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Coacervate-Based Instant and Repeatable Underwater Adhesive with Anticancer and Antibacterial Properties

ACS APPLIED MATERIALS & INTERFACES 2021年第40期13卷 48239-48251页

作者： Peng, Qiongyao Wu, Qiuqiu chen, Jingsi Wang, Tao Wu, Meng Yang, Diling Peng, xuwen Liu, Jifang Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Guangzhou Med Univ Affiliated Hosp 6 Qingyuan Peoples Hosp Qingyuan 511500 Guangdong Peoples R China

Underwater adhesion is a great challenge for the development of adhesives as the attractive interfacial intermolecular interactions are usually weakened by the surface hydration layer. The coacervation process of sessile organisms like marine mussels and sandcastle worms has inspired substantial research interest in the fabrication of long-lasting underwater adhesives, but they generally suffer from time-consuming curing triggered by surrounding environmental changes and cannot reserve the adhesiveness once damaged. Herein, an instant and repeatable underwater adhesive was developed based on the coacervation of tannic acid (TA) and poly(ethylene glycol)(77)-b-poly(propylene glycol)(29)-b-poly(ethylene glycol)(77) (PEG-PPG-PEG, F68), which was driven by hydrogen-bonding interaction, and the hydrophobic cores of F68 micelles offered an additional cross-linking to enhance the mechanical properties. The TA-F68 coacervates could be facilely painted on different substrates, exhibiting robust and instant underwater adhesion (with adhesion strength up to 1.1 MPa on porcine skin) and excellent repeatability (at least 1000 cycles), superior to the previously reported coacervates. Due to the biological activities of TA, the underwater adhesive displayed innate anticancer and antibacterial properties against different types of cancer cells and bacteria, showing great potential for diverse biomedical applications, such as injectable drug carriers, tissue glues, and wound dressings.

关键词： instant and repeatable underwater adhesive coacervation hydrogen-bonding interaction hydrophobic interaction anticancer antibacterial

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Effect of hydraulic retention time on effluent pH in anammox bioreactors: Characteristics of effluent pH and pH as an indicator of reactor performance

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JOURNAL OF ENVIRONMENTAL MANAGEMENT 2021年 280卷 111716-111716页

作者： Karasuta, Chayangkun Wang, Xiaojun Zheng, xuwen chen, Yongxing chen, Zhenguo South China Univ Technol Sch Environm & Energy Guangzhou 510006 Peoples R China Minist Educ Key Lab Pollut Control & Ecosyst Restorat Ind Clu Beijing Peoples R China Hua An Biotech Co Ltd Foshan 528300 Peoples R China

In order to assess the performance of anaerobic ammonium oxidation (anammox) bioreactors, it is necessary to study the stoichiometry of the anammox reaction and pH. This study focused on the effect of the hydraulic retention time (HRT) on the effluent pH in anammox-upflow anaerobic sludge blanket (UASB) bioreactors. Anammox-UASB bioreactors with and without a recirculation system were used to investigate the effluent pH and bioreactor performance. It was concluded that under varying HRT conditions, the decrease in effluent pH did not indicate the deterioration of nitrogen removal, but did indicate that the nitrogen removal efficiency was reduced owing to a sudden increase in the nitrogen loading rate resulting from the decrease in HRT. Moreover, the results showed that the HRT directly affected the concentration of OH-, which affected the increase/decrease in effluent pH. This study demonstrated that effluent pH is a more powerful tool than previous techniques used to assess bioreactor performance. We suggest that the effluent pH could be used for preliminary assessment.

