Cutaneous melanoma is one of the aggressive cancers. Recent studies have shown that Photobiomodulation (PBM) can inhibit the proliferation of melanoma cells. However, it is not clear that the effect of PBM light mode ...
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Cutaneous melanoma is one of the aggressive cancers. Recent studies have shown that Photobiomodulation (PBM) can inhibit the proliferation of melanoma cells. However, it is not clear that the effect of PBM light mode on the inhibition of melanoma cells. Herein, we investigated the difference of influence between continuous wave (CW) and Pulse PBM on B16F10 melanoma cells. Our results suggested that Pulse mode had a more sig-nificant inhibition on the viability of B16F10 melanoma cells than CW mode under the PBM light parameter of wavelength, dose, and average irradiance at 457 nm, 1.14 J/cm(2), and 0.19 mW/cm(2). Besides, we revealed the differentially expressed genes of B16F10 melanoma cells under the various treatments of PBM light mode (not PBM treatment, CW mode, and Pulse mode) by RNA sequencing. Together, our data suggested that Pulse-PBM can improve the effect of PBM on cells significantly and there may be different molecular mechanisms be-tween Pulse and CW mode including anti-proliferative and cell necrosis. The study shed new light on investi-gating the molecular mechanisms of various PBM light modes on B16F10 melanoma cells.
The multicomponent reactions of o-, m, or p-iodophenols, arylboronic acids, and dichloromethane (DCM) have been designed for the synthesis of various bisaryloxy methanes via one-pot procedure consists of Williamson et...
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The multicomponent reactions of o-, m, or p-iodophenols, arylboronic acids, and dichloromethane (DCM) have been designed for the synthesis of various bisaryloxy methanes via one-pot procedure consists of Williamson etherification and Suzuki coupling. (C) 2016 Elsevier Ltd. All rights reserved.
Room temperature ferromagnetism (RTFM) was observed in unirradiated rutile TiO2 single crystals prepared by the floating zone method due to oxygen vacancy (V-O) defects. D-D neutrons mainly collide elastically with Ti...
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Room temperature ferromagnetism (RTFM) was observed in unirradiated rutile TiO2 single crystals prepared by the floating zone method due to oxygen vacancy (V-O) defects. D-D neutrons mainly collide elastically with TiO2, producing V-O, titanium vacancies (V-Ti) and other point defects;the density and kind of defect is related to the neutron irradiation fluence. D-D neutron irradiation is used to regulate the concentration and type of defect, avoiding impurity elements. As the irradiation fluence increases, the saturation magnetization (M-s) first increases, then decreases and then increases. To verify the origin of RTFM, the CASTEP module was used to calculate the magnetic and structural properties of point defects in TiO2. V-O induces a 2.39 mu(B) magnetic moment, Ti3+ and F+ induce 1.28 mu(B) and 1.70 mu(B) magnetic moments, respectively, while V-Ti induces a magnetic moment of similar to 4 mu(B). Combining experimental and theoretical results, increases in V-O concentration lead to M-s increases;more V-O combine with electrons to form F+, inducing a smaller magnetic moment. V-O and V-Ti play a key role and M-s changes accordingly with larger fluence. V-O, F+ and V-Ti are the most likely origins of RTFM.
Background: Vast economic and healthcare status discrepancies exist among regions in China, contributing to different treatment patterns. This study was aimed to investigate the current status of pharmacotherapy for a...
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Background: Vast economic and healthcare status discrepancies exist among regions in China, contributing to different treatment patterns. This study was aimed to investigate the current status of pharmacotherapy for acute ischemic stroke (AIS) and outcomes in China and explore the geographic variation in stroke care. Methods: This study was a multicenter prospective registry study, which collected the data of patients with AIS from 80 hospitals in 46 cities in 2015-2017 across China. Poor functional outcome defined as a modified Rankin Scale score of 3-6 was assessed at 3 and 12 months. Multivariate logistic regression was used. Results: Among 9973 eligible patients, the number of receiving intravenous thrombolysis (IVT), antiplatelet agents, anticoagulants, statin and human urinary kallidinogenase was 429 (4.3%), 9363 (93.9%), 1063 (10.7%), 6828 (74.7%) and 5112 (51.2%), respectively. Multivariable analysis showed IVT use in northeastern was significantly more frequent than in eastern region (OR = 3.17, 95% CI, 2.53-3.99), while the antiplatelets agents use were less frequent (OR = 0.46, 95%CI: 0.38-0.57). The proportions of poor outcomes at 3 and 12 months were 20.7% and 15.8%, respectively. Multivariate analysis showed AIS patients from northeastern and central region had significantly lower risk of poor outcome at month 3 and 12 than those from eastern region (all P < 0.05). Conclusions: There was a low IVT use and a high antiplatelet agent and statin use for AIS in China. The pharmacotherapy and prognosis of AIS had variation by geographic region.
Understanding functions and co-occurrence patterns of microbial communities in various ecosystems enriches the knowledge on ecosystem characteristics and microbial ecology. However, such analyses have rarely been repo...
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