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活血通降方对反流性食管炎大鼠食管损伤和xCT/VEGF-B/GPX4信号通路的影响

中国中医药信息杂志 2022年第12期29卷 87-92页

作者：刘琰唐艳萍李培彩刘磊刘茜杨磊郝旭雯天津中医药大学研究生院天津301617 天津市南开医院天津300100

目的观察活血通降方对反流性食管炎(RE)大鼠食管损伤的影响,从xCT/VEGF-B/GPX4铁死亡信号通路探讨其作用机制。方法采用改良部分贲门肌切开术+外置幽门部分结扎术制备RE大鼠模型。将成模大鼠随机分为模型组及活血通降方低、高剂量组,每... 详细信息

目的观察活血通降方对反流性食管炎(RE)大鼠食管损伤的影响,从xCT/VEGF-B/GPX4铁死亡信号通路探讨其作用机制。方法采用改良部分贲门肌切开术+外置幽门部分结扎术制备RE大鼠模型。将成模大鼠随机分为模型组及活血通降方低、高剂量组,每组12只,另取12只作为空白组。造模成功当日开始给药,活血通降方低、高剂量组给药剂量分别为3.68、7.35 g/(kg·d),每日早晚各1次,连续灌胃14 d,空白组和模型组予5 mL生理盐水灌胃。观察大鼠食管黏膜损伤情况,HE染色观察黏膜组织病理变化,试剂盒检测食管组织丙二醛(MDA)、谷胱甘肽(GSH)、活性氧(ROS)含量,Western blot检测食管组织胱氨酸/谷氨酸反向转运体(xCT)、血管内皮生长因子B(VEGF-B)、谷胱甘肽过氧化物酶4(GPX4)蛋白表达,ELISA检测血清白细胞介素(IL)-1β、IL-17、IL-10含量。结果与空白组比较,模型组大鼠食管黏膜损伤明显,肉眼及病理评分显著升高,食管组织MDA、ROS含量增加,GSH含量减少,xCT、VEGF-B、GPX4蛋白表达降低,血清IL-1β、IL-17含量增加,IL-10含量减少,差异均有统计学意义(P<0.05,P<0.01);与模型组比较,活血通降方低、高剂量组大鼠食管黏膜损伤改善,肉眼及病理评分显著降低,食管组织MDA、ROS含量减少,xCT、VEGF-B、GPX4蛋白表达升高,血清IL-1β、IL-17含量减少,IL-10含量增加,活血通降方高剂量组大鼠食管组织GSH含量增加,差异均有统计学意义(P<0.05,P<0.01)。结论活血通降方可缓解RE大鼠食管黏膜炎症,修复食管损伤,其机制可能与激活xCT/VEGF-B/GPX4信号通路,增加其抗氧化性,提高抗氧化因子GSH水平,清除食管中过多的ROS,调节相关炎症因子水平,影响食管细胞铁死亡有关。

关键词：活血通降方反流性食管炎 xCT/VEGF-B/GPX4信号通路铁死亡食管损伤

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Comparison between minimally invasive plate osteosynthesis and open reduction-internal fixation for proximal humeral fractures: a meta-analysis based on 1050 individuals

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BMC MUSCULOSKELETAL DISORDERS 2019年第1期20卷 1-11页

作者： Li, Feilong liu, Xuqiang Wang, Fuqiang Gu, Zhiping Tao, Qianyuan Yao, Cong Luo, xuwen Nie, Tao Nanchang Univ Dept Orthoped Affiliated Hosp 1 Nanchang Jiangxi Peoples R China

Background: This meta-analysis aimed to compare the clinical outcomes and complications of minimally invasive plate osteosynthesis (MIPO) and open reduction-internal fixation (ORIF) in patients with proximal humeral fractures. Methods: We searched PubMed, EMBASE, Ovid, and the Cochrane Library to identify all relevant studies from inception to April 2019. Cochrane Collaboration's Review Manage 5.3 was used for meta-analysis. Results: Sixteen studies involving 1050 patients (464 patients in the MIPO group and 586 patients in the ORIF group) were finally included. According to the meta-analysis, MIPO was superior to ORIF in operation time, blood loss, postoperative pain, fracture union time, and constant score. However, MIPO was associated with more exposure to radiation and axillary nerve injury. No significant differences were found in length of hospital stays and complication except for axillary nerve injury. Conclusion: The present evidence indicates that compared to ORIF, MIPO had advantages in functional outcomes, operation time, blood loss, postoperative pain, and fracture union time for the treatment of PHFs. However, the MIPO technique had a higher rate of axillary nerve injury and longer radiation time compared to ORIF.

