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武汉大学学报（工学版） 2022年第10期55卷 1027-1033页

作者：刘元德安旭文黄天翔甘肃省张掖公路事业发展中心甘肃张掖734000 武汉大学土木建筑工程学院湖北武汉430072 湖北省交通投资集团有限公司湖北武汉430050

根据道路等级、气候条件和路面混凝土的功能要求,以道路废弃混凝土为再生集料,设计了粗粒式密级配AC-25C型、中粒式密级配AC-16C型和玛蹄脂SMA-20型沥青混凝土,以再生集料取代率和沥青用量为试验变化参数,制作了标准的马歇尔试件,分别... 详细信息

根据道路等级、气候条件和路面混凝土的功能要求,以道路废弃混凝土为再生集料,设计了粗粒式密级配AC-25C型、中粒式密级配AC-16C型和玛蹄脂SMA-20型沥青混凝土,以再生集料取代率和沥青用量为试验变化参数,制作了标准的马歇尔试件,分别对再生集料沥青混凝土的密度、稳定度、流值进行了试验研究。结果表明:按建议级配配置的再生集料沥青混凝土,可根据需要用于高速公路、一级公路和其他等级的公路路面。研究成果不仅可为废弃混凝土的再生利用提供试验依据和技术支持,还可为同类工程提供参考。

关键词：废弃混凝土再生集料试验研究沥青混凝土

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XGB-SEGA coupled energy saving method for wastewater treatment plants

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APPLIED WATER SCIENCE 2024年第2期14卷 29页

作者： Wang, Zijian Zhou, xuwen Wang, Hao huang, Zehan Ji, Jiantao Peng, Zhaoxu Jiang, Kun Beijing Univ Technol Fac Architecture Civil & Transportat Engn Beijing 100124 Peoples R China Zhengzhou Univ Sch Water Conservancy & Transportat Zhengzhou 450001 Peoples R China Harbin Inst Technol Sch Civil & Environm Engn Shenzhen 518055 Peoples R China Cent Plains Environm Protect Co Ltd Zhengzhou 450001 Peoples R China Zhengzhou Univ Sch Ecol & Environm Zhengzhou 450001 Peoples R China CSD Water Serv CO Ltd Beijing 100124 Peoples R China

To reduce the amount of energy consumed in wastewater treatment plants, nine methods were used to select the key operation parameters that affected energy consumption according to daily operation records, and an intelligent operation management system based on a genetic algorithm was constructed by mapping the relationships between energy consumption and the key operation parameters. The results showed that the prediction and management of energy consumption could be achieved by incorporating the strengthened elastic genetic algorithm into the extreme gradient boosting model. The main parameters affecting energy consumption were the influent flow rate, effluent total nitrogen, NH4+-N loading rate, etc., and the energy consumption could be reduced by 13-27% (with an average of 22%). The parameters were all selected from the daily operation records of the wastewater treatment plant, and no additional complex data acquisition system was needed to collect specific parameters. This study provided a cost-effective strategy to reduce energy consumption in wastewater treatment plants.

关键词： Energy saving Extreme gradient boosting (XGB) Genetic algorithm optimization Carbon neutrality Wastewater treatment

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The dynamic of platelet count as a novel and valuable predictor for 90-day survival of hepatitis B virus-related acute-on-chronic liver failure patients

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CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY 2021年第2期45卷 101482-101482页

作者： Xu, xuwen Hou, Zhouhua Xu, Yuyuan Gu, Huimin Liang, Guangyu huang, Yukun Southern Med Univ Nanfang Hosp Dept Infect Dis 1838 North Guangzhou Ave Guangzhou 510515 Peoples R China Cent South Univ Xiangya Hosp Dept Infect Dis Changsha Peoples R China

Background: The prognosis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is extremely poor due to multiple organ dysfunction. Objectives: To investigate the prognostic risk factors and create a 90-day prognostic predictive model for the patients with HBV-ACLF. Methods: Demographic information, clinical examination, and laboratory test results of the enrolled patients were collected to study the prognostic risk factors. Univariate and multivariate analysis and stepwise Logistic regression were performed to develop the predictive model. External validation was performed to verify the model. Results: A total of 333 HBV-ACLF patients and 86 HBV-non-ACLF patients were included in this study. Age, alpha-fetoprotein (AFP), total bilirubin (TBIL), platelet (PLT), and international normalized ratio (INR) were found to be independent risk factors for poor outcomes of HBV-ACLF patients. The formula identified for the linear predictor (LP) of the prognosis of HBV-ACLF patients is thus: LPACLF = -5.04-0.056 x age-0.002 x AFP-0.010 x PLT + 0.002 x TBIL + 0.877 x INR. The area under curve (AUC) of the receiver operating characteristic curve (ROC) was 0.7835 (95% CI 0.7248-0.8423). Conclusions: A predictive model with good calibration and discrimination for 90-day survival ofHBVACLF patients, including 5 variables, namely age, AFP, PLT, TBIL, and INR was established. Platelet count was a sensitive and dynamic variable for the prognosis of HBV-ACLF. (c) 2020 Elsevier Masson SAS. All rights reserved.

