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Manganese-based virus-mimicking nanomedicine with triple immunomodulatory functions inhibits breast cancer brain metastasis

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BIOMATERIALS 2025年 320卷 123262-123262页

作者： Zhao, Zhenhao Zhou, Jingyi Li, xuwen Zhang, Tongyu Tian, Zonghua Sun, Tao jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Minist EducKey Lab Smart Drug DeliveryState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Hindered by the challenges of blood-brain barrier (BBB) hindrance, tumor heterogeneity and immunosuppressive microenvironment, patients with breast cancer brain metastasis have yet to benefit from current clinical treatments, experiencing instead a decline in quality of life due to radiochemotherapy. While virus-mimicking nanosystems (VMN) mimicking viral infection processes show promise in treating peripheral tumors, the inability to modulate the immunosuppressive microenvironment limits the efficacy against brain metastasis. Accordingly, a VMN-based triple immunomodulatory strategy is initially proposed, aiming to activate innate and adaptive immune responses and reverse the immunosuppressive microenvironment. Here, manganese-based virus-mimicking nanomedicine (Vir-HD@HM) with intratumoral drug enrichment is engineered. Vir-HD@HM can induce the immune response through the activation of cGAS-STING by mimicking the in vivo infection process of herpesviruses. Meanwhile, DNAzyme mimicking the genome can rescue the epigenetic silencing of PTEN with the assistance of Mn2+, thus ameliorating the immunosuppressive metastatic microenvironment and achieving synergistic sensitizing therapeutic efficacy. In vivo experiments substantiate the efficacy of VirHD@HM in recruiting NK cells and CD8+ T cells to metastatic foci, inhibiting Treg cells infiltration, and prolonging murine survival without adjunctive radiochemotherapy. This study demonstrates that Vir-HD@HM with triple immunomodulation offers an encouraging therapeutic option for patients with brain metastasis.

关键词： Breast cancer brain metastasis Virus-mimicking nanosystem Immune activation Immunosuppressive microenvironment regulation PTEN cGAS-STING

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Assessing the impact of marketization on energy poverty

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ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY 2025年第4期27卷 9257-9286页

作者： Shi, Xinjie Zeng, Pei Cui, Liu Gao, xuwen Qiu, Tongwei jiang, Qiang Fu, Linlin China Acad Rural Dev Zhejiang Univ Sch Publ Affairs Hangzhou Peoples R China Zhejiang Univ Res Ctr Common Prosper Innovat Ctr Yangtze River Delta Future Reg Dev Lab Jiaxing Peoples R China Zhejiang Univ & Huzhou City Ctr Common Prosper Huzhou Peoples R China Zhejiang Univ Inst Common Prosper & Dev Hangzhou Peoples R China Nanjing Agr Univ Coll Econ & Management Nanjing Peoples R China Guangxi Univ Sci & Technol Sch Econ & Management Liuzhou Peoples R China Zhejiang Acad Agr Sci Inst Rural Dev Hangzhou Peoples R China

In conjunction with economic growth, improving the quality of life for its citizens is a central concern for the Chinese government. Energy poverty, a topic closely linked to people's quality of life, has garnered global attention. This study examines the relationship between marketization and energy poverty by constructing provincial-level panel data using the fixed effect model. To address endogeneity, the instrumental variable method is further employed. The study obtains two major findings. First, the study reveals a significant upward trend in marketization in China in recent years, with a concomitant decrease in energy poverty. Here, the causal (and negative) effects of marketization on energy poverty are identified. Second, the mechanism analysis shows that this effect operates through (i) improvements in the quantity of energy supply (rather than energy supply efficiency), (ii) the accumulation of human capital that promotes the use of clean energy, and (iii) an increase in people's income. This study makes three key contributions. First, it empirically analyzes the impact of marketization on energy poverty from a macro-perspective. Second, it systematically discusses the pathways through which marketization operates. Third, drawing on several theories, it provides a deeper understanding of the theoretical connection between marketization and energy poverty.

