检索结果-内蒙古大学图书馆

Time-dependent gut microbiota analysis of juvenile Oreochromis niloticus by dietary supplementation of resveratrol

ARCHIVES OF MICROBIOLOGY 2020年第1期202卷 43-53页

作者： Zheng, Yao Hu, Gengdong Wu, Wei Qiu, Liping Bing, xuwen chen, Jiazhang Chinese Acad Fishery Sci Fishery Ecoenvironm Monitoring Ctr Lower Reaches Freshwater Fisheries Res Ctr Minist AgrLab Qual & Safety Risk Assessment Aqua 9 Shanshui East Rd Wuxi 214081 Jiangsu Peoples R China Minist Agr Key Lab Control Qual & Safety Aquat Prod Beijing 100141 Peoples R China

To evaluate the changes in bacterial diversity at various time points under resveratrol supplementation, we aimed to investigate the diversification of gut microbiota and the changes in total genetic diversity. We performed 16S rDNA gene sequencing at different time points (15, 30, and 45 days) to analyze the gut microbiota of tilapia. Fusobacteria, Proteobacteria, and Bacteroidetes (15 days) or Cyanobacteria (30 and 45 days) were found to be the three most abundant phyla. Cyanobacteria (15 and 30 days), Proteobacteria (15 days), Firmicutes and Chlamydiae (30 and 45 days), Planctomycetes (30 days), Bacteroidetes, Actinobacteria, and Fusobacteria (45 days) in the 0.05 g/kg RES group increased as compared to that in the controls. Proteobacteria and Cyanobacteria significantly decreased and increased at 30 and 45 days, respectively, while the reverse pattern was observed at 15 days. The Bacteroidetes:Firmicutes and Proteobacteria:Cyanobacteria ratios were significantly increased (15 and 45 days, P < 0.05) and decreased (30 days, P < 0.05). RES supplementation did not affect the richness and diversity of the gut microbiota in tilapia. Our findings may contribute to the development of strategies for the management of diseases.

关键词： Resveratrol GIFT Gut microbiota 16S rDNA Chinese medical herbs

来源：评论

学校读者我要写书评

暂无评论

Recent Advances in Mechano-Responsive Hydrogels for Biomedical Applications

引用

ACS APPLIED POLYMER MATERIALS 2020年第3期2卷 1092-1107页

作者： chen, Jingsi Peng, Qiongyao Peng, xuwen Han, Linbo Wang, Xiaogang Wang, Jianmei Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Shenzhen Technol Univ Coll Hlth Sci & Environm Engn Shenzhen 518118 Peoples R China Taiyuan Univ Sci & Technol Heavy Machinery Engn Res Ctr Educ Minist Taiyuan 030024 Peoples R China

Mechanical responsiveness is prevalent in biological systems and plays an essential role in many biomechanical processes. The past two decades have witnessed enormous effort devoted to the development of biomimetic mechano-responsive hydrogels which are capable of adapting their physical and chemical properties to external mechanical stimuli. Due to the combination of tissue similarity and mechano-responsive properties, this type of hydrogel offers great advantages for diverse biomedical applications. Strain-stiffening and self-healing hydrogels duplicate the physiological properties of biological tissues, serving as promising candidates for artificial tissues, tissue scaffolds, and wound dressings. The shear-thinning property provides the hydrogels injectability, and the regional delivery contributes to minimally invasive treatment. Mechanochromic hydrogels allow the direct visualization of mechanical stress, holding great promise in biosensing and diagnosing. This review highlights the most recent developments in mechano-responsive hydrogels with various applications in the biomedical field. Different types of mechano-responsive hydrogels are introduced with focus on their responsive mechanisms, design strategies, and in vitro/in vivo performances, providing useful insights into the understanding and future research directions of mechano-responsive hydrogels with applications in biomedical engineering.