关键词： Platelet Alpha-fetoprotein Acute-on-chronic liver failure Prognosis

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Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4899-4913页

作者： Meng Wang Hekai Chen Tuan Zhang Zhikuan Zhang xuwen Xiang Meng Gao Yilan Guo Shuangshuang Jiang Kejun Yin Mintao Chen Jian huang Xincheng Zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin State Key Laboratory of Membrane Biology School of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesKey Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Graduate School of Pharmaceutical Sciences the University of TokyoTokyo 113-0033Japan Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100032China Toll Biotech Co. Ltd.(Beijing)Beijing 102209China

Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular *** them,TLR7,in particular,has been suggested to be a target for various inflammatory disorders and autoimmune diseases including systemic lupus erythematosus(SLE);but few small-molecule inhibitors with elaborated mechanism have been reported in ***,we reported a well-characterized human TLR7-specific small-molecule inhibitor,TH-407b,with promising potency and negligible cytotoxicity through a novel binding ***,TH-407b not only effectively inhibited TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrated potent inflammation suppressing activities in primary peripheral blood mononuclear cells(PBMCs)derived from SLE ***,TH-407b showed prominent efficacy in vivo,improved survival rate and ameliorated symptoms of SLE model *** obtain molecular insights into the TH-407b derivatives’inhibition mechanism,we performed the structural analysis of TLR7/TH-407b complex using cryogenic electron microscopy(cryo-EM)*** an atomistic resolution cryo-EM structure of the TLR family,it not only of value to facilitate structure-based drug design,but also shed light to methodology development of small proteins using ***,TH-407b has unveiled an inhibition strategy for TLR7 via stabilizing its resting/inactivated *** a resting state could be generally applicable to all TLRs,rendering a useful method for targeting this group of important immunological receptors.

关键词： TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

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基于Ecopath模型的五里湖生态系统营养结构和能量流动研究

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中国水产科学 2012年第3期19卷 471-481页

作者：黄孝锋邴旭文陈家长南京农业大学无锡渔业学院江苏无锡214081 中国水产科学研究院淡水渔业研究中心江苏无锡214081 农业部淡水渔业和种质资源利用重点实验室江苏无锡214081 内陆渔业生态环境和资源重点开放实验室江苏无锡214081

根据2006年和2009年对五里湖渔业资源和生态环境调查数据,利用Ecopath with Ecosim软件,构建这两个时期五里湖生态系统能量通道模型,比较分析了实施净水渔业前后生态系统的结构和能量流动特征。模型包括大型、其他食鱼性鱼类、湖鲚、鲤... 详细信息

根据2006年和2009年对五里湖渔业资源和生态环境调查数据,利用Ecopath with Ecosim软件,构建这两个时期五里湖生态系统能量通道模型,比较分析了实施净水渔业前后生态系统的结构和能量流动特征。模型包括大型、其他食鱼性鱼类、湖鲚、鲤、鲫、野杂鱼、鲢、草食性鱼类、大型虾蟹类、软体动物、其他底栖动物、浮游动物、沉水植物、其他维管植物、浮游植物、碎屑等17个功能组,基本覆盖了能量流动的途径。营养网络分析表明,增殖放养滤食性鱼类和贝类,扩大了五里湖生态系统的规模,增加了生态系统的发育程度和生态系统营养级ⅠⅡ的能量转换效率,滤食性生物与生态系统其他功能组生态位的重叠程度也有所增加。该系统各功能组间的联系加强且系统趋向稳定,但生态系统的物质流转速度和物质再循环的比例有所降低。

关键词：五里湖生态通道模型生态系统结构能量流动

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FPC的图像采集与表面曲向消除方法

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电子测量与仪器学报 2015年第6期29卷 895-900页

