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Optimized prediction of sugar content in 'Snow' pear using near-infrared diffuse reflectance spectroscopy combined with chemometrics

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SPECTROSCOPY LETTERS 2019年第7期52卷 376-388页

作者： liu, xuwen Wu, Xin li, Guanglin Southwest Univ Coll Engn & Technol 2 Tiansheng Rd Chongqing 400715 Peoples R China Chongqing Coll Elect Engn Sch Elect & Internet Things Chongqing Peoples R China

In near-infrared spectroscopy applications, the original spectra often contain redundant information, which will seriously affect the performance of chemometric models. Therefore, preprocessing, effective wavelengths selection, and appropriate regression models are essential. The objective of this study was to optimize the nondestructive determination multivariate calibration model of sugar content in 'Snow' pears, using near-infrared diffuse reflectance spectroscopy combined with chemometrics. All data (sugar content reference values and spectra data) from three measuring positions (P1, P2, and P3, marked around the pear's equator at angular distances of approximately 120 degrees) were divided into four grouped datasets, namely Set-1 (P1), Set-2 (P2), Set-3 (P3), and Set-4 (average of the three measuring positions). All subsequent optimized processes were performed based on each grouped dataset. First, different preprocessing methods were tested and an optimal method was determined. Then, synergy interval partial least squares and synergy interval partial least squares-competitive adaptive reweighted sampling were applied to select effective regions and effective wavelengths from all wavelengths, respectively, and partial least squares regression models were established and analyzed. In addition, support vector regression models were also established for comparative study. After comprehensive analysis of prediction accuracy and model complexity, the partial least squares regression model based on the 16 selected effective wavelengths for Set-4 was optimal, with the correlation coefficient for prediction, root-mean-square error of prediction, and residual predictive deviation of 0.9701, 0.2311, and 4.12, respectively. The results indicated that with these optimized processes, the multivariate calibration model of sugar content in 'Snow' pears was effectively optimized for each dataset. In addition, it is concluded that partial least squares regression was superior t

关键词： Effective wavelengths selection model optimization near-infrared reflectance spectroscopy 'Snow' pear sugar content

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基于微型无人机遥感数据的城市水环境信息提取初探

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中国环境监测 2018年第3期34卷 141-147页

作者：侍昊李旭文牛志春李卫正王甜甜张悦江苏省环境监测中心江苏南京210036 南京林业大学现代分析测试中心江苏南京210037

近年来,黑臭水体整治已经成为各级政府的重要工作内容。为更好地开展黑臭水体筛查和监管工作,提出基于多旋翼无人机搭载多光谱相机的遥感监测方案,尝试采用影像特征变换结合面向对象分类方法提取黑臭水体的遥感信息。结果表明:(1)无人... 详细信息

近年来,黑臭水体整治已经成为各级政府的重要工作内容。为更好地开展黑臭水体筛查和监管工作,提出基于多旋翼无人机搭载多光谱相机的遥感监测方案,尝试采用影像特征变换结合面向对象分类方法提取黑臭水体的遥感信息。结果表明:(1)无人机影像上地物具有更加丰富的色彩和纹理;(2)与主成分变换和纹理分析方法相比,光谱指数对典型地物具有较好的判别能力;(3)采用标准最邻近分类法提取城市水环境信息,能够获得较高分类精度。

关键词：黑臭水体无人机多光谱影像特征变换信息提取

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误诊为脊柱结核的真菌性脊柱炎临床及影像特征分析

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中国防痨杂志 2024年第9期46卷 1109-1114页

作者：李翔浦英付旭文杞敏魏佳璐寸新华昆明市第三人民医院/云南省传染性疾病临床医学中心医学影像科昆明650041 昆明市第三人民医院/云南省传染性疾病临床医学中心骨科昆明650041

收集昆明市第三人民医院2021年1月至2024年1月收治的6例初诊误诊为脊柱结核的真菌性脊柱炎患者,对患者临床资料及影像学资料进行分析。结果发现,6例患者中,4例为男性,中位年龄58岁,2例既往有感染部位的手术史,1例并发慢性肝衰竭;4例脓液... 详细信息