关键词： mechano-responsive hydrogel strain-stiffening self-healing shear-thinning mechanochromic

来源：评论

学校读者我要写书评

暂无评论

Gestational diabetes mellitus prediction model: A risk factors analysis of pregnant women with gestational diabetes mellitus but have normal oral glucose tolerance test results in the second trimester of pregnancy

引用

TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S57-S63页

作者： Lu, Jiayu Zhang, Song Jiang, Hongqing Yang, Lin Hao, Dongmei Yang, Yimin Li, xuwen chen, Aiqing Shao, Jing Liu, Xiaohong Beijing Univ Technol Fac Environm & Life Sci Beijing Int Base Sci & Technol Cooperat Intelligent Physiol Measurement & Clin Translat Beijing 100124 Peoples R China Haidian Maternal & Children Hlth Hosp Beijing 100080 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Oral glucose tolerance test (OGTT) is a standard for the diagnosis of gestational diabetes mellitus (GDM). However, clinically, some cases with normal results were diagnosed as GDM in the third trimester. OBJECTIVE: To establish a risk model based on energy metabolism, epidemiology, and biochemistry that could predict the GDM pregnant women with normal OGTT results in the second trimester. METHODS: Qualitative and quantitative data were analyzed to find out the risk factors, and the binary logistic backward LR regression was used to establish the prediction model of each factor and comprehensive factor, respectively. RESULTS: The risk factors including the rest energy expenditure per kilogram of body weight, oxygen consumption per kilogram of body weight, if more than the weight gain criteria of the Institute of Medicine, the increase of body mass index between the second trimester and pre-pregnancy, and fasting blood glucose. By comparison, the comprehensive model had the best prediction performance, indicating that 85% of high-risk individuals were correctly classified. CONCLUSION: Energy metabolism, epidemiology, and biochemistry had better recognition ability for the GDM pregnant women with normal OGTT results in the second trimester. The addition of metabolic factors in the second trimester also improved the overall prediction performance.

关键词： Prediction model gestational diabetes mellitus rest energy metabolism

来源：评论

学校读者我要写书评

暂无评论

仿刺参中两种新海参烷型皂苷

引用

高等学校化学学报 2023年第4期44卷 27-34页

作者：孙志恒刘桂英王冰姿陈义夫冯月竹金永日李绪文吉林大学化学学院长春130012 辽宁省海洋水产科学研究院大连116023

从仿刺参(Apostichopus japonicus Selenka)乙醇提取物中分离得到2个新的海参烷型皂苷类化合物,通过波谱数据分析并结合理化性质鉴定其分别为3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃喹诺糖]-4-O-[... 详细信息

从仿刺参(Apostichopus japonicus Selenka)乙醇提取物中分离得到2个新的海参烷型皂苷类化合物,通过波谱数据分析并结合理化性质鉴定其分别为3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃喹诺糖]-4-O-[β-D-吡喃葡萄糖]-β-D-吡喃木糖}-海参烷-7(8),25(26)-二烯-16-酮(化合物1,命名为Holotoxin E1)和3β-O-{2-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃葡萄糖]-4-O-[β-D-吡喃葡萄糖-(1→3)-β-D-吡喃葡萄糖]-β-D-吡喃木糖}-海参烷-7(8),25(26)-二烯-16-酮(化合物2,命名为Holotoxin E2).采用CCK-8法考察了包含上述2个新成分在内的共6个海参烷型皂苷对乳腺癌MDA-MB-231细胞和肝癌HepG2细胞的细胞毒活性.结果表明,除Holotoxin E2外,其余5种化合物对MDA-MB-231(IC50=2.386~4.686μmol/L)和HepG2(IC50=5.909~18.860μmol/L)均具有较好的抑制作用.

关键词：仿刺参海参烷型皂苷分离结构鉴定细胞毒活性

来源：评论

学校读者我要写书评

暂无评论

基于多尺度卷积编码器的说话人验证网络

引用

计算机科学 2024年第S01期51卷 75-80页

作者：刘小湖陈德富李俊周旭文胡姗周浩浙江工业大学信息工程学院杭州310023 浙江讯飞智能科技有限公司杭州310000

说话人验证是一种有效的生物身份验证方法,说话人嵌入特征的质量在很大程度上影响着说话人验证系统的性能。最近,Transformer模型在自动语音识别领域展现出了巨大的潜力,但由于Transformer中传统的自注意力机制对局部特征的提取能力较弱... 详细信息

