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Conventional dendritic cells 2, the targeted antigen-presenting-cell, induces enhanced type 1 immune responses in mice immunized with CVC1302 in oil formulation

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IMMUNOLOGY LETTERS 2024年 267卷 106856-106856页

作者： Du, Luping Lu, Haiyan Qiao, xuwen Zhang, Yuanpeng Hou, Liting Yu, Xiaoming cheng, Haiwei chen, Jin Zheng, Qisheng Hou, Jibo Tong, Guangzhi Jiangsu Acad Agr Sci Inst Vet Immunol & Engn Nanjing 210014 Jiangsu Peoples R China Jiangsu Acad Agr Sci Natl Res Ctr Engn & Technol Vet Biol Nanjing 210014 Jiangsu Peoples R China Minist Sci & Technol Nanjing Jiangsu Key Lab Food Qual & Safety State Key Lab Cultivat Base Nanjing 210014 Jiangsu Peoples R China Chinese Acad Agr Sci Shanghai Vet Res Inst Shanghai 200241 Peoples R China Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China Jiangsu Acad Agr Sci 45 Zhongling StRoom A111 Nanjing Jiangsu Peoples R China

Multifunctional CD4+ T helper 1 (Th1) cells, producing IFN-gamma, TNF-alpha and IL-2, define a correlate of vaccinemediated protection against intracellular infection. In our previous study, we found that CVC1302 in oil formulation promoted the differentiation of IFN-gamma+/TNF-alpha+/IL-2+Th1 cells. In order to extend the application of CVC1302 in oil formulation, this study aimed to elucidate the mechanism of action in improving the Th1 immune response. Considering the signals required for the differentiation of CD4+ T cells to Th1 cells, we detected the distribution of innate immune cells and the model antigen OVA-FITC in lymph node (LN), as well as the quantity of cytokines produced by the innate immune cells. The results of these experiments show that, cDC2 and OVAFITC localized to interfollicular region (IFR) of the draining lymph nodes, inflammatory monocytes localized to both IFR and T cell zone, which mainly infiltrate from the blood. In this inflammatory niche within LN, CD4+ T cells were attracted into IFR by CXCL10, secreted by inflammatory monocytes, then activated by cDC2, secreting IL-12. Above all, CVC1302 in oil formulation, on the one hand, targeted antigen and inflammatory monocytes into the LN IFR in order to attract CD4+ T cells, on the other hand, targeted cDC2 to produce IL-12 in order to promote optimal Th1 differentiation. The new finding will provide a blueprint for application of immunopotentiators in optimal formulations.

关键词： CVC1302 Oil formulation Interfollicular region Inflammatory niche Th1 cells

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Simulation Analysis of Thermal Runaway Characteristics of Lithium-Ion Batteries

Simulation Analysis of Thermal Runaway Characteristics of Li...

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2023 IEEE International Conference on Power Science and Technology, ICPST 2023

作者： Hao, Zhi He, Yadong chen, Jun Luo, Shaowen Zhou, xuwen Lu, Baopeng State Grid Gansu Electric Power Company Dingxi Power Supply Company Dingxi China Lanzhou Jiaotong University School of New Energy and Power Engineering Lanzhou China

ISBN: (纸本)9798350311358

Lithium-ion batteries have become the first choice for electric vehicle power batteries and energy storage power plants due to their good output characteristics and high energy density. Taking the lithium battery as the research object, a battery monomer heat production model is established to explore the heat generation mechanism of the lithium-ion battery, and the simulation results show that the internal temperature field of lithium-ion battery is unevenly distributed, and the middle temperature is higher than the surrounding temperature. The experimental analysis of the thermal runaway characteristics of the lithium-ion battery under the pinning conditions shows that the temperature change trend of the battery is the same at each point during the pinning period, but the temperature at the pinning point is the highest. With the increase of the battery SOC, the maximum temperature at each temperature point increases, but the growth rate of the maximum temperature becomes gradually slower. © 2023 IEEE.

