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CUG-STCN: A seabed topography classification framework based on knowledge graph-guided vision mamba network

INTERNATIONAL JOURNAL OF APPliED EARTH OBSERVATION AND GEOINFORMATION 2025年 136卷

作者： Wang, Haoyi Chen, Weitao li, Xianju liang, Qianyong Qin, xuwen li, Jun China Univ Geosci Fac Comp Sci Wuhan 430074 Peoples R China China Univ Geosci Key Lab Geol Survey & Evaluat Minist Educ Wuhan 430074 Peoples R China China Geol Survey Guangzhou Marine Geol Survey Guangzhou 511400 Peoples R China China Geol Survey China Aero Geophys Survey & Remote Sensing Ctr Nat Beijing 100083 Peoples R China

Multibeam sounding is a high-precision remote sensing method for seabed detection. Seabed topography classification is crucial for marine science research, resource exploration and engineering. When using multibeam data for seabed topography automatic classification, the fuzzy boundaries of different topographic entities, redundancy of multimodal data, and the lack of geological knowledge guidance have led to low classification accuracy. Thus, a knowledge graph-guided vision mamba seabed topography classification network (CUG-STCN) was constructed, consisting of three modules: (1) The long sequence modeling mamba-based encoder addresses the fuzzy seabed topography boundary. It uses 2D-selective-scan to create image blocks in different scanning directions. By combining with the selective state space model to capture long-range dependencies and ensure transmission of spatial context information while maintaining linear computational complexity. (2) The crossmodal information interaction and fusion module addresses the redundancy of multimodal information. By employing a bidirectional information interaction mechanism, it captures the correlations of seabed topography between different modalities and achieving feature fusion. (3) The seabed topography knowledge graph-guided semantic perception module guides the geological knowledge. It constructs seabed topography knowledge vectors through entity query and word embedding, using the similarity between vectors to create a similarity measurement matrix. It provides geological knowledge, enhancing the modeling capability of complex seabed topography relationship. CUG-STCN achieves OA of 90.11% and mIOU of 48.50%, outperforming six mainstream networks, which at most, achieve the OA and mIOU improvements of 5.37% and 14.18%. Notably, the application of CUG-STCN in other regions demonstrates its strong generalization performance.

关键词： Multibeam Seabed topography Mamba Knowledge graph Remote sensing

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Steroidal saponins from Allium chinense and their inhibitory effects on pancreatic lipase

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PHYTOCHEMISTRY LETTERS 2023年第1期55卷 22-29页

作者： Xie, Huili Shi, Xiaolei Wang, Bingzi Zhao, Dexin Sun, Zhiheng Chen, Yifu Feng, Yuezhu Jin, Yongri li, xuwen Jilin Univ Coll Chem Changchun 130012 Peoples R China Jilin Univ Coll Food Sci & Engn Changchun 130062 Peoples R China

Allium chinense *** is an important medicinal and edible homologous plant and indigenous to China and grown in other countries. Phytochemical studies have shown that it is rich in biologically active natural products. Herein, five new and twelve known steroidal saponins were isolated from the bulbs of Allium chinense ***. These compounds were structurally determined by analysis of their NMR, IR and HR-ESI-MS data. All isolates were evaluated for inhibition of porcine pancreatic lipase activity. Compounds 4, 7 and 10 exhibited potent inhibition of porcine pancreatic lipase. The relationship between structure and activity of these compounds is also investigated in this paper.

