检索结果-内蒙古大学图书馆

Thermally-activated upconversion based on triplet fusion for deep red photoactivation of Ru(ii) complexes

NEW JOURNAL OF CHEMISTRY 2024年第15期48卷 6886-6892页

作者： Niu, Pengfei Da, xuwen hu, Rui Yu, Tianjun Chen, Jinping Zhou, Qianxiong Luo, Guiwen Zeng, Yi Li, Yi Tech Inst Phys & Chem Chinese Acad Sci Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Inst Chem Chinese Acad Sci Key Lab Photochem Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Expanding the anti-Stokes shift in triplet-triplet annihilation upconversion (TTA-UC) systems and harvesting light within the biological transparency window (700-900 nm) are of great importance for their biomedical applications. In this study, we have developed a TTA-UC system that converts deep red-light into blue photons using a highly endothermic sensitization pair, wherein the triplet energy level of the sensitizer is 0.19 eV below that of the acceptor. The thermally activated triplet energy transfer compensates the energy loss during intersystem crossing (ISC) of the sensitizer, achieving a 0.82 eV anti-Stokes shift upconversion with over 6% quantum yield. This TTA-UC system activates a Ru(ii)-based photoactivated chemotherapeutic agent, causing DNA to bleach under 700 nm LED irradiation. These results demonstrate a feasible way to develop upconversion systems that operate within the biological transparency window, with potential applications in biological phototherapy.

关键词： Transparency

来源：评论

学校读者我要写书评

暂无评论

Nomogram to screen older adult patients attending the radiology department for sarcopenia

引用

BMC GERIATRICS 2025年第1期25卷 1-9页

作者： Yuan, Guiying Ye, Guoxi hu, Jianguang hu, huimin Shi, Chanmei Zhang, Ye huang, Junbing Li, Zhiqiong Zeng, xuwen Tan, Rongshao Xiong, Yuchao Jinan Univ Guangzhou Red Cross Hosp Dept Resp Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Radiol 396 Tongfu Rd Guangzhou Guangzhou 510220 Guangdong Provi Peoples R China Jinan Univ Guangzhou Red Cross Hosp Dept Nephrol Guangzhou Peoples R China Jinan Univ Guangzhou Red Cross Hosp Inst Dis Oriented Nutr Res Dept Clin Nutr Guangzhou Peoples R China

BackgroundSarcopenia is an age-related syndrome that can impact the physical and mental health of older adults. However, it is often overlooked in clinical practice. Therefore, we aim to construct a nomogram based on simplified discriminant parameters for screening older adult patients for sarcopenia *** cross-sectional study included 654 patients aged >= 60 years who underwent an examination in the radiology department between October 2023 and June 2024. Patients were diagnosed with sarcopenia according to the method and cutoff value criteria proposed the Asian Working Group on Sarcopenia (AWGS) 2019 criteria. Calf circumference (CC), SARC-F score, mid-upper arm circumference (MUAC), and SARC-CalF score were used as simplified discriminant parameters for sarcopenia. The discriminative ability of these parameters for sarcopenia was assessed using receiver operating characteristic analysis. Additionally, we included each screening parameter and evaluated it's important for screening for the presence of sarcopenia via univariate and multivariate logistic regression analysis to develop a new screening nomogram model. The performance of the nomogram was evaluated using receiver operating characteristic curves, and the performance of the nomogram model was compared to that of CC, SARC-F, MUAC, and the SARC-CalF using the Delong *** the 654 subjects, 120 (18.3%) were diagnosed with sarcopenia, and the areas under the curve (AUCs) of the CC, SARC-F, MUAC, and SARC-CalF were 0.73, 0.61, 0.66, and 0.70, respectively. The multivariate analysis results revealed that older age, male sex, low CC, low MUAC, and low strength were related to sarcopenia. A nomogram model constructed with these five variables had an AUC of 0.84. The DeLong test showed that the diagnostic efficacy of the joint model was significantly higher than that of CC, SARC-F, MUAC, and *** simple nomogram based on simplified discriminant parameters offers personalized

