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Development of Innovative Experiment Program for Biomedical Engineering and Research and Practice of the Practical Ability Cultivation for Undergraduates

Development of Innovative Experiment Program for Biomedical ...

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IEEE Workshop on Advanced Research and Technology in Industry Applications (WARTIA)

作者： Yang lin Zhang Song Cui Jingxuan Yang Yimin Sun Kaiji li xuwen li Chengjie Hao Dongmei Beijing Univ Technol Biol Engn & Life Sci Coll Beijing Peoples R China

ISBN: (纸本)9781479969890

In order to improve University Quality Education, and develop the practical ability of research and innovation of Undergraduates majoring in Biomedical Engineering, this project probes into the development of innovative experiment program for Biomedical Engineering and research on the practical ability cultivation for undergraduates from various aspects, intended to choose interesting experiment topics, encourage independent innovative experiments and efficient innovation team, on the basis of a comparison between Chinese and foreign implementation of innovative experimental program of Biomedical Engineering, combing with the applicants' teaching experiences, as well as the theories and methods in education, engineer and medicine. Moreover, it proposes a set of training hands-on ability processes with its own characteristics for Biomedical Engineering majors, which is "be experimental - participator - leader- thinking after experiment", conducive to promote students to learn by doing, research while learning and innovate in research, as well as of great significance to enhance their innovative ability to research, practical ability and comprehensive quality.

关键词： component Innovative experiment Biomedical Engineering Practical ability

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Employing supercritical n-butanol to remove the EVA film for the delamination of photovoltaic laminated module

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JOURNAL OF SUPERCRITICAL FLUIDS 2025年 219卷

作者： Wang, xuwen liu, Zhifeng Ruan, Haoda li, Xinyu Zhang, Lei Hefei Univ Technol Sch Mech Engn Hefei 230009 Peoples R China Anhui Prov Key Lab Low Carbon Recycling Technol & Hefei 230009 Peoples R China State Key Lab Environm Adaptabil lndustrial Prod Guangzhou 510300 Peoples R China

The rapid advancement of the photovoltaic (PV) industry has elevated the recycling and reuse of decommissioned PV modules to critical challenges, essential for tackling environmental concerns and achieving resource reutilization. To facilitate the efficient layering of PV modules and recovery of valuable materials, this study proposes a PV module degradation and recycling process utilizing supercritical n-butanol. A systematic evaluation was conducted to assess the effects of various factors on the dissolution ratio of PV modules, with an appropriate range of process parameters selected for optimization. A second-order regression model was developed to predict the dissolution ratio of the EVA film. Comparison of actual dissolution ratio with model predictions confirmed the high accuracy of the fitted model. Finally, characterization and elemental analysis of cells recovered from the supercritical process demonstrated the effectiveness of this recycling method, achieving more thorough degradation on the cell surfaces.

关键词： Photovoltaic Supercritical n-butanol Degradation Recycling Characterization

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Study of Pulse Wave Changes in Patients with End-stage Renal Disease Receiving Hemodialysis Treatment Pulse Wave changes in Hemodialysis 4

Study of Pulse Wave Changes in Patients with End-stage Renal...

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4th International Symposium on Artificial Intelligence for Medicine Science (ISAIMS)

作者： li, Ziwei Wang, Chong Yang, lin Yang, Jie li, Ying lian, Cuiting Hao, Dongmei li, Guangfei Yang, Yimin li, xuwen Beijing Univ Technol Fac Environm & Life Sci Beijing Peoples R China Capital Med Univ Beijing Jishuitan Hosp Beijing Peoples R China

ISBN: (纸本)9798400708138

This study presents a novel experimental approach to investigate the changes in pulse wave patterns and pulse wave characteristic parameters in patients before, during, and after hemodialysis by analyzing radial artery pulse waves collected at time intervals from end-stage renal disease patients receiving hemodialysis. The results show that the morphology of the pulse wave is characterized by diversity between patients due to different vascular elasticity, but five categories can be classified according to the shape. When individuals of the same waveform Type-Are studied, we found that there were significant differences in some of the characteristic parameters of the pulse wave at different times of the day as the hemodialysis process progressed, a finding that also verifies the existence of hemodynamic changes during hemodialysis.

