There are limited treatment options for cartilage defects in clinical practice because of the lack of suitable biomaterials. Here, we evaluated the effects of collagen type II sponge on the articular cartilage repairi...
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There are limited treatment options for cartilage defects in clinical practice because of the lack of suitable biomaterials. Here, we evaluated the effects of collagen type II sponge on the articular cartilage repairing process using a cartilage injury of a rabbit knee joint model. We showed that the home-made collagen type II sponges appeared to have a suitable pore size of 93.26 +/- 38.4 mu m for chondrocyte growth. MRI with H&E staining results demonstrated that the effusion absorption in the collagen type II sponge treated group was quicker than that of the control group. Moreover, sporadic cartilage signals first appeared at 6 weeks in the collagen type II sponge treated group. Safranin O staining and immunohistochemical analysis confirmed that the newly formed cartilage expresses glycosaminoglycan and type II collagen matrix. Using Sirius red polarized light staining, we showed that the newly formed cartilage-like areas from the collagen type II treated group are significantly greater than those of the control group. Taken together, our data demonstrated that the home-made collagen type II sponge is able to promote cartilage repair in the cartilage injury of a rabbit knee joint model. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 96B: 267-275, 2011.
Task level breakdown provides high level information for operation performance bottleneck analysis. Creating a task level breakdown requires prior knowledge of the application server program logic and can be very time...
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In this paper, we present vimShark, an automated monitoring/analyzing/ replaying tool which identifies and extracts VMware vSphere Web Services API to effectively understand the communications between various vSphere ...
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In this paper, we present vimShark, an automated monitoring/analyzing/replaying tool which identifies and extracts VMware vSphere Web Services API to effectively understand the communications between various vSphere c...
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In this paper, we present vimShark, an automated monitoring/analyzing/replaying tool which identifies and extracts VMware vSphere Web Services API to effectively understand the communications between various vSphere components and Virtual Infrastructure Management (VIM) solutions. This has proven useful in the performance analysis of various VMware management solution products with VMware vCenter Server and VMware ESX (hypervisor) hosts. The contribution of this paper is twofold. 1) vimShark-recorder and analyzer is non-intrusive and easy to install, while incurring negligible CPU and memory overhead. It understands vSphere Web Services API messages by decoding them, providing detailed information and stats that are useful for the analysis of VIM communication between vCenter server, ESX hosts and various VIM solution products. 2) vimShark-replayer serves as a replay/workload generator tool for vSphere Web Services API. It analyzes the vimShark traces and generates Java code to replay the same traces on any underlying vSphere setup. The efficacy of vimShark has been demonstrated with various VIM solution products including VMware vCloud Director, VMware vCenter Site Recovery Manager, VMware vCenter Update Manager, VMware vCenter Capacity IQ, and VMware vSphere Client.
Objective There are limited treatment options for cartilage defects in clinical practice due to the lack of suitable ***, we evaluated the effects of type Ⅱ collagen sponge on the articular cartilage repairing proces...
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Objective There are limited treatment options for cartilage defects in clinical practice due to the lack of suitable ***, we evaluated the effects of type Ⅱ collagen sponge on the articular cartilage repairing process using a cartilage injury of a rabbit knee joint *** showed that the type Ⅱ collagen sponges generated from our modified method appeared to have a suitable pore size of 93.26 ± 38.4 micron for chondrocyte *** with H&E staining results demonstrated that the effusion absorption in the type Ⅱ collagen sponge treated group was quicker than that of the control group.
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