收集昆明市第三人民医院2021年1月至2024年1月收治的6例初诊误诊为脊柱结核的真菌性脊柱炎患者,对患者临床资料及影像学资料进行分析。结果发现,6例患者中,4例为男性,中位年龄58岁,2例既往有感染部位的手术史,1例并发慢性肝衰竭;4例脓液/血液培养或病理学真菌阳性;5例表现为感染脊柱节段疼痛,仅1例表现为发热;2例出现外周血白细胞总数及中性粒细胞计数升高,6例C反应蛋白及血红细胞沉降率升高,3例G试验阳性;5例为腰椎病变,1例为颈椎病变;5例为单节段受累,1例为短节段受累;X线检查仅3例表现为骨质破坏;CT检查6例累及脊柱的前柱及中柱,4例骨质破坏以椎间盘为中心,2例骨质破坏以椎体为中心;5例骨质破坏周围无骨质硬化带,在MRI上骨质破坏表现为等T_(1)WI高T_(2)WI/T_(2)WI脂肪抑制信号,而骨质破坏周围骨质表现为低T_(1)WI低T_(2)WI,T_(2)WI脂肪抑制呈高信号,1例骨质破坏周围出现骨质硬化,在MRI骨质破坏表现为等T_(1)WI高T_(2)WI/T_(2)WI脂肪抑制信号,而骨质破坏周围骨质表现为低T_(1)WI高T_(2)WI/T_(2)WI脂肪抑制信号,6例均未出现压缩性骨折、后凸畸形、腰大肌脓肿的影像学表现。

关键词：结核脊柱真菌病磁共振成像放射摄影术

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Design, Synthesis and Biological Evaluation of Quinazoline Derivatives as TXNIP Inhibitors for the Treatment of Type 2 Diabetes Mellitus

SSRN

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SSRN 2022年

作者： li, Aiyun Guan, li Su, Wanzhen Zhao, Ning Song, xuwen Wang, Jin Tang, Xiaoxiao li, Weize Jiao, Xiangying Key Laboratory of Cellular Physiology Ministry of Education Department of Physiology Shanxi Medical University Taiyuan030001 China College of Pharmacy Xi’an Medical University Xi’an710021 China

Thioredoxin interacting protein (TXNIP) is a potential target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesized and evaluated as TXNIP inhibitor to protect palmitate (PA)-induced β cells injury and for T2DM treatment. Most of compounds displayed potent pancreatic β cells protective activities especially for the compounds D-2 and C-1. In cell viability assay, compounds D-2 and C-1 could effectively promote β cells survival and protect β cells from PA-induced β cells apoptosis. Further cellular mechanism of action studies demonstrated that their potent β cells protective activities against PA-induced β cells apoptosis were achieved by reducing intracellular reactive oxygen species (ROS) production and modulating TXNIP-NLRP3 inflammasome signaling, and thus alleviating oxidative stress injury and inflammatory response. Besides, compounds D-2 and C-1 could inhibit TXNIP protein expression both in physiological condition and in PA-treated Min6 pancreatic β cells. Subsequent experiment showed that compounds D-2 and C-1 decrease TXNIP protein expression via accelerating its protein degradation. The present study evidently showed that compounds D-2 and C-1 were two potent pancreatic β cells protective agents as TXNIP inhibitors and might serve as promising lead candidates for the treatment of T2DM. © 2022, The Authors. All rights reserved.

关键词： Proteins

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Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models

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SAUDI JOURNAL OF BIOLOGICAL SCIENCES 2020年第9期27卷 2485-2490页

作者： Qin, Zhenlong Wang, Lei li, Guoyan Qian, xuwen Zhang, Jie Guo, Ying liu, Guokai Beijing Univ Chinese Med Affiliated Hosp 3 Dept Anesthesiol Beijing 100029 Peoples R China Beijing Univ Chinese Med Dongzhimen Hosp Dept Anesthesiol 5 Haiyuncang Hutong Beijing 100700 Peoples R China

Objective: To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. Methods: The healthy male Sprague wrote - Dawley (SD) rats were taken as the research object, and they were randomly divided into model group (group A), beside the sciatic nerve and injection of 5 mm amitriptyline group (group B), beside the sciatic nerve and injection of 10 mm amitriptyline group (group C), beside the sciatic nerve and injection of 15 mm amitriptyline group (group D), intraperitoneal injection of amitriptyline group (group E). Pain induced by selective injury of sciatic nerve branches in rats, pain induced by chronic compression of sciatic nerve, diabetic neuropathic pain and fibromyalgia were conducted to determine the pain threshold of mechanical stimulation in rats after drug administration. Results: The pain threshold of mechanical stimulation in the local amitriptyline group (group B, C, D) was significantly higher than that in the group A and group E at each time point after drug treatment, and the pain threshold of mechanical stimulation gradually increased with the increase of concentration. There was no statistically significant difference in mechanical stimulation pain threshold between group A and group E at each time point after drug treatment. Conclusion: Para-sciatic injection of amitriptyline at different concentrations has analgesic effects on neuropathic pain, diabetic neuropathic pain and fibromyalgia in rat models, and amitriptyline directly ACTS on the local sciatic nerve. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