关键词： Anammox Hydraulic retention time Nitrogen removal efficiency pH Preliminary assessment Reactor performance

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Comparison of complete nitritation-denitrification and partial nitritation-anammox for iron oxide wastewater treatment

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JOURNAL OF CLEANER PRODUCTION 2021年 294卷 126281-126281页

作者： chen, Zhenguo chen, Yongxing Zheng, xuwen Wang, Xiaojun Wang, Yongqing chen, Jing South China Univ Technol Sch Environm & Energy Guangzhou 510006 Peoples R China South China Univ Technol Sch Chem & Chem Engn Guangzhou 510641 Peoples R China Minist Educ Key Lab Pollut Control & Ecosyst Restorat Ind Clu Guangzhou Peoples R China Changsha Univ Sci & Technol Sch Hydraul Engn Changsha 410114 Peoples R China

Cost-effective nitrogen removal from iron oxide wastewater is a limitation in the sustainable development of the iron oxide manufacturing industry. Two processes, namely, complete nitritation (in a sequencing batch reactor with zeolite powder, ZSBR) combined with traditional denitrification and partial nitritation (in the same ZSBR) combined with anaerobic ammonium oxidation (anammox), were successfully developed and then compared for long-term nitrogen removal from iron oxide wastewater. Stable and complete nitritation with nitrite accumulation ratio (NAR) > 95.1% was achieved in the ZSBR. Nitrogen removal rates (NRRs) of up to 4.083 +/- 0.727 kg N/m(3)/d were obtained subsequently in a denitrifying upflow sludge blanket reactor at an influent chemical oxygen demand/total nitrogen ratio of 2.5. Efficient partial nitritation was also achieved with effluent NO2--N/NH4+-N ratios of 1.1-1.5 and NAR > 92.0% in the ZSBR, with a final NRR of 1.175 kg N/m(3)/d in the subsequent anammox reactor. The addition of zeolite achieved persistent free ammonia inhibition on nitrite oxidizing bacteria in the ZSBR and resulted in efficient and controllable nitrite accumulation. The total chemical cost in the complete nitritation-denitrification process was 3.32 USD/kg NH4+-N, which was 1.14 times higher than that in the partial nitritation-anammox process. Both processes were effective and reliable in achieving nitrogen removal from iron oxide wastewater for the sustainable development of the iron oxide manufacturing industry. (C) 2021 Elsevier Ltd. All rights reserved.

关键词： Nitrogen removal Iron oxide Nitritation Zeolite Free ammonia

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Reconciling the Cooperative-Competitive Patterns among Tumor and Immune Cells for Triple-Negative Breast Cancer Treatment Using Multimodule Nanocomplexes

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ADVANCED MATERIALS 2024年第26期36卷 2312219-2312219页

作者： Li, xuwen Guo, Qin chen, Qinjun Chu, Yongchao Zhang, Yiwen chen, Hongyi Zhao, Zhenhao Wang, Yu Luo, Yifan Li, Chufeng You, Haoyu Song, Haolin Su, Boyu Jalili, Kiyumars Sun, Tao Jiang, chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug DeliveryMinist EducState Key Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Sahand Univ Technol Fac Polymer Engn POB 51317-11111 Tabriz Iran Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China

Targeting the competitive-cooperative relationships among tumor cells and various immune cells can efficiently reverse the immune-dysfunction microenvironment to boost the immunotherapies for the triple-negative breast cancer treatment. Hence, a bacterial outer membrane vesicle-based nanocomplex is designed for specifically targeting malignant cells and immune cells to reconcile the relationships based on metabolic-immune crosstalk. By uniquely utilizing the property of charge-reversal polymers to realize function separation, the nanocomplexes could synergistically regulate tumor cells and immune cells. This approach could reshape the immunosuppressive competition-cooperation pattern into one that is immune-responsive, showcasing significant potential for inducing tumor remission in TNBC models. A multimodule nanocomplex dual targeting tumor-associated macrophages (TAMs) and tumor cells is devised to reconcile cooperative-competitive patterns among multiple cells through metabolic-immune regulation. The reversion of metabolic disequilibrium-immunosuppression tumor microenvironment is observed in TNBC models after treatment, contributing to the tumor remission. image

