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Single-Atom Fe-Anchored Nano-Diamond With Enhanced Dual-Enzyme Mimicking Performance for H2O2 and Glutathione Detection

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 2022年 9卷 790849页

作者： Liu, Ying Yan, Jianghong huang, Yu Sun, Zhiheng Zhang, Huijing Fu, Lihaoyuan Li, xuwen Jin, Yongri Jilin Univ Coll Chem Changchun Peoples R China First Clin Hosp Jilin Prov Acad Tradit Chinese Med Changchun Peoples R China

Glutathione (GSH) is an important antioxidant and free radical scavenger that converts harmful toxins into harmless substances and excretes them out of the body. In the present study, we successfully prepared single-atom iron oxide-nanoparticle (Fe-NP)-modified nanodiamonds (NDs) named Fe-NDs via a one-pot in situ reduction method. This nanozyme functionally mimics two major enzymes, namely, peroxidase and oxidase. Accordingly, a colorimetric sensing platform was designed to detect hydrogen peroxide (H2O2) and GSH. Owing to their peroxidase-like activity, Fe-NDs can oxidize colorless 3,3 ',5,5 '-tetramethylbenzidine (TMB) into blue with sufficient linearity at H2O2 concentrations of 1-60 mu M and with a detection limit of 0.3 mu M. Furthermore, using different concentrations of GSH, oxidized TMB can be reduced to TMB, and the color change from blue to nearly colorless can be observed by the naked eye (linear range, 1-25 mu M;detection limit, 0.072 mu M). The established colorimetric method based on oxidase-like activity can be successfully used to detect reduced GSH in tablets and injections with good selectivity and high sensitivity. The results of this study exhibited reliable consistency with the detection results obtained using high-performance liquid chromatography (HPLC). Therefore, the Fe-NDs colorimetric sensor designed in this study offers adequate accuracy and sensitivity.

关键词： nanodiamond single-atom Fe peroxidase-like and oxidase-like activity colorimetric sensor glutathione

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Recent advances in theoretical studies on transition-metal-catalyzed regioselective C-H functionalization of indoles

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JOURNAL OF MOLECULAR MODELING 2022年第9期28卷 267-267页

作者： Ma, Hongsheng Yu, Tongyan Chi, Longxiao huang, Cong Li, xuwen Zhang, Rui Deng, Chao Nanjing Agr Univ Coll Sci Jiangsu Key Lab Pesticide Sci Nanjing 210095 Peoples R China Nanjing Agr Univ Coll Sci Dept Chem Nanjing 210095 Peoples R China

Indole compounds are widely found in natural products and drug candidates. The transition-metal-catalyzed regioselective C-H bond functionalization of indoles as the most efficient method for the synthesis of various functionalized indoles has been extensively studied in the past two decades due to its advantages of step economy and atom economy. In general, the catalysts included the transition-metals (Pd, Rh, Ru, Cu, Co, Fe, Zn, and Ga) and these reactions were accomplished with a remarkably wide range of coupling reagents for construction of various C-C and C-X (X =N, O, S) bonds. However, the general and important rules of the regioselectivity are not clear to date. Therefore, a comprehensive analysis through previous reported theoretical studies on transition-metal-catalyzed regioselective C-H bond functionalization of indoles was crucial and significant. In this review, we found that when the C-H bond activation process was the rate-determining step, the regioselectivity ordinarily occurred at the C7 or C4 positions (on benzene ring), and otherwise, the regioselectivity often occurred at C2 position (on pyrrole ring). For indoline substrates, the C-H bond functionalization occurred at the benzene ring.

