The androgen receptor is a ligand-dependent transcriptional factor and an essential therapeutic target for prostate cancer. Competitive binding of antagonists to the androgen receptor can alleviate aberrant activation...
The androgen receptor is a ligand-dependent transcriptional factor and an essential therapeutic target for prostate cancer. Competitive binding of antagonists to the androgen receptor can alleviate aberrant activation of the androgen receptor in prostate cancer. In recent years, computer-aided drug design has played an essential part in the discovery of novel androgen receptor antagonists. This review summarizes the recent advances in the discovery of novel androgen receptor antagonists through computer-aided drug design approaches;and discusses the applications of molecular modeling techniques to understand the resistance mechanisms of androgen receptor antagonists at the molecular level.
隐含碳排放限值是建筑结构碳排放量化调控与减碳目标保障的关键指标。本文从社会“碳中和”所需减碳路径出发,依据建筑结构保有与需求量中的新建与既有结构构成比例,提出减碳目标分解方法,为既有结构低碳维护与新建结构低碳设计提供与宏观年度减碳需求相匹配的限值预设依据。依托“双碳”目标的减碳需求构建行业预期发展情景,得出在维持现状、常规预估、拆除限制、减量预估四类典型情景下,2022年我国新建建筑结构隐含碳排放限值分别为442.6 kg CO_(2)e·m^(-2)、456.2 kg CO_(2)e·m^(-2)、485.9 kg CO_(2)e·m^(-2)、616.0 kg CO_(2)e·m^(-2)(对应结构设计使用年限50年);给出2022—2060年建筑结构建造与维护碳排放限值的变化趋势,厘清了新建结构总量控制、既有结构延寿等减碳措施促使结构单体隐含碳排放限值宽松的成效。进一步从概率化调控、区域特征量化、可操作性、数据驱动优化等方面,提出了建筑结构隐含碳排放限值设定的相关建议。
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