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Research on the three-dimensional visual management and control for marine intelligent mould bed based on digital twin

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SHIPS AND OFFSHORE STRUCTURES 2024年第6期19卷 756-768页

作者： Zhou, Honggen Yan, Zhanghui Jing, xuwen Chen, Yu liu, Jinfeng Zou, Xiaofeng Kang, Chao Li, Bingqiang Xie, Yang Yan, Dejun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Peoples R China CSSC Huangpu Wenchong Shipbuilding Co Ltd Guangdong Prov Key Lab Adv Welding Technol Ships Guangzhou Peoples R China Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212100 Jiangsu Peoples R China

Mould bed is crucial for supporting the ship subsection and controlling its deformation during shipbuilding. However, its visualisation and control process intelligence are often inadequate, leading to reduced accuracy and efficiency in ship subsection construction. Aiming at the problem, a three-dimensional (3D) visual monitoring method for the marine intelligent mould bed is proposed based on digital twin, and the overall framework of the management and control system is designed. Meanwhile, a fuzzy PID control principle optimised by the genetic algorithm is proposed to better control the deformation of the ship subsection. On this basis, the verification of the developed system is carried out based on the physical intelligent mould bed, and the 3D visual management and control of the marine intelligent mould bed are realised. It provides a foundation for improving the accuracy and efficiency of ship subsection construction.

关键词： Digital twin intelligent mould bed management and control system visual monitoring adaptive control

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Insight into Iron Leaching from an Ascorbate-Oxidase-like Fe-N-C Nanozyme and Oxygen Reduction Selectivity

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2023年第27期62卷 e202302463-e202302463页

作者： Cao, xuwen Zhu, Caixia Hong, Qing Chen, Xinghua Wang, Kaiyuan Shen, Yanfei liu, Songqin Zhang, Yuanjian Southeast Univ Sch Chem & Chem Engn Jiangsu Engn Lab Smart Carbon Rich Mat & Device Jiangsu Prov Hitech Key Lab Biomed Res Nanjing 211189 Peoples R China Southeast Univ Med Sch Nanjing 210009 Peoples R China

Ascorbate (H(2)A) is a well-known antioxidant to protect cellular components from free radical damage and has also emerged as a pro-oxidant in cancer therapies. However, such "contradictory" mechanisms underlying H(2)A oxidation are not well understood. Herein, we report Fe leaching during catalytic H(2)A oxidation using an Fe-N-C nanozyme as a ferritin mimic and its influence on the selectivity of the oxygen reduction reaction (ORR). Owing to the heterogeneity, the Fe-N-x sites in Fe-N-C primarily catalyzed H(2)A oxidation and 4 e(-) ORR via an iron-oxo intermediate. Nonetheless, trace O-2(center dot-) produced by marginal N-C sites through 2 e(-) ORR accumulated and attacked Fe-N-x sites, leading to the linear leakage of unstable Fe ions up to 420 ppb when the H(2)A concentration increased to 2 mM. As a result, a substantial fraction (ca. 40 %) of the N-C sites on Fe-N-C were activated, and a new 2+2 e(-) ORR path was finally enabled, along with Fenton-type H(2)A oxidation. Consequently, after Fe ions diffused into the bulk solution, the ORR at the N-C sites stopped at H2O2 production, which was the origin of the pro-oxidant effect of H(2)A.

关键词： Antioxidants Iron Nanozymes Oxygen Reduction Selectivity Pro-Oxidants

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A Wide Range and High Repeatability MEMS Pressure Sensor Based on Graphene

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IEEE SENSORS JOURNAL 2022年第18期22卷 17737-17745页

作者： Zhu, Zehua Wang, Junqiang Wu, Chenyang Chen, xuwen liu, Xiaofei Li, Mengwei North Univ China Natl Key Lab Instrumentat Sci & Dynam Measurement Taiyuan 030051 Peoples R China North Univ China Acad Adv Interdisciplinary Res Taiyuan 030051 Peoples R China