关键词： Indole C-H functionalization Mechanism Regioselectivity Transition-metals

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Association between structural brain features and gene expression by weighted gene co-expression network analysis in conversion from MCI to AD

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BEHAVIOURAL BRAIN RESEARCH 2021年第0期410卷 113330-113330页

作者： Wang, xuwen huang, Kexin Yang, Fan Chen, Dihun Cai, Suping huang, Liyu Xidian Univ Sch Life Sci & Technol Xian 710071 Shaanxi Peoples R China

Alzheimer's disease (AD) is a neurodegenerative disease. Mild cognitive impairment (MCI) represents a state of cognitive function between normal cognition and dementia. Longitudinal studies showed that some MCI patients remained in a state of MCI, and some developed AD. The reason for these different conversions from MCI remains to be investigated. 180 MCI participants were followed for eight years. 143 MCI patients maintained the MCI state (MCI_S), and the remaining thirty-seven MCI patients were re-evaluated as having AD (MCI_AD). We obtained 1,036 structural brain characteristics and 15,481 gene expression values from the 180 MCI participants and applied weighted gene co-expression network analysis (WGCNA) to explore the relationship between structural brain features and gene expression. Regulating mediator effect analysis was employed to explore the relationships among gene expression, brain region measurements and clinical phenotypes. We found that 60 genes from the MCI_S group and 18 genes from the MCI_AD group respectively had the most significant correlations with left paracentral lobule and sulcus (***) and right subparietal sulcus (***) thickness;CTCF, UQCR11 and WDR5B were the mutual genes between the two groups. The expression of CTCF gene and clinical score are completely mediated by *** thickness, and the UQCR11 and WDR5B gene expression levels significantly regulate the mediating effect pathway. In conclusion, the factors affecting the different conversions from MCI are closely related to *** thickness and the CTCF, UQCR11 and WDR5B gene expression levels. Our results add a theoretical foundation of imaging genetics for conversion from MCI to AD.

关键词： Weighted gene co-expression network analysis Structural magnetic resonance imaging CTCF UQCR11 and WDR5B genetic expression Regulatory mediator effect analysis Conversion

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A Three-Dimensional Cyclic Multiplication - Convolution Neural Network for Hyperspectral Image Classification

A Three-Dimensional Cyclic Multiplication - Convolution Neur...

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Symposia and Workshops on Ubiquitous, Autonomic and Trusted Computing, UIC-ATC

作者： Xiaorui Xiong Zihan huang Zhongyin Sheng Zihan Xu xuwen He Qiaoling Lin School of Mathematics and Computer Science Wuhan Polytechnic University Wuhan China

Hyperspectral images have a large amount of spectral and spatial information, and play a significant role in remote sensing. However, the traditional image classification techniques are no longer applicable to the developing hyperspectral remote sensing images, and how to reasonably utilize the rich feature information of hyperspectral images to obtain high-accuracy classification results has become one of the most important research topics at present. This paper proposes a new 3D convolutional neural network to solve the problem of feature wastage in hyperspectral images. The framework cycles the convolutional kernel size, and the number of convolutional kernels increases in a multiplicative relationship for hyperspectral image classification (CM-CNN). Compared with existing neural network frameworks on different datasets, CMCNN achieves the highest Kappa coefficient and confusion matrix accuracy, which are stable at above 95%. From the classification results, there are almost no obvious classification errors.

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Impermeability Performance and Corrosion Resistance Mechanism of Basalt Fiber Recycled Concrete Under the Coastal Tidal Environment

SSRN

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SSRN 2023年

作者： Yang, Wenrui huang, Yuewen Tang, Zhiyi Xiong, Xiaolong Li, Chengwei Zhong, xuwen Liu, Liai Zhou, Hai Zhang, Xun School of Civil and Architectural Engineering East China University of Technology Nanchang330012 China

