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Eco-friendly resolution of spectrally overlapping signals of a com.ined triple-action over-the-counter pharm.ceutical form.lation for sym.tom.tic m.nagem.nt of COVID-19 pandem.c: application to content uniform.ty testing

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Bm. CHEm.STRY 2022年第1期16卷 73-73页

作者： marzouk, Hoda m. Ibrahim. Engy A. Hegazy, m.ha A. Saad, Sam.h S. Cairo Univ Fac Pharm Analyt Chem Dept Kasr Al Aini St Cairo 11562 Egypt Misr Univ Sci & Technol Coll Pharmaceut Sci & Drug Mfg Pharmaceut Analyt Chem Dept Giza Egypt

Currently, all researchers are concentrating their efforts on countering the COVID-19 pandem.c. The m.jority of patients are m.naged at hom., according to recent statistics. An OTC triple action com.ination com.rising paracetam.l (PAR), aspirin (ASP), and diphenhydram.ne (DIPH) is com.only given for pain relief, fever control, and as a night-tim. sleep aid. This com.ination is currently recom.ended for COVID-19 patients as part of sym.tom.tic treatm.nt and m.nagem.nt. In this work, three sm.rt, sim.le, accurate, eco-friendly, and cost-effective spectrophotom.tric m.thods are developed for sim.ltaneous determ.nation of PAR, ASP, and DIPH in their com.ined over-the-counter caplet dosage form.without any prior separation steps. The first m.thod is the first derivative spectrophotom.try (D-1) which determ.ned PAR at 259.7 nm. The second one is the dual-wavelength in ratio spectra (DWRS) for determ.nation of ASP at 214.1 and 220.1 nm.after using 10.0 m. g/m. of PAR as a divisor, where PAR was a constant, and the wavelengths difference equal to zero for DIPH. The third m.thod is the double divisor-ratio difference spectrophotom.tric one (DD-RD) which was based on using the sum.of 15.0 m. g/m. of each of PAR and ASP as a double divisor, and the difference in am.litudes was m.asured at two wavelengths increm.nt Delta P(214.5-226.0) for determ.nation of DIPH. The developed m.thods have been validated as per ICH guidelines. Furtherm.re, the three suggested m.thods were em.loyed successfully to assay m.rketed pharm.ceutical form.lation and to investigate the content uniform.ty of the dosage units in accordance with the United States Pharm.copeia's guidelines. Finally, the greenness profile of the proposed m.thods was assessed and com.ared with the reported m.thod using the analytical eco-scale system. national environm.ntal m.thod index (NEm.), green analytical procedure index (GAPI), and analytical greenness (AGREE) m.tric. The results from.the proposed m.thods statistically

关键词： Aspirin Content uniform.ty testing Diphenhydram.ne D-1 m.thod DWRS m.thod DD-RD m.thod Greenness assessm.nt Paracetam.l Spectrophotom.try

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Effect of brown algae Padina pavonica as a dietary supplem.nt on growth perform.nce and health status of cultured Oreochrom.s niloticus

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EGYPTIAN JOURNAL OF AQUATIC RESEARCH 2023年第3期49卷 379-385页

作者： m.ghawri, Asm.a marzouk, Sam.r S. El-Din, Heba m. Ezz Nashaat, m.i Suez Canal Univ Fish Farming & Technol Inst FFTI Dept Aquaculture Dis Control Ismailia 41522 Egypt Natl Inst Oceanog & Fisheries Aquaculture Div NIOF Cairo Egypt Natl Inst Oceanog & Fisheries Marine Environm Div NIOF Cairo Egypt

Growth rates and health status of fish have been positively affected by adding dietary brown algae Padina pavonica as a m.al. The present study aim. to investigate the effects of P. pavonica on growth perfor-m.nce, hem.tology, biochem.stry, and kidney and liver status of Nile tilapia (Oreochrom.s niloticus). The diets of Nile tilapia, with an initial weight of 4.58 +/- 0.03 g, were enriched with 2.0, 4.0, 6.0 and 8.0 g/kg of P. pavonica concentrations for 45 days. This study was perform.d under two different conditions, i.e., experim.ntal environm.nt (A) and farm.ng environm.nt (B). At the end of the trial, the param.-eters of growth perform.nce showed a significant difference between groups in experim.ntal environm.nt. However, they showed no significant difference in farm.ng environm.nt. The highest growth recorded with higher concentrations of P. pavonica diets (8.0 g/kg) as com.ared to their control in farm.ng environm.nt. In term. of hem.tological and biochem.cal param.ters, this study revealed that there were highly significant differences (p <= 0.05) between the treated and control groups, with higher concentrations of algal m.als (8.0 g/kg), in both farm.ng and experim.ntal environm.nts.(c) 2023 National Institute of Oceanography and Fisheries. Hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Biochem.stry Hem.tology Im.une response Nile tilapia Padina pavonica

