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Predictors of response to ovulation induction using letrozole in women with polycystic ovary syndrome

BMC ENDOCRINE DISORDERS 2023年第1期23卷 1-7页

作者： Guo, Zaixin chen, shuwen chen, Zhiyan Hu, Pan Hao, Yanfang Yu, Qi Peking Union Med Coll & Chinese Acad Med Sci Peking Union Med Coll Hosp Natl Clin Res Ctr Obstet & Gynecol Dis Dept Obstet & Gynecol Beijing Peoples R China Peking Univ Dept Obstet & Gynecol Shenzhen Hosp Beijing Peoples R China

BackgroundThis study aimed to evaluate the predictive value of the initial screening characteristics of women with anovulatory polycystic ovary syndrome (PCOS) who did or did not respond to 2.5 mg letrozole (LET).MethodsThe clinical and laboratory characteristics of women with PCOS who underwent LET treatment were evaluated. Women with PCOS were stratified according to their responses to LET (2.5 mg). The potential predictors of their responses to LET were estimated using logistic regression *** retrospective study included 214 eligible patients with a response to 2.5 mg LET (n = 131) or no response to 2.5 mg LET (n = 83). PCOS patients who responded to 2.5 mg LET showed better outcomes than those who did not (2.5 mg LET) for pregnancy rate, live birth rate, pregnancy rate per patient, and live birth rate per patient. Logistic regression analyses showed that late menarche (odds ratio [OR], 1.79 [95% confidence intervals (CI), 1.22-2.64], P = 0.003), and increased anti-mullerian hormone (AMH) (OR, 1.12 [95% CI, 1.02-1.23], P = 0.02), baseline luteinizing hormone (LH)/ follicle stimulating hormone (FSH) (OR, 3.73 [95% CI, 2.12-6.64], P < 0.001), and free androgen index (FAI) (OR, 1.37 [95% CI, 1.16-1.64], P < 0.001) were associated with a higher possibility of no response to 2.5 mg *** patients with an increased LH/FSH ratio, AMH, FAI, and late menarche may need an increased dosage of LET for a treatment response, which could be helpful in designing a personalized treatment strategy.

关键词： Polycystic ovary syndrome Letrozole Ovulation

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Design and implementation of energy saving control and regulation system for metallurgical furnace 1

Design and implementation of energy saving control and regul...

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1st EAI International Conference on Multimedia Technology and Enhanced Learning, ICMTEL 2016

作者： chen, shuwen chen, Yongshen Guo, Weiwei School of Materials and Metallurgy University of Science and Technology Liaoning Anshan114051 China

ISBN: (纸本)9781631900600

This paper from the perspective of saving fuel gas, reasonable design of temperature control system. The thermostat is designed S7-200 series PLC adoption. The communication method of the computer and programmable controller (PLC) temperature control system is described. Software part of the application of the PLC principle to achieve system control. Hardware part of the temperature sensing element thermocouple temperature field, flow meter, fuel flow regulation, adjusting the thermocouple output electrical signal supply line for comparison with the given values, if there is a difference, the difference through the operational amplifier and issued a directive to the actuator, the actuator to perform the task. The simulation interface of the application configuration, virtual reality condition, the master-slave real-time monitoring system composed of computer and PLC to give full play to the their respective advantages in the industrial control, realize the decentralized control and centralized monitoring and other new features. Write part of the program, to research on energy efficient and reasonable utilization as the theme, combined with typical furnace, energy for metallurgical furnace the huge energy consumption equipment rational utilization and effective control method is put forward to improve the reasonable design of the program, resulting in applications get effective implementation, for enterprises to save energy, create economic benefits to contribute.