关键词： Lithium-ion batteries

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Amphiphilic ionic liquid hydrogel electrolytes with high ionic conductivity towards dendrite-free ultra-stable aqueous zinc ion batteries

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JOURNAL OF ENERGY STORAGE 2024年 89卷

作者： Gu, Ying Zheng, xuwen Zhou, Zheng chen, Guangxin chen, Shimou Li, Qifang Beijing Univ Chem Technol State Key Lab Chem Resource Engn Beijing 100029 Peoples R China Beijing Univ Chem Technol Minist Educ Key Lab Carbon Fiber & Funct Polymers Beijing 100029 Peoples R China Beijing Univ Chem Technol Coll Mat Sci & Engn Beijing 100029 Peoples R China

Aqueous zinc ion batteries (AZIBs) are highly promising as large-scale energy storage devices with high capacity, safety, and low cost. However, the parasitic reaction on the of Zn anode and the growth of Zn dendrites greatly prevent the practical application of AZIBs. Here, we propose an effective strategy with hydrogel electrolytes by adding dual amphiphilic ionic liquids into acrylamide, allowing for the occurrence of the following phenomena related to the Zn anode: 1) Zn2+ preferential adsorption by the amphiphilic ionic groups to regulate the electrodeposition behavior of Zn2+ on the Zn(002) crystal surface and inhibit the growth of Zn dendrites;2) water removal from the Zn2+ solvation sheath, reducing water activity and inhibiting side reactions;3) improved environmental adaptability of the hydrogel electrolyte through enhancing its mechanical properties and adhesion. The obtained hydrogel electrolyte has a high ionic conductivity of 41.47 mS/cm, a highly reversible Zn plating/stripping cycle of 1400 h in Zn||Zn symmetric batteries and an enhanced electrochemical performance in Zn||NVO full batteries (94 % capacity retention at 5.0 A g- 1/3000 cycles). Even under harsh conditions (10 mA cm -2/10 mAh cm -2), these cells maintained excellent cycling stability. This study provides new ideas for the practical applications of AZIBs.

关键词： Amphiphilic ionic liquid Hydrogel electrolyte Zn anode Aqueous zinc ion batteries

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Steroidal saponins from Allium chinense and their inhibitory effects on pancreatic lipase

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PHYTOCHEMISTRY LETTERS 2023年第1期55卷 22-29页

作者： Xie, Huili Shi, Xiaolei Wang, Bingzi Zhao, Dexin Sun, Zhiheng chen, Yifu Feng, Yuezhu Jin, Yongri Li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China Jilin Univ Coll Food Sci & Engn Changchun 130062 Peoples R China

Allium chinense *** is an important medicinal and edible homologous plant and indigenous to China and grown in other countries. Phytochemical studies have shown that it is rich in biologically active natural products. Herein, five new and twelve known steroidal saponins were isolated from the bulbs of Allium chinense ***. These compounds were structurally determined by analysis of their NMR, IR and HR-ESI-MS data. All isolates were evaluated for inhibition of porcine pancreatic lipase activity. Compounds 4, 7 and 10 exhibited potent inhibition of porcine pancreatic lipase. The relationship between structure and activity of these compounds is also investigated in this paper.

关键词： Allium chinense Steroidal saponins Extraction and isolation Structure identification Lipase inhibitory activity

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Copper-catalyzed tandem aryl-halogen hydroxylation and CH₂Cl₂-based N,O-acetalization toward the synthesis of 2,3-dihydrobenzoxazinones

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ORGANIC & BIOMOLECULAR CHEMISTRY 2017年第16期15卷 3423-3426页

作者： chen, xuwen Hao, Wenyan Liu, Yunyun Jiangxi Normal Univ Coll Chem & Chem Engn Nanchang 330022 Jiangxi Peoples R China

The concise synthesis of 2,3-dihydro-4H-benzo[e][1,3]oxazin-4-ones has been accomplished by copper-catalyzed tandem reactions of o-halobenzamides, LiOH and dichloromethane. The arylhalogen bond hydroxylation and subsequent N,O-acetalization on CH2Cl2 are enabled under catalytic conditions which allows the generation of C(sp(2))-O, C(sp(3))-O and C(sp(3))-N bonds to give the target products.

