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中国农学通报 2020年第28期36卷 72-77页

作者：陈秀萍贺漫媚王伟李许文郑永晓张继方代色平广州市林业和园林科学研究院广州510405

为筛选并评价兜兰的耐热性指标,以广州迁地引种的‘魔帝’兜兰和‘肉饼’兜兰为材料,通过研究其生理指标叶绿素相对含量(SPAD)、过氧化氢酶(CAT)、过氧化物酶(POD)、丙二醛(MDA)、可溶性蛋白、可溶性糖、脯氨酸含量,研究其在高温胁迫后... 详细信息

为筛选并评价兜兰的耐热性指标,以广州迁地引种的‘魔帝’兜兰和‘肉饼’兜兰为材料,通过研究其生理指标叶绿素相对含量(SPAD)、过氧化氢酶(CAT)、过氧化物酶(POD)、丙二醛(MDA)、可溶性蛋白、可溶性糖、脯氨酸含量,研究其在高温胁迫后(25、32、38℃分别处理5、10、15天)的生理生化反应,利用表观观测和隶属函数法综合分析其耐热性。结果表明,同一栽培条件下,耐热性综合评价‘,肉饼’兜兰>‘魔帝’兜兰。对7个生理指标的耐热系数进行主成分分析,SPAD、CAT和POD 3项指标的累积贡献率达66.92%。研究结果可为2种兜兰在迁地引种及其园林绿化中的应用提供理论依据。

关键词：兜兰高温生理指标耐热性评价

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iModulonDB 2.0: dynamic tools to facilitate knowledge-mining and user-enabled analyses of curated transcriptomic datasets

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NUCLEIC ACIDS RESEARCH 2024年第D1期53卷 D99-D106页

作者： Catoiu, Edward A. Krishnan, Jayanth li, Gaoyuan Lou, xuwen A. Rychel, Kevin Yuan, Yuan Bajpe, Heera Patel, Arjun Choe, Donghui Shin, Jongoh Burrows, Joshua Phaneuf, Patrick, V Zielinski, Daniel C. Palsson, Bernhard O. Univ Calif San Diego Dept Bioengn La Jolla CA 92101 USA Tech Univ Denmark Novo Nord Fdn NNF Ctr Biosustainabil DK-2800 Lyngby Denmark

iModulons-sets of co-expressed genes identified through independent component analysis (ICA) of high-quality transcriptomic datasets-provide an unbiased, modular view of an organism's transcriptional regulatory network. Established in 2020, iModulonDB (***) serves as a centralized repository of curated iModulon sets, enabling users to explore iModulons and download the associated transcriptomic data. This update reflects a significant expansion of the database-19 new ICA decompositions (+633%) spanning 8 925 expression profiles (+1370%), 503 studies (+2290%) and 12 additional organisms (+400%)-and introduces new features to help scientists decipher the mechanisms governing prokaryotic transcriptional regulation. To facilitate comprehension of the underlying expression profiles, the updated user-interface displays essential information about each data-generating study (e.g. the experimental conditions and publication abstract). Dashboards now include condition-specific coloring and highlight data generated from genetically perturbed strains, enabling users to rapidly interpret disruptions in transcriptional regulation. New interactive graphs rapidly convey omics-derived indicators (e.g. the explained variance of ICA decompositions, genetic overlap between iModulons and regulons). Direct links to operon diagrams (BioCyc) and protein-protein interaction networks (STRING) provide users with seamless access to external resources for further assessment of iModulons. Lastly, a new suite of search-driven and species-wide analysis tools promotes user-engagement with iModulons, reinforcing iModulonDB's role as a dynamic, interactive knowledgebase of prokaryotic transcriptional regulation.

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Memristive Artificial Synapses for Neuromorphic Computing

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Nano-Micro Letters 2021年第5期13卷 218-245页

作者： Wen Huang xuwen Xia Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang liang Chu Xing’ao li New Energy Technology Engineering Laboratory of Jiangsu Province and School of Science Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced MaterialsSchool of Materials Science and EngineeringNanjing University of Posts and Telecommunications(NUPT)9 Wenyuan RoadNanjing 210023People’s Republic of China College of Electronic and Optical Engineering and College of Microelectronics Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China Department of Materials Science and Engineering University of WashingtonSeattleWA 98195‑2120USA

Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann *** computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary *** synaptic functions with these devices is critical in neuromorphic *** the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic *** this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical *** working mechanisms of the devices are analyzed in *** is followed by a discussion of the progress in mimicking synaptic *** addition,existing application scenarios of various synaptic devices are ***,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected.