关键词： Allium chinense Steroidal saponins Extraction and isolation Structure identification lipase inhibitory activity

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Carbon sequestration in overlying methane hydrate layers via hydrate technology: Feasibility and synergistic benefits

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ENVIRONMENTAL TECHNOLOGY & INNOVATION 2025年 37卷

作者： Zhang, Zhaobin li, Yuxuan li, Shouding He, Jianming Xie, Zhuoran li, Xiao Lu, Cheng Qin, xuwen Chinese Acad Sci Inst Geol & Geophys Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Chinese Acad Sci Innovat Acad Earth Sci Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China China Geol Survey Minist Nat Resources Oil & Gas Resources Survey Beijing 100083 Peoples R China China Geol Survey Minist Nat Resources Beijing 100037 Peoples R China

Excessive carbon dioxide emissions pose a global environmental issue, and carbon sequestration technology offers a solution. This study based on independently developed simulator proposes a novel approach for carbon dioxide sequestration in the overlying layers of methane hydrate reservoirs using carbon dioxide hydrate technology. The feasibility and risks of this method are evaluated over a time scale of 100,000 years. Results show that carbon dioxide migrates upwards after injection, forming highly saturated hydrate shells at the migration front. Within these carbon dioxide hydrate shells, a portion of the carbon dioxide is sequestered in liquid and dissolved forms;however, over tens of thousands of years, 20% of the COQ will dissolve, while less than 1% will escape. The study highlights the synergy between methane hydrate extraction and carbon sequestration, as the cold seawater down draw effect from extraction enhances sequestration efficiency and safety. Given the widespread distribution of methane hydrate reservoirs globally, this research provides new insights into carbon sequestration technology.

关键词： Carbon dioxide sequestration Hydrate Carbon dioxide hydrate shells Carbon dioxide escapes Methane hydrate extraction

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Factors associated with blooms of cyanobacteria in a large shallow lake, China

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ENVIRONMENTAL SCIENCES EUROPE 2018年第1期30卷 1-15页

作者： li, Di Wu, Naicheng Tang, Song Su, Guanyong li, xuwen Zhang, Yong Wang, Guoxiang Zhang, Junyi liu, Hongling Hecker, Markus Giesy, John P. Yu, Hongxia Nanjing Univ Sch Environm State Key Lab Pollut Control & Resource Reuse Nanjing 210046 Jiangsu Peoples R China Jiangsu Environm Monitoring Ctr Nanjing 210036 Jiangsu Peoples R China Univ Kiel Dept Hydrol & Water Resources Management D-24118 Kiel Germany Chinese Ctr Dis Control & Prevent Natl Inst Environm Hlth Beijing 100021 Peoples R China Nanjing Univ Sci & Technol Sch Environm & Biol Engn Jiangsu Key Lab Chem Pollut Control & Resources R Nanjing 210094 Jiangsu Peoples R China Nanjing Normal Univ Sch Environm Nanjing 210023 Jiangsu Peoples R China Wuxi Environm Monitoring Ctr Wuxi 214000 Jiangsu Peoples R China Univ Saskatchewan Toxicol Ctr Saskatoon SK S7N 5B3 Canada Univ Saskatchewan Sch Environm & Sustainabil Saskatoon SK S7N 5C3 Canada Univ Saskatchewan Dept Vet Biomed Sci Saskatoon SK S7N 5B3 Canada Univ Saskatchewan Toxicol Ctr Saskatoon SK S7N 5B3 Canada Michigan State Univ Dept Zool E Lansing MI 48824 USA Michigan State Univ Ctr Integrat Toxicol E Lansing MI 48824 USA Univ Hong Kong Sch Biol Sci Hong Kong Hong Kong Peoples R China