关键词： bacterial outer membrane CD24 l-arginine metabolic regulation T cell activation tumor-associated macrophages repolarization

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Zeolite biofilm aeration filter plays a pre-nitritation role in autotrophic nitrogen removal from iron oxide red wastewater

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JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2020年第12期95卷 3261-3269页

作者： Feng, Xinghui Wang, Xiaojun Wang, Ruixin Zheng, xuwen Zhong, Zhong chen, Xiaozhen South China Univ Technol Sch Environm & Energy Guangzhou Peoples R China Minist Educ Key Lab Pollut Control & Ecosyst Restorat Ind Clu Guangzhou Peoples R China Hua An Biotech Co Ltd Foshan Peoples R China

BACKGROUND The completely autotrophic nitrogen removal over nitrite (CANON) system has excellent performance in treating ammonium-rich wastewater and it depends on ammonia oxidizing bacteria (AOB) working together with anammox bacteria in a reactor. Higher ammonium nitrogen loading requires higher aeration to provide sufficient dissolved oxygen (DO) for nitritation, whereas high-strength aeration in theCANON will destroy the sludge structure and inhibit the activity of anammox bacteria. The present study uses a stable pre-nitritation system to reduce a part of nitritation and also decrease aeration intensity in the CANON. RESULTS Continuous aeration to maintain the DO concentration between 1.5 and 4.3 mg L(-1)in the CANON achieved a stable nitrogen removal rate (1.22 kg N m(-3)d(-1)) from iron oxide red wastewater with 400-1016 mg N L(-1)after 183 days of operation. Using a mixed alkalinity donor [sodium carbonate (Na2CO3) and bicarbonate (NaHCO3)] in the combined system can save approximate to 14.1-28.2% of the alkalinity cost compared with using NaHCO(3)only. CONCLUSIONS A zeolite biofilm aeration filter (ZBAF) used in a pre-nitritation process can tolerate high DO concentration of <= 6.5 mg L(-1)for nitritation and avoid all of the nitritation taking place in the CANON system. This can protect the sludge structure and anammox bacteria from high-strength aeration erosion. (c) 2020 Society of Chemical Industry

关键词： pre-nitritation zeolite dissolved oxygen control Anammox granular sludge

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Bronchoalveolar Lavage as Potential Diagnostic Specimens to Genetic Testing in Advanced Nonsmall Cell Lung Cancer

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TECHNOLOGY IN CANCER RESEARCH & TREATMENT 2023年 22卷

作者： Lin, xuwen Cai, Yazhou Zong, chenyu chen, Binbin Shao, Di Cui, Hao Li, Zheng Xu, Ping Peking Univ Resp Dept Shenzhen Hosp 1120 Lianhua Rd Shenzhen 518034 Peoples R China BGI Shenzhen BGI Genom Shenzhen Peoples R China Zhuhai Maternal & Child Hlth Hosp Zhuhai Peoples R China Cent South Univ Hunan Canc Hosp NHC Key Lab Carcinogenesis 88 Xiangya Rd Changsha 410005 Hunan Peoples R China Cent South Univ Xiangya Sch Med Affiliated Canc Hosp 88 Xiangya Rd Changsha 410005 Peoples R China