关键词： Synaptic devices Neuromorphic computing Electrical pulses Optical pulses Photoelectric synergetic effects

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Causal Relationship Between Type 2 Diabetes Mellitus and Preeclampsia: A Bidirectional Two-Sample Mendelian Randomized Study

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International Journal of Women's Health 2025年 17卷 1725-1737页

作者： xuwen Song Yikang Wang Pengsheng li Yafei Wang Xinghui Wen Qingwen Nie Wanlu An Huan Wang Fang He Department of Obstetrics and Gynecology Department of Cardiovascular Surgery The Affiliated Hospital of Qingdao University Qingdao Shandong Province People’s Republic of China Department of Obstetrics Affiliated Foshan Maternity & Child Healthcare Hospital Southern Medical University Foshan Guangdong Province People’s Republic of China Department of Obstetrics and Gynecology The Second People’s Hospital of Guiyang Guiyang Guizhou Province People’s Republic of China

BackgroundObservational epidemiologic investigations into the link between diabetes mellitus and preeclampsia (PE) have been conducted, but genetic evidence is still lacking. We utilized a two-sample Mendelian randomization (MR) analysis to shed light on the potential influence of type 2 diabetes mellitus (T2DM) on PE at the genetic prediction *** carried out a two-sample bidirectional MR analysis, utilizing genetic variants associated with T2DM (N=461,920) and PE (N=219,817) from the largest available genome-wide association studies. Using inverse variance weighting (IVW) and five validated approaches—MR-Egger, MR-RAPS, ConMix, weighted median, and weighted mode—we derived a potential causal association between T2DM and PE. The relationship between PE and T2DM was explored using reverse MR *** two-sample MR analysis indicated a causal link between T2DM and PE, with an odds ratio of 1.10 (95% CI, 1.02–1.18; P=0.01). The weighted mode method yielded an odds ratio of 1.22 (95% CI, 1.06–1.40; P=0.019), and the weighted median method produced an odds ratio of 1.19 (95% CI, 1.04–1.36; P=0.022). However, no significant association was detected in the MR-Egger analysis. Heterogeneity was noted in the analysis of T2DM and PE, but no significant horizontal pleiotropy was observed. The results of the reverse MR analysis indicated no significant causal association between PE and *** the first time, MR analysis showed a positive causal link from T2DM to PE, but not vice versa. The limited number of SNPs in reverse analysis may affect reliability. Future studies should use more instrumental variables to strengthen findings. Further experiments are also needed to explore underlying mechanisms.

关键词： causal effect type 2 diabetes mellitus preeclampsia genome-wide association study

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Screening and Expression Analysis of POD Gene in POD-H2O2 Pathway on Bud Dormancy of Pear (Pyrus pyrifolia)

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FORESTS 2024年第3期15卷 434页

作者： Xiang, xuwen Song, Keke li, Yinyin Zhang, Chenyu Zhou, Ruiqi Feng, Yu You, Jingnan Wu, Jingdong Zhang, Yanhui Jiang, Cuicui li, Yongyu Fujian Agr & Forestry Univ Coll Hort Key Lab Minist Educ Genet Breeding & Multiple Utilizat Cro Fuzhou 350002 Peoples R China Fujian Agr & Forestry Univ Inst Nat Prod Hort Plants Fuzhou 350002 Peoples R China Agr & Rural Bur Jianning Cty Econ Crop Stn Sanming 354500 Peoples R China Agr & Rural Bur Yongtai Cty Econ Crop Stn Fuzhou 350700 Peoples R China Fujian Acad Agr Sci Fruit Res Inst Fuzhou 350002 Peoples R China

Bud endodormancy represents a pivotal and intricate biological process influenced by both genetic and epigenetic factors, the exact mechanism of which remains elusive. Hydrogen peroxide (H2O2) functions as a signalling molecule in the regulation of dormancy, with peroxidase (POD) playing a crucial role in governing H2O2 levels. Our prior transcriptomic and metabolomic investigations into diverse pear dormancy phases posited that POD predominantly oversees pear bud dormancy. In this study, we utilised qRT-PCR to screen the most significantly expressed gene, Pyrus pyrifolia POD4-like (PpPOD4-like), from seven POD genes. Subsequently, H2O2 test kits, overexpression methods, and subcellular localisation techniques were employed to assess changes in H2O2 content, POD activity, PpPOD4-like expression, and its cellular positioning during pear bud dormancy. Subcellular localisation experiments revealed that PpPOD4-like is situated on the cell membranes. Notably, H2O2 content exhibited a rapid increase during endodormancy and decreased swiftly after ecodormancy. The fluctuation pattern of POD activity aligned with that of H2O2 content. Additionally, PpPOD4-like expression was markedly upregulated, displaying an overall upward trajectory. Our findings indicate that PpPOD4-like modulates H2O2 levels by regulating POD activity, thereby actively participating in the intricate regulation of pear dormancy processes.