关键词： Hemodialysis Hemodynamics Pulse wave

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INDIVIDUAliZED SPORTS MANAGEMENT SCHEME FOR PREGNANT WOMEN IN CHINA

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JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2019年第8期19卷

作者： Yang, lin Luo, Qi Lu, Yang Zhang, Song Yang, Yimin li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Beijing 100124 Peoples R China Beijing Elect Power Hosp Beijing 100073 Peoples R China Beijing Aerosp Chang Feng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

In recent years, pregnant women in China generally face problems such as unbalanced and excessive nutrition, lack of proper exercise during pregnancy, which shows a significant increase in weight during pregnancy, leading to an increasing trend of perinatal complications. At present, there is less sports health management system for pregnant women throughout pregnancy. In view of this, based on the existing research in related fields, this study deeply explores the appropriate monitoring methods of pregnant women's sports in China. In this study, effective and convenient testing methods and evaluation criteria were proposed for pregnant women's sports and psychology. The research idea was a method based on the pulse wave to detect pregnant women's cardiac reserve capacity, and grading the Diastolic/Systolic value of pregnant women as a reference for grading individualized target heart rate range of moderate intensity exercise. The effective time and energy expenditure of pregnant women were assessed by monitoring the exercise process. The purpose is to help and guide pregnant women in the whole process of pregnancy self-movement management, and thus improve the quality of maternal health care services in China.

关键词： Pregnancy health sports management pulse wave, exercise assessment

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Research of the assessable method of postpartum hemorrhage

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TECHNOLOGY AND HEALTH CARE 2016年第Suppl 2期24卷 S465-S469页

作者： Chi, Zhenyu Zhang, Song Wang, Yang Yang, lin Yang, Yimin li, xuwen Beijing Univ Technol Coll Life Sci & Bioengn Beijing Peoples R China Shenzhen Huada Gene Res Inst Shenzhen Guangdong Peoples R China

BACKGROUND: Postpartum hemorrhage (PPH) is the most common cause of parturient death worldwide [1]. However, most cases of PPH can be avoided. OBJECTIVE: This paper employs statistical methods to screen risk factors of PPH and calculate relevant parameters. METHODS: Multivariable logistic regression analysis was applied to obtain the regression equation and odds ratio (OR) value. The determined risk factors were assigned comprehensive and reasonable scores according to scientific relevance and reasoning according to the OR value. P-PPH values were calculated in order to assess the morbidity of PPH. RESULTS: The scores of pregnant women could be intuitively used to show the risk of getting PPH. CONCLUSIONS: Through the above methods, a comprehensive risk evaluation method of detecting PPH was developed.

关键词： Postpartum hemorrhage high risk factors comprehensive scores

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Analysis of heart rate variation and foetal quiet sleep cycle correlation for normal and suspicious foetuses

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BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 2018年第4期32卷 988-992页

作者： li, Guangfei Zhang, Song Yang, lin li, Shufang Wang, Yan Zhao, Yangyu Yang, Yimin Hao, Dongmei li, xuwen Zhang, Lei Xu, Mingzhou Beijing Univ Technol Coll Life Sci & Bioengn Beijing Peoples R China Peking Univ Hosp 3 Obstet & Gynecol Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China Beijing Aerosp Changfeng Co Ltd Beijing Peoples R China

Cardiotocography (CTG) is the basic method of monitoring foetal condition in the perinatal period. However, due to the limited insight into the CTG generation mechanism, some CTG recordings can be mistreated as a predictor of neonatal asphyxia, leading to a wrong assessment of the foetal status and improper obstetric intervention. Therefore, in case of suspicious CTG indications, a reliable verification of the true foetal status is vital for reducing the clinical diagnosis false-positive rate and avoiding the unnecessary obstetrician intervention. The paper presents the results obtained for 44 foetuses on the shares of three heart rate variation (HRV) ranges and quiet sleep cycles. This approach uses the parameters of the HRV range shares and quiet sleep cycles to analyse different types of foetuses. The results obtained show that most parameters reveal significant differences between normal and suspicious groups. This is quite lucrative for defining a set of coefficients, whose incorporation into a classifier will improve the accuracy of distinguishing the normal foetuses from suspicious ones.