关键词： Energy poverty Marketization Instrumental variable China

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Parameters Optimization Method for ADRC of Permanent Magnet Synchronous Motor Based on CMA-ES 43

Parameters Optimization Method for ADRC of Permanent Magnet ...

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43rd Chinese Control Conference (CCC)

作者： jiang, Tianjian Yang, Yang Li, Zhiyuan Yang, Tianqi Chen, xuwen Nanjing Univ Posts & Telecommun Coll Automat Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Coll Aritif Intelligence Nanjing 210023 Peoples R China Nanjing Univ Posts & Telecommun Coll Internet Things Nanjing 210023 Peoples R China

ISBN: (纸本)9798350366907;9789887581581

Active disturbance rejection control (ADRC) is widely used to control permanent magnet synchronous motors (PMSM). However, the settings of gain parameters in ADRC is often dependent on engineers' experience. Also, it is difficult to design the parameters accurately by hand to achieve satisfactory results. A method based on evolution strategy with covariance matrix adaptation (CMA-ES) for optimizing the gain parameters of ADRC is proposed. By setting up some optimization tasks and using the CMA-ES algorithm, reinforcement learning is performed on the parameters of ADRC. In view of the high population size and complexity of CMA-ES, we adopt a parallel computation method to speed up the optimization process. The method can effectively optimize the ADRC gain parameters to adapt to the specified application environment, and at the same time reduce the dependence of setting ADRC parameters on human experience as well as time consumption. Finally, we verify that this CMA-ES-based parameter optimization method can effectively improve the control performance of the motor by running simulations and comparing the motor speed changes before and after optimization.

关键词： Permanent-magnet Synchronous Motor Active Disturbance Rejection Control Field-oriented Control Swarm Optimization High Throughput Computing Modern Control

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农艺与种业专业学位研究生校企联合培养模式实践探索

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科教文汇 2022年第24期 6-9页

作者：赵延明苏成付江绪文张海艳穆平张晓军青岛农业大学山东青岛266109

文章阐述了农艺与种业专业学位研究生校企联合培养模式在种业领域高素质复合型创新人才培养中的重要意义,以及在研究生端正学习态度、提高创新能力、促进全面协调发展、提高论文质量等方面的作用。

关键词：校企联合培养研究生农艺与种业

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Cocrystals of axially N-embedded quasi-carbon nanohoops via modulating the electron affinity of guest acceptors

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SCIENCE CHINA-CHEMISTRY 2025年 1-8页

作者： Zhang, Li Qiu, Shuhai Hu, Shunlong Xu, Hanren Sun, xuwen jiang, Wei Qu, Da-Hui Wang, Zhaohui East China Univ Sci & Technol Feringa Nobel Prize Scientist Joint Res Ctr Key Lab Adv Mat & Joint Int Res Lab Precis Chem & Sch Chem & Mol EngnInst Fine ChemFrontiers Sci C Shanghai 200237 Peoples R China Tsinghua Univ Dept Chem Key Lab Organ Optoelect & Mol Engn Beijing 100084 Peoples R China

Organic donor-acceptor cocrystals of pi-conjugated molecues have shown diverse applications in materials science. However, most cocrystals exist in neutral forms dominated by pi-pi interactions, while the ionic congeners and corresponding properties are rarely studied due to difficulties in harnessing the degree of charge transfer. Herein, we report cocrystals of axially N-embedded quasi-carbon nanohoops (DPP-D and DPP-T) with electron deficient guests. By modulating the electron affinity of the acceptor guests, the electronic structures of the complexes can be tuned from neutral to ionic states. Specifically, DPP-D interacts with TCNB molecules to form neutral superstructures via intermolecular pi-pi interactions, giving rise to a deep-red emission in the solid state. In contrast, an ionic complex showing near-infrared region absorptions and paramagnetic character on account of strong charge-transfer interactions is generated when DDQ molecules are involved. Their unique properties can be explained by different degrees of charge transfer and assembly modes, which have clearly been manifested by crystal structures and theoretical calculations. Our studies provide rare examples of pi-conjugated macrocycle-based donor-acceptor cocrystals in both neutral and ionic forms, and give insight to the design of multicomponent carbon nanomaterials.

