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An Algorithm for the Noninvasive and Personalized Measurement of Microvascular Blood Viscosity Using Physiological Parameters

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BIOMED RESEARCH INTERNATIONAL 2020年第0期2020卷 000-000页

作者： Sun, Ge Yang, lin Wang, Weiwei Zhang, Song Luo, Zhichang Wu, Guanghui liu, Xiaohong Hao, Dongmei Yang, Yimin li, xuwen Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Chinese Acad Med Sci Fuwai Hosp Beijing 100037 Peoples R China Capital Med Univ Beijing Inst Heart Lung & Blood Vessel Dis Beijing Anzhen Hosp Beijing 100029 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

Blood viscosity is one of the important parameters to characterize hemorheological properties of the human body. Its real-time and dynamic measurement has important physiological significance for studying the development and prevention of chronic diseases. This study researched noninvasive and personalized measurement of microvascular blood viscosity. In the microcirculation capillary network blood flow model, combined with pulse wave parameters, multiple regression analysis was used to fit the simulated radius of personalized physiological blood vessels to calculate the microvascular blood viscosity. The fitted value related to the simulated radius of the physiological blood vessel had a high correlation with the corresponding theoretically derived value (correlation coefficient: 0.904,P <= 0.001). The calculated value of the microvascular blood viscosity had a certain correlation with the clinical whole blood viscosity at a low shear rate (correlation coefficient: 0.443,P<0.05). This algorithm could provide effective means for noninvasive and long-term individual monitoring and family health care.

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Scheduling optimization of AGVs in workshop based on cost-efficiency-emission competition mechanism

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PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE 2023年第20期237卷 4828-4839页

作者： Chen, Ye Jing, xuwen Lu, Xiang Zhou, Honggen li, Haipeng Kang, Chao liu, Jinfeng li, Jun Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang Peoples R China China Merchants Cruise Shipbldg Co Ltd Nantong Peoples R China Jiangsu Univ Sci & Technol Sch Mech Engn Mengxi Rd Zhenjiang 212013 Peoples R China

The untimely material transportation induced by the backward logistics scheduling method in the ship panel block construction workshop is a complex engineering issue with multi-parameter coupling. To overcome the problem, the cost-efficiency-carbon emission competition model is proposed to solve the scheduling optimization for the AGVs in ship panel block construction workshop. Firstly, the logistics path plan of the panel block construction workshop is obtained by establishing the path-planning node map of panel block construction workplace. Secondly, a scheduling model for AGVs is constructed based on the competition mechanism of the lowest transportation cost, maximum transportation efficiency, and lowest carbon emission. Then, the optimized schedule is achieved by a novel hybrid method of the genetic and population migration algorithm considering the competition mechanism. Finally, the case validation indicates that the solving ability of the proposed hybrid method is improved by 52.4% compared with Genetic Algorithm under competitive mechanism. Besides, the results demonstrate material transportation time can be reduced by 17.5%.

关键词： Scheduling optimization automatic guided vehicle competition mechanism similarity ship panel block

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Enhancing CO2 hydrate sequestration through underlying methane hydrate production: A novel strategy for carbon storage

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ENERGY 2025年 326卷

作者： li, Yuxuan Zhang, Zhaobin Zhang, Bo Chalaturnyk, Rick li, Shouding He, Jianming Xie, Zhuoran Bian, Hang li, Xiao Lu, Cheng Qin, xuwen Chinese Acad Sci Inst Geol & Geophys Key Lab Deep Petr Intelligent Explorat & Dev Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China Univ Alberta Donadeo Innovat Ctr Engn Dept Civil & Environm Engn Edmonton AB T6G 1H9 Canada China Geol Survey Minist Nat Resources Beijing 100037 Peoples R China

Seafloor CO2 sequestration in the form of gas hydrates offers expansive geological opportunities for carbon neutrality strategies. Guided by phase equilibrium conditions, this study employs a self-developed multi-physical simulator to investigate how methane hydrate production beneath a CO2 sequestration zone can facilitate carbon storage. A dual-horizontal-well model is constructed and validated based on field measurements. Through numerical simulations, the effects of methane hydrate production timing, CO2 injection rate, and injection depth on carbon sequestration over a 100,000-year timescale are examined. Two novel metrics-sequestration efficiency and safe distance-are introduced. Results indicate that extracting methane hydrates in the later stages of CO2 injection is optimal. Furthermore, an efficient sequestration window exists for both injection rate and depth. By exploring the relationship between sequestration efficiency and storage safety, this study provides a new perspective for implementing CO2 sequestration pathways.