关键词： Minimally invasive plate osteosynthesis (MIPO) Open reduction-internal fixation (ORIF) Proximal humeral fractures Meta-analysis

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Research on Contribution Rate of Commingled Multi-layer Tight Gas Reservoir in Sulige Gas Field 7th

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7th International Field Exploration and Development Conference (IFEDC)

作者： Li, Xiaofeng xuwen Fan, Jiwu Liao, Hongmei Jin, Suobao liu, Lili Yuejun PetroChina Changqing Oilfield Co Res Ctr Sulige Gasfield Xian 710018 Shaanxi Peoples R China Natl Engn Lab Explorat & Dev Low Permeabil Oil & Xian 710018 Shaanxi Peoples R China

ISBN: (纸本)9789811075605;9789811075599

Sulige gas field is a typical tight sandstone gas reservoir in China, the main production interval was identified in the Shihezi formation and Shanxi formation, and the development wells are produced by commingled method. Therefore, it is necessary to obtain the reliable contribution rate of different formation by carrying out the gas production test before studying the contribution rate of different formation and dynamic performance. However, most gas wells in tight gas reservoir rarely perform production logging test from the term of cost control. This brings a great challenge to effectively understand the contribution rate of different formation, and the contribution rate with time also causes great uncertainties in estimating the utilization extent of different formation. In order to solve this problem, it is necessary to study the factors which influence the contribution rate and its change of different formation under commingling conditions and lay the foundation for further understanding dynamics performance for different formation. Before studying the contribution rate of different formation against formation coefficient, storage coefficient, fracture length, and fracture conductivity, a conceptual model of single well is established based on the reservoir characteristics and test data of the Sulige gas field. The main factors which influence the contribution rate were determined by gray correlation method, also established a forecasting model of the contribution rate of different formation by multiple regression method. The results show that formation coefficient, storage coefficient affect the contribution rate greatly, and the half-length of the fracture and fracture conductivity only have impact on the contribution rate at the initial stage. Compared with real contribution rate of different formation, 80% of the forecasting results are in good agreement with the test results, which basically satisfy the engineering requirements. The main contributions of

关键词： Commingled multi-layer tight gas reservoir Contribution rate Factor Gray correlation method Sulige gas field

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^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断价值:Meta分析

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国际医学放射学杂志 2022年第4期45卷 414-419页

作者：张慈慈段丽霞刘雅慧欧志强叶郭锡曾旭文广州市红十字会医院放射科广州510220

目的系统评价^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断价值。方法检索PubMed、EMbase、Cochrane Library、中国知网、万方数据、维普数据库从2010年1月—2020年5月公开发表的关于^(18)F-FDG PET/MRI诊断恶性肿瘤淋巴结转移的中英... 详细信息

目的系统评价^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断价值。方法检索PubMed、EMbase、Cochrane Library、中国知网、万方数据、维普数据库从2010年1月—2020年5月公开发表的关于^(18)F-FDG PET/MRI诊断恶性肿瘤淋巴结转移的中英文文献,根据纳入、排除标准筛选并提取数据,采用诊断准确性研究质量评价工具-2(QUADAS-2)评价纳入文献质量,应用Meta-Disc 1.4软件进行分析。采用不一致指数(I2)和Cochran-Q检验进行异质性分析,并计算合并敏感度、特异度、阳性似然比、阴性似然比及相应95%CI,绘制汇总受试者操作特征(SROC)曲线并计算曲线下面积(AUC)。采用阈值效应和亚组分析探讨异质性的来源。亚组分析根据研究类型、原发肿瘤类型、是否合并有增强MRI进行分组分析。结果共纳入25篇文献,包括1347例肿瘤病人,^(18)F-FDG PET/MRI诊断恶性肿瘤淋巴结转移的合并敏感度、特异度、阳性似然比、阴性似然比、AUC值分别为0.85(95%CI:0.81~0.88)、0.92(95%CI:0.90~0.93)、6.63(95%CI:4.50~9.79)、0.22(95%CI:0.16~0.29)、0.92。亚组分析结果显示,前瞻性研究中的^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移的诊断效能高于回顾性研究,AUC值分别为0.92、0.88;无增强MRI的研究诊断效能高于有增强MRI的研究,AUC值分别为0.93、0.91;^(18)F-FDG PET/MRI对胃肠癌淋巴结转移的诊断效能最高,其次为宫颈癌、肺癌、乳腺癌,AUC值分别为0.96、0.95、0.93、0.90。结论^(18)F-FDG PET/MRI对恶性肿瘤淋巴结转移具有较高的诊断价值。

