs1059004 to the functional brain network, and may help enhance the present understanding of the role of risk gene in the functional dysconnectivity of schizophrenia.

关键词： Schizophrenia Oligodendrocyte lineage transcription factor 2 Functional connectivity Functional network Graph theoretical analysis

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