关键词： Energy utilization

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A off-on pH fluorescence probe derived from phenanthro[9,10-d]imidazol-fluorescein based on ESIPT and ICT

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RESEARCH ON CHEMICAL INTERMEDIATES 2018年第1期44卷 491-502页

作者： Li, Shaoxin Zhao, Bing Kan, Wei Wang, Liyan Song, Bo chen, shuwen Qiqihar Univ Chem & Chem Engn Inst Qiqihar 161006 Peoples R China Univ Sci & Technol Liao Ning Sch Met & Mat Anshan 114051 Peoples R China

A novel pH fluorescence probe (PIF), derived from phenanthro[9,10-d]imidazole bound to the fluorescein, is designed and synthesized based on the intramolecular hydrogen bond and then its spectra properties are investigated. Probe PIF exhibits negligible fluorescence intensity at acidic pH condition due to ESIPT quenching caused by the formation of the intramolecular hydrogen bonds, and a significant fluorescence enhancement in neutral and weak alkaline environments because of the strengthened ICT process arose from the fracture of the intramolecular hydrogen bonds. The studies of UV-Vis and fluorescence spectra mean that probe PIF is able to respond linearly and reversibly over pH from 6.5 to 9.0 with pK (a) of 7.0. Moreover, the pH responses of probe PIF are stable and not disturbed by the common cations and anions. The possible response mechanism has been proposed according to the analysis of H-1 NMR and DFT calculations.

关键词： pH fluorescence Probephenanthro[9,10-d]imidazole-coumarin Fluorescein ESIPT ICT

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Algae separation from urban landscape water using a high density microbubble layer enhanced by micro-flocculation

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WATER SCIENCE AND TECHNOLOGY 2014年第5期70卷 811-818页

作者： chen, shuwen Xu, Jingcheng Liu, Jia Wei, Qiaoling Li, Guangming Huang, Xiangfeng Tongji Univ Coll Environm Sci & Engn Minist Educ Key Lab Yangtze River Water Environm Shanghai 200092 Peoples R China

Eutrophication of raw water results in outbreaks of algae, which hinders conventional water treatment. In this study, high density microbubble layers combined with micro-flocculation was adopted to remove algae from urban landscape water, and the effects of pressure, hydraulic loading, microbubble layer height and flocculation dosage on the removal efficiency for algae were studied. The greatest removal efficiency for algae, chemical oxygen demand, nitrogen and phosphorus was obtained at 0.42 MPa with hydraulic loading at 5 m/h and a flocculation dosage of 4 mg/L using a microbubble layer with a height of 130 cm. Moreover, the size, clearance distance and concentration of microbubbles were found to be affected by pressure and the height of the microbubble layer. Based on the study, this method was an alternative for algae separation from urban landscape water and water purification.

关键词： algae separation high density microbubble layer micro-flocculation urban landscape water

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The empirical research of contrarian and momentum strategies in Chinese stock market (1993-2010)

The empirical research of contrarian and momentum strategies...

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International Conference on Management and Service Science, MASS 2011

作者： Pan, Yueming chen, shuwen Case Study Center School of Management D.U.T. Dalian China Dalian Social Security Researth Center China

ISBN: (纸本)9781424465811

According to the EMH (Efficient Market Hypothesis), the price of stock should reflect available information correctly and quickly, investors can not obtain the abnormal return based on the past stock return. However, in the recent years, many practitioners and academics found there are some anomaly phenomenon existed in the stock market which caused strong debate with EMH (Efficient Market Hypothesis), such as continuation return and reversal return. Then, continuation return and reversal return can cause the momentum and contrarian investing strategies, respectively. If the momentum and contrarian trading strategies can generate abnormal return, it means the market is efficient. On the other hand, whether momentum and contrarian trading strategies can effect in some country's stock market, which is very important for individual and institutional investors. After China joined into WTO, which has played an important role in global stock market. Therefore, in this paper, following the method examined by Jegadeesh and Titman (2001), we studied the effects of momentum and contrarian trading strategies in the China's stock market over 17 - year from 1994 to 2010. © 2011 IEEE.