关键词：恶性肿瘤淋巴结转移正电子发射计算机体层成像磁共振成像 Meta分析

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绿植光伏屋顶技术研究现状及存在的问题

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广州建筑 2024年第1期52卷 105-108页

作者：刘兆祥徐雯雯闫贵海龚超杨永友张涛中冶建筑研究总院(深圳)有限公司深圳518055 中冶建筑研究总院有限公司北京100088

绿植屋顶不仅可以有效美化建筑外观,还可以有效降低建筑能耗;光伏屋顶则可以在提供可再生能源的同时降低建筑物本身的能耗。为了充分利用二者的优势,学者们提出了绿植光伏屋顶的概念,将光伏屋顶和绿植屋顶进行有机结合,充分发挥了两者... 详细信息

绿植屋顶不仅可以有效美化建筑外观,还可以有效降低建筑能耗;光伏屋顶则可以在提供可再生能源的同时降低建筑物本身的能耗。为了充分利用二者的优势,学者们提出了绿植光伏屋顶的概念,将光伏屋顶和绿植屋顶进行有机结合,充分发挥了两者的优势。本文通过文献调研,对绿植光伏屋顶技术的研究现状及存在的问题进行了总结。绿植光伏屋顶具有提高能量效率、提高经济效率、降低碳排放及降低灰尘等优点,相较于单独的光伏或绿植屋顶更具优势。但是其发展仍面临缺乏综合实验研究和全生命周期分析,配套理念及设施不足等缺点,本文研究可以为绿色光伏屋顶后续研究提供参考。

关键词：绿植光伏屋顶绿植屋顶光伏组件研究现状存在问题

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绿色建造评价框架体系

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绿色建造与智能建筑 2022年第11期 7-11页

作者：肖绪文李翠萍于震平黄宁刘星中国建筑股份有限公司同济大学建筑工程系中国建筑业协会绿色建造与智能建筑分会中国建筑土木建设有限公司

绿色建造方式有利于建筑领域的可持续发展。绿色建造包含了工程立项、设计、施工各阶段,并强调建造全过程的协同管理。绿色建造示范工程已在我国开展了试点工作。为了定量判断绿色建造工程实践工作的水平,亟需出台有关的评价标准。本文... 详细信息

绿色建造方式有利于建筑领域的可持续发展。绿色建造包含了工程立项、设计、施工各阶段,并强调建造全过程的协同管理。绿色建造示范工程已在我国开展了试点工作。为了定量判断绿色建造工程实践工作的水平,亟需出台有关的评价标准。本文简述了绿色建造主要内容,提出了主要评价指标,据此构建了评价框架体系,为绿色建造评价标准的编制提供参考。

关键词：绿色建造评价指标评价框架

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Surface interaction mechanisms in mineral flotation: Fundamentals, measurements, and perspectives

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ADVANCES IN COLLOID AND INTERFACE SCIENCE 2021年 295卷 102491页

作者： Xie, Lei Wang, Jingyi Lu, Qiuyi Hu, Wenjihao Yang, Diling Qiao, Chenyu Peng, xuwen Peng, Qiongyao Wang, Tao Sun, Wei liu, Qi Zhang, Hao Zeng, Hongbo Cent South Univ Sch Minerals Proc & Bioengn Changsha 410083 Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Cent South Univ Sch Met & Environm Changsha 410083 Peoples R China

As non-renewable natural resources, minerals are essential in a broad range of biological and technological applications. The surface interactions of mineral particles with other objects (e.g., solids, bubbles, reagents) in aqueous suspensions play a critical role in mediating many interfacial phenomena involved in mineral flotation. In this work, we have reviewed the fundamentals of surface forces and quantitative surface property-force relationship of minerals, and the advances in the quantitative measurements of interaction forces of mineral-mineral, bubble-mineral and mineral-reagent using nanomechanical tools such as surface forces apparatus (SFA) and atomic force microscope (AFM). The quantitative correlation between surface properties of minerals at the solid/water interface and their surface interaction mechanisms with other objects in complex aqueous media at the nanoscale has been established. The existing challenges in mineral flotation such as characterization of anisotropic crystal plane or heterogeneous surface, low recovery of fine particle flotation, and in-situ electrochemical characterization of collectorless flotation as well as the future work to resolve the challenges based on the understanding and modulation of surface forces of minerals have also been discussed. This review provides useful insights into the fundamental understanding of the intermolecular and surface interaction mechanisms involved in mineral processing, with implications for precisely modulating related interfacial interactions towards the development of highly efficient industrial processes and chemical additives.

