In a heavy-fermion system, the competition between the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction and the Kondo effect determines the ground-state properties, including superconductivity, magnetic orderings, and...
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In a heavy-fermion system, the competition between the Ruderman-Kittel-Kasuya-Yosida (RKKY) interaction and the Kondo effect determines the ground-state properties, including superconductivity, magnetic orderings, and non-Fermi-liquid states. However, the temperature-dependent development of this competition remains unclear, particularly within the framework of ferromagnetic ground states. Here, the electronic structure and heavy quasiparticle band properties are exhaustively studied in CeNiSb2, a prototypical ferromagnetic Kondo lattice, using high-resolution angle-resolved photoemission spectroscopy. Our measurements reveal the three-dimensional electronic structure and Fermi surface topologies in CeNiSb2. The discrepancy of the quasiparticle bands along the Γ-M direction indicates band-dependent hybridization between the f electrons and conduction electrons (c−f hybridization), which may arise from differences in the conduction-band properties. The intensity of the quasiparticle band increases monotonically with decreasing temperature and deviates from the Kondo-like behavior at low temperature. This evolution provides a comprehensive picture of how the RKKY interaction and the Kondo effect develop and influence the behavior of f electrons across the temperature range. Our experimental results offer a spectroscopic study of the quasiparticle band and its temperature-dependent evolution in CeNiSb2, which may be crucial for understanding the underlying physics in heavy fermion compounds.
Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. ...
Accumulating evidence shows that RAGE has an important function in the pathogenesis of sepsis. However, the mechanisms by which RAGE transduces signals to downstream kinase cascades during septic shock are not clear. Here, we identify SLP76 as a binding partner for the cytosolic tail of RAGE both in vitro and in vivo and demonstrate that SLP76 binds RAGE through its sterile alpha motif (SAM) to mediate downstream signaling. Genetic deficiency of RAGE or SLP76 reduces AGE-induced phosphorylation of p38 MAPK, ERK1/2 and IKK alpha/beta, as well as cytokine release. Delivery of the SAM domain into macrophages via the TAT cell-penetrating peptide blocks proinflammatory cytokine production. Furthermore, administration of TAT-SAM attenuates inflammatory cytokine release and tissue damage in mice subjected to cecal ligation and puncture (CLP) and protects these mice from the lethality of sepsis. These findings reveal an important function for SLP76 in RAGE-mediated pro-inflammatory signaling and shed light on the development of SLP76-targeted therapeutics for sepsis.
The rational tailoring and molecular-level engineering of stable cathode-electrolyte interphases (CEIs) is paramount to advancing the performance of next-generation high-energy, layered nickel-rich oxide-based lithium...
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The rational tailoring and molecular-level engineering of stable cathode-electrolyte interphases (CEIs) is paramount to advancing the performance of next-generation high-energy, layered nickel-rich oxide-based lithium metal batteries. However, developing well-tailored electrolyte additives with rationally controlled interfacial chemistry remains highly challenging. Here, two lithium borates: lithium (2-methoxy-15-crown-5)trifluoroborate (C-LiMCFB) and lithium (15-methoxy-2,5,8,11,14-pentaoxahexadecan)trifluoroborate (L-LiMCFB), incorporating cyclic 15-crown-5 (15C5) and linear pentaethylene glycol monomethyl ether (PEGME) as respective host groups tethered to the boron center are designed and synthesized. In C-LiMCFB, the supramolecular polydentate chelation/de-chelation of the 15C5 with Li + can sequentially deactivate/activate the anodic decomposition of the C─O bonds, therefore leading to the controlled cleavage pathway of B─O and C─O bonds. The controlled interfacial chemistry leads to the formation of a uniform CEI layer, rich in lithium boron–oxygen clusters interwoven with LiF, on the NCM811 surface. This novel CEI configuration demonstrates an exceptional balance of mechanical robustness, adhesiveness, and toughness, providing highly desirable protection for the NCM811 cathode. The discovery of these novel supramolecular boron-based lithium salts not only unlocks supramolecular chemistry for rational electrolyte tuning but also provides a deeper understanding of the CEI formation mechanism in high-energy lithium metal batteries.
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