The development of the modernization process has resulted in the consumption of natural resources and the accumulation of construction waste, and the environmental bearing capacity faces severe challenges to a certain extent. The recovery and reuse of concrete is one of the effective ways to alleviate the environmental load. However, pouring concrete with recycled aggregate inevitably reduces the strength of the building. More seriously, the coastal tidal environment can have a coupled effect of salt erosion and dry-wet cycles on concrete components, thereby shortening the service life of concrete. The incorporation of fibers can improve the performance of the Recycled Aggregate Concrete (RAC) under special conditions. This article analyzes the changes in the performance of concrete specimens under different Basalt Fiber (BF) volume ratios (0%, 0.5%, 1.0%, and 1.5%) and composite salt simulated accelerated erosion cycles (0 d, 30 d, 60, and 90 d). The comparison results of RAC in apparent corrosion morphology, internal microstructure, and impermeability test show that BF can inhibit the expansion of microcracks and micropores in the test block and improve the overall compactness of the internal structure of RAC. When the fiber content of BF is 1.0%, the toughening effect of concrete is optimal, and impermeability and corrosion resistance of RAC are also significantly improved. Furthermore, the corrosion damage mechanism of Basalt Fiber Recycled Aggregate Concrete (BFRAC) under the combined effects of composite salts and dry-wet cycles was comprehensively summarized and substantiated through chemical reaction principles. The paper proposed a salt solution erosion model of BFRAC, which elucidates the mechanism of fiber crack resistance and explains the accelerated corrosion mechanism of salt solution from the perspective of "ion crack channels." The proposed model provides theoretical support for the salt erosion damage of fiber-reinforced concrete. © 2023, The Author

关键词： Erosion

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Economic evaluation of varicella vaccination strategies in Jiangsu province, China: a decision-tree Markov model

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HUMAN VACCINES & IMMUNOTHERAPEUTICS 2021年第11期17卷 4194-4202页

作者： Wang, Qiang Xiu, Shixin Yang, Liuqing huang, Jinxin Cui, Tingting Shi, Naiyang Wang, xuwen Shen, Yuan Chen, Enpin Lu, Bing Jin, Hui Lin, Leesa Southeast Univ Sch Publ Hlth Dept Epidemiol & Hlth Stat 87 Dingjiaqiao Nanjing 210009 Peoples R China Southeast Univ Sch Publ Hlth Key Lab Environm Med Engn Minist Educ Nanjing Peoples R China Wuxi Ctr Dis Control & Prevent Dept Immunizat Planning Wuxi Jiangsu Peoples R China London Sch Hyg & Trop Med Dept Infect Dis Epidemiol London England Hong Kong Sci Pk Lab Data Discovery Hlth D24H Hong Kong Peoples R China

This study evaluated different varicella vaccination strategies in Jiangsu province, China. A decision-tree Markov model was used to evaluate the cost effectiveness of various varicella vaccination strategies for children, including direct and selective vaccination (serotesting pre-vaccination). A cohort of one-year-old children was followed through 60 one-year Markov cycles. The parameter estimation was based on field work, the literature, and statistical yearbooks. We calculated the incremental cost-utility ratio (ICUR) using the saved quality-adjusted life year (QALY). One-way and probability sensitivity analyses were performed to assess uncertainty. Among 100,000 cohort members, one-dose and two-dose direct vaccination averted 8061 and 10,701 varicella cases, respectively, compared with no vaccination. Furthermore, compared with no vaccination, one-dose and two-dose direct vaccination saved one QALY at the ICUR of USD 21,401.33 and USD 35,420.81, respectively, at less than three times the per capita gross domestic product (USD 47,626.86) of Jiangsu. The ICURs of the one-dose and two-dose selective strategies versus no vaccination were USD 42,623.62 and USD 51,406.35 per QALY gained, respectively. The cost effectiveness results were most sensitive to the QALY loss of outpatients and vaccine prices. Thus, in Jiangsu, one-dose and two-dose direct varicella vaccination in children could be cost effective at the willingness to pay threshold of three times provincial GDP per capita from a societal perspective. The findings were sensitive to the vaccine price and health utility of varicella cases.