关键词： Foetal heart rate foetal quiet sleep HRV range share

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FLAVONOIDS FROM THE LEAVES OF Actinidia kolomikta

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CHEMISTRY OF NATURAL COMPOUNDS 2010年第2期46卷 205-208页

作者： Lu, Juan Jin, Yongri liu, Guiying Zhu, Na Gui, Mingyu Yu, Aimin li, xuwen Jilin Univ Coll Chem Changchun 130021 Peoples R China Changchun Normal Univ Coll Chem Changchun 130021 Peoples R China

One new acetylated flavonoid, kaempferide-7-O-(4 ''-O-acetyl)-alpha-L-rhamnoside, and six known flavonoids were isolated from the EtOAc fraction of the leaves of Actinidia kolomikta (Rupr. et Maxim.) Planch. The chemical structures of the isolated compounds were established by application of chemical and spectroscopic analysis. The new acetylated flavonoid was screened for its protective effect on human erythrocytes against AAPH-induced hemolysis, and it can slow the hemolysis induced by AAPH.

关键词： Actinidia kolomikta Actinidiaceae acetylated flavonoid AAPH-induced hemolysis

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Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss

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JOURNAL OF PSYCHIATRIC RESEARCH 2023年第1期162卷 11-20页

作者： li, Guangfei li, Yashuang Zhang, Zhao Chen, Yu li, Bao Hao, Dongmei Yang, lin Yang, Yimin li, xuwen li, Chiang-Shan R. Beijing Univ Technol Fac Environm & Life Dept Biomed Engn Beijing Peoples R China Beijing Int Sci & Technol Cooperat Base Intelligen Beijing Peoples R China Beijing Inst Technol Sch Life Sci Dept Biomed Engn Beijing Peoples R China Yale Univ Sch Med Dept Psychiat New Haven CT USA Yale Univ Sch Med Dept Neurosci New Haven CT USA Yale Univ Sch Med Interdept Neurosci Program New Haven CT USA Yale Univ Wu Tsai Inst New Haven CT USA Beijing Univ Technol 220 Life Sci Bldg 100 Pingleyuan Beijing 100124 Peoples R China Connecticut Mental Hlth Ctr S112 34 Pk St New Haven CT 06519 USA

Ventral striatum (VS) processes rewarding and punishing stimuli. Women and men vary in externalizing and internalizing traits, which may influence neural responses to reward and punishment. To investigate sex dif-ferences in how individual traits influence VS responses to reward and punishment, we curated the data of the Human Connectome Project and identified 981 (473 men) subjects evaluated by the Achenbach Adult Self-Report Syndrome Scales. We processed the imaging data with published routines and extracted VS response (beta) to win and to loss vs. baseline in a gambling task for correlation with externalizing and internalizing symptom severity. Men vs. women showed more severe externalizing symptoms and higher VS response to monetary losses (VS-loss beta) but not to wins. Men but not women showed a significant, positive correlation between VS-loss beta and externalizing traits, and the sex difference was confirmed by a slope test. The correlations of VS-loss vs. exter-nalizing and of VS-win vs. externalizing and those of VS-loss vs. externalizing and of VS-loss vs. internalizing traits both differed significantly in slope, confirming its specificity, in men. Further, the sex-specific relationship between VS-loss beta and externalizing trait did not extend to activities during exposure to negative emotion in the face matching task. To conclude, VS responses to loss but not to win and their correlation with externalizing rather than internalizing symptom severity showed sex differences in young adults. The findings highlight the relationship of externalizing traits and VS response to monetary loss and may have implications for psychological models of externalizing behaviors in men.

