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A study of a fetal heart rate calculation system based on R-R interval

TECHNOLOGY AND HEALTH CARE 2020年第S1期28卷 S187-S195页

作者： Zhang, Yisong Zhang, Song Yang, lin Yang, Yimin li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Intelligent Physiol Measurement & Clin Translat Beijing Int Base Sci & Technol Cooperat Beijing 100024 Peoples R China Beijing Aerosp ChangFeng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Fetal electrocardiogram (FECG) can be obtained in a non-invasive manner to monitor fetal growth status. OBJECTIVE: In this study, a fetal heart rate (FHR) calculation system was proposed, which consists of the FECG recorder (MF-HOLTER) and the FECG monitoring software (FECG-MS). The abdomen electrocardiogram (AECG) of pregnant woman is acquired through the MF-HOLTER. The FECG-MS packs the AECG data and calls the FECG separation algorithm to obtain the separated FECG and the fetal QRS (FQRS) position. The FHR is further obtained by calculating the R-R interval value. At the same time, this study proposed a FQRS position correction algorithm to calculate the correct FHR values. METHOD: In order to verify the accuracy of the FHR calculation, the ECG signal of FLUKE's PS320 FETAL SIMULATOR and clinical data were simultaneously tested. RESULTS: The accuracy rate is over 98% in processing the simulator's data. In processing clinical data, the FHR values obtained by both the system proposed in this study and Monica AN24 are very close, and the difference is less than 1 bpm. CONCLUSION: The results show that the FHR calculation system is accurate and stable, and has a positive application value and prospect.

关键词： Fetal ECG fetal heart rate R-R interval fetal QRS position correction

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Click-Nucleic-Acid-Containing Codelivery System Inducing Collapse of Cellular Homeostasis for Tumor Therapy through Bidirectional Regulation of Autophagy and Glycolysis

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ACS APPliED MATERIALS & INTERFACES 2020年第52期12卷 57757-57767页

作者： Guo, Qin Chen, Qinjun Zhang, Yujie Zhou, Wenxi li, xuwen li, Chao Zhang, Yiwen Chen, Hongyi liu, Peixin Chu, Yongchao Sun, Tao Jiang, Chen Fudan Univ State Key Lab Med Neurobiol Key Lab Smart Drug Delivery Minist Educ Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China

As a rapid proliferating tissue, tumor cells have to optimize nutrient utilization to withstand harsh conditions. Several approaches have been explored to inhibit the growth and metastasis of tumor by disrupting the reprogrammed tumor metabolism. However, nutrient limitations within solid tumors may induce the metabolic flexibility of malignant cells to sustain growth and survival using one nutrient to fill metabolite pools normally supplied by the other. To overcome this predicament, a promising click-nucleic-acid-containing platform for codelivery of rapamycin, anti-PFKFB4 siRNA, and targeting ligand aptamer AS1411 was applied. PFKFB4 could act as a promising target for tumor therapy for being a molecular fulcrum that could couple glycolysis to autophagy by promoting aggressive metastatic tumors. The downregulation of PFKFB4 can help inhibit the SRC3/Akt/mTOR pathway, leading autophagy to the direction of promoting apoptosis of tumor cells, which is induced by the collapse of tumor cellular homeostasis, while low dosages of rapamycin could decrease surgery-induced immune dysfunction. Enhanced tumor autophagy, favorable in vivo antitumor efficacy, and effective systematic immune activation are observed after treatment, suggesting that autophagy and glycolysis can serve as an integrated target for tumor treatment.

关键词： tumor metabolism codelivery click nucleic acid immune activation tumor therapy

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The Driver's Design and Implementation of PCIe High Speed Image Acquisition Card Based on WDF

The Driver's Design and Implementation of PCIe High Speed Im...

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2017 6th International Conference on Advanced Materials and Computer Science(ICAMCS 2017)

作者： Qiang Wu liang Xu xuwen li College of Information and Communication Engineering Faculty of Information TechnologyBeijing University of Technology College of Life Science and Bioengineering Beijing University of Technology

As a common high-speed interface,PCIe interface is very extensive in the field of data *** a development framework of Microsoft,WDF（Windows Driver Foundation）driver model can reduce the difficulty of the *** on the PCIe high-speed image acquisition card which is developed by ourselves,this paper designed a stable and reliable WDF driver for the high data transmission rate in the image acquisition process,and used the memory allocation method in WDF to share buffer with the *** order to enhance the speed of the image acquisition,this paper designed a ring buffer mechanism to ensure the continuity and stability in the image acquisition and transmission process.

关键词： Windows Driver PCIe Bus WDF Model DMA Transmission Ring Buffer

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Stereo Matching Algorithm of Color Image Based on Weber's Law and Census

Stereo Matching Algorithm of Color Image Based on Weber's La...