关键词： Varicella vaccination children cost utility decision tree model China

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Investigation of anionic group effects on the shale inhibition performance of fatty acid-based ionic liquids and their inhibition mechanism

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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2022年第0期636卷 128135-128135页

作者： Jia, Han Wang, Shaoyan Wang, Zhe Wang, Qiang Jia, Haidong Song, Lin Qin, xuwen Fan, Fangning Li, Zhe huang, Pan China Univ Petr East China Key Lab Unconvent Oil & Gas Dev Minist Educ Qingdao 266580 Peoples R China China Univ Petr East China Shandong Key Lab Oilfield Chem Sch Petr Engn Qingdao 266580 Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada

Ionic liquids (ILs) have been introduced as novel high-performance shale inhibitors. The inhibition performance and mechanism of the cation groups in ILs have been widely investigated, whereas the effects of the anionic groups in ILs on the inhibitory capacity have rarely been reported. In this work, a series of fatty acid-based ionic liquids (FAILs) with different anionic groups, methyltrioctylammonium octanoate ([N8881][C8:0]), methyltrioctylammonium laurate ([N8881][C12:0]), and methyltrioctylammonium palmitate ([N8881][C16:0]), were synthesized to evaluate their inhibition ability via the sodium bentonite (Na-Bent) immersion test, the linear swelling test, and the shale hot-rolling recovery test. Compared with the traditional inhibitor KCl (2 wt%), FAIL [N8881][C8:0] showed greater inhibition performance at a much lower concentration (0.1 wt%). The inhibition mechanism of FAILs was further analysed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential measurements, and contact angle measurements. It was speculated that the best inhibition ability and thermal stability of [N8881][C8:0] should be attributed to the intensive interaction and the sizematching effect between cationic and anionic groups. The present study provided novel insight into the research and development of high-efficiency shale inhibitors.

关键词： Shale inhibitor Fatty acid-based ionic liquids Size-matching effect Intermolecular interaction Inhibition mechanism

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新时代视域下红色文化网络传播路径研究

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学术探索 2023年第12期 59-65页

作者：丛旭文黄晶梅刘遵龙长春大学马克思主义学院长春大学网络安全学院吉林长春130022

红色文化是中国共产党领导人民在革命、建设和改革进程中创造的先进文化,具有鲜明的政治属性、深厚的历史渊源、丰富的文化内涵和强大的精神力量。我们必须高度重视红色文化,依托网络技术创新红色文化的传播形式,以网络为载体创新红色... 详细信息

红色文化是中国共产党领导人民在革命、建设和改革进程中创造的先进文化,具有鲜明的政治属性、深厚的历史渊源、丰富的文化内涵和强大的精神力量。我们必须高度重视红色文化,依托网络技术创新红色文化的传播形式,以网络为载体创新红色文化的传播方式。本文结合当前网络环境,分析新时代视域下红色文化网络传播的现实意义和传播困境,探讨红色文化网络传播路径,为进一步推动红色文化网络传播提供有益借鉴。

关键词：新时代红色文化网络传播路径

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CT征象联合外周血嗜酸性粒细胞对鉴别儿童胸肺型并殖吸虫病与结核性胸膜炎的价值研究

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中国防痨杂志 2023年第1期45卷 38-44页

作者：李翔付旭文许艳玲干玮杞敏黄瑛昆明市第三人民医院/云南省传染性疾病临床医学中心医学影像科昆明650041 昆明市第三人民医院/云南省传染性疾病临床医学中心感染性疾病科及儿童传染病科昆明650041

目的:探讨胸部CT征象联合外周血嗜酸性粒细胞百分比对鉴别儿童胸肺型并殖吸虫病与结核性胸膜炎的价值。方法:回顾性收集昆明市第三人民医院2019年1月至2021年12月首次确诊的儿童胸肺型并殖吸虫病患者及结核性胸膜炎患者,其中儿童胸肺型... 详细信息