关键词： endodormancy overexpression H2O2 POD genes

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Enhanced Near-Infrared Electrochemiluminescence from Trinary Ag-In-S to Multinary Ag-Ga-In-S Nanocrystals via Doping-in-Growth and Its Immunosensing Applications

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ANALYTICAL CHEMISTRY 2021年第4期93卷 2160-2165页

作者： Fu, li Fu, Kena Gao, xuwen Dong, Shuangtian Zhang, Bin Fu, Shanji Hsu, Hsien-Yi Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China City Univ Hong Kong Sch Energy & Environm Kowloon Tong Hong Kong 999077 Peoples R China City Univ Hong Kong Dept Mat Sci & Engn Kowloon Tong Hong Kong 999077 Peoples R China Shandong Univ Dept Clin Lab Qilu Hosp Jinan 250012 Peoples R China

Screening toxic-element-free and biocompatible electrochemiluminophores was crucial for electrochemiluminescence (ECL) evolution. Herein, L-glutathione (GSH)-capped Ag-Ga-In-S (AGIS) nanocrystals (NCs) were prepared by doping Ag-In-S (AIS) NCs in a doping-in-growth way and utilized as a model for both ECL modulating and developing multinary NC-based electrochemiluminophores with enhanced ECL performance than trinary NCs. AGIS NCs not only primarily preserved the morphology, size, phase structure, and water monodisperse characteristics of MS NCs with broadened band gap but also demonstrated obviously enhanced oxidative-reduction ECL than MS NCs. Importantly, ECL of AGIS NCs was located at the near-infrared region with a maximum emission wavelength of 744 nm and could be utilized for an ECL immunoassay with human prostate-specific antigen (PSA) as a model, which exhibited a linearity range from 0.05 pg/mL to 1.0 ng/mL and a low limit of detection of 0.01 pg/mL (S/N = 3). This work provided a promising alternative to the traditional binary NCs for developing toxic- element-free and biocompatible electrochemiluminophores with efficient near-infrared ECL.

关键词： Electrochemiluminescence Infrared

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Hydrogels for the removal of the methylene blue dye from wastewater: a review

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ENVIRONMENTAL CHEMISTRY LETTERS 2022年第4期20卷 2665-2685页

作者： Yang, Yinchuan Zhu, Qinlin Peng, xuwen Sun, Jingjing li, Cong Zhang, Xinmiao Zhang, Hao Chen, Jiabin Zhou, Xuefei Zeng, Hongbo Zhang, Yalei Tongji Univ Coll Environm Sci & Engn State Key Lab Pollut Control & Resources Reuse Shanghai 200092 Peoples R China Tongji Univ Shanghai Inst Pollut Control & Ecol Secur Shanghai 200092 Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G IH9 Canada Univ Shanghai Sci & Technol Coll Environm & Architecture Shanghai 200093 Peoples R China Sinopec Beijing Res Inst Chem Ind Environm Protect Res Inst Beijing 100013 Peoples R China

Water pollution is a major environmental issue with the rapid development of industry. Therefore, advanced technologies and materials are needed to remove pollutants from contaminated waters. The adsorption process displays many advantages such as high adaptability and removal efficiency for water sources of varying quality. Hydrogels have recently attracted attention due to their high adsorption capacity and structural stability, yet several issues remain to be explored, such as the number of reuse and engineering applications. Here, we review hydrogels for the removal of methylene blue from wastewater, with focus on hydrogel preparation and properties, adsorption performance and mechanisms, reusability and comparison with biological and chemical oxidation methods.