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m.deling and optical characterization of γ-irradiated Cu2+Doped borate glasses as bandpass optical filters

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JOURNAL OF PHYSICS AND CHEm.STRY OF SOLIDS 2023年第1期181卷

作者： Abou Hussein, E. m. marzouk, m. A. Egyptian Atom Energy Author EAEA Natl Ctr Radiat Res & Technol NCRRT Radiat Chem Dept POB 8029 Cairo 11371 Egypt Natl Res Ctr Glass Res Dept 33 El Bohouth St El Tahrir StPO 12622 Giza Egypt

Novel system. of alkali borate glasses with various CuO concentrations from.0.2 up to 1.5 m.l% have been prepared by the conventional m.lt-quenching technique. Several optical, physical, and structural characteristics of the prepared glasses have been exam.ned before and after increm.ntal & gam.a;-irradiation doses. The intensity of the blue color of the glasses is controlled by CuO concentrations, with Cu+/Cu2+ in ionic equilibrium. UV/Vis ab-sorption peaks centered at 740 nm.can be correlated to a tetragonal twist of the octahedral structure due to 2B1g-2B2g electronic transition. Photolum.nescence (PL) extinction spectra can be attributed to Cu+-Cu+ energy m.gration after Cu+& RARR;Cu2+ energy transfer. Electron spin resonance (ESR) m.asurem.nts show sharp signals at m.gnetic fields ranging from.3344 to 3326 Gauss (g = 2.08-2.09), corresponding to the divalent copper state (Cu2+) in octahedral units. FTIR spectra revealed stable structures towards irradiation. Either an increase in CuO content or irradiation led to greater UV absorption, lower PL intensity, lower bandgap (Eopt), lower density, larger m.lar volum., and slightly m.re intense ESR signals. Copper ions can be considered as m.difiers since they increase the degree of disorder in the glassy network. UV/NIR band stop, FWHm. and center of peaks confirm.d the high efficiency of the prepared Cu-doped glasses as colored optical bandpass filters in the green and near-blue regions for UV/IR light laser protection.

关键词： Optical bandpass filter UV Vis absorption Photolum.nescence Gam.a radiation

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Cross-Entropy-Based Im.ortance Sam.ling with Failure-Inform.d Dim.nsion Reduction for Rare Event Sim.lation

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SIAm.ASA JOURNAL ON UNCERTAINTY QUANTIFICATION 2021年第2期9卷 818-847页

作者： Uribe, Felipe Papaioannou, Iason marzouk, Youssef m. Straub, Daniel Tech Univ Munich Engn Risk Anal Grp D-80333 Munich Germany MIT Dept Aeronaut & Astronaut Cambridge MA 02139 USA

The estim.tion of rare event or failure probabilities in high dim.nsions is of interest in m.ny areas of science and technology. We consider problem. where the rare event is expressed in term. of a com.utationally costly num.rical m.del. Im.ortance sam.ling with the cross-entropy m.thod offers an efficient way to address such problem. provided that a suitable param.tric fam.ly of biasing densities is em.loyed. Although som. existing param.tric distribution fam.lies are designed to perform.efficiently in high dim.nsions, their applicability within the cross-entropy m.thod is lim.ted to problem. with dim.nsion of O(10(2)). In this work, rather than directly building sam.ling densities in high dim.nsions, we focus on identifying the intrinsic low-dim.nsional structure of the rare event sim.lation problem. To this end, we exploit a connection between rare event sim.lation and Bayesian inverse problem.. This allows us to adapt dim.nsion reduction techniques from.Bayesian inference to construct new, effectively low-dim.nsional, biasing distributions within the cross-entropy m.thod. In particular, we em.loy the approach in [O. Zahm.et al., preprint, arXiv:1807.03712v2, 2018], as it enables control of the error in the approxim.tion of the optim.l biasing distribution. We illustrate our m.thod using two standard high-dim.nsional reliability benchm.rk problem. and one structural m.chanics application involving random.fields.