关键词： n-doped carbon nanohoop donor-acceptor cocrystal charge transfer interaction ionic state

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Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead

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ADVANCED MATERIALS 2024年第11期36卷 2309582-2309582页

作者： Li, xuwen Sun, Tao jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Minist EducKey Lab Smart Drug Delivery Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Cancer metabolism plays multifaceted roles in the initiation and progression of tumors, and interventions in metabolism are considered fundamental approaches for cancer control. Within the vast metabolic networks of tumors, there exist numerous potential therapeutic targets, intricately interconnected with each other and with signaling networks related to immunity, metastasis, drug resistance, and more. Based on the characteristics of the tumor microenvironment, constructing drug delivery systems for multi-level modulation of the tumor microenvironment is proven as an effective strategy for achieving multidimensional control of cancer. Consequently, this article summarizes several features of tumor metabolism to provide insights into recent advancements in intelligent drug delivery systems for achieving multi-level regulation of the metabolic microenvironment in cancer, with the aim of offering a novel paradigm for cancer treatment. Latest advancements in intelligent drug delivery systems (DDS) exhibit distinctive advantages, including precise sensing, programmability, feedback control, and intrinsic activity. These attributes render them conducive to facilitating multi-dimensional therapeutic approaches grounded in metabolic ***

关键词： intelligent delivery systems metabolism regulation nanomedicine tumor metabolism

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糖浸种对盐胁迫玉米种子萌发和幼苗生长的影响

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种子 2021年第8期40卷 51-56页

作者：张成冉徐广海宋朝玉伊祖涛江绪文孙鹏张海艳青岛农业大学农学院山东青岛266109 青岛市农业科学研究院山东青岛266071 山东登海华玉种业有限公司山东莱州261411

以耐盐玉米品种伟科702和盐敏感玉米品种蠡玉16为试验材料,在150 mmol·L^(-1) NaCl胁迫下,采用不同浓度(5、10、15 g·L^(-1))外源糖(葡萄糖、果糖、蔗糖、壳聚糖、海藻糖)浸种处理,分析外源糖对玉米种子发芽指标、幼苗生长、... 详细信息

以耐盐玉米品种伟科702和盐敏感玉米品种蠡玉16为试验材料,在150 mmol·L^(-1) NaCl胁迫下,采用不同浓度(5、10、15 g·L^(-1))外源糖(葡萄糖、果糖、蔗糖、壳聚糖、海藻糖)浸种处理,分析外源糖对玉米种子发芽指标、幼苗生长、叶绿素含量、SOD活性、POD活性和MDA含量的影响。结果表明,外源糖处理后两个品种的发芽势、发芽率、最终发芽率、发芽指数、生物量、叶绿素含量、SOD活性和POD活性均显著增大,且随着糖浓度的增加呈先升高后下降的趋势,浓度为10 g·L^(-1)时最高;平均发芽时间和MDA含量减小,且随着糖浓度的增加呈先下降后上升的趋势,浓度为10 g·L^(-1)时最低。不同糖处理间比较,果糖处理的各项指标显著优于其他糖处理。因此,外源糖浸种能有效改善盐胁迫下玉米幼苗生长状况,10 g·L^(-1)果糖的改善效果最好。

关键词：玉米盐胁迫糖种子萌发幼苗生长抗氧化酶

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Research on residual stress evolution of diesel engine piston manufacturing based on finite element method

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JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING 2022年第11期44卷 1-17页

作者： He, Qiang Zhou, Chuanlong Jing, xuwen jiang, Yonggang Zhou, Honggen Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212000 Jiangsu Peoples R China Cssc Huangpu Wenchong Shipbldg Co Ltd Guangzhou 510715 Peoples R China