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International Conference on Intelligent Information Hiding and Multimedia Signal Processing (IIHMSP)

作者： Qiang Wu Xiangnan Zhao xuwen li College of Electronic Information and Control Engineering Beijing University of Technology Beijing China College of Life Science and Bioengineering Beijing University of Technology Beijing China

The algorithm presented here is used on unmanned aerial vehicles system. In 2013,*** proposed a matching cost computation model(or function), This matching cost model combined three kinds of constraints, the cost function is formulated by combining three individual costs:a cost computed on an extended census transformation of the images, the absolute difference cost, taking into account information from colour channels, and a cost based on the principal image *** show that the cost function is excellent performance in similar *** it to the stereo matching of ancient buildings, it is favorable for practical. However, this experiment, in color mutated region, leaded to blurred ***, our proposed method added color space structural information, which based on HVS Weber's law, to the cost function. we use the differential excitation of WLD reflects the structure of color *** robust cost measures can reduce percent of bad pixels in mutated color region. The proposed method use color image, which is used after epipolar line rectification.

关键词： Image color analysis Cost function Transforms Robustness Computed tomography Stereo vision Skeleton

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Effect of Carburized Layer Depth on the Wear Reliability of Cams

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INTERNATIONAL JOURNAL OF AUTOMOTIVE TECHNOLOGY 2025年第3期26卷 799-812页

作者： Tang, Jie Chen, Jianzhi Shang, Fanmin Jing, xuwen Zhou, Honggen li, Guochao Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Peoples R China Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang 212003 Peoples R China

The carburizing process is the key technology to improve the wear properties of cams;however, the influence mechanisms of the carburized depth on the wear reliability of cams are still unclear. In this work, the multi-body dynamic simulation with the AVL_EXCITE TD software and the accelerated wear experiments of the cam-roller pairs were combined to analyze the wear reliability of cams with different carburized depths of 0 mm, 0.8 mm and 1.4 mm. The results indicate that allowable wear depth of the cam is predicted to be 0.916 mm according to the degradation rule of the valve fullness coefficient. The maximum wear failure life of different carburized cams corresponding to the wear reliability of 99% was determined to be 1.0 x 107 cycles, 3.2 x 109 cycles and 3.5 x 109 cycles based on the combination of online detection data and the multi-body dynamics simulation. The relationship model between the wear failure life of the carburized cams and the carburized depth is established, and the optimal carburized layer depth of 1.20 mm is speculated from the model. The present work can provide new clues for improving the wear resistance of mechanical components.

关键词： Carburized layer depth Wear reliability Simulation Accelerated wear experiments Cam

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Study on Vehicle Video Blackbox with Acceleration Sensitive Function

Study on Vehicle Video Blackbox with Acceleration Sensitive ...

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International Conference on MultiMedia and Information Technology, MMIT

作者： Qiang Wu Kebin Jia xuwen li College of Electronic and Control Engineering Beijing University of Technology Beijing China College of Life Science and Bio-engineering Beijing University of Technology Beijing China

This paper studies on a new type vehicle video blackbox with acceleration sensitive function. Different with common blackbox on car, the system can record and store the analog video to H.264 bi stream files when acceleration exceeds the limitation value. The acceleration sensitive algorithm is derived. Experiments and calibration results are also given.

关键词： Vehicles Acceleration Signal processing algorithms Video compression MPEG 4 Standard Automatic voltage control IEC standards ISO standards Educational institutions Paper technology

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Facile synthesis of 3D N-doped porous carbon nanosheets as highly active electrocatalysts toward the reduction of hydrogen peroxide

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NANOSCALE 2018年第31期10卷 14923-14930页

作者： Lu, Nannan Zhang, Tingting Yan, Xiaoyi Gu, Yue liu, He Xu, Zhiqian Xu, Haixin li, xuwen Zhang, Zhiquan Yang, Ming Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China Jilin Univ Hosp 1 Dept Breast Surg Changchun 130012 Jilin Peoples R China

Constructing three-dimensional (3D) conductive frameworks with high specific surface areas and porous structures is indispensable for their applications as electrocatalysts. In this work, we illustrate for the first time that 3D N-doped porous carbon nanosheets (3D-NS), which are synthesized via a facile one-pot pyrolysis reaction using glucose and melamine as raw materials, can serve as high performance and green electrocatalysts for the reduction of H2O2. Moreover, a series of 3D-NS samples with a controllable content of nitrogen were obtained by adjusting the calcination temperature. From our research, the 3D-NS obtained at 900 degrees C possessed high specific surface areas, porous structures, proper dosages of N atoms, suitable degrees of graphitization and defects. Furthermore, we also illustrate their application in H2O2 electrochemical sensing in physiological environments. Under optimum conditions, the 3D-NS-based sensor displays a wide linear scope in the range of 0.5-14 000 mu M and a low detection limit of 0.18 mu M (S/N = 3). Therefore, with desirable selectivity, stability and anti-interference performance, the proposed sensor can be feasibly applied to detect H2O2 in human serum samples.