关键词： Bubble-mineral-reagent interaction Mineral flotation Dewatering process Surface interactions atomic force microscope (AFM) Surface forces apparatus (SFA)

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三峡库区重要支流农村生活污水处理技术及应用模式

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长江技术经济 2024年第3期8卷 91-98页

作者：李明芦秀青吴晓常顼雯朱俊霞陈莎莎刘伟长江水利水电开发集团(湖北)有限公司长江生态(湖北)科技发展有限责任公司武汉430010

三峡库区重要支流人口密度高、土地利用强度大、污水总量大,是三峡水库水质安全最为敏感的区域。通过对重要支流农村生活污水情况开展实地调查,在梳理分析研究区生活污水水质水量特点和处理难点的基础上,遵循处理与利用相结合的原则,推... 详细信息

三峡库区重要支流人口密度高、土地利用强度大、污水总量大,是三峡水库水质安全最为敏感的区域。通过对重要支流农村生活污水情况开展实地调查,在梳理分析研究区生活污水水质水量特点和处理难点的基础上,遵循处理与利用相结合的原则,推荐稳定高效的生态处理工艺和维护简单、投资少的污泥处理方式与资源化处置方式,因地制宜地提出该区域的农村生活污水处理模式和生活污水处理设施建设管理模式。研究成果可为三峡库区高质量发展、生态环境保护和乡村振兴提供技术参考。

关键词：重要支流农村生活污水实地调查处理技术建设管理模式

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Research progress, problems and prospects of mine water treatment technology and resource utilization in China

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CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY 2020年第4期50卷 331-383页

作者： Zhang, Siyu Wang, Hao He, xuwen Guo, Shaoqing Xia, Yu Zhou, Yuexi liu, Kai Yang, Shipeng China Univ Min & Technol Sch Chem & Environm Engn Beijing 100083 Peoples R China Chinese Res Inst Environm Sci Res Ctr Water Pollut Control Technol Beijing Peoples R China Chinese Acad Sci Res Ctr Ecoenvironm Sci Beijing Peoples R China Tsinghua Univ Sch Environm Beijing Peoples R China

The National Development and Reform Commission and the Energy Bureau jointly issued the 'Plant Water Utilization Development Plan' on January 29, 2013, which requires that China should gradually establish a more complete legal system, macro management and technical support system for mine water in 2015. But so far, due to the influence of geological conditions and other factors, the impurity composition and content of mine water is very different. Based on the comprehensive summary of the theory, method, application technology, practical engineering and processing technology of mine water disaster and its reutilization in China. This article systematically analyzed the latest research progress and achievements, which include basic theory, hydrogeology (supplement) exploration, advanced detection and monitoring as well as early warning. These can further promote application of current technology, develop new technology and methods, point out the challenges and the existing problems of the mine water field, the gaps with requirements of fast, intensive, and large-scale development of the coal industry in China. Finally, the development trends, future important scientific innovation and key technology were discussed. The prospects of the industry and technology were also forecast.

关键词： Mine water resource utilization treatment technology

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Smart hypoxia-responsive transformable and charge-reversible nanoparticles for the deep penetration and tumor microenvironment modulation of pancreatic cancer

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BIOMATERIALS 2022年 287卷 121599-121599页

作者： Chen, Hongyi Guo, Qin Chu, Yongchao Li, Chao Zhang, Yiwen liu, Peixin Zhao, Zhenhao Wang, Yu Luo, Yifan Zhou, Zheng Zhang, Tongyu Song, Haolin Li, xuwen Li, Chufeng Su, Boyu You, Haoyu Sun, Tao Jiang, Chen Fudan Univ Key Lab Smart Drug Delivery State Key Lab Med Neurobiol Dept PharmaceutSch PharmInst Brain SciMinist Ed Shanghai 201203 Peoples R China Fudan Univ Inst Brain Sci MOE Frontiers Ctr Brain Sci Sch PharmDept Pharmaceut Shanghai 201203 Peoples R China

The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well as establishing an immunosuppressive tumor microenvironment (TME). However, forcibly destroying the stroma barrier would break the balance of delicate signal transduction and dependence between tumor cells and matrix components. Uncontrollable growth and metastasis would occur, making PDAC more difficult to control. Hence, we design and construct an aptamer-decorated hypoxia-responsive nanoparticle s(DGL)(n)@Apt co-loading gemcitabine monophosphate and STAT3 inhibitor HJC0152. This nanoparticle can reverse its surficial charge in the TME, and reduce the size triggered by hypoxia. The released ultra-small DGL particles loading gemcitabine monophosphate exhibit excellent deep-tumor penetration, chemotherapy drugs endocytosis promotion, and autophagy induction ability. Meanwhile, HJC0152 inhibits overactivated STAT3 in both tumor cells and tumor stroma, softens the stroma barrier, and reeducates the TME into an immune-activated state. This smart code -livery strategy provides an inspiring opportunity in PDAC treatment.

关键词： Hypoxia-responsive Sizereduction Chargereversal Deeppenetration TMEmodulation

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