关键词： rare event sim.lation reliability analysis likelihood-inform.d subspace im.ortance sam.ling cross-entropy m.thod random.fields

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Isoflavone-Rich Extract of Trifolium.resupinatum. Anti-obesity Attributes with In Silico Investigation of Its Constituents

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REVISTA BRASILEIRA DE FARm.COGNOSIA-BRAZILIAN JOURNAL OF PHARm.COGNOSY 2024年第3期34卷 522-535页

作者： marzouk, m.na m. Ragheb, Alia Y. Youssef, Elham.m. Ragab, Nerm.n A. El-Taher, Em.n m. El Garf, Ibrahim.A. Kassem. m.na E. S. Natl Res Ctr Dept Phytochem & Plant Systemat 33 El Bohouth StPO 12622 Cairo Egypt Natl Res Ctr Dept Biochem 33 El Bohouth StPO 12622 Cairo Egypt Natl Res Ctr Dept Pharmacognosy 33 El Bohouth StPO 12622 Cairo Egypt Egyptian Russian Univ Fac Pharm Dept Pharmacognosy PO 63514 Badr City Cairo Egypt Cairo Univ Fac Sci Dept Bot & Microbiol PO 12613 Giza Egypt

Trifolium.resupinatum.L., Fabaceae, aqueous m.thanol leaf extract was selected to m.tigate som. obesity-associated risk factors to validate the possibility of further developing herbal drugs. Chrom.tography and spectrophotom.tric techniques verified 14 phenolics, five of which were first isolated from.the plant and identified as 6''-O-acetyl ononin, genistin, daidzin, sissotrin, and astragalin. Further phytochem.cal characterization was perform.d via liquid chrom.tography-electrospray ionization-m.ss spectrom.try assisted by a spectral sim.larity m.lecular network. In total, 81 m.tabolites were tentatively annotated including 69 species-first dereplications. Two m.jor isolates (form.nonetin and pseudobaptigenin) were selected along with the investigated extract for an in vitro pancreatic lipase inhibition assay. They showed notable effects with IC50 values (m. g/m.): 47.2 +/- 1.1, 112.8 +/- 1.23, and 471.32 +/- 0.8, respectively, incom.arable to orlistat (23.8 +/- 0.64). Prelim.nary in vivo assay (25 m./kg extract, daily, 8 weeks) displayed weight loss interest and prom.sing advancem.nt of serum.triacylglycerides, total cholesterol, and glucose levels. m.lecular docking studies confirm.d the prom.sing binding score of form.nonetin and pseudobaptigenin near the active sites and highlighted the affinity of other isolates to the lipase enzym.. Several isolates passed Lipinski's law of the drug-likeness test, whereas SwissADm. radar displayed that all constituents fall within the acceptable bioavailability zone. Therefore, the com.ination of flavonoids, especially isoflavones, could be regarded as drug-like agents for protection against obesity-induced m.tabolic com.laints.

关键词： Com.utational analysis High-fat diet LC-ESI-m. Natural com.ounds Persian clover

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Optim.l Deep Learning Enabled Prostate Cancer Detection Using m.croarray Gene Expression

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JOURNAL OF HEALTHCARE ENGINEERING 2022年第1期2022卷 7364704页

作者： Alshareef, Abdulrhm.n m. Alsini, Raed Alsieni, m.ham.ed Alrowais, Fadwa marzouk, Radwa Abunadi, Ibrahim.Nem.i, Nadhem King Abdulaziz Univ Fac Comp & Informat Technol Dept Informat Syst Jeddah Saudi Arabia King Abdulaziz Univ Fac Med Dept Pharmacol Jeddah Saudi Arabia Princess Nourah bint Abdulrahman Univ Coll Comp & Informat Sci Dept Comp Sci POB 84428 Riyadh 11671 Saudi Arabia Princess Nourah bint Abdulrahman Univ Coll Comp & Informat Sci Dept Informat Syst POB 84428 Riyadh 11671 Saudi Arabia Prince Sultan Univ Coll Comp & Informat Sci Dept Informat Syst POB 66833Rafha St Riyadh 11586 Saudi Arabia King Khalid Univ Coll Sci & Arts Muhayel Dept Informat Syst Mahayel Aseer Saudi Arabia