作者：陈旭文刘桂雄黄坚揭阳职业技术学院揭阳522051 华南理工大学广州510640

挠性电路板(FPC)的图像采集与预处理是自动检测的基础。针对检测缺陷不同提出3种照明方案,对欲检测缺陷拥有较好成像效果,若检测所有缺陷,可采用2种方案结合分别采集图片;只有在同轴光照明下才可准确识别FPC折痕缺陷,为区别折痕与表面曲... 详细信息

挠性电路板(FPC)的图像采集与预处理是自动检测的基础。针对检测缺陷不同提出3种照明方案,对欲检测缺陷拥有较好成像效果,若检测所有缺陷,可采用2种方案结合分别采集图片;只有在同轴光照明下才可准确识别FPC折痕缺陷,为区别折痕与表面曲向,研究FPC表面曲向消除方法(CSE),根据FPC基材表面曲向区域挠度引起的灰度值渐变情况,以最小像素个数、最大灰度梯度、均方差为筛选条件,识别图像中的表面曲向区域,以表面曲向区域中的灰度极小值为真实灰度值,消除图像中的表面曲向。利用高斯滤波与CSE结合对图像进行预处理,图像信噪比比高斯滤波提升5.80 d B。

关键词：挠性电路板图像采集图像预处理表面曲向消除

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Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4914-4933页

作者： Chao huang Yang Jin Panpan Fu Kongying Hu Mengxue Wang Wenjing Zai Ting Hua Xinluo Song Jianyu Ye Yiqing Zhang Gan Luo Haiyu Wang Jiangxia Liu Jieliang Chen xuwen Li Zhenghong Yuan Key Laboratory of Medical Molecular Virology(MOE/NHC) Research Unit of Cure of Chronic Hepatitis B Virus Infection(CAMS)Shanghai Frontiers Science Center of Pathogenic Microbes and InfectionSchool of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China Shanghai Institute of Infectious Disease and Biosecurity Shanghai 200032China Guixi Hospital of Chinese Medicine Guixi 335400China

Due to the limitations of current anti-HBV therapies, the HBV core (HBc or HBcAg) protein assembly modulators (CpAMs) are believed to be potential anti-HBV agents. Therefore, discovering safe and efficient CpAMs is of great value. In this study, we established a HiBiT-based high-throughput screening system targeting HBc and screened novel CpAMs from an in-house marine chemicals library. A novel lead compound 8a, a derivative of the marine natural product naamidine J, has been successfully screened for potential anti-HBV activity. Bioactivity-driven synthesis was then conducted, and the structure‒activity relationship was analyzed, resulting in the discovery of the most effective compound 11a (IC50 = 0.24 μmol/L). Furthermore, 11a was found to significantly inhibit HBV replication in multiple cell models and exhibit a synergistic effect with tenofovir disoproxil fumarate (TDF) and IFNa2 in vitro for anti-HBV activity. Treatment with 11a in a hydrodynamic-injection mouse model demonstrated significant anti-HBV activity without apparent hepatotoxicity. These findings suggest that the naamidine J derivative 11a could be used as the HBV core protein assembly modulator to develop safe and effective anti-HBV therapies.

关键词： Anti-HBV HBV coreprotein Coreproteinassembly modulators Marine natural products HiBiT

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Multi-Target Feeding-Behavior Recognition Method for Cows Based on Improved RefineMask

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SENSORS 2024年第10期24卷 2975页

作者： Li, xuwen Gao, Ronghua Li, Qifeng Wang, Rong Liu, Shanghao huang, Weiwei Yang, Liuyiyi Zhuo, Zhenyuan Tianjin Agr Univ Coll Comp & Informat Engn Tianjin 300384 Peoples R China Beijing Acad Agr & Forestry Sci Res Ctr Informat Technol Beijing 100097 Peoples R China Northwest A&F Univ Coll Informat Engn Xianyang 712100 Peoples R China Beijing Univ Agr Coll Intelligent Sci & Engn Beijing 100096 Peoples R China