关键词： Sarcopenia Nomogram Calf circumference SARC-F SARC-CalF

来源：评论

学校读者我要写书评

暂无评论

Development and Validation of a Screening Tool for Generalized Anxiety and Major Depressive Disorder in Patients with Chronic Obstructive Pulmonary Disease

引用

LUNG 2025年第1期203卷 1-12页

作者： Liu, Meishan Yang, xuwen Wang, Dong Fang, Jiexin Li, Boyu An, Li Chang, Yuhan Liu, Haiman hu, Yongdong huang, Kewu Capital Med Univ Beijing Inst Resp Med Dept Resp & Crit Care Med 8Gongti South Rd Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp 8Gongti South Rd Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp Dept Clin Psychol 8Gongti South Rd Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp Dept Pharm Beijing Peoples R China

PurposeAnxiety and depression are often underdiagnosed in patients with chronic obstructive pulmonary disease (COPD). This study aimed to develop and validate a screening tool for anxiety and depression in COPD *** COPD patients were consecutively recruited from November 2021 to October 2023 and underwent a psychiatric interview to diagnose generalized anxiety disorder (GAD) and/or major depressive disorder (MDD) based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Patients were split into training and validation sets according to their recruitment time. We assessed known risk factors and used core items from the Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS) to develop a prediction nomogram. Multivariable logistic regression with least absolute shrinkage and selection operator (LASSO) were used to construct the *** the enrolled COPD patients (n = 329), 58 (25.6%) in the training cohort and 33 (32.4%) in the validation cohort were diagnosed with GAD and/or MDD. Three variables were identified in the prediction nomogram: COPD Assessment Test score and two core items from PHQ-ADS. The under the curve (AUC) value for the nomogram was 0.826 (95% CI: 0.755-0.897) and 0.855 (95% CI: 0.767-0.942) in the training and validation cohorts, respectively. The calibration curve was close to the diagonal. The discriminatory power of the screening nomogram was comparable to that of PHQ-ADS (AUC: 0.826 vs. 0.831, P = 0.832).ConclusionThe new screening tool for GAD and MDD in COPD patients is concise and valid, with discriminatory power comparable to existing anxiety/depression screening questionnaires.

关键词： Chronic obstructive pulmonary disease Anxiety Depression Screening Nomogram

来源：评论

学校读者我要写书评

暂无评论

High expression of aryl hydrocarbon receptor (AhR) plays an important role in the formation of fibrous epulis

引用

ORAL DISEASES 2022年第8期28卷 2258-2266页

作者： Zeng, xuwen Xia, Siying Yan, Xiangzhen hu, Congjiao An, Kangkang Luo, Lijun Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dept Periodont Sch Stomatol Shanghai Peoples R China

Objectives Epulis is considered to be a massive reactive lesion rather than a true neoplasia. AhR is thought to be associated with inflammation and development of neoplasms. Here, we aimed to observe the expression of AhR in fibrous epulis and explore its role and possible mechanism in the pathogenesis of epulis. Materials and Methods Epulis and normal gingival tissues were collected, and AhR expression was detected at the mRNA and protein levels by quantitative polymerase chain reaction (qPCR) and immunohistochemistry, respectively. The expression levels of proinflammatory cytokines and apoptosis-related factor genes in human periodontal ligament cells (hPDLCs) and human gingival fibroblasts (hGFs) transfected with AhR short interfering RNA (siRNA) or negative control siRNA, upon stimulation with lipopolysaccharide of Porphyromonas gingivalis (Pg-LPS), were then examined. Finally, the expression levels of the proinflammatory cytokines and apoptosis-related factor genes in the epulis tissues were observed by qPCR. Results AhR expression in fibrous epulis was significantly increased at both the mRNA and protein levels. The expression of proinflammatory cytokines and apoptosis-related factor genes in hPDLCs transfected with AhR siRNA was significantly decreased when stimulated with Pg-LPS. The same trends were observed for hGFs. The opposite trend was detected in the epulis tissues. Conclusion AhR may be a key factor in fibrous epulis pathogenesis that acts by regulating the expression of BCL2 family genes and inflammatory factor-related genes.