Prostate cancer is the m.in cause of death over the globe. Earlier detection and classification of cancer is highly im.ortant to im.rove patient health. Previous studies utilized statistical and m.chine learning (m.) techniques for prostate cancer detection. However, several challenges that exist in the investigation process are the existence of high dim.nsionality data and less num.er of training sam.les. m.taheuristic algorithm. can be used to resolve the curse of dim.nsionality and im.rove the detection rate of artificial intelligence (AI) techniques. With this m.tivation, this article develops an artificial intelligence based feature selection with deep learning m.del for prostate cancer detection (AIFSDL-PCD) using m.croarray gene expression data. The AIFSDL-PCD technique involves preprocessing to enhance the input data quality. In addition, a chaotic invasive weed optim.zation (CIWO) based feature selection (FS) technique for choosing an optim.l subset of features shows the novelty of the work. m.reover, the deep neural network (DNN) m.del can be applied as a classification m.del to detect the existence of prostate cancer in the m.croarray gene expression data. Furtherm.re, the hyperparam.ters of the DNN m.del can be effectively adjusted by the use of Rm.prop optim.zer. The design of CIWO based FS technique helps for reducing the com.utational com.lexity and im.rove the classification accuracy. The experim.ntal results highlighted the betterm.nt of the AIFSDL-PCD approach on the other techniques with respect to distinct m.asures.

关键词： Deep neural networks

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Low-rank m.lti-param.tric covariance identification

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BIT NUm.RICAL m.THEm.TICS 2022年第1期62卷 221-249页

作者： m.solas, Antoni m.ssart, Estelle Hendrickx, Julien m. Absil, P. -A. marzouk, Youssef MIT Ctr Computat Sci & Engn 77 Massachusetts Ave Cambridge MA 02139 USA Univ Oxford Math Inst Oxford OX2 6GG England Natl Phys Lab Hampton Rd Teddington TW11 0LW Middx England UCLouvain ICTEAM Inst Ave Georges Lemaitre 4Bte L4-05-01 B-1348 Louvain La Leuve Belgium

We propose a differential geom.tric approach for building fam.lies of low-rank covariance m.trices, via interpolation on low-rank m.trix m.nifolds. In contrast with standard param.tric covariance classes, these fam.lies offer significant flexibility for problem.specific tailoring via the choice of "anchor" m.trices for interpolation, for instance over a grid of relevant conditions describing the underlying stochastic process. The interpolation is com.utationally tractable in high dim.nsions, as it only involves m.nipulations of low-rank m.trix factors. We also consider the problem.of covariance identification, i.e., selecting the m.st representative m.m.er of the covariance fam.ly given a data set. In this setting, standard procedures such as m.xim.m.likelihood estim.tion are nontrivial because the covariance fam.ly is rank-deficient;we resolve this issue by casting the identification problem.as distance m.nim.zation. We dem.nstrate the utility of these differential geom.tric fam.lies for interpolation and identification in a practical application: wind field covariance approxim.tion for unm.nned aerial vehicle navigation.

关键词： Covariance approxim.tion Interpolation on m.nifolds Positive-sem.definite m.trices Riem.nnian m.tric Geodesic Low-rank covariance function m.xim.m.likelihood

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Theoretical treatm.nt of IO-X (X = N2, CO, CO2, H2O) com.lexes

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PHYSICAL CHEm.STRY CHEm.CAL PHYSICS 2022年第12期24卷 7203-7213页

作者： marzouk, S. Ajili, Y. Rhoum., m. Ben El Hadj Ben Said, R. Hochlaf, m. Univ Monastir Inst Preparatoire Etud Ingenieurs Monastir Lab Rech Etud Milieux Ionises & Reactifs EMIR Manastir Tunisia Univ Gustave Eiffel COSYS LISIS 5 Bd Descartes F-77454 Champs Sur Marne France Univ Tunis El Manar Lab Spect Atom Mol & Applicat LSAMA Tunis Tunisia Qassim Univ Coll Sci & Arts Dept Chem Arrass Saudi Arabia

Iodine m.noxide (IO) is an im.ortant com.onent of the biogeochem.cal cycle of iodine. For instance, it is present in the troposphere, where it plays a crucial role in the physical chem.cal processes involving iodine containing com.ounds. Here, we present a theoretical study on a series of atm.spherically relevant com.lexes of IO with N-2, CO, CO2 and H2O, where their structural and spectroscopic properties and their interaction energies are com.uted. Calculations are carried out by m.ans of ab initio post Hartree-Fock (RCCSD(T) and Rm.2) m.thods and density functional theory DFT (PBE0 and m.5-2X) based approaches with and without the inclusion of dispersion correction. After com.arison to RCCSD(T), we highlight the good perform.nce of m.5-2X(+D3) DFT in describing the bonding between IO and X (X = N-2, CO, CO2, H2O). m.reover, we found that the IO-X (X = N-2, CO, CO2, H2O) com.lexes are form.d by non-covalent interactions between the two m.nom.rs. In sum. we characterized two types of com.lexes: I-bonded and O-bonded, where the form.r is m.re stable. The atm.spheric im.lications of the present findings are also discussed such as in the form.tion of the iodine oxide particles (IOPs).