说话人验证是一种有效的生物身份验证方法,说话人嵌入特征的质量在很大程度上影响着说话人验证系统的性能。最近,Transformer模型在自动语音识别领域展现出了巨大的潜力,但由于Transformer中传统的自注意力机制对局部特征的提取能力较弱,难以提取有效的说话人嵌入特征,因此Transformer模型在说话人验证领域的性能难以超越以往的基于卷积网络的模型。为了提高Transformer对局部特征的提取能力,文中提出了一种新的自注意力机制用于Transformer编码器,称为多尺度卷积自注意力编码器(Multi-scale Convolutional Self-Attention Encoder,MCAE)。利用不同尺度的卷积操作来提取多时间尺度信息,并通过融合时域和频域的特征,使模型获得更丰富的局部特征表示,这样的编码器设计对于说话人验证是更有效的。通过实验表明,在3个公开的测试集上,所提方法的综合性能表现更佳。与传统的Transformer编码器相比,MCAE也是更轻量级的,这更有利于模型的应用部署。

关键词：说话人验证说话人嵌入自注意力机制 Transformer编码器多尺度卷积

来源：评论

学校读者我要写书评

暂无评论

“双减”政策背景下学校体育“家校社”协同育人的问题检视与实践超越

引用

体育科技文献通报 2023年第2期31卷 157-159,163页

作者：李旭雯刘辉陈凯长沙市雅礼实验中学湖南长沙410000

“双减”政策颁布的目的旨在从根本上释放学生学习压力,并将学校体育“家校社”协同育人发展推至新阶段。如何最大化发挥家庭体育、学校体育、社会体育的各自特色,实现1+1+1>3的育人效果,亟需深思。本文运用文献综述法、逻辑分析法... 详细信息

“双减”政策颁布的目的旨在从根本上释放学生学习压力,并将学校体育“家校社”协同育人发展推至新阶段。如何最大化发挥家庭体育、学校体育、社会体育的各自特色,实现1+1+1>3的育人效果,亟需深思。本文运用文献综述法、逻辑分析法等研究方法,探析“双减”政策背景下学校体育“家校社”协同育人实践问题,提出相应改进策略建议。研究认为,问题检视:“家校社”体育认知程度浅显;“家校社”体育资源供给乏力;“家校社”合作机制条件欠缺。建议:觉醒认知意识,更新学校体育“家校社”三方教育观念;凝聚体质合力,整合学校体育“家校社”三方优势资源;融合信息技术,塑造学校体育“家校社”三方交流平台。

关键词： “双减”政策家校社协同育人学校体育

来源：评论

学校读者我要写书评

暂无评论

Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

引用

ACS APPLIED MATERIALS & INTERFACES 2020年第52期12卷 57757-57767页

作者： Guo, Qin chen, Qinjun Zhang, Yujie Zhou, Wenxi Li, xuwen Li, Chao Zhang, Yiwen chen, Hongyi Liu, Peixin Chu, Yongchao Sun, Tao Jiang, chen Fudan Univ State Key Lab Med Neurobiol Key Lab Smart Drug Delivery Minist Educ Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China

As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization to withstand harsh conditions. Several approaches have been explored to inhibit the growth and metastasis of tumor by disrupting the reprogrammed tumor metabolism. However, nutrient limitations within solid tumors may induce the metabolic flexibility of malignant cells to sustain growth and survival using one nutrient to fill metabolite pools normally supplied by the other. To overcome this predicament, a promising click-nucleic-acid-containing platform for codelivery of rapamycin, anti-PFKFB4 siRNA, and targeting ligand aptamer AS1411 was applied. PFKFB4 could act as a promising target for tumor therapy for being a molecular fulcrum that could couple glycolysis to autophagy by promoting aggressive metastatic tumors. The downregulation of PFKFB4 can help inhibit the SRC3/Akt/mTOR pathway, leading autophagy to the direction of promoting apoptosis of tumor cells, which is induced by the collapse of tumor cellular homeostasis, while low dosages of rapamycin could decrease surgery-induced immune dysfunction. Enhanced tumor autophagy, favorable in vivo antitumor efficacy, and effective systematic immune activation are observed after treatment, suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatment.