关键词： CO 2 sequestration Methane hydrate production Multi-physical Sequestration efficiency Storage safety

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Pioneering Insights into the Reaction Kinetics of Metastable Intermolecular Composites Based on Metal Fluorides: Virtually non-existent condensed Phase Combustion Products and Ultra-Efficient Reactivity

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ADVANCED SCIENCE 2025年第14期12卷 e2415073页

作者： liu, xuwen li, Jingwei Feng, Shenghua Jia, Yongsheng Hu, Maocong Yao, Yingkang Sun, Jinshan Xie, Quanmin Sang, Hongqian Jianghan Univ State Key Lab Precis Blasting Wuhan 430113 Peoples R China Jianghan Univ Hubei Key Lab Blasting Engn Wuhan 430056 Peoples R China Anhui Univ Sci & Technol Sch Chem & Blasting Engn Huainan 232001 Peoples R China Jianghan Univ Sch Optoelect Mat & Technol Wuhan 430056 Peoples R China

As a typical representative of Metastable intermolecular composites (MICs), the energy release of nano-thermites relying on aluminum-oxygen reaction is limited by the formation of high boiling point condensed phase products. Low pressure output performance constitutes another pivotal factor influencing their efficacy. In this work, metal fluorides BiF3 at different scales were incorporated into nano-thermites as oxidants, thereby facilitating the tunability of the released energy. The boiling points of all resultant reaction products fall below the combustion temperature, theoretically abolishing the agglomeration of condensed-phase products, thus preventing the entrapment of active metals. Additionally, it facilitates the smooth conduction of heat flux, thereby averting losses in biphasic flow dynamics. The n-Al/n-BiF3 system exhibits a significant amplification in reactive kinetic properties in stark contrast to the n-Al/n-Bi2O3 system. The reduction in ignition threshold is ascribed to a novel reaction kinetics mechanism within the n-Al/BiF3 system. The highly electronegative fluorine within BiF3 corrodes the Al2O3 shell, inducing a "pre-ignition" reaction. The application of Density Functional Theory (DFT) evaluations has further corroborated the n-Al/n-BiF3 system's preeminence in electron transfer capacity between the oxidizing agent and fuel, thereby furnishing an molecular-electronic basis for its potent reactive kinetic properties.

关键词： combustion mechanism metal fluorides metastable intermolecular composites nanostructured energetic materials pre-ignition reactions

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ImageSem Group at ImageCLEFmedical Caption 2022 task: Generating Medical Image Descriptions based on Vision-Language Pre-training

ImageSem Group at ImageCLEFmedical Caption 2022 task: Genera...

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2022 Conference and Labs of the Evaluation Forum, CLEF 2022

作者： Wang, xuwen li, Jiao Institute of Medical Information and Library Chinese Academy of Medical Sciences Peking Union Medical College Beijing100020 China

This paper presents the work of ImageSem group in the ImageCLEFmedical Caption 2022 task. In the caption prediction subtask, we employed the bootstrapping language-image pre-training (BliP) framework for generating medical image descriptions. We submitted 2 runs using exclusively the official training data and achieved the BLEU score of 0.2211, which ranked 9th among the participating teams. Despite the lower BLEU score, we achieved a relatively balanced performance across all other metrics, such as the ROUGE of 0.1847, the METEOR of 0.0675, the CIDEr of 0.2513, the SPICE of 0.0393 and the BERTScore of 0.6059, showing the potential of better verbal fluency via fine-tuning the medical caption generation task grounded by vision-language pre-training (VLP). © 2022 Copyright for this paper by its authors.