关键词： Momentum

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The long non-coding RNA LSINCT5 promotes malignancy in non-small cell lung cancer by stabilizing HMGA2

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CELL CYCLE 2018年第10期17卷 1188-1198页

作者： Tian, Yuheng Zhang, Nali chen, shuwen Ma, Yuan Liu, Yanyan Zhengzhou Univ Dept Resp Luoyang Cent Hosp Luoyang Peoples R China

Long non-coding RNAs (lncRNAs) can actively participate in tumorigenesis in various cancers. However, the involvement of lncRNA long stress induced non-coding transcripts 5 (LSINCT5) in non-small cell lung cancer (NSCLC) remains largely unknown. Here we showed a novel lncRNA signature in NSCLC through lncRNA profiling. Increased LSINCT5 expression positively correlates with malignant clinicopathological features and poor survival. LSINCT5 can promote migration and viability of various NSCLC cells in vitro and also enhance lung cancer progression in vivo. RNA immunoprecipitation followed by mass spectrometry has identified that LSINCT5 interacts with HMGA2. This physical interaction can increase the stability of HMGA2 by inhibiting proteasome-mediated degradation. Therefore, LSINCT5 may possibly contribute to NSCLC tumorigenesis by stabilizing the oncogenic factor of HMGA2. This novel LSINCT5/HMGA2 axis can modulate lung cancer progression and might be a promising target for pharmacological intervention.

关键词： LSINCT5 HMGA2 NSCLC

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A Comparative Study on Image Segmentation Models in COVID-19 Diagnosis 1

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29th International Conference on Computational and Experimental Engineering and Sciences, ICCES 2023

作者： Xu, Sheng chen, shuwen chen, Mike School of Physics and Information Engineering Jiangsu Second Normal University Nanjing211200 China Jiangsu Province Engineering Research Center of Basic Education Big Data Application Nanjing211200 China

ISBN: (数字)9783031449475

ISBN: (纸本)9783031449468

With Omicron sweeping the world, it has brought huge pressure on the healthcare system, and quick diagnosis of pneumonia caused by COVID-19 using chest computed tomography (CT) scans plays a key role in saving lives. Image processing techniques have been widely used to analyze CT scans and other medical images, which also facilitate the diagnosis and treatment of Coronavirus disease. This article introduces several image segmentation models that are used to facilitate the diagnosis of COVID-19 and applies several recently proposed deep learning (DL) models to the task, including UNEt TRansformers (UNETR++) and Dual Attention-guided Efficient Transformer (DAE-Former). We compare the performance of these models and provide a thorough analysis of different methods. The experimental results show that for the task of segmenting COVID-19 lesion areas, both Transformer-based models obtained better performance in terms of the value of mIoU compared with U-Net, a CNN-based model, while U-Net obtained higher accuracy. The DAE-Former model has superior anti-noise ability to UNETR++, whereas UNETR++ is more robust in terms of domain transfer. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

关键词： COVID-19

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Kinetic study of the novolac resin curing process using model fitting and model-free methods

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THERMOCHIMICA ACTA 2011年第1-2期523卷 63-69页

作者： Zhang, Chao Binienda, Wieslaw K. Zeng, Liming Ye, Xiaochuan chen, shuwen Univ Akron Dept Civil Engn Akron OH 44325 USA Wuhan Univ Technol Wuhan Peoples R China

The curing behavior of novolac type phenolic resin was studied through differential scanning calorimetry (DSC) using model fitting and model-free (isoconversion) kinetic methods. For the model fitting kinetic study, a piecewise fitting approach was developed to describe the dependence of cure reaction rate on temperature and curing degree. The piecewise model displayed excellent modeling ability. In the model-free kinetic study, Friedman, and Kissinger-Akahira-Sunose methods were used to calculate the curing activation energy. The dependence curve of activation energy on conversion and the piecewise model fitting results both displayed a change in the kinetic reaction mechanism from the autocatalytic to n-order regime. According to the isothermal prediction results, the model-free kinetic methods show much better prediction ability, compared with the model fitting methods. Also. Friedman and Kissinger-Akahira-Sunose methods were found to show similar results in predicting the isothermal curing behavior of this novolac resin. (C) 2011 Elsevier B.V. All rights reserved.