关键词： tumor metabolism codelivery click nucleic acid immune activation tumor therapy

来源：评论

学校读者我要写书评

暂无评论

Adhesive Coacervates Driven by Hydrogen-Bonding Interaction

引用

SMALL 2020年第43期16卷 2004132-2004132页

作者： Peng, Qiongyao chen, Jingsi Zeng, Zicheng Wang, Tao Xiang, Li Peng, xuwen Liu, Jifang Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China

Coacervation plays a critical role in numerous biological activities such as constructing biological tissues and achieving robust wet adhesion of marine sessile organisms, which conventionally occurs when oppositely charged polyelectrolytes are mixed in aqueous solutions driven by electrostatic attraction. Here, a novel type of adhesive coacervate is reported, driven by hydrogen-bonding interactions, readily formed by mixing silicotungstic acid and nonionic polyethylene glycol in water, providing a new approach for developing coacervates from nonionic systems. The as-prepared coacervate is easily paintable underwater, show strong wet adhesion to diverse substrates, and has been successfully applied as a hemostatic agent to treat organ injuries without displaying hemolytic activity, while with inherent antimicrobial properties thus avoiding inflammations and infections due to microorganism accumulation. This work demonstrates that coacervation can occur in salt-free environments via non-electrostatic interactions, providing a new platform for engineering multifunctional coacervate materials as tissue glues, wound dressings and membrane-free cell systems.

关键词： adhesive coacervates antimicrobial properties coacervation hydrogen bonding wet adhesion

来源：评论

学校读者我要写书评

暂无评论

Online Monitoring of Ship Block Construction Equipment Based on the Internet of Things and Public Cloud: Take the Intelligent Tire Frame as an Example

引用

KSII TRANSACTIONS ON INTERNET AND INFORMATION SYSTEMS 2021年第11期15卷 3970-3990页

作者： Cai, Qiuyan Jing, xuwen chen, Yu Liu, Jinfeng Kang, Chao Li, Bingqiang Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212100 Jiangsu Peoples R China

In view of the problems of insufficient data collection and processing capability of multi source heterogeneous equipment, and low visibility of equipment status at the ship block construction site. A data collection method for ship block construction equipment based on wireless sensor network (WSN) technology and a data processing method based on edge computing were proposed. Based on the Browser/Server (B/S) architecture and the OneNET platform, an online monitoring system for ship block construction equipment was designed and developed, which realized the visual online monitoring and management of the ship block construction equipment status. Not only that, the feasibility and reliability of the monitoring system were verified by using the intelligent tire frame system as the application object. The research of this project can lay the foundation for the ship block construction equipment management and the ship block intelligent construction, and ultimately improve the quality and efficiency of ship block construction.

关键词： Ship block construction equipment monitoring WSN edge computing Web

来源：评论

学校读者我要写书评

暂无评论

Fabrication and properties of MEMS compatible energetic arrays based on carbon-based copper azide

引用

APPLIED SURFACE SCIENCE 2022年 577卷 150643-150643页

作者： Liu, xuwen Hu, Yan chen, Bingwen Wei, Hai Su, Jiaxin Yang, Caimin Hu, Jiaheng Ye, Yinghua Shen, Ruiqi Nanjing Univ Sci & Technol Sch Chem & Chem Engn Nanjing 210094 Peoples R China Minist Ind & Informat Technol Micronano Energet Devices Key Lab Nanjing 210094 Peoples R China

Copper azide is a promising primary explosive with low toxicity and high energy density. However, due to the extreme electrostatic sensitivity, it does not have many practical applications in the miniaturized pyrotechnics. In this work, we constructed an energetic composite, embedding in oriented carbon nanotubes (CNTs) arrays grown on a silicon substrate, which is compatible with the micmfabrication technique of Micro-Electro-Mechanical Systems (MEMS). Since it has excellent electrical conductivity and mechanical strength, oriented CNTs, as nano-containers of Cu(N-3)(2), can availably reduce the electrostatic sensitivity and bring about the directional output of detonation energy. The oriented CNTs arrays were prepared by magnetron sputtering, anodization and chemical vapor deposition successively. Electrochemical deposition was used to deposit copper nanoparticles in the cavities of CNTs, which were converted into copper azide by subsequent in-situ azide reaction. The electrostatic sensitivity test, thermal performance analysis and laser ignition experiment were conducted on the energetic composite, respectively. The results show that the energetic composite kept safe under an electrostatic stimulation of 3.18 mJ, while original copper azide exploded when subjected to stimulation of 0.05 mJ. The energetic composite opens a new route of introducing hazardous primary explosives into micro-initiators and modern pyrotechnics.

关键词： Composite energetic materials Copper azide Oriented CNTs array Template method Electrochemical deposition Electrostatic safety

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：