Background: Eutrophication of freshwater systems can result in blooms of phytoplankton, in many cases cyanobacteria. This can lead to shifts in structure and functions of phytoplankton communities adversely affecting the quality of drinking water sources, which in turn impairs public health. Relationships between structures of phytoplankton communities and concentrations of the toxicant, microcystin-leucine-arginine (MC-LR), have not been well examined in large shallow lakes. The present study investigated phytoplankton communities at seven locations from January to December of 2015 in Tai Lake, and relationships between structures and diversities of phytoplankton communities and water quality parameters, including concentrations of MC-LR and metals, were analyzed. Results: A total of 124 taxa of phytoplankton were observed, and the predominant taxa were Microcystis sp. and Dolichospermum flos-aquae of Cyanophyta and Planctonema sp. of Chlorophyta. The greatest diversities of phytoplankton communities, as indicated by species richness, Simpson, Shannon-Wiener, the Berger and Parker, and the Pielou evenness indices, were observed in spring. Furthermore, productivity of phytoplankton was significantly and negatively correlated with diversities. These results demonstrated that Simpson, Shannon-Wiener, the Berger and Parker, and the Pielou evenness indices of phytoplankton communities were significantly related to trophic status and overall primary productivity in Tai Lake. In addition, temperature of surface water, pH, permanganate index, biochemical oxygen demand, total phosphorus, arsenic, total nitrogen/total phosphorous ratio, and MC-LR were the main factors associated with structures of phytoplankton communities in Tai Lake. Conclusion: The present study provided helpful information on phytoplankton community structure and diversity in Tai Lake from January to December of 2015. Our findings demonstrated that Simpson, Shannon-Wiener, the Berger and Parker, and the

关键词： Eutrophication Nutrients Phosphorus Nitrogen Phytoplankton productivity Diversity Microcystin-LR

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Determination of IgG by electron spin resonance spectroscopy using Fe₃O₄ nanoparticles as probe

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MICROCHEMICAL JOURNAL 2018年 141卷 444-450页

作者： Tian, Sizhu Jiang, Jia Zang, Shuang Wang, Kun Yu, Yong li, xuwen Zhang, Hanqi Yu, Aimin Zhang, Ziwei Jilin Univ Coll Chem Qianjin St 2699 Changchun 130012 Jilin Peoples R China Jilin Univ Coll Instrumentat & Elect Engn West Minzhu St 938 Changchun 130061 Jilin Peoples R China

A novel electron spin resonance (ESR) spectroscopy method for determination of rabbit IgG was presented. Anti rabbit IgG antibody was bound to Fe3O4 nanoparticles (FeNPs). The FeNPs were used as probe to give ESR signal. After the optimization of the assay, a molar ratio 500:1 of antibody to FeNPs was selected. The sepharose beads were used as solid phase and used to separate the analyte from the sample solution. Two typical immunoassay formats, sandwich and competitive formats, were applied to the determination of IgG. The analytical sensitivities obtained by sandwich and competitive formats were 0.13 mu g mL(-1) and 0.56 mu g mL(-1), respectively. The two formats were applied to the determination of the rabbit IgG in rabbit serum. The diluted sample was directly analyzed and other additional sample treatment was not required. The analytical results of the spiked samples indicated that the recoveries of the analytes were acceptable. Furthermore, the sample preparation time used in this method is shorter than most existing immunoassay methods.

关键词： Electron spin resonance Sandwich Competitive Fe3O4 nanoparticles Sepharose beads Rabbit serum

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Intelligent Delivery Systems in Tumor Metabolism Regulation: Exploring the Path Ahead

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ADVANCED MATERIALS 2024年第11期36卷 2309582-2309582页

作者： li, xuwen Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Minist EducKey Lab Smart Drug Delivery Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Cancer metabolism plays multifaceted roles in the initiation and progression of tumors, and interventions in metabolism are considered fundamental approaches for cancer control. Within the vast metabolic networks of tumors, there exist numerous potential therapeutic targets, intricately interconnected with each other and with signaling networks related to immunity, metastasis, drug resistance, and more. Based on the characteristics of the tumor microenvironment, constructing drug delivery systems for multi-level modulation of the tumor microenvironment is proven as an effective strategy for achieving multidimensional control of cancer. Consequently, this article summarizes several features of tumor metabolism to provide insights into recent advancements in intelligent drug delivery systems for achieving multi-level regulation of the metabolic microenvironment in cancer, with the aim of offering a novel paradigm for cancer treatment. Latest advancements in intelligent drug delivery systems (DDS) exhibit distinctive advantages, including precise sensing, programmability, feedback control, and intrinsic activity. These attributes render them conducive to facilitating multi-dimensional therapeutic approaches grounded in metabolic ***