关键词： Image analysis

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Corn Stover-derived nanocellulose and lignin-modified particles: Pickering emulsion stabilizers and potential quercetin sustained-release carriers

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FOOD CHEMISTRY 2025年第Pt 2期465卷 142021页

作者： Wu, Xinling Zhang, Qiang Zhou, Deyi Zhang, li Zhou, Haigen Gao, Xiaodi Fang, xuwen Huo, Chao Zhang, Jinsong Jilin Univ Coll Biol & Agr Engn Changchun 130022 Peoples R China

Pickering emulsions (PEs) have wide applications in delivering nutraceuticals. However, the impact of extracting nanocellulose from corn stover on stabilizing PEs and delivering nutraceuticals remains unclear. In this study, four types of nanocellulose, cellulose nanocrystals (CNC), cellulose nanofibers (CNF), lignin-containing cellulose nanocrystals (LCNC), and lignin-containing cellulose nanofibers (LCNF) were successfully prepared from corn stover, an agricultural waste. Among them, LCNC and LCNF exhibited stable reticulated microstructures, lower crystallinity, and excellent thermal stability. Besides, lignin enhanced the nanoparticles' hydrophobicity, promoting the formation of more ideally amphiphilic particles, resulting in denser emulsions at the oil-water interface. Furthermore, emulsions stabilized by LCNC and LCNF demonstrated remarkable resistance to quercetin degradation under UV light exposure (with residual level exceeding 90 %) and improved quercetin's bioaccessibility during the in vitro digestion tests, achieving the highest bioaccessibility of 48.3 %. This study provided an innovative perspective on utilizing stover-derived materials for stabilizing PEs and delivering lipophilic nutrients.

关键词： Corn Stover nanocellulose lignin Pickering emulsion Quercetin delivery In vitro digestion

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Development and Validation of a Screening Tool for Generalized Anxiety and Major Depressive Disorder in Patients with Chronic Obstructive Pulmonary Disease

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LUNG 2025年第1期203卷 1-12页

作者： liu, Meishan Yang, xuwen Wang, Dong Fang, Jiexin li, Boyu An, li Chang, Yuhan liu, Haiman Hu, Yongdong Huang, Kewu Capital Med Univ Beijing Inst Resp Med Dept Resp & Crit Care Med 8Gongti South Rd Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp 8Gongti South Rd Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp Dept Clin Psychol 8Gongti South Rd Beijing 100020 Peoples R China Capital Med Univ Beijing Chao Yang Hosp Dept Pharm Beijing Peoples R China

PurposeAnxiety and depression are often underdiagnosed in patients with chronic obstructive pulmonary disease (COPD). This study aimed to develop and validate a screening tool for anxiety and depression in COPD *** COPD patients were consecutively recruited from November 2021 to October 2023 and underwent a psychiatric interview to diagnose generalized anxiety disorder (GAD) and/or major depressive disorder (MDD) based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Patients were split into training and validation sets according to their recruitment time. We assessed known risk factors and used core items from the Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS) to develop a prediction nomogram. Multivariable logistic regression with least absolute shrinkage and selection operator (LASSO) were used to construct the *** the enrolled COPD patients (n = 329), 58 (25.6%) in the training cohort and 33 (32.4%) in the validation cohort were diagnosed with GAD and/or MDD. Three variables were identified in the prediction nomogram: COPD Assessment Test score and two core items from PHQ-ADS. The under the curve (AUC) value for the nomogram was 0.826 (95% CI: 0.755-0.897) and 0.855 (95% CI: 0.767-0.942) in the training and validation cohorts, respectively. The calibration curve was close to the diagonal. The discriminatory power of the screening nomogram was comparable to that of PHQ-ADS (AUC: 0.826 vs. 0.831, P = 0.832).ConclusionThe new screening tool for GAD and MDD in COPD patients is concise and valid, with discriminatory power comparable to existing anxiety/depression screening questionnaires.

关键词： Chronic obstructive pulmonary disease Anxiety Depression Screening Nomogram

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Centrifugation free and air-assisted liquid-liquid microextraction based on deep eutectic solvent for determination of rare ginsenosides in