Within the current process of large-scale dairy-cattle breeding, to address the problems of low recognition-accuracy and significant recognition-error associated with existing visual methods, we propose a method for recognizing the feeding behavior of dairy cows, one based on an improved RefineMask instance-segmentation model, and using high-quality detection and segmentation results to realize the recognition of the feeding behavior of dairy cows. Firstly, the input features are better extracted by incorporating the convolutional block attention module into the residual module of the feature extraction network. Secondly, an efficient channel attention module is incorporated into the neck design to achieve efficient integration of feature extraction while avoiding the surge of parameter volume computation. Subsequently, the GIoU loss function is used to increase the area of the prediction frame to optimize the convergence speed of the loss function, thus improving the regression accuracy. Finally, the logic of using mask information to recognize foraging behavior was designed, and the accurate recognition of foraging behavior was achieved according to the segmentation results of the model. We constructed, trained, and tested a cow dataset consisting of 1000 images from 50 different individual cows at peak feeding times. The method's effectiveness, robustness, and accuracy were verified by comparing it with example segmentation algorithms such as MSRCNN, Point_Rend, Cascade_Mask, and ConvNet_V2. The experimental results show that the accuracy of the improved RefineMask algorithm in recognizing the bounding box and accurately determining the segmentation mask is 98.3%, which is higher than that of the benchmark model by 0.7 percentage points;for this, the model parameter count size was 49.96 M, which meets the practical needs of local deployment. In addition, the technologies under study performed well in a variety of scenarios and adapted to various light environment

关键词： RefineMask instance segmentation feeding behavior behavioral recognition

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Single-Atom Fe-Anchored Nano-Diamond With Enhanced Dual-Enzyme Mimicking Performance for H2O2 and Glutathione Detection

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2022年 9卷 790849页

作者： Liu, Ying Yan, Jianghong huang, Yu Sun, Zhiheng Zhang, Huijing Fu, Lihaoyuan Li, xuwen Jin, Yongri Jilin Univ Coll Chem Changchun Peoples R China First Clin Hosp Jilin Prov Acad Tradit Chinese Med Changchun Peoples R China

Glutathione (GSH) is an important antioxidant and free radical scavenger that converts harmful toxins into harmless substances and excretes them out of the body. In the present study, we successfully prepared single-atom iron oxide-nanoparticle (Fe-NP)-modified nanodiamonds (NDs) named Fe-NDs via a one-pot in situ reduction method. This nanozyme functionally mimics two major enzymes, namely, peroxidase and oxidase. Accordingly, a colorimetric sensing platform was designed to detect hydrogen peroxide (H2O2) and GSH. Owing to their peroxidase-like activity, Fe-NDs can oxidize colorless 3,3 ',5,5 '-tetramethylbenzidine (TMB) into blue with sufficient linearity at H2O2 concentrations of 1-60 mu M and with a detection limit of 0.3 mu M. Furthermore, using different concentrations of GSH, oxidized TMB can be reduced to TMB, and the color change from blue to nearly colorless can be observed by the naked eye (linear range, 1-25 mu M;detection limit, 0.072 mu M). The established colorimetric method based on oxidase-like activity can be successfully used to detect reduced GSH in tablets and injections with good selectivity and high sensitivity. The results of this study exhibited reliable consistency with the detection results obtained using high-performance liquid chromatography (HPLC). Therefore, the Fe-NDs colorimetric sensor designed in this study offers adequate accuracy and sensitivity.

关键词： nanodiamond single-atom Fe peroxidase-like and oxidase-like activity colorimetric sensor glutathione

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Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

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JOURNAL OF MEDICINAL CHEMISTRY 2018年第19期61卷 8613-8624页

作者： Pang, Peichen Chen, Jiean Li, Xijian Li, Miyang Yu, Huidong Zhao, Jean J. Ni, Jing Wang, xuwen Sun, Huiyong Tian, Sheng Zhu, Feng Liu, Feng huang, Yong Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Peking Univ State Key Lab Chem Oncogen Key Lab Chem Genom Shenzhen Grad Sch Shenzhen 518055 Guangdong Peoples R China Rongene Pharma Co Ltd Guangzhou 510663 Guandong Peoples R China Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Dept Biol Chem & Mol Pharmacol Boston MA 02215 USA Soochow Univ Coll Pharmaceut Sci Suzhou 215123 Jiangsu Peoples R China

Camptothecin (CPT) has been shown to block disassembly of the topoisomerase I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability, and severe toxicity of CPTs have limited their clinical applications. Herein, we report the design and synthesis of H2O-soluble and orally bioavailable hexacyclic CPT derivatives. By analysis of a virtual chemical library and cytotoxicity screening in vitro, 9 and 11 were identified as potential prodrugs and chosen for further characterization in vivo. Both compounds exhibited remarkable anticancer and anti-inflammation efficacies in animals and improved drug-like profiles.

关键词： Mixtures Rodent models Solubility Genetics Toxicity

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