目的:探讨胸部CT征象联合外周血嗜酸性粒细胞百分比对鉴别儿童胸肺型并殖吸虫病与结核性胸膜炎的价值。方法:回顾性收集昆明市第三人民医院2019年1月至2021年12月首次确诊的儿童胸肺型并殖吸虫病患者及结核性胸膜炎患者,其中儿童胸肺型并殖吸虫病患者58例(吸虫组),结核性胸膜炎患者45例(结核组)。分析其临床症状、胸部CT影像学表现及实验室检查结果;利用二元logistic回归建立CT征象的影像模型和结合CT征象与嗜酸性粒细胞的联合模型,计算及对比两个诊断模型的鉴别诊断效能。结果:利用CT征象建立的影像模型显示,出现包裹性胸腔积液(OR=5.11,95%CI:1.64~15.97)和肺部结节(OR=12.33,95%CI:2.51~60.65)时,诊断为结核性胸膜炎的可能性更高,而出现胸膜钙化(OR=0.17,95%CI:0.04~0.68)和隧道征(OR=0.01,95%CI:0.00~0.15)时,诊断为结核性胸膜炎的可能性更低;通过绘制受试者工作特征曲线(ROC),曲线下面积(AUC)为0.850(95%CI:0.777~0.922),敏感度为79.3%(95%CI:66.6%~88.8%),特异度为75.6%(95%CI:60.5%~87.1%)。利用CT征象和嗜酸性粒细胞百分比建立联合模型显示,出现肺部结节(OR=11.56,95%CI:1.76~75.71)时,诊断为结核性胸膜炎的可能性更高,而出现隧道征(OR=0.02,95%CI:0.00~0.48)和嗜酸性粒细胞百分比升高(OR=0.02,95%CI:0.01~0.08)时,诊断为结核性胸膜炎的可能性更低;通过绘制ROC曲线,AUC为0.934(95%CI:0.885~0.982),敏感度为89.7%(95%CI:78.8%~96.1%),特异度为88.9%(95%CI:75.9%~96.3%)。联合模型鉴别诊断效能高于影像模型,其AUC差异有统计学意义(Z=-2.401,P=0.016)。结论:对于儿童胸肺型并殖吸虫病与结核性胸膜炎的鉴别,联合模型鉴别诊断效能高于影像模型;出现肺部结节、嗜酸性粒细胞百分比未升高时更倾向于诊断儿童结核性胸膜炎。

关键词：结核,胸膜并殖吸虫病诊断,鉴别体层摄影术,X线计算机

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Community structure of benthic macroinvertebrates in native and introduced mangroves of northern Beibu Gulf, China: Implication for restoring mangrove ecosystems

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MARINE POLLUTION BULLETIN 2022年 180卷 113796页

作者： Zhen, Wenquan Kwan, Kit Yue Wang, Chun-Chieh Wu, xuwen Guo, Guo Deng, Qiuxiang huang, Xing Wang, Xueping Zhu, Junhua Xu, Peng Beibu Gulf Univ Coll Marine Sci Beibu Gulf Ocean Dev Res Ctr Guangxi Key Lab Beibu Gulf Marine Biodivers Conse Qinzhou 535011 Peoples R China Guangxi Acad Sci Guangxi Beibu Gulf Marine Res Ctr Guangxi Key Lab Marine Environm Sci Nanning 530007 Peoples R China Chinese Acad Sci Inst Oceanol Qingdao 266071 Peoples R China Guangxi Beihai Coastal Natl Wetland Pk Beihai 536000 Peoples R China

Introduced mangroves are widely used to restore mangrove ecosystems in South China. Results of potential impacts on indicative benthic macroinvertebrates are divergent. We explored the community structure of benthic macroinvertebrates in the mangrove ecosystem of northern Beibu Gulf, China across four habitats: native Avicennia marina mangrove, introduced Laguncularia racemosa mangrove, native-introduced mixed mangrove, and unvegetated intertidal flat. Based on the Hill number, community structure was estimated from the dimensions of estimated species richness, diversity, evenness, and species composition similarity. Benthic macroinvertebrates in the unvegetated flat significantly differed from the other three assemblages in mangroves;introduced L. racemosa mangrove had relatively distinct benthic macroinvertebrate assemblage from the native A. marina and the mixed mangroves, with lower species richness and similarity but higher diversity and evenness. Considering the lack of unanimous conclusion of potential impact on benthic macroinvertebrates under complex species interactions, native mangroves should be of top priority in ecosystem restoration.

关键词： Taxonomic diversity Species composition similarity Hill number Tidal flat Avicennia marina Laguncularia racemosa

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