Background: There is limited knowledge on the yield of performing capture-based targeted ultradeep sequencing on bronchoalveolar lavage (BAL) specimens from advanced nonsmall cell lung cancer (NSCLC) patients. This study aimed to evaluate gene variations and performance characteristics in BAL and tissue specimens using targeted sequencing. Methods: This cohort study retrospectively enrolled 20 patients with advanced NSCLC. The variant detection percentage, correlation of tumor mutation burden (TMB), and allele frequency heterogeneity (AFH) were compared between paired BAL and tissue samples. A three-tiered system was also applied for the interpretation of gene variants according to the guidelines. Results: No statistical difference was observed in variant detection between BAL and tissue samples (P = .591 for variant tier and P = .409 for variant type). In general, BAL achieved higher detection rates in tier I variants (96.2% vs 84.6%) and gene fusions (75% vs 50%) compared with tissue samples;tissue samples had better variants detection rates for other variants, such as tier II (89.6% vs 76.0%), tier III (87.1% vs 72.6%), single nucleotide variant (SNV, 89.6% vs 76.5%), insertion/deletion/duplication (InDel, 74.6% vs 69.8%) and copy number variation (CNV, 93.8% vs 43.8%). Besides, there were significant correlations of TMB (R-2 = 0.96, P < .001) and AFH (R-2 = 0.87, P < .001) between BALs and paired tissues. Conclusions: The findings demonstrate that BAL may serve as a supplement in liquid biopsy for mutation detection and for routine utilization in clinical settings.

关键词： bronchoalveolar lavage capture-based targeted sequencing tumor mutation burden allele frequency heterogeneity advanced nonsmall cell lung cancer

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Coacervation-driven instant paintable underwater adhesives with tunable optical and electrochromic properties

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JOURNAL OF MATERIALS CHEMISTRY A 2021年第22期9卷 12988-13000页

作者： Peng, Qiongyao chen, Jingsi Wang, Tao Gong, Lu Peng, xuwen Wu, Meng Ma, Yuhao Wu, Feiyi Yang, Diling Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Univ Alberta Dept Biomed Engn Edmonton AB T6G 2V2 Canada

Coacervation generally refers to liquid-liquid phase separation when mixing oppositely charged polyelectrolytes in an aqueous solution, which produces a polyelectrolyte-dense coacervate phase in a dilute solution phase. Coacervation plays a crucial role in many biological processes such as the versatile underwater adhesion of sessile organisms, cellular compartmentalization, and cell replication, which inspires a surge of biomimetic designs of underwater adhesives. However, conventional coacervate-based underwater adhesives are usually weak and lack functionalities, limiting their practical applications in biomedical and engineering fields. Herein, a novel instant underwater adhesive is presented based on coacervation via one-step mixing of aqueous solutions of silicotungstic acid (SiW) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (P123) micelles, driven by hydrogen-bonding and hydrophobic interactions. The as-prepared adhesive possesses instant and excellent underwater adhesion (up to 479.6 kPa on poly(methyl methacrylate)) and can be facilely painted underwater on diverse substrates, showing resistance to water flush as well as repeatable stretching and bending of the substrates, superior to many previously reported coacervates. The adhesive also exhibits outstanding stability in high-salt aqueous solutions up to 3 M for at least 1200 h. The introduction of P123 endows the adhesives with thermo-responsive optical properties, while the innate reduction-related color switch of SiW offers electrochromic properties. The functional adhesives hold great promise in bioengineering applications and for the fabrication of novel flexible electronics such as smart aqueous batteries and low-power electrochromic windows.

关键词： Substrates

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PLA光学纯度和等温退火处理对熔喷非织造布结构与性能的影响

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印染 2025年第2期51卷 45-48页

作者：李旭文于本成王鹏王金剑陈鹏传化智联股份有限公司浙江杭州311215 中国科学院宁波材料技术与工程研究所浙江省生物基高分子材料技术与应用重点实验室宁波市高分子材料重点实验室浙江宁波315201

选用4种不同PLA原料制备熔喷非织造布,测试了纤维直径、热结晶性能、表面电压和过滤效率衰减,并将熔融指数接近但光学纯度不同的PLA原料制备的驻极非织造布进行等温退火处理,以探究结晶对非织造布力学性能的影响。结果表明:光学纯度较高... 详细信息