Residual stresses generated during casting and heat treatment are one of the major challenges faced by piston manufacturing. Therefore, the change of piston residual stress from casting stage to heat treatment stage is studied by orthogonal experiment and single factor experiment. A finite element model is established to simulate the casting process and heat treatment process, the parameters such as pouring temperature, mold temperature and shake-out temperature are mainly considered in the casting simulation, while the parameters such as heating rate, holding temperature, holding time and cooling rate are mainly studied in the heat treatment simulation. At the same time, the residual stress of the piston after casting and heat treatment is measured by X-ray diffraction to verify the simulation results. The results show that the average residual stress at each measuring point of the piston is 223.6 MPa when there is no sand falling in the casting stage. The residual stress field of the piston is redistributed after sand falling, and the average residual stress value is 161 MPa, which is reduced by 29% before and after sand falling. Heat treatment can significantly reduce or even eliminate the residual stress. The average residual stress of piston is reduced to 15.2 MPa, accompanied by the great release of residual stress. This study provides a cross-software multi-process residual stress analysis method, which is of great significance for reducing and eliminating casting residual stress.

关键词： Residual stress Casting Heat treatment Numerical simulation Orthogonal optimization

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糯玉米自交系籽粒淀粉理化特性的相关和聚类分析

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扬州大学学报（农业与生命科学版） 2021年第3期42卷 97-103页

作者：徐广海张成冉孙鹏赵延明江绪文孙晴晴张海艳青岛农业大学农学院/山东省旱作农业重点实验室山东青岛266109

以54个糯玉米自交系为材料,对其籽粒淀粉物质组成和理化特性进行相关和聚类分析。结果表明:供试材料淀粉理化特性在自交系间差异显著,淀粉理化特性与淀粉物质组成含量密切相关。淀粉糊化特性参数之间显著相关。蛋白质含量、脂肪含量、... 详细信息

以54个糯玉米自交系为材料,对其籽粒淀粉物质组成和理化特性进行相关和聚类分析。结果表明:供试材料淀粉理化特性在自交系间差异显著,淀粉理化特性与淀粉物质组成含量密切相关。淀粉糊化特性参数之间显著相关。蛋白质含量、脂肪含量、直链淀粉含量与膨胀势、峰值黏度、低谷黏度、崩解值、最终黏度呈显著负相关,与蓝值(蛋白质含量除外)、糊化温度呈显著正相关;直链淀粉含量与碘结合力呈极显著正相关,与回复值呈极显著负相关。根据糊化特性可将54个糯玉米自交系聚为3类,3类自交系的个数分别为29、17、8。各类之间的差异主要反映为其黏度值的大小,第Ⅰ类黏度值大,类内变异系数小;第Ⅲ类黏度值小,类内变异系数大;第Ⅱ类介于两者之间。因此,类群Ⅰ中的自交系材料具有黏度高、易糊化等优良特性且表现稳定,可作为骨干亲本用于糯玉米淀粉品质的改良。

关键词：糯玉米淀粉理化特性相关分析聚类分析

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创赛视角下中国种业人才培养模式探索与实践——以“登海杯”全国大学生种艺竞赛为例

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农业技术与装备 2022年第8期 131-133页

作者：江绪文孙群李贺勤杨今胜颜理想李登海王建华青岛农业大学山东青岛266109 中国农业大学北京100193 山东登海种业股份有限公司山东莱州261417

在“双创教育”“双一流”“新种科”等建设背景下,教育部高等学校种子科学与工程专业教指委协同中国作物学会作物种子专业委员会联合多家单位首建“全国大学生种艺竞赛”,为中国种业振兴创新创业人才培养提供了重要平台。文章回顾中国... 详细信息

在“双创教育”“双一流”“新种科”等建设背景下,教育部高等学校种子科学与工程专业教指委协同中国作物学会作物种子专业委员会联合多家单位首建“全国大学生种艺竞赛”,为中国种业振兴创新创业人才培养提供了重要平台。文章回顾中国种业人才培养史,以“登海杯”全国大学生种艺竞赛为例,从创赛视角探索实践人才培养新模式,为现代种业高质量发展提供人才智力支撑。

关键词：种业大学生竞赛种子科学与工程

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