Potential-selective electrochemiluminescence (ECL) with tunable maximum-emission-potential ranging from 0.95 to 0.30 V is achieved using AgInS2/ZnS nanocrystals, which is promising in the design of multiplexed bioassa...
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Potential-selective electrochemiluminescence (ECL) with tunable maximum-emission-potential ranging from 0.95 to 0.30 V is achieved using AgInS2/ZnS nanocrystals, which is promising in the design of multiplexed bioassay on commercialized ECL setups. The model system AgInS2/ZnS/N2H4 exhibits efficient ECL around 0.30 V and can be exploited for sensitive immunoassays with less electrochemical interference and crosstalk.
Patients diagnosed with radioiodine refractory thyroid cancer (RAIR-TC) are not amenable to novel I-131 therapy due to the reduced expression of sodium iodide symporter (Na+/I- symporter, NIS) and/or the impairment of...
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Patients diagnosed with radioiodine refractory thyroid cancer (RAIR-TC) are not amenable to novel I-131 therapy due to the reduced expression of sodium iodide symporter (Na+/I- symporter, NIS) and/or the impairment of NIS trafficking to the plasma membrane. RAIR-TC patients have a relatively poor prognosis with a mean life expectancy of 3-5 years, contributing to the majority of TC-associated mortality. Identifying RAIR-TC patients and selecting proper treatment strategies remain challenging for clinicians. In this review, we demonstrate the updated clinical scenarios or the so-called "definitions" of RAIR-TC suggested by several associations based on I-131 uptake ability and tumor response post-I-131 therapy. We also discuss current knowledge of the molecular alterations involved in membrane-localized NIS loss, which provides a preclinical basis for the development of targeted therapies, in particular, tyrosine kinase inhibitors (TKIs), redifferentiation approaches, and immune checkpoint inhibitors.
In this study, a series of semi-interpenetrating network (semi-IPN) structure proton exchange membranes (PEMs) based on linear polyolefins and cross-linked poly(phenylene oxide) (cPPO) was fabricated for fuel cell app...
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In this study, a series of semi-interpenetrating network (semi-IPN) structure proton exchange membranes (PEMs) based on linear polyolefins and cross-linked poly(phenylene oxide) (cPPO) was fabricated for fuel cell applications. The newly synthesized membranes exhibit better flexibility and higher chemical and thermal stability than cPPO membrane owing to a semi-IPN structure. After treatment with Fenton's reagent at 80 degrees C for 240 h, all the synthesized semi-IPN membranes (cPPO-[AN-VBIm]x) show a remaining mass of >90%, indicating good oxidation stability. The proton conductivity and fuel cell performance of cPPO-[AN-VBIm](50) membranes (91 mS cm(-1) at 160 degrees C and 514 mW cm(-2) at 140 degrees C, respectively) are better than those of cPPO membranes (51 mS cm(-1) and 87 mW cm(-2), respectively under the same conditions). This study contributes significantly toward membrane research, reporting a facile and efficient method for fabricating high-performance phosphoric acid-doped membranes for high-temperature fuel cell applications that could guide future studies on efficient and practicable high-temperature PEMs.
Cotton fiber (Gossypium hirsutum) serves as an ideal model for investigating the molecular mechanisms of plant cell elongation at the single-cell level. Brassinosteroids (BRs) play a crucial role in regulating plant g...
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Cotton fiber (Gossypium hirsutum) serves as an ideal model for investigating the molecular mechanisms of plant cell elongation at the single-cell level. Brassinosteroids (BRs) play a crucial role in regulating plant growth and development. However, the mechanism by which BR influences cotton fiber elongation remains incompletely understood. In this study, we identified EXORDIUM-like (GhEXL3) through transcriptome analysis of fibers from BR-deficient cotton mutant pagoda 1 (pag1) and BRI1-EMS-SUPPRESSOR 1 (GhBES1.4, encoding a central transcription factor of BR signaling) overexpression cotton lines. Knockout of GhEXL3 using CRISPR/Cas9 was found to impede cotton fiber elongation, while its overexpression promoted fiber elongation, suggesting a positive regulatory function for GhEXL3 in fiber elongation. Furthermore, in vitro ovule culture experiments revealed that the overexpression of GhEXL3 partially counteracted the inhibitory effects of brassinazole (BRZ) on cotton fiber elongation, providing additional evidence of GhEXL3 involvement in BR signaling pathways. Moreover, our findings demonstrate that GhBES1.4 directly binds to the E-box (CACGTG) motif in the GhEXL3 promoter region and enhances its transcription. RNA-seq analysis revealed that overexpression of GhEXL3 upregulated the expression of EXPs, XTHs, and other genes associated with fiber cell elongation. Overall, our study contributes to understanding the mechanism by which BR regulates the elongation of cotton fibers through the direct modulation of GhEXL3 expression by GhBES1.4.
A numerical analysis model of the transient temperature field was established to address the issue of temperature field measurement in a silicon carbide annealing furnace. Numerical simulations of the vacuum annealing...
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A numerical analysis model of the transient temperature field was established to address the issue of temperature field measurement in a silicon carbide annealing furnace. Numerical simulations of the vacuum annealing process yielded temperature distributions at 550 degrees C, 1200 degrees C, and 1700 degrees C. Real-time temperature measurements using internal thermocouples were conducted at two points within the furnace, showing actual temperature variations. The comparison between simulated and measured data revealed that the maximum error during the holding stage was within 3 %. Based on this, an analysis of the temperature distribution inside the silicon carbide vacuum annealing furnace was performed. The results indicate that increasing the holding temperature during the annealing process effectively reduces the time needed for the workpieces to stabilize at a uniform temperature and improves temperature uniformity by the end of the process. Additionally, by the end of the annealing process, the highest temperatures of the workpieces are concentrated primarily in the middle pieces. The temperature difference among workpieces near the center is minimal, remaining within 2 degrees C. By the end of the holding phase, 43.64 % of the workpieces in the furnace meet the process requirements. This study offers valuable insights for the structural design and temperature control of silicon carbide vacuum annealing furnaces.
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