Graphene pressure sensors have attracted extensive attention due to their excellent performance. However, the range and linearity of conventional suspension graphene pressure sensors are too small to meet commercial requirements. In this article, we propose a wide range and high repeatability MEMS pressure sensor based on graphene array structure. Single-layer chemical vapor deposition (CVD) graphene was transferred at the root of silicon pressure-bearing elastic diaphragm, and it was simultaneously protected by the Si3N4 nanofilm. In addition, the Au/Sn eutectic bonding technology was employed to complete the hermetic package of the sensor. Pressure tests showed that the repeatability error of the pressure sensor in the range of 0-20 MPa was 4.062% full scale output (FSO) and the hysteresis was 2.118% FSO. Furthermore, the temperature resistance studies confirmed that the Si3N4 nanofilm can effectively protect graphene due to its extremely high thermal stability. And with excellent characteristics of high long-term stability, it can work stably in humid environments. Conclusionally, this research provides significant exploration to promote the practicality and commercialization of graphene devices.

关键词： Graphene high repeatability MEMS pressure sensors wide range

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Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay

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ANALYTICAL CHEMISTRY 2022年第45期94卷 15801-15808页

作者： Zou, Guizheng Gao, xuwen liu, Xiancheng Zeng, Ying Zhang, Qingqing Zhang, Bin Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China Shenzhen Lifotron Technol Co Ltd Shenzhen 518055 Peoples R China

The investigation on electrochemiluminescence (ECL) multiplexing bioassays mainly focuses on simultaneously detecting either proteins or nucleic acids. To overcome the limitation of a short waveband for spectrum-resolved ECL multiplexing bioassays, herein, a highly monochromatic (FWHM <40 nm) and bandgap-engineered ECL luminophore, that is, mercaptopropionic acid-capped and Zn2+-mediated aggregation-induced emission (AIE) assembly of Au nanocrystals (NCs) (Zn2+-AIE-AuNCs), of strong emission and the maximum emission wavelength at 485 nm is developed. The highly monochromatic and bandgap-engineered ECL (485 nm) of Zn2+-AIE-AuNCs can multiplex with the single-waveband and surface-defect-involved ECL (775 nm) of dual-stabilizer-capped CuInS2@ZnS NCs (CIS@ZnS-NCs), enabling a spectrum-resolved ECL multiplexing strategy with different NCs luminophores of a similar particle size as tags. This ECL multiplexing strategy can be utilized to simultaneously detect antigen and DNA probe together without any additional signal amplification procedure and obvious spectroscopic cross-talk, in which the highly monochromatic ECL from Zn2+-AIE-AuNCs is utilized to dynamically determine human carcinoembryonic antigen from 1 pg/mL to 50 ng/mL with a limit of detection (LOD) of 0.3 pg/mL, while the single -waveband ECL from CIS@ZnS-NCs is employed to linearly detect wild-type p53 from 1 pM to 50 nM with a LOD of 0.5 pM. The ECL immunoassay of the proposed strategy is free from the interference of the synchronously conducted DNA probe assay and vice versa, which would open an avenue to couple the immunoassay and DNA probe assay together for clinical colon and breast cancer identification.

关键词： Hybridization probe Immunoassay Electrochemiluminescence Aggregation-induced emission

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Scheduling optimization of AGVs in workshop based on cost-efficiency-emission competition mechanism

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PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE 2023年第20期237卷 4828-4839页

作者： Chen, Ye Jing, xuwen Lu, Xiang Zhou, Honggen Li, Haipeng Kang, Chao liu, Jinfeng Li, Jun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Peoples R China China Merchants Cruise Shipbldg Co Ltd Nantong Peoples R China Jiangsu Univ Sci & Technol Sch Mech Engn Mengxi Rd Zhenjiang 212013 Peoples R China

