Correction for 'Mechanistic investigations into synergistically enhanced radiative-charge-transfer in Au-Ag bimetallic nanoclusters' by Jianbo liu et al., Chem. Commun., 2020, 56, 5665-5668, DOI: 10.1039/D0CC0...
Correction for 'Mechanistic investigations into synergistically enhanced radiative-charge-transfer in Au-Ag bimetallic nanoclusters' by Jianbo liu et al., Chem. Commun., 2020, 56, 5665-5668, DOI: 10.1039/D0CC02047H.
Hyperlipidemia is one of the important risk factors of cardiovascular and cerebrovascular diseases. Monitoring of adverse reactions of hypolipidemic drugs is very crucial for clinical administration. In this study, in...
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ISBN:
(纸本)9781538667774
Hyperlipidemia is one of the important risk factors of cardiovascular and cerebrovascular diseases. Monitoring of adverse reactions of hypolipidemic drugs is very crucial for clinical administration. In this study, in order to explore the occurrence characteristics of ADRs for hypolipidemic drugs, we manually annotated and normalized the ADRs of hypolipidemic drugs from Chinese adverse event reports. Totally 579 records are involved in the study. Also we constructed a new dictionary of ADRs and a classification standard of the Severity of ADR to standardize the description of adverse drug reactions. Finally, we got a dictionary of ADR which have 171 terms, of 129 are from WHO-ART and 42 are self-defined. A new classification criteria for the severity of ADRs were built and each record were annotated by the criteria. Our annotated corpus, ADR dictionary and the classification standard can provide data source and dictionary resource to support future machine-learning-based ADR mining to better explore ADRs of hypolipidemic drugs.
利用高效液相色谱三重四极杆串联质谱(HPLC-MS/MS),建立了环境水样中卤代甲基磺酸的分析方法.通过对固相萃取、色谱柱、流动相和质谱条件的优化,确定了最佳萃取和分析条件.选用WAX固相萃取柱对卤代甲基磺酸进行富集,再依次用2 m L的5%...
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利用高效液相色谱三重四极杆串联质谱(HPLC-MS/MS),建立了环境水样中卤代甲基磺酸的分析方法.通过对固相萃取、色谱柱、流动相和质谱条件的优化,确定了最佳萃取和分析条件.选用WAX固相萃取柱对卤代甲基磺酸进行富集,再依次用2 m L的5%氨水甲醇溶液、2%甲酸甲醇溶液和20%二氯甲烷甲醇溶液(均为体积比)进行洗脱.选用Acclaim HILIC-10为色谱分离柱,以乙腈和100 mmol·L^(-1)甲酸铵水溶液为流动相,分离目标化合物,采用串联质谱负离子扫描和多反应监测模式进行检测.方法对5种卤代甲基磺酸(三氟甲基磺酸、一氯甲基磺酸、二氯甲基磺酸、三氯甲基磺酸和一溴甲基磺酸)的线性范围为0.05—50μg·L^(-1),线性相关系数r>0.99,各化合物的检出限(S/N=3)在0.005—0.039μg·L^(-1)之间.将建立的分析方法应用于实际样品中卤代甲基磺酸的测定,所得加标回收率在67.5%—95.4%之间,峰面积相对标准偏差(n=5)在8.5%—13.0%之间,可满足饮用水环境样品中痕量卤代甲基磺酸的分析.
Constructing three-dimensional (3D) conductive frameworks with high specific surface areas and porous structures is indispensable for their applications as electrocatalysts. In this work, we illustrate for the first t...
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Constructing three-dimensional (3D) conductive frameworks with high specific surface areas and porous structures is indispensable for their applications as electrocatalysts. In this work, we illustrate for the first time that 3D N-doped porous carbon nanosheets (3D-NS), which are synthesized via a facile one-pot pyrolysis reaction using glucose and melamine as raw materials, can serve as high performance and green electrocatalysts for the reduction of H2O2. Moreover, a series of 3D-NS samples with a controllable content of nitrogen were obtained by adjusting the calcination temperature. From our research, the 3D-NS obtained at 900 degrees C possessed high specific surface areas, porous structures, proper dosages of N atoms, suitable degrees of graphitization and defects. Furthermore, we also illustrate their application in H2O2 electrochemical sensing in physiological environments. Under optimum conditions, the 3D-NS-based sensor displays a wide linear scope in the range of 0.5-14 000 mu M and a low detection limit of 0.18 mu M (S/N = 3). Therefore, with desirable selectivity, stability and anti-interference performance, the proposed sensor can be feasibly applied to detect H2O2 in human serum samples.
The concise synthesis of 2,3-dihydro-4H-benzo[e][1,3]oxazin-4-ones has been accomplished by copper-catalyzed tandem reactions of o-halobenzamides, LiOH and dichloromethane. The arylhalogen bond hydroxylation and subse...
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The concise synthesis of 2,3-dihydro-4H-benzo[e][1,3]oxazin-4-ones has been accomplished by copper-catalyzed tandem reactions of o-halobenzamides, LiOH and dichloromethane. The arylhalogen bond hydroxylation and subsequent N,O-acetalization on CH2Cl2 are enabled under catalytic conditions which allows the generation of C(sp(2))-O, C(sp(3))-O and C(sp(3))-N bonds to give the target products.
Thallium is a trace metal with a toxicity greater than that of Pb, Cd and Hg. This study complements the authors' previous research, with main focus on contamination by Tl and accompanying metals (Pb, Zn, Cd, and ...
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Thallium is a trace metal with a toxicity greater than that of Pb, Cd and Hg. This study complements the authors' previous research, with main focus on contamination by Tl and accompanying metals (Pb, Zn, Cd, and Cu) in sediments from an area historically affected by Pb-Zn smelting in Shaoguan city (northern Guangdong Province, South China). In order to provide complex data on the geochemistry of anthropogenic Tl in sediments, total contents and geochemical fractionation of Tl and the other metals were comparatively studied for two different sediment profiles, core A from the Pb-Zn smelter outlet (a major Tl pollution point-source) and core B from the inlet of the North River (natural water courses near the smelter). Surprisingly high enrichment of Tl was observed across both depth profiles, with varying distribution patterns versus depth. Further comparison of Tl contents and its geochemical fractions in the upper, middle and bottom horizons of core A and core B, in combination with mineralogical phases of the sediments, clearly demonstrated both lateral and vertical mobility of Tl, due to complex processes such as mechanical disturbance/mixing, long-term alteration/dissolution of smelter-derived particles, and vertical migration of Tl through colloidal (or microparticle) transport with alumino-phyllosilicates and Fe/Mn (hydr) oxides. Relatively high abundance of Tl in the labile fractions of all selected sediments from both locations highlights a potentially significant environmental risk to the local ecological system in the near future. (C) 2017 Published by Elsevier Ltd.
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