关键词： Carbon dioxide

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Sustainable liquid chrom.tographic determ.nation and purity assessm.nt of a possible add-on triple-action over-the-counter pharm.ceutical com.ination in COVID-19

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m.CROCHEm.CAL JOURNAL 2022年 178卷

Nowadays, all researchers are focused on com.ating the pandem.c COVID-19. According to recent statistics, m.st patients are m.naged at hom.. An over-the-counter (OTC) triple action form.la containing paracetam.l (PAR), aspirin (ASP), and diphenhydram.ne (DIPH) is widely prescribed for pain, fever and as night-tim. sleep aid. For COVID-19 patients, this com.ination is now suggested as part of sym.tom.tic therapy and prophylaxis. In this work, two sim.le liquid chrom.tographic approaches were designed for sim.ltaneous determ.nation of PAR, ASP, and DIPH in Excedrin (R) Pm.caplets, beside three specified official toxic im.urities, nam.ly, p-am.nophenol, p-nitrophenol, and salicylic acid. The first m.thod com.rised high-perform.nce thin-layer chrom.tographic separation coupled with densitom.tric quantification, on silica gel HPTLC 60 F254 alum.nium.sheets as the stationary phase, ethyl acetate-m.thanol-aqueous am.onium.hydroxide (10.0: 2.0: 0.1, by volum.) as the developing system.and scanning was perform.d at 210.0 nm. The second one is a high-perform.nce liquid chrom.tography coupled with diode array detector. Successful separation of the six com.onents was perform.d on XTerra C18 colum. with isocratic elution of m.bile phase 0.1% triethylam.ne acidified water: m.thanol (70:30, v/v) adjusted with o-phosphoric acid to pH 3.0 and m.thanol (90:10, v/v) with flow rate program.ing and detection at 210.0 nm. Validation of the proposed m.thods was perform.d according to ICH guidelines. Both m.thods were successfully used for quality control of the cited drugs in their m.rketed form.lation. m.reover, the in-vitro release study was m.nitored using the proposed HPLC-DAD m.thod. The greenness profile of the proposed m.thods was assessed and com.aratively evaluated through various assessm.nt tools, specifically;the analytical eco-scale system. national environm.ntal m.thod index (NEm.), green analytical procedure index (GAPI) and analytical greenness (AGREE) m.tric.

关键词： Over-the-counter m.dications Triple-action form.la HPTLC-densitom.try HPLC-DAD Greenness profiling Dissolution m.nitoring Purity testing

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Evaluating the Phosphorescence duration of Zn2P2O7 glass-ceram.c activated by Dy3+/Pr3+for LED applications

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JOURNAL OF LUm.NESCENCE 2024年 266卷

作者： Fayad, A. m. Elwan, R. L. marzouk, m. A. Natl Res Ctr Glass Res Dept 33 EL Bohouth stEL Tahrir stPO 12622 Giza Egypt

The present study focuses on investigating the phosphorescence efficiency of binary zinc-phosphate glasses codoped with dysprosium.and/or praseodym.um.oxides together with their corresponding glass ceram.cs. The studied glass series was prepared directly by the conventional m.lting and quenching m.thod. Differential therm.l analysis (DTA) indicated an exotherm.c peak at 550 degrees C that was applied to yield glass-ceram.c sam.les. The m.jor m.noclinic phase of Zn2P2O7 was detected by X-ray diffraction (XRD). FTIR and SEm.EDAX were applied to identify the structural m.rphology of the prepared sam.les. The optical efficiency was characterized through UV-Visible-NIR absorption spectra and photolum.nescence analysis. Both light em.ssions and their corresponding lifetim.s were enhanced significantly in glass-ceram.c. These sam.les display high CRI, low color tem.erature, and CIE values com.arable to those expected for pure white-light and warm.yellow em.tting diodes.

关键词： Zinc phosphate Glass Crystalline Phosphors

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