选用4种不同PLA原料制备熔喷非织造布,测试了纤维直径、热结晶性能、表面电压和过滤效率衰减,并将熔融指数接近但光学纯度不同的PLA原料制备的驻极非织造布进行等温退火处理,以探究结晶对非织造布力学性能的影响。结果表明:光学纯度较高的PLA原料的结晶性能要优于光学纯度低的,光学纯度对熔喷PLA驻极非织造布的纤维平均直径和过滤效率没有影响;不同光学纯度PLA原料制备的熔喷非织造布都存在表面电压和过滤效率随放置时间延长而降低的现象,其中光学纯度较高的PLA原料制备的非织造布表面电压和过滤效率的保留率较高,捕获电荷能力更强;熔喷PLA驻极非织造布的结晶度和力学性能随退火时间的延长而提高,高光学纯度原料制备的驻极非织造布的力学性能增幅最大。

关键词：光学纯度退火结晶非织造布表面电压过滤效率

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Multiple pre-harvest applications of antagonist Pseudomonas fluorescens ZX induce resistance against blue and green molds in postharvest citrus fruit

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LWT-FOOD SCIENCE AND TECHNOLOGY 2022年 155卷

作者： Wang, Zhirong Zhong, Tao chen, Xuhui Xiang, xuwen Du, Muying Zalan, Zsolt Kan, Jianquan Southwest Univ Coll Food Sci 2 Tiansheng Rd Chongqing 400715 Peoples R China Chinese Hungarian Cooperat Res Ctr Food Sci Chongqing 400715 Peoples R China Minist Agr Lab Qual & Safety Risk Assessment Agroprod Storag Chongqing 400715 Peoples R China Hungarian Univ Agr & Life Sci Food Sci & Technol Inst Buda CampusHerman Otto Str 15 H-1022 Budapest Hungary

The pre-harvest applications of antagonists are promising strategies to minimize various postharvest diseases. Given this, we sought to evaluate the capability of Pseudomonas fluorescens ZX in inducing resistance of postharvest citrus fruit against blue and green molds, caused by Penicillium italicum and Penicillium digitatum, respectively. Results showed that pre-treatment with P. fluorescens ZX significantly inhibited blue and green molds, generally providing stronger protection with increasing number of sprays. More specifically, three applications of the antagonist reduced disease incidence by about 47% and 41%, reduced lesion diameter by around 40% and 28%, and reduced disease index by approximately 69% and 57%, when exposed to blue and green molds, respectively. Mechanistically, these protective effects might be linked to the increased activities of superoxide dismutase, ascorbate peroxidase, peroxidase, and polyphenoloxidase, along with substantial response of phenolic acids (syringic, p-coumaric, ferulic, and sinapinic acids) and flavonoids (rutin, neohesperidin, hesperetin, sinensetin and tangeretin). P. fluorescens ZX survived well on fruit surface, and more importantly, pretreatments exhibited no negative effects on fruit quality;on the contrary, it partly improved fruit quality during postharvest storage. Collectively, these results indicated that multiple pre-harvest applications of P. fluorescens ZX are useful for control of postharvest diseases.

关键词： Pseudomonas fluorescens ZX Pre-harvest application Induced resistance Biocontrol Postharvest diseases

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基于直方图均衡化的径赛图像增强技术研究

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汽车实用技术 2019年第4期45卷 51-53页

作者：卢步涛洪庆达陈旭文郑顺新揭阳职业技术学院信息工程系广东揭阳522000

受现场环境影响,难以获取清晰的径赛比赛图像,影响比赛结果的判决。分析了数字图像增强技术的基本原理,重点对直方图均衡化技术进行研究,并应用其对原始图像进行处理,利用matlab工具进行仿真实验,结果证明,直方图均衡化技术有效改善图... 详细信息

受现场环境影响,难以获取清晰的径赛比赛图像,影响比赛结果的判决。分析了数字图像增强技术的基本原理,重点对直方图均衡化技术进行研究,并应用其对原始图像进行处理,利用matlab工具进行仿真实验,结果证明,直方图均衡化技术有效改善图像对比度,有利比赛结果判决。

关键词：径赛图像直方图均衡化图像增强 matlab

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