关键词： Kinetics Novolac resin Curing behavior Piecewise fitting Differential scanning calorimetry

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DESIGN OF HIGH EFFICIENCY AND LARGE SEPARATING ANGLE BEAM SPLITTER BASED ON PHOTONIC CRYSTAL CAVITY RESONATOR

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MODERN PHYSICS LETTERS B 2011年第24期25卷 1963-1969页

作者： Guo, Hao Liao, Qinghua Yu, Tianbao chen, shuwen Huang, Yongzhen Nanchang Univ Dept Phys Nanchang 330047 Peoples R China Chinese Acad Sci Inst Semicond State Key Lab Integrated Optoelect Beijing 100083 Peoples R China

We present the design and simulation of an ultracompact high efficiency beam splitter based on propagation properties of the light waves in waveguide and cavity resonator. The splitting properties of the beam splitter have been numerically simulated and analyzed using the plane wave expansion (PWE) method and finite difference time domain (FDTD) method. Then in order to minimize backward reflections and to obtain equal distribution of power, we placed a cavity resonator waveguides to optimize the devices. It is shown that a beam splitter with high efficiency and large separating angle for TM mode can be achieved. There is no doubt that these excellent features will provide the structure a promising applying prospect for photonic integrated circuit.

关键词： Photonic crystal waveguides beam splitter uniform energy distribution photonic crystal cavity resonator

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Preparation of CNTs Coated with Polydopamine-Ni Complexes and Their Catalytic Effects on the Decomposition of CL-20

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ACS OMEGA 2021年第35期6卷 22866-22875页

作者： Atamanov, Meiram Lyu, Jie-Yao chen, shuwen Yan, Qi-Long Northwestern Polytech Univ Internal Flow & Thermostruct Lab Sci & Technol Combust Xian 710072 Peoples R China

To improve the condensed-phase reaction rate of epsilon-CL-20, polydopamine (PDA)-nickel complex-coated multiwalled carbon nanotubes (CNTs) have been prepared and used as combustion catalysts. The PDA-Ni complex has been prepared and in situ coprecipitated with epsilon-CL-20 by an antisolvent crystallization process in its dimethyl sulfoxide (DMSO) solution. It has been shown that crystalline CL-20 composites included with PDA-Ni complexes are polygon-shaped with a smooth surface and an average diameter of 10-15 mu m, whereas it is 140 mu m for raw epsilon-CL-20 crystals. The catalytic reactivity of the complex on thermolysis of CL-20 has been investigated using the differential scanning calorimetry (DSC) and thermogravimetry (TG)-coupled Fourier transform infrared (FT-IR) spectroscopy technique. It has been found that CNT@PDA-Ni complexes have catalytic effects on the decomposition of epsilon-CL-20 by decreasing/shifting of the exothermic peak from T-p = 240.1 to 238.7 degrees C. The FT-IR spectra of CL-20 decomposition products under the effect of the catalyst predominantly show peaks at 1274, 1644 and 1596, 1912, 2265, and 1956-1800 cm(-1), indicating the presence of fragments with N2O, NO2, NO, HNCO, and NO/CO, respectively. The change in the epsilon-CL-20 decomposition mechanism should be attributed to the catalytic action of CNT, decreasing the formation of NO2. Also, under the effect of the carbon-based catalyst, the HNCO formation was detected at another temperature in comparison with raw CL-20, with peak absorption at 224.1 vs 232.3 degrees C and the evolution was completed at 250.8 vs 246.2 degrees C, respectively.

关键词： Degradation Absorption Organic reactions Catalysts Carbon nanotubes

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