The untimely material transportation induced by the backward logistics scheduling method in the ship panel block construction workshop is a complex engineering issue with multi-parameter coupling. To overcome the problem, the cost-efficiency-carbon emission competition model is proposed to solve the scheduling optimization for the AGVs in ship panel block construction workshop. Firstly, the logistics path plan of the panel block construction workshop is obtained by establishing the path-planning node map of panel block construction workplace. Secondly, a scheduling model for AGVs is constructed based on the competition mechanism of the lowest transportation cost, maximum transportation efficiency, and lowest carbon emission. Then, the optimized schedule is achieved by a novel hybrid method of the genetic and population migration algorithm considering the competition mechanism. Finally, the case validation indicates that the solving ability of the proposed hybrid method is improved by 52.4% compared with Genetic Algorithm under competitive mechanism. Besides, the results demonstrate material transportation time can be reduced by 17.5%.

关键词： Scheduling optimization automatic guided vehicle competition mechanism similarity ship panel block

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Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities

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JOURNAL OF NATURAL PRODUCTS 2024年第12期87卷 2680-2694页

作者： Chen, xuwen Li, Hongtao Wang, Meiting Sun, Donghui Lu, Jiani Zhu, Tong Chen, Hongzhuan Chen, Lili liu, Shunying East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China Shanghai Univ Tradit Chinese Med Inst Interdisciplinary Integrat Med Res Shanghai Frontiers Sci Ctr TCM Chem Biol Longhua Hosp Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Shanghai Inst Infect Dis & Biosecur Inst Interdisciplinary Integrat Med Res Shanghai Frontiers Sci Ctr TCM Chem Biol Shanghai 201203 Peoples R China

Danshensu extracted with traditional Chinese medicine Salvia miltiorrhiza has a wide range of bioactivities. Danshensu containing a catechol moiety has a moderate inhibitory effect on SARS-CoV-2 3CLpro (IC50 = 2.2 mu M) by a reversible covalent interaction and exhibits good anti-inflammatory activity. To enhance the inhibitory activity, we introduced Michael receptors into the side chain of danshensu as a possible covalent warhead and blocked the covalent binding sites of catechol moiety to yield chalcone derivatives. The resulting chalcone derivatives, A4 and A7, were found to inhibit SARS-CoV-2 3CLpro in vitro with IC50 values of 83.2 and 261.3 nM, respectively. Furthermore, A4 and A7 inhibit viral replication in the SARS-CoV-2 replicon system with EC50 values of 19.9 and 11.7 mu M, respectively. Time-dependent inhibition experiment and mass spectrometry show that A4 acted as a noncovalent mixed inhibitor, while A7 likely binds covalently at Cys145. The interaction mechanism between SARS-CoV-2 3CLpro and A4 or A7 was characterized by molecular docking studies. Additionally, both A4 and A7 demonstrated potent anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. These promising results suggest that chalcone derivatives A4 and A7 can serve as bifunctional molecules with both antivirus and anti-inflammatory properties.

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A self-enhanced chemiexcited PDT system for targeted and efficient treatment of deeply seated tumors

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INORGANIC CHEMISTRY FRONTIERS 2024年第17期11卷 5598-5611页

作者： Da, xuwen Xu, Yunli Wang, Lei liu, Xiulian Peng, Yatong Wu, Yao Zhou, Wanpeng Wang, Wentao Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Univ Chinese Acad Sci Wenzhou Inst Wenzhou 325000 Peoples R China