关键词： Tricyclic antidepressants Rat model Neuropathic pain Diabetic neuropathic pain Fibromyalgia

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润房镜联合普拉洛芬滴眼液对白内障术后中重度干眼症的疗效分析

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中国现代医学杂志 2023年第1期33卷 95-98页

作者：高立祁涛许文彬张瑞帆崇州市人民医院眼耳鼻喉科四川崇州611230 四川省人民医院眼科四川成都610072

目的探讨润房镜联合普拉洛芬滴眼液对白内障术后中重度干眼症的疗效。方法选取2020年3月—2021年8月崇州市人民医院收治的108例白内障术后中重度干眼症患者,采用随机数字表法分为对照组(采用普拉洛芬滴眼液治疗)和联合组(采用润房镜+... 详细信息

目的探讨润房镜联合普拉洛芬滴眼液对白内障术后中重度干眼症的疗效。方法选取2020年3月—2021年8月崇州市人民医院收治的108例白内障术后中重度干眼症患者,采用随机数字表法分为对照组(采用普拉洛芬滴眼液治疗)和联合组(采用润房镜+普拉洛芬滴眼液治疗),每组54例。比较两组患者的泪膜破裂时间(BUT)、泪液分泌试验(SIT)、眼表疾病指数(OSDI)、角膜荧光素染色评分(FL)、临床疗效、视觉质量及不良反应。结果联合组治疗前后BUT、SIT的差值高于对照组(P <0.05)。联合组治疗前后OSDI、FL评分的差值高于对照组(P <0.05)。联合组总有效率高于对照组(P <0.05)。联合组与对照组治疗期间不良反应总发生率比较,差异无统计学意义(P>0.05)。结论润房镜联合普拉洛芬滴眼液治疗白内障术后中重度干眼症可改善临床症状,提高临床疗效和视觉质量,且安全可靠。

关键词：白内障干眼症润房镜普拉洛芬滴眼液疗效

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Reliability optimization of process parameters for marine diesel engine block hole system machining using improved PSO

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SCIENTIFIC REPORTS 2021年第1期11卷 1-13页

作者： Zhou, Honggen Yang, Weibin Sun, li Jing, xuwen li, Guochao Cao, liping Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212000 Jiangsu Peoples R China Shaanxi Diesel Engine Heavy Ind Co Ltd Xingping 713100 Peoples R China

The processing quality of the block hole system affects the working performance of the marine diesel engine block directly. Choosing an appropriate combination of process parameters is a prerequisite to improving the accuracy of the block hole system. Uncertain fluctuations of process parameters during the machining process would affect the process reliability of the block hole system, resulting in an ultra-poor accuracy. For this reason, the RBF method is used to establish the relationship between the verticality of the cylinder hole and process parameters, including cutting speed, depth of cut, and feed rate. The minimum cylinder hole verticality is taken as the goal and the process reliability constraints of the cylinder hole are set based on Monte Carlo, a reliability optimization model of processing parameters for cylinder hole is established in this paper. Meanwhile, an improved particle swarm algorithm was designed to solve the model, and eventually, the global optimal combination of process parameters for the cylinder hole processing of the diesel engine block in the reliability stable region was obtained.

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Controlling n-Type Molecular Doping via Regiochemistry and Polarity of Pendant Groups on Low Band Gap Donor-Acceptor Copolymers

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MACROMOLECULES 2021年第8期54卷 3886-3896页

作者： Ye, Gang liu, Jian Qiu, Xinkai Stater, Sebastian Qiu, li liu, Yuru Yang, xuwen Hildner, Richard Koster, L. Jan Anton Chiechi, Ryan C. Shenzhen Univ Ctr Biomed Opt & Photon Cs CBOP Shenzhen 518060 Peoples R China Shenzhen Univ Coll Phys & Optoelect Engn Key Lab Optoelect Devices & Syst Shenzhen 518060 Peoples R China Stratingh Inst Chem NL-9747 AG Groningen Netherlands Zernike Inst Adv Mat NL-9747 AG Groningen Netherlands Yunnan Univ Natl Ctr Int Res Photoelect & Energy Mat Sch Mat & Energy Yunnan Key Lab Micro Nano Mat & Technol Kunming 650091 Yunnan Peoples R China