关键词： apoptosis aryl hydrocarbon receptor fibrous epulis P gingivalis

来源：评论

学校读者我要写书评

暂无评论

The catalytic thermal decomposition of ammonium perchlorate on CuMxOy (M = Fe, Ni, Co and Zn) catalysts and their applications in solid propellant

引用

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 2023年第13期148卷 6013-6026页

作者： hu, Yinghui Wang, xuwen Hao, Jingwei Jiang, Shouhang Zhang, Jian Yang, Yulin Lin, Kaifeng Zheng, Jian Shuai, Yong Harbin Inst Technol Sch Chem & Chem Engn MIIT Key Lab Crit Mat Technol New Energy Convers & Harbin 150001 Peoples R China Harbin Inst Technol Sch Energy Sci & Engn Harbin 150001 Peoples R China China Aerosp Sci & Technol Corp 16 Fucheng Rd Beijing 100048 Peoples R China

The excellent thermal decomposition efficiency of ammonium perchlorate (AP) is of great importance for obtaining propellant with fast specific impulse. In this study, four CuMxOy catalysts, including M = Fe, Ni, Co, and Zn, were synthesized and then used for catalyzing AP decomposition and hydroxyl-terminated polybutadiene (HTPB)-based solid propellant combustion. The existed synergistic effect in CuMxOy catalysts improved the catalytic activity and the most active CuZnO catalyst decreased the AP high-temperature decomposition temperature (HTD) from 412.5 to 289.4 ?. Kinetic studies indicated that CuMxOy catalysts inhibited the conversion of N2O to a fully oxidized product and decreased the activation energy (E-a) in HTD to concentrate AP decomposition to significantly decrease the heat loss, thereby increasing their decomposition efficiency. When applying the CuMxOy catalysts in the HTPB (hydroxyl-terminated polybutadiene)-based solid propellant, a faster burning rate and stronger optical emission spectrum were obtained. The CuMxOy catalyst is a potential additive for the preparation of outstanding combustion solid propellants.

关键词： Bimetal oxide catalyst Ammonium perchlorate Thermal decomposition Catalytic mechanism Burning rate

来源：评论

学校读者我要写书评

暂无评论

Identification, Characterization, and Receptor Binding Mechanism of New Umami Peptides from Traditional Fermented Soybean Paste (Dajiang)

引用

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2023年第48期71卷 18953-18962页

作者： Cao, Kaixin An, Feiyu Wu, Junrui Ji, Shuaiqi Rong, Yaozhong Hou, Yuchen Ma, xuwen Yang, Wenxin hu, Longkun Wu, Rina Shenyang Agr Univ Coll Food Sci Shenyang 110866 Liaoning Peoples R China Engn Res Ctr Food Fermentat Technol Shenyang 110866 Liaoning Peoples R China Key Lab Microbial Fermentat Technol Innovat Shenyang 110866 Liaoning Peoples R China Shanghai Totole Food Co Ltd Shanghai 201812 Peoples R China

Dajiang, a traditional Chinese condiment, is made from fermented soybeans. It is highly popular among consumers as a result of its delicious umami flavor, which mainly originates from umami peptides. To examine the mechanism of umami taste in Dajiang, we selected Dajiang samples with strong umami taste and subjected them to purification and identification analysis using ethanol precipitation, gel chromatography, reversed-phase high-performance liquid chromatography, and ultraperformance liquid chromatography-tandem mass spectrometry. Subsequently, on the basis of toxicity and umami prediction analysis, we screened, synthesized, and characterized three novel bean umami peptides in Dajiang: TLGGPTTL, 758.4174 Da;GALEQILQ, 870.4811 Da;and HSISDLQ, 911.4713 Da. Their sensory threshold values were 0.25, 0.40, and 0.17 mmol/L, respectively. Furthermore, molecular docking results showed that hydrogen-bonding and hydrophobic interactions are important interaction forces in the binding of umami peptide to taste receptors. Ser147 and Glu148 of the T1R3 taste receptor are important amino acid residues for binding of the three umami peptides. This study uncovers the mechanism of umami-peptide-driven flavor in fermented soybean products.