关键词： Hydroxylation

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Transcytosis-Triggering Nanoparticles for Overcoming Stromal Barriers and Reversing Immunosuppression in Pancreatic Cancer Combinatorial Therapy

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NANO LETTERS 2025年第7期25卷 2949-2959页

作者： Zhang, Shilin You, Haoyu Fan, Hongrui chen, Yun Song, Haolin Zhao, Zhenhao chen, Qinjun Wang, Yu Tian, Zonghua Wu, Yuxing Zhou, Zheng Guo, Yun Su, Boyu Li, xuwen Jia, Ru Fang, Mingzhu Jiang, chen Sun, Tao Fudan Univ Minhang Hosp Key Lab Smart Drug Delivery State Key Lab Med NeurobiolMinist Educ Shanghai 201203 Peoples R China Fudan Univ Frontiers Ctr Brain Sci Sch Pharm MOE Shanghai 201203 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China Fujian Med Univ Binhai Campus Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Fuzhou 350212 Peoples R China

In pancreatic ductal adenocarcinoma (PDAC), stromal cells and matrix proteins form a dense physical barrier that, while preventing the outward spread of tumor cells, also limits the penetration of drugs and CD8+ T cells inward. Additionally, the overactivated TGF-beta/SMAD signaling pathway further promotes matrix proliferation and immune suppression. Therefore, crossing the stromal barrier while preserving the integrity of the stroma, releasing drugs intratumorally, remodeling the stroma, and activating the immune system is a promising drug delivery strategy. In this work, a type of enamine N-oxides modified nanoparticle was prepared, with stearic acid-modified gemcitabine prodrug (GemC18) and pSMAD2/3 inhibitor galunisertib encapsulated. The peripheral enamine N-oxides can trigger transcytosis and then respond to hypoxia and acidic microenvironments, turning the surface charge of the nanoparticles to a positive charge and enhancing penetration. The released galunisertib inhibits the TGF-beta/SMAD signaling pathway, reshapes the matrix, activates antitumor immunity, and combines with gemcitabine (Gem) to kill tumor cells.

关键词： Drug delivery system transcytosis tumor penetration enamine N-oxide TGF-beta/SMAD signalingpathway

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An efficient synthesis of iminoisoindolione derivatives by cobalt-catalyzed oxidative isocyanide insertion

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TETRAHEDRON 2017年第6期73卷 758-763页

作者： Zou, Feihua chen, xuwen Hao, Wenyan Jiangxi Normal Univ Coll Chem & Chem Engn Nanchang 330022 Jiangxi Peoples R China

A Cobalt-catalyzed oxidative isocyanide insertion of aminoquinoline benzamides has been developed. The reaction proceeded smoothly by using Ag2CO3 as the oxidant in PhCI at 120 degrees C and delivered products in moderate to excellent yields with excellent functional group tolerance. The transformation is supposed to undergo the ortho C-H activation and isocyanide insertion of C-Co species toward the benzamides. Attractive features of this system include the use of low cost cobalt catalyst, the easy-handling operation, and readily available substrates. (C) 2016 Elsevier Ltd. All rights reserved.

关键词： Oxidative isocyanide insertion Cobalt-catalyzed Iminoisoindoliones Heterocycles C-H activation

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Seabed erosion and deposition formulas applied to a 2D hydrodynamic harbor engineering simulation

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ARABIAN JOURNAL OF GEOSCIENCES 2022年第6期15卷 1-19页

作者： Li, Yuting Fang, xuwen Li, Ruijie Song, Zhiyao Peng, Guoqiang chen, Peng Nanjing Normal Univ Key Lab Virtual Geog Environm Minist Educ PRC Nanjing 210023 Peoples R China Nanjing Normal Univ State Key Lab Cultivat Base Geog Environm Evolut Nanjing 210023 Peoples R China Nanjing Normal Univ Jiangsu Ctr Collaborat Innovat Geog Informat Reso Nanjing 210023 Peoples R China Xiamen Univ Coll Ocean & Earth Sci Xiamen 361102 Peoples R China Hohai Univ Key Lab Coastal Disaster & Def Minist Educ Nanjing 210098 Peoples R China Hohai Univ Coll Oceanog Nanjing 210098 Peoples R China Hohai Univ Coll Harbour Coastal & Offshore Engn Nanjing 210098 Peoples R China Shaanxi Normal Univ Sch Geog & Tourism Xian 710062 Peoples R China