关键词： intelligent delivery systems metabolism regulation nanomedicine tumor metabolism

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Effect of Carburized Layer Depth on the Wear Reliability of Cams

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INTERNATIONAL JOURNAL OF AUTOMOTIVE TECHNOLOGY 2025年第3期26卷 799-812页

作者： Tang, Jie Chen, Jianzhi Shang, Fanmin Jing, xuwen Zhou, Honggen li, Guochao Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Peoples R China Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang 212003 Peoples R China

The carburizing process is the key technology to improve the wear properties of cams;however, the influence mechanisms of the carburized depth on the wear reliability of cams are still unclear. In this work, the multi-body dynamic simulation with the AVL_EXCITE TD software and the accelerated wear experiments of the cam-roller pairs were combined to analyze the wear reliability of cams with different carburized depths of 0 mm, 0.8 mm and 1.4 mm. The results indicate that allowable wear depth of the cam is predicted to be 0.916 mm according to the degradation rule of the valve fullness coefficient. The maximum wear failure life of different carburized cams corresponding to the wear reliability of 99% was determined to be 1.0 x 107 cycles, 3.2 x 109 cycles and 3.5 x 109 cycles based on the combination of online detection data and the multi-body dynamics simulation. The relationship model between the wear failure life of the carburized cams and the carburized depth is established, and the optimal carburized layer depth of 1.20 mm is speculated from the model. The present work can provide new clues for improving the wear resistance of mechanical components.

关键词： Carburized layer depth Wear reliability Simulation Accelerated wear experiments Cam

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Comprehensive feasibility analysis of carbon dioxide hydrate sequestration: A numerical study based on horizontal well networks

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ENVIRONMENTAL TECHNOLOGY & INNOVATION 2025年 37卷

作者： li, Yuxuan Zhang, Zhaobin li, Shouding He, Jianming Xie, Zhuoran li, Xiao Lu, Cheng Qin, xuwen Chinese Acad Sci Inst Geol & Geophys State Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China Minist Nat Resources China Geol Survey Beijing 100037 Peoples R China

Carbon dioxide sequestration is a crucial strategy for achieving carbon neutrality. This study explores a novel approach to carbon dioxide storage in marine environments in the form of hydrate, addressing the stringent site requirements of traditional geological storage methods. Using a custom-developed simulator, a conceptual model for carbon dioxide sequestration in subsea reservoirs under a horizontal well network configuration was constructed. Key factors, including seawater depth, injection depth, and well spacing, were analyzed through simulations to quantify carbon dioxide storage capacity and assess associated risks under various sequestration scenarios. The results indicate that increasing seawater depth boosts both COQ storage capacity and safety, while deeper injection enhances safety but reduces hydrate storage capacity and raises leakage potential. Closer well spacing improves early-stage safety but increases long-term risks. The study outlines distinct sequestration stages and provides detailed analyses of COQ migration and phase transformations over time, contributing insights for advancing COQ sequestration strategies.

关键词： Carbon dioxide sequestration Hydrate Horizontal well network Seawater depth Injection depth Well spacing

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Development of a new characteristic parameter - waveform index of finger blood volume pulse

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Computer Assisted Surgery 2016年第sup1期21卷 6-10页

作者： Wu, Wenjie Yang, lin Zhang, Song Hao, Dongmei Yang, Yimin li, xuwen Wu, Guanghui Zhang, Lei Luo, Zhichang Beijing Univ Technol Coll Life Sci & Bioengn 100 Ping Le Yuan Beijing 100124 Peoples R China Beijing Anzhen Hosp Beijing Peoples R China Beijing Yes Med Devices Co Ltd Beijing Peoples R China