关键词： Dajiang umami peptides taste characteristics molecular docking

来源：评论

学校读者我要写书评

暂无评论

Cocrystals of axially N-embedded quasi-carbon nanohoops via modulating the electron affinity of guest acceptors

引用

Science China Chemistry 2025年

作者： Li Zhang Shuhai Qiu Shunlong hu Hanren Xu xuwen Sun Wei Jiang Da-hui Qu Zhaohui Wang Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materi-obiology and Dynamic Chemistry Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of Chemistry Tsinghua University

Organic donor-acceptor cocrystals of π-conjugated molecues have shown diverse applications in materials science. However,most cocrystals exist in neutral forms dominated by π-π interactions, while the ionic congeners and corresponding properties are rarely studied due to difficulties in harnessing the degree of charge transfer. Herein, we report cocrystals of axially N-embedded quasi-carbon nanohoops(DPP-D and DPP-T) with electron deficient guests. By modulating the electron affinity of the acceptor guests, the electronic structures of the complexes can be tuned from neutral to ionic states. Specifically, DPP-D interacts with TCNB molecules to form neutral superstructures via intermolecular π-π interactions, giving rise to a deep-red emission in the solid state. In contrast, an ionic complex showing near-infrared region absorptions and paramagnetic character on account of strong charge-transfer interactions is generated when DDQ molecules are involved. Their unique properties can be explained by different degrees of charge transfer and assembly modes, which have clearly been manifested by crystal structures and theoretical calculations. Our studies provide rare examples of π-conjugated macrocycle-based donor-acceptor cocrystals in both neutral and ionic forms, and give insight to the design of multicomponent carbon nanomaterials.

关键词：

来源：评论

学校读者我要写书评

暂无评论

A cohort of five cases with asymmetric conjoined twining and literature review

引用

PEDIATRIC SURGERY INTERNATIONAL 2022年第1期38卷 169-181页

作者： Zhi, Xiufang hu, Bo Zhao, xuwen Chen, Jing Gu, Chunyu Pu, Linjie Fang, Yulian Cai, Chunquan Tianjin Med Univ Grad Coll Tianjin 300070 Peoples R China Tianjin Univ Childrens Hosp Tianjin Childrens Hosp Tianjin 300134 Peoples R China Tianjin Childrens Hosp Dept Neonatal Surg Tianjin 300134 Peoples R China Tianjin Childrens Hosp Dept Radiol Tianjin 300134 Peoples R China Tianjin Pediat Res Inst Tianjin 300134 Peoples R China Tianjin Key Lab Birth Defects Prevent & Treatment Tianjin 300134 Peoples R China Tianjin Childrens Hosp Dept Neurosurg 238 Longyan Rd Tianjin 300134 Peoples R China

Purpose Asymmetric conjoined twining (ACT) is a form of conjoined twining which is a rare malformation of monochorionic monoamniotic twin pregnancy. Most publications were single case reports. We reported a cohort of five cases with ACT from a single tertiary medical center and reviewed the case reports of ACT over the last decade to enrich the clinical research of this disease and summarized the clinical features of the disease. Methods We reviewed five cases of ACT admitted in Tianjin Children's Hospital from 17 March, 2008, through 7 March 2017. The cohort was analysed from general information, imaging manifestations, separation surgery, histopathological findings, outcome and follow-up. We searched the English literatures on case reports of ACT over the past decade from the PubMed database and presented details about the clinical characteristics, treatment, and prognosis of all cases. Results There were four males and one female in our cohort. Among the five cases, two parasites were located in epigastrium, two in rachis, and one in retroperitoneum (fetus in fetu, FIF). All of the parasites were separated successfully by operation in five cases and were confirmed to be ACT by histopathology reports. Four patients made an uneventful recovery except for one case of wound infection. All of them were doing well in follow-up. In the literature review, we found 41 cases of exoparasitic heteropagus twining (EHT) and 63 cases of FIF. Conclusions ACT is very rare and usually diagnosed by prenatal ultrasonography (US). Computed tomography (CT) and magnetic resonance imaging (MRI) examinations are essential imaging examinations before separation surgery to delineate the anatomical relationship between the autosite and the parasite. In general, the separation surgery of ACT is less complicated and the prognosis is better compared with the symmetric conjoined twining (SCT).