关键词： Electrocatalysts

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Microenvironment-tailored micelles restrain carcinoma-astrocyte crosstalk for brain metastasis

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JOURNAL OF CONTROLLED RELEASE 2022年 349卷 520-532页

作者： Zhao, Zhenhao Zhang, Yujie li, Chao li, xuwen Chu, Yongchao Guo, Qin Zhang, Yiwen Xia, Weiyi liu, Peixin Chen, Hongyi Wang, Yu li, Chufeng Sun, Tao Jiang, Chen Fudan Univ Sch Pharm Dept Pharmaceut Key Lab Smart Drug Delivery Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China

Breast-to-brain metastatic cells can interact with the surrounding cells, including astrocytes and microglia, to generate a pro-tumorigenic niche. Breast-to-brain metastasis can be treated using a dual strategy of eliminating metastatic tumor cells and normalizing their localized microenvironment. The effective accumulation of drugs at the action site of metastasis is crucial to realizing the above strategy, especially when dealing with the bloodbrain barrier (BBB)-penetrating and tumor-targeting tactics. Here, we establish an in-situ microenvironmenttailored micelle (T-M/siRNA) to co-deliver therapeutic siRNA and paclitaxel (PTX) into the breast-to-brain metastasis. Anchored with a D-type cyclic peptide, T-M/siRNA can penetrate the BBB and subsequently target the brain metastases. Upon internalization by metastatic tumor cells, T-M/siRNA can release PTX in the highlevel glutathione (GSH), resulting in killing cancer cells. Meanwhile, the micellar structure is dissociated, resulting in lowering the charge density to release the loaded siRNA that can targeted downregulate the expression of protocadherin 7 (PCDH7). Treatment of model mice revealed that T-M/siRNA can inhibit the abnormal activation of astrocytes and immunosuppressive activation of microglia, resulting in significantly enhanced synergistic anti-tumor efficacy. This study indicates that the micelle system can serve as a hopeful strategy to treat breast-to-brain metastasis.

关键词： Breast -to -brain metastasis Micelle Microenvironment Protocadherin 7 Paclitaxel

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Design of infrared imaging processing system for uncooled LWIR base on UAV platform

Design of infrared imaging processing system for uncooled LW...

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2017 5th International Conference on Frontiers of Manufacturing Science and Measuring Technology(FMSMT 2017)

作者： Qiang Wu Jia He xuwen li College of Information and Communication Engineering Faculty of Information TechnologyBeijing University of Technology College of Life Science and Bioengineering Beijing University of Technology

ISBN: (纸本)9781510840232

For uncooled LWIR system function limitations and lack of real-time image processing problems. The design scheme of high performance uncooled LWIR image processing system based on UAV system platform is proposed. The solution uses TI's TMS320C6657 DSP and Altera's EP3C25F324 FPGA processor as the system computing core, makes the long wave infrared image acquisition, FPGA image preprocessing, DSP image processing into one. And designed a set of systems in line with the external needs of the communication program.

关键词： TMS320C6657 Uncooled long wave infrared Image acquisition

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Design of High-Speed Image Transmission Board Based on PCI-Express

Design of High-Speed Image Transmission Board Based on PCI-E...

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2017 5th International Conference on Frontiers of Manufacturing Science and Measuring Technology(FMSMT 2017)

作者： Yongxian Yu xuwen li Qiang Wu College of Information and Communication Engineering Faculty of Information TechnologyBeijing University of Technology College of Life Science and Bioengineering Beijing University of Technology

ISBN: (纸本)9781510840232

This paper designs and implements a high speed image transmission board of external DDR3 SDRAM based on PCI-Express to meet the requirement of high frame rate in high speed image data transmission system. Transmission board uses XIliNX Kintex7 series chip XC7 K70 T as the master chip, through the PCI-Express DMA logic for data exchange with the host computer, and uses external DDR3 cache to solve the problems of high frame rate and real-time in large amount of data transmission. Transmission board uses LVDS high-speed differential interface as an external interface with the design of a set of LVDS interface timing. In the experiment, the gray scale visible image with 1024*1025 byte size is transmitted and tested. It can verify the transmission rate of 50 frames per second respectively, and the data transmission is stable and reliable, which can provide some reference value for high speed data transmission system.

关键词： FPGA Kintex7 PCI-Express DDR3 SDRAM LVDS

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