Traditional photodynamic therapy (PDT) is almost ineffective against deeply seated tumors due to the limited penetration depth of external light. The development of chemiexcited PDT is promising to address this issue, but it is still challenging to construct simple, efficient and targeted chemiexcited PDT systems. In this work, CPPO (bio(3,5,6-trichloro-2-n-pentyloxycarbonylphenyl) oxalate) and [Ru(phen)2(PIP-OCH3)](PF6)2 (Ru3, where phen = 1,10-phenanthroline, PIP-OCH3 = 2-(4-methoxy phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline) with efficient photocatalytic NADH (reduced nicotinamide adenine dinucleotide) oxidation were co-encapsulated with DSPE-PEG 2000 to form Ru3/CPPO@PEG nanoparticles (NP3). Once internalized by cancer cells, Ru3 can be excited with the chemical energy produced by the reaction between CPPO and endogenous H2O2. The subsequent oxidation of intracellular NADH and generation of H2O2in situ by excited Ru3 will further promote the sustained occurrence of the chemical reaction, realizing self-enhanced chemiexcited PDT. NP3 could effectively deplete intracellular NADH, inhibit ATP synthesis, increase the H2O2 content, and produce reactive oxygen species (ROS) within cancer cells, thus exhibiting efficient chemiexcited PDT activity against various cancer cells. Notably, minimal cytotoxicity was observed towards normal cells. Good therapeutic effects against subcutaneously implanted and lung metastatic tumors were also observed for NP3. The current findings may provide new insights for development of novel chemiexcited PDT. NP3 with H2O2 supplementation and self-enhanced chemiexcited PDT system are developed, exhibiting efficient chemiexcited PDT activity towards subcutaneously implanted and lung metastatic tumors, providing new insights for development of novel chemiexcited PDT.

关键词： Photodynamic therapy

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Impermeability performance and corrosion resistance mechanism of basalt fiber recycled concrete under the coastal tidal environment

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CONSTRUCTION AND BUILDING MATERIALS 2024年 411卷

作者： Yang, Wenrui Huang, Yuewen Tang, Zhiyi Xiong, Xiaolong Li, Chengwei Zhong, xuwen liu, Liai Zhou, Hai Zhang, Xun East China Univ Technol Sch Civil & Architectural Engn Nanchang 330012 Peoples R China Wuhan Univ Technol Sch Transportat & Logist Engn Wuhan 430063 Peoples R China

The application of Recycled Aggregate Concrete (RAC) can effectively reduce resource consumption and mitigate environmental pollution. Under the coastal tidal environments, the performance of concrete is significantly impacted by environmental degradation. Incorporating fibers into RAC can enhance its performance in such special conditions. This study investigates the variations in properties of RAC with different Basalt Fiber (BF) volume ratios (0%, 0.5%, 1.0%, 1.5%) under composite salt dry-wet cyclic erosion cycles (0 d, 30 d, 60 d, 90 d). The results from apparent corrosion morphology analysis, internal microstructure examination, and impermeability testing demonstrate that BF can effectively inhibit the expansion of micro cracks and micropores within the test block while improving the overall compactness of the internal structure of RAC. When the BF content reaches 1.0%, it exhibits an optimal toughening effect on RAC with significantly improved impermeability and corrosion resistance properties. Furthermore, this paper comprehensively summarizes and verifies the corrosion damage mechanism of Basalt Fiber Recycled Aggregate Concrete (BFRAC) under composite salt dry-wet cycles through chemical reaction principles. A salt solution erosion model for BFRAC is proposed to elucidate fiber crack resistance mechanisms and explain accelerated corrosion caused by ion crack channels within salt solutions. This proposed model provides theoretical support for understanding salt erosion damage in fiberreinforced concrete.

关键词： Coastal tidal environment Basalt fiber Recycled concrete Impermeability Corrosion mechanism

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Deciphering the role of genotype-by-environment interaction in summer maize hybrids based on multiple traits using envirotyping techniques and genotype by yield x trait approaches

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FIELD CROPS RESEARCH 2025年 326卷

作者： Yue, Haiwang Olimpio, das Gracas Dias Kaio Zhu, Jiashuai Bu, Junzhou Wei, Jianwei liu, Pengcheng Yang, Haoxiang Jiang, xuwen Hebei Acad Agr & Forestry Sci Dryland Farming Inst Hebei Prov Key Lab Crops Drought Resistance Res Hengshui 053000 Peoples R China Qingdao Agr Univ Coll Agron Qingdao 266109 Peoples R China Univ Fed Vicosa Dept Gen Biol BR-36571000 Vicosa MG Brazil Univ Melbourne Fac Sci Parkville Vic 3052 Australia