关键词： Hydrogel Methylene blue Adsorption Dye Wastewater treatment

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Research and development of the high precision low field dipole magnet for CEPC Booster

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JOURNAL OF INSTRUMENTATION 2024年第2期19卷 P02006页

作者： Kang, Wen Zhou, Jianxin li, Yuhui Dai, xuwen Guo, Runbing Mu, Zhihui Pan, Juntong Yang, Mei Chen, Fusan Chinese Acad Sci Inst High Energy Phys Beijing Peoples R China

In the Conceptual Design Report (CDR) stage of the Circular Electron and Positron Collider (CEPC), the injection energy of the Booster is 10 GeV and minimal working field of the dipole magnets is only 29 G, the magnets with iron cores could not meet the requirement of the field precision due to the remnant field. In the CEPC Technical Design Report (TDR) stage, the injection energy of the Booster is increased to 30 GeV and the minimal working field of the dipole magnets is raised to 95 G so that the influence of the remnant field becomes relatively small, the iron core dipole magnets can be used for the Booster. In this paper, the technical design of the CEPC Booster dipole magnets is described, the development and test of a full scale prototype pure dipole magnet are presented.

关键词： Acceleration cavities and superconducting magnets (high-temperature superconductor, radiation hardened magnets, normal-conducting, permanent magnet devices, wigglers and undulators) Instrumentation for particle accelerators and storage rings - high energy (linear accelerators, synchrotrons)

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TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives

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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2023年第1期38卷 Article: 2166937页

作者： li, Aiyun Guan, li Su, Wanzhen Zhao, Ning Song, xuwen Wang, Jin Tang, Xiaoxiao li, Weize Jiao, Xiangying Shanxi Med Univ Key Lab Cellular Physiol Minist Educ Taiyuan 030001 Peoples R China Shanxi Med Univ Dept Physiol Taiyuan 030001 Peoples R China Xian Med Univ Coll Pharm Xian 710021 Peoples R China

Thioredoxin interacting protein (TXNIP) is a potential drug target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesised, and evaluated to inhibit TXNIP expression and protect from palmitate (PA)-induced beta cell injury. In vitro cell viability assay showed that compounds D-2 and C-1 could effectively protect beta cell from PA-induced apoptosis, and subsequent results showed that these two compounds decreased TXNIP expression by accelerating its protein degradation. Mechanistically, compounds D-2 and C-1 reduced intracellular reactive oxygen species (ROS) production and modulated TXNIP-NLRP3 inflammasome signalling, and thus alleviating oxidative stress injury and inflammatory response under PA insult. Besides, these two compounds were predicted to possess better drug-likeness properties using SwissADME. The present study showed that compounds D-2 and C-1, especially compound D-2, were potent pancreatic beta cell protective agents to inhibit TXNIP expression and might serve as promising lead candidates for the treatment of T2DM.

关键词： Quinazoline derivatives TXNIP inhibition oxidative stress and inflammation pancreatic beta cell apoptosis T2DM

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Identifying key elements for evidence-base medicine using pretrained model and graph convolution network

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Procedia Computer Science 2023年 221卷 557-564页

作者： Fengchun Yang Xiaowei Xu Meng Wu xuwen Wang liu Shen Qing Qian Jiao li Institute of Medical Information Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100020 China Key Laboratory of Medical Information Intelligent Technology Chinese Academy of Medical Sciences Beijing 100020 China

Objective: Evidence-based medicine (EBM) provides a framework to support clinicians' decision-making processes using the best evidence currently available in the field. The key elements of clinical research can be defined by a framework called PICO, which identifies the sentences in a medical literature text that belong to the four key elements reported in clinical trials: Participants/Problem (P), Intervention (I), Comparison (C) and Outcome (O). This study aims to establish an effective detection method for key elements of evidence-based medical research. Methods: Based on the text features of key elements framework, we propose a deep learning model BERTGCN which combined large-scale pretraining model and graph convolution network (GCN) for detecting key elements of evidence-based medicine. In this model, the sentences which are initialized with pre-trained BERT representations and the words in the EBM evidence were recognized as the sentence nodes and word of the graph which were used to train GCN model. At the same time, the sentences were used to fine tune the pretraining model. Results: We tested our proposed approach over PubMed-PICO dataset is a data set containing tens of thousands of EBM key elements extracted from PubMed. The F1-score of P/I/O in the model we proposed reached 91.3%, 85.8% and 90.0% respectively. Experimental results show that our model outperforms the current optimal model. Conclusions: BERTGCN is able to leverage the advantages of both worlds: large-scale pretraining and transudative learning to improve the efficiency of detecting evidence-based medical evidence from research publications.

关键词： evidence-based medicine natural language process graph convolution network evidence identification

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