关键词： Externalizing VS Punishment Sex differences fMRI

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A novel injectable calcium phosphate-based nanocomposite for the augmentation of cannulated pedicle-screw fixation

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INTERNATIONAL JOURNAL OF NANOMEDICINE 2017年第20170427期12卷 3395-3406页

作者： Sun, Haolin liu, Chun liu, Huiling Bai, Yanjie Zhang, Zheng li, xuwen li, Chunde Yang, Huilin Yang, Lei Peking Univ Dept Orthoped Hosp 1 8 Xishiku St Beijing 100034 Peoples R China Soochow Univ Inst Orthoped Dept Orthoped Affiliated Hosp 1 Suzhou Peoples R China Soochow Univ Sch Publ Hlth Med Coll Suzhou Peoples R China Soochow Univ IRCTO Suzhou Peoples R China

Polymethyl methacrylate (PMMA)-augmented cannulated pedicle-screw fixation has been routinely performed for the surgical treatment of lumbar degenerative diseases. Despite its satisfactory clinical outcomes and prevalence, problems and complications associated with high-strength, stiff, and nondegradable PMMA have largely hindered the long-term efficacy and safety of pedicle-screw fixation in osteoporotic patients. To meet the unmet need for better bone cement for cannulated pedicle-screw fixation, a new injectable and biodegradable nanocomposite that was the first of its kind was designed and developed in the present study. The calcium phosphate-based nanocomposite (CPN) exhibited better anti-pullout ability and similar fluidity and dispersing ability compared to clinically used PMMA, and outperformed conventional calcium phosphate cement (CPC) in all types of mechanical properties, injectability, and biodegradability. In term of axial pullout strength, the CPN-augmented cannulated screw reached the highest force of similar to 120 N, which was higher than that of PMMA (similar to 100 N) and CPC (similar to 95 N). The compressive strength of the CPN (50 MPa) was three times that of CPC, and the injectability of the CPN reached 95%. In vivo tests on rat femur revealed explicit biodegradation of the CPN and subsequent bone ingrowth after 8 weeks. The promising results for the CPN clearly suggest its potential for replacing PMMA in the application of cannulated pedicle-screw fixation and its worth of further study and development for clinical uses.

关键词： calcium phosphate nanocomposite injectable biodegradable pedicle screw lumbar degenerative disease osteoporosis

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Case study on the combined use of surface seawater injection and depressurization for sustainable natural gas hydrate extraction

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JOURNAL OF CLEANER PRODUCTION 2025年 494卷

作者： Zhang, Zhaobin li, Yuxuan li, Shouding He, Jianming li, Xiao Lu, Cheng Qin, xuwen Chinese Acad Sci Inst Geol & Geophys Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China China Geol Survey Minist Nat Resources Beijing 100037 Peoples R China

In response to the issue of inefficient extraction of natural gas hydrates due to a lack of heat supplementation during long-term production, a combined extraction method integrating surface seawater injection and depressurization has been proposed. Under the premise that the surface seawater injection pipeline possesses certain thermal insulation properties, this method can sustainably harness solar energy to replenish the thermal energy of gas hydrate reservoirs. Numerical simulations based on a validated three-dimensional heterogeneous model from the 2013 Nankai Trough pilot production in Japan demonstrate that this method significantly enhances hydrate extraction efficiency compared to depressurization alone. The results show that, over a 500-day production scenario, methane recovery efficiency can be enhanced by up to 150%. The study reveals that only an appropriate injection temperature can effectively improve the efficiency of hydrate exploitation. Compared to the depressurization-only method, this extraction approach increases the temperature driving force (TDF) near the injection well improved by up to 12 K. However, higher injection rates suppress depressurization effects, requiring a balance between injection temperature and rate. The proposed approach also facilitates more uniform reservoir deformation, reducing localized subsidence risks. These findings suggest that the combined surface seawater injection and depressurization method provides an effective and environmentally friendly solution for sustainable hydrate exploitation.

关键词： Natural gas hydrate Surface seawater injection Injection temperature and rate Temperature driving force Reservoir deformation

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