关键词： Asymmetric conjoined twining Separation surgery Autosite Parasite

来源：评论

学校读者我要写书评

暂无评论

Direct Arylation Polycondensation of β-Fluorinated Bithiophenes to Polythiophenes: Effect of Side Chains in C-Br Monomers

引用

MACROMOLECULES 2022年第18期55卷 8095-8105页

作者： Zhang, xuwen Shi, Yibo Dang, Yanfeng Liang, Ziqi Wang, Zhongli Deng, Yunfeng Han, Yang hu, Wenping Geng, Yanhou Tianjin Univ Sch Mat Sci & Engn Tianjin 300072 Peoples R China Tianjin Univ Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Collaborat Innovat Ctr Chem Sci & Engn Tianjin Sch Mat Sci & Engn Tianjin 300072 Peoples R China Tianjin Univ Dept Chem Tianjin 300072 Peoples R China Collaborat Innovat Ctr Chem Sci & Engn Tianjin Tianjin Key Lab Mol Optoelect Sci Tianjin 300072 Peoples R China Tianjin Univ Natl Univ Singapore Joint Sch Int Campus Fuzhou 350207 Peoples R China Tianjin Univ Int Campus Fuzhou 350207 Peoples R China

Six polythiophenes (PThs) were synthesized via direct arylation polycondensation (DArP) with beta-fluorinated bithiophenes, that is, 4,4' -difluoro-2,2'-bithiophene (2FBT) and 3,3',4,4'-tetrafluoro-2,2'-bithiophene (4FBT), as the C-H monomers and 5,5'-dibromo-2,2'-bithiophenes DCBT-2Br, DABT-2Br, and DTBT-2Br that carry alkoxycarbonyl, alkyl, and alkylthienyl side chains at 4,4'-positions, respectively, as the C-Br monomers. Both 2FBT and 4FBT are highly reactive for DArP, and high molecular weight PThs with unobservable chain defects were successfully synthesized from 2FBT/DCBT-2Br, 2FBT/DABT-2Br, 2FBT/DTBT-2Br, and 4FBT/DTBT-2Br. However, the DArP of 4FBT with DCBT-2Br and DABT-2Br produced PThs containing C-H/C-H homo-coupling defects along with relatively lower molecular weights. Detailed theoretical analysis suggests that the occurrence of C-Br reduction-provoked C-H/C-H homo-coupling for 4FBT/DCBT-2Br and 4FBT/DABT-2Br monomer pairs originated from the poor selectivity between the cis- and trans-forms of transition states in the concerted metalation-deprotonation (CMD) process is responsible for the formation of structural defects and depressed molecular weights. This research reveals that a C-H monomer with high reactivity and selectivity is not sufficient for the synthesis of well-defined conjugated polymers via DArP, and the structure of the C-Br monomer also has a significant impact on the results of DArP via influencing the catalytic cycles.

关键词： Defects Monomers Polymerization Polymers Selectivity

来源：评论

学校读者我要写书评

暂无评论

A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells

引用

INORGANIC CHEMISTRY FRONTIERS 2022年第10期9卷 2290-2297页

作者： Da, xuwen Yu, Fei-hu Zhang, Chao Wang, Zhanhua Jian, Yao Hou, Yuanjun Chen, Yong Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Precise control of luminescence and singlet oxygen generation is important for selective photo-theranostic applications. In this work, bioorthogonal assembly based on d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions was first proposed for selective cancer cell imaging and photodynamic therapy (PDT) treatment as a proof of concept. [Au(NHC)(2)](+) (NHC = N-heterocyclic carbene) cations loaded on hyaluronic acid were selectively taken up by cancer cells. The subsequent incubation with [MX2](-) (M = Au or Cu and X = halide or arylacetylide) anions led to the bioorthogonal assembly of C3 + A5/A10 in cancer cells with luminescence turn-on and singlet oxygen generation upon irradiation. This work not only demonstrates that d(10)MIDLINE HORIZONTAL ELLIPSISd(10) metallophilic interactions can be readily harnessed for developing bioorthogonal assembly to realize precise cancer cell imaging and PDT, but also can stimulate the development of supramolecular interaction based bioorthogonal chemistry.

关键词： Cancer cells

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：