We demonstrate the impact of the type and position of pendant groups on the n-doping of low-band gap donor-acceptor (D-A) copolymers. Polar glycol ether groups simultaneously increase the electron affinities of D-A copolymers and improve the host/dopant miscibility compared to nonpolar alkyl groups, improving the doping efficiency by a factor of over 40. The bulk mobility of the doped films increases with the fraction of polar groups, leading to a best conductivity of 0.08 S cm(-1) and power factor (PF) of 0.24 mu W m(-1) K-2 in the doped copolymer with the polar pendant groups on both the D and A moieties. We used spatially resolved absorption spectroscopy to relate commensurate morphological changes to the dispersion of dopants and to the relative local doping efficiency, demonstrating a direct relationship between the morphology of the polymer phase, the solvation of the molecular dopant, and the electrical properties of doped films. Our work offers fundamental new insights into the influence of the physical properties of pendant chains on the molecular doping process, which should be generalizable to any molecularly doped polymer films.

关键词： Impurities Ethers Alcohols Doping Copolymers

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The spectral characteristics of biochar-derived dissolved organic matter at different pyrolysis temperatures

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JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING 2021年第5期9卷

作者： He, Changjun He, xuwen li, Jiajia Luo, Yong li, Junchao Pei, Ying Jiang, Jinyuan Chinese Res Inst Environm Sci Res Ctr Environm Pollut Control Technol 8 An Wai Da Yang Fang Beijing 100012 Peoples R China China Univ Min & Technol Beijing Sch Chem & Environm Engn Beijing 100083 Peoples R China

Comprehensive assessment of the dissolved organic matter (DOM) released from biochar is essential because it affects the migration and transformation of pollutants. The pyrolysis temperature and feedstock are the main factors affecting the amount and structure of DOM released from biochar. In this study, biochar-derived DOM was produced from three feedstocks at five temperatures (200-600 degrees C), and the effects of the pyrolysis temperature and feedstock on its components were investigated using UV-vis, Synchronous fluorescence, excitation emission matrix-parallel factor (EEM-PARAFAC) analysis and Fourier transform infrared-two-dimensional-correlation spectroscopy (FTIR-2D-COS). It was found that the biochar-derived DOM contents of the fruit peel and dewatered sludge biochar gradually decreased with increasing pyrolysis temperature;however, the DOM content of fresh human manure biochar increased at 600 degrees C, and a higher DOM content was obtained at low temperatures. The SUVA 254 and SUVA 260 shown that most of the aromatic substances in the DOM existed in the hydrophobic fraction. Moreover, the DOM mainly contained humic acid-like substances and protein-like substances. As the pyrolysis temperature increased, the protein-like and humic acid substances exhibited opposite trends, with higher protein-like contents at high temperatures. In addition, based on the FTIR-2D-COS analysis, the variations in the functional groups of the DOM depended on the pyrolysis temperature and the type of feedstock. This study highlights the importance of combining multiple optical techniques to evaluate biochar-derived DOM and provides valuable information for biochar applications.

关键词： Human Manure-Biochar Dissolved Organic Matter (DOM) FTIR-2D-COS Protein-like Humic acid-like

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Impact analysis of different axis layouts of detached breakwater on flow and sediment transport

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ARABIAN JOURNAL OF GEOSCIENCES 2021年第8期14卷 705-705页

作者： Yu, Haitao Luo, Feng li, Ruijie liu, Yanran Fang, xuwen li, Yuting Hohai Univ Minist Educ Key Lab Coastal Disaster & Def Nanjing 210098 Peoples R China Hohai Univ Coll Harbour Coastal & Offshore Engn Nanjing 210098 Peoples R China Hohai Univ Coll Oceanog Nanjing 210098 Peoples R China Nanjing Environm Monitoring Ctr Nanjing 210098 Peoples R China Xiamen Univ Marine Monitoring & Informat Serv Ctr Xiamen 361005 Peoples R China Nanjing Normal Univ Key Lab Virtual Geog Environm Nanjing 210023 Peoples R China

An incorporation and application of a two-dimensional, unstructured grid hydrodynamic model with a suspended sediment transport module is presented in the study. The model has a satisfactory verification with available measured data. After the verification, the variation of tidal current field and the seabed evolution are simulated. Based on the simulation results, the paper compares and analyzes the effects of different axis layouts of detached breakwater on flow field and seabed evolution. The results show that after the construction of the breakwater, the flow velocity of the both sides of the breakwater decreases, the flow velocity of the east entrance increases, and the erosion and siltation of sediment are consistent with the change of the flow field. In addition, the smaller the angle between the breakwater axis and the depth contour is, the smaller the impact on the change of the tidal current field and sediment erosion and siltation is.

关键词： Detached breakwater Axis layout Flow and sediment transport Hydrodynamic model

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