Background: Finger blood volume pulse (F-BVP) contains abundant human cardiovascular system information, including information regarding circulation in the heart, blood vessel function, and the microcirculation system. Pulse waveform analysis is a method for analyzing F-BVP. Methods and results: A new parameter of F-BVP, called waveform index (WI), was extracted, defined, subsequently compared between groups of different cardiovascular function, and compared with age and systolic blood pressure. WI values of the negative and positive groups were 0.209 +/- 0.066 (p<.001) and 0.305 +/- 0.066 (p<.001), respectively. The classification threshold value of WI was 0.24, revealing a sensitivity of 77%, a specificity of 68% and a classification accuracy of 73%. The odds ratio (OR) was 7.164, indicating that subjects with WI > 0.24 had a 7.164 times greater risk of suffering from cardiovascular disease than of not suffering from cardiovascular disease. Age and systolic blood pressure had consistent correlation with WI, in addition, WI had the same trend with age and systolic blood pressure. Conclusion: Because WI of F-BVP was determined according to only F-BVP waveform and increases in age and systolic blood pressure, different values of WI represent different cardiovascular physiological conditions. To a certain extent, the changes of WI reflect the changes of human cardiovascular function. Therefore, WI has the potential to be widely used in disease screening and clinical practice.

关键词： Finger blood volume pulse waveform index cardiovascular function classification threshold value

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Targeting Hypoxia and Autophagy Inhibition via Delivering Sonodynamic Nanoparticles With HIF-2α Inhibitor for Enhancing Immunotherapy in Renal Cell Carcinoma

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ADVANCED HEALTHCARE MATERIALS 2024年第32期13卷 e2402973页

作者： Zhu, Yihao li, Yajian li, xuwen Yu, Yuan Zhang, lingpu Zhang, Hanchen Chen, Can Chen, Dong Wang, Mingshuai Xing, Nianzeng Yang, Feiya Wasilijiang, Wahafu Ye, Xiongjun Chinese Acad Med Sci & Peking Union Med Coll Dept Urol Natl Canc Ctr Natl Clin Res Ctr CancCanc Hosp Beijing 100021 Peoples R China Chinese Acad Sci Hangzhou Inst Med Zhejiang Canc Hosp Hangzhou 310022 Zhejiang Peoples R China Chinese Acad Sci Inst Chem Lab Polymer Phys & Chem Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Zunyi Med Univ Affiliated Hosp 2 Dept Oncol Zunyi 563000 Guizhou Peoples R China Shanxi Med Univ Canc Hosp Dept Urol Shanxi Prov Canc HospShanxi HospCanc HospChine Xian 030013 Shanxi Peoples R China

Immune checkpoint blockers (ICBs) therapy stands as the first-line treatment option for advanced renal cell carcinoma (RCC). However, its effectiveness is hindered by the immunosuppressive tumor microenvironment (TME). Sonodynamic therapy (SDT) generates tumor cell fragments that can prime the host's antitumor immunity. Nevertheless, the hypoxic microenvironment and upregulated autophagy following SDT often lead to cancer cell resistance. In response to these challenges, a hypoxia-responsive polymer (Poly(4,4 '-azobisbenzenemethanol-PMDA)-mPEG(5k), P-APm) encapsulating both a HIF-2 alpha inhibitor (belzutifan) and the ultrasonic sensitize (Chlorin e6, Ce6) is designed, to create the nanoparticle APm/Ce6/HIF. APm/Ce6/HIF combined with ultrasound (US) significantly suppresses tumor growth and activates antitumor immunity in vivo. Moreover, this treatment effectively transforms the immunosuppressive microenvironment from "immune-cold" to "immune-hot", thereby enhancing the response to ICBs therapy. The findings indicate that APm/Ce6/HIF offers a synergistic approach combining targeted therapy with immunotherapy, providing new possibilities for treating RCC.

关键词： HIF-2 alpha immunotherapy renal cell carcinoma sonodynamic therapy

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