Context: The use of high-yielding, stable, and widely adaptable summer maize hybrids is essential for the sustainable cultivation of maize globally. However, contemporary breeding programs face challenges in identifying genotypes that exhibit consistent performance while maintaining desired agronomic characteristics across diverse environments. Dynamic shifts in global meteorological and edaphic conditions have impacted the evaluation of summer maize performance in China's multi-environment trials (METs). Multi-perspective analysis of genotype-by-environment interactions (GEI) is then essential for characterizing maize yield stability and trait expression across agroecological zones. Objective: This study aims to comprehensively evaluate the performance and stability of maize genotypes in the Huang-Huai-Hai region by integrating environmental techniques (ETs) with multi-trait selection methods. Methods: Twenty-eight maize hybrids and a check hybrid (ZD958) were evaluated across 29 locations in the Huang-Huai-Hai region of China during the 2019-2021 cropping seasons, using a randomized complete block design (RCBD) with three replications. Results: Based on 30 years (1993-2023) of environmental data, which included 19 meteorological and 6 soil physicochemical factors, the ETs classified the 29 locations across eight provinces into six distinct mega-environments (MEs). The additive main effects and multiplicative interaction (AMMI) model analysis revealed that genotype (G), environment (E), and their interaction (GxE) significantly influenced (p < 0.05) for all agronomic parameters from 2019 to 2021. The combined performance of grain yield and other agronomic traits-such as growth period, plant height, ear height, lodging rate, barren stalk rate, grain moisture content at harvest, ear row number, bare tip length, and 100-grain weight-across different MEs was assessed using the genotype by yield x trait (GYT) biplot approach. The integration of GYT biplots with ETs effe

关键词： Multi-environment trials Environmental techniques Genotype by environment interaction Mega-environments Maize (Zea mays L.) GYT biplot

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High-quality chromosome-level genome assembly of the whitespotted conger (Conger myriaster)

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SCIENTIFIC DATA 2025年第1期12卷 1-9页

作者： Han, Shenglei Li, Chen Li, Shuo Chen, Yan Wang, Chenggang liu, Kaiqiang liu, Yuyan Wang, Hong-Yan Wang, Qian Cao, xuwen Shi, Bao Shao, Changwei Jiangsu Ocean Univ Jiangsu Key Lab Marine Bioresources & Environm Lianyungang 222005 Peoples R China Chinese Acad Fishery Sci Yellow Sea Fisheries Res Inst State Key Lab Mariculture Biobreeding & Sustainabl Qingdao 266071 Shandong Peoples R China Qingdao Marine Sci & Technol Ctr Lab Marine Fisheries Sci & Food Prod Proc Qingdao 266237 Shandong Peoples R China Haiyang Yellow Sea Fisheries Co Ltd Yantai 265100 Peoples R China Chinese Acad Fishery Sci Hebei Key Lab Bohai Sea Fish Germplasm Resources C Beidaihe Cent Expt Stn Qinhuangdao 066100 Peoples R China

The whitespotted conger (Conger myriaster) is an ecologically and economically significant benthic marine species widely distributed across East Asia's coastal waters. Despite this importance, the genomic resources for this species remain limited, hindering evolutionary and aquaculture research. Here, we present the first high-quality chromosome-level genome assembly of C. myriaster using PacBio CLR, WGS, 10X Genomics and Hi-C data. The resulting 1.09 Gb genome assembly exhibits excellent contiguity, with 97.49% of sequences anchored onto 19 chromosomes. The assembled genome achieved a BUSCO completeness stands at 98.00%, containing 34.80% repetitive sequences and 24,063 predicted protein-coding genes. This foundational genomic resource overcomes a major limitation, providing the essential framework for future investigations into the evolutionary adaptations and for the genetic improvement of C. myriaster in aquaculture.

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