In coastal engineering, predicting seabed erosion and deposition can help understand hydrodynamic changes of the coastal area. The present work aims to address the prevalent challenge that there is often a shortage of measured data in coastal areas. In this paper, a new seabed erosion and deposition formula with four forms is proposed and combined with 2D hydrodynamic harbor engineering simulation of Daishan Island situated in Zhejiang province, China. The simulation shows that (1) in the open channel, the proposed new formula considers the friction coefficient before and after trenching, thus providing a more accurate prediction result;(2) in the sheltered channels, the proposed new formula can roughly estimate the deposition intensity;(3) in the basin entrance, the proposed new formula provides an estimation better aligned with reality than existing formulae. Meanwhile, the recovery saturation coefficient is not a constant;it can be set at 0.31 in the obtained formulas for calculations during the back silting, and at 0.11 during scouring. Therefore, the proposed new formula provides an improved solution to prediction of seabed erosion and deposition and is applicable to Daishan coastal area in different situations.

关键词： Tidal current and sediment Channel deposition Seabed erosion and deposition Erosion and deposition formula

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Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4899-4913页

作者： Meng Wang Hekai chen Tuan Zhang Zhikuan Zhang xuwen Xiang Meng Gao Yilan Guo Shuangshuang Jiang Kejun Yin Mintao chen Jian Huang Xincheng Zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin State Key Laboratory of Membrane Biology School of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesKey Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Graduate School of Pharmaceutical Sciences the University of TokyoTokyo 113-0033Japan Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100032China Toll Biotech Co. Ltd.(Beijing)Beijing 102209China

Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular *** them,TLR7,in particular,has been suggested to be a target for various inflammatory disorders and autoimmune diseases including systemic lupus erythematosus(SLE);but few small-molecule inhibitors with elaborated mechanism have been reported in ***,we reported a well-characterized human TLR7-specific small-molecule inhibitor,TH-407b,with promising potency and negligible cytotoxicity through a novel binding ***,TH-407b not only effectively inhibited TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrated potent inflammation suppressing activities in primary peripheral blood mononuclear cells(PBMCs)derived from SLE ***,TH-407b showed prominent efficacy in vivo,improved survival rate and ameliorated symptoms of SLE model *** obtain molecular insights into the TH-407b derivatives’inhibition mechanism,we performed the structural analysis of TLR7/TH-407b complex using cryogenic electron microscopy(cryo-EM)*** an atomistic resolution cryo-EM structure of the TLR family,it not only of value to facilitate structure-based drug design,but also shed light to methodology development of small proteins using ***,TH-407b has unveiled an inhibition strategy for TLR7 via stabilizing its resting/inactivated *** a resting state could be generally applicable to all TLRs,rendering a useful method for targeting this group of important immunological receptors.

关键词： TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

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新型城镇化背景下我国失地农民培训与就业机制研究

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北京联合大学学报（人文社会科学版） 2023年第3期21卷 116-124页

作者：丛旭文陈立行长春大学行政学院吉林长春130000 日本关西学院大学社会学研究科日本

“十四五”时期,我国仍处在新型城镇化高速发展期,推进新型城镇化的首要任务是促进失地农民的稳定就业,失地农民的就业培训及就业质量问题有待进一步解决。本文是在针对新型城镇化背景下失地农民培训与就业问题实证分析基础上,从多主体... 详细信息

“十四五”时期,我国仍处在新型城镇化高速发展期,推进新型城镇化的首要任务是促进失地农民的稳定就业,失地农民的就业培训及就业质量问题有待进一步解决。本文是在针对新型城镇化背景下失地农民培训与就业问题实证分析基础上,从多主体协同提升失地农民培训质量、加强失地农民培训意愿和需求分析、建立线上线下融合培训模式、完善失地农民就业培训监督机制、拓展失地农民就业公共服务渠道、构建失地农民新就业形态劳动者权益保障等方面,提出新型城镇化背景下失地农民培训与就业的对策建议,提升失地农民的培训质量、保障失地农民的就业质量。

关键词：新型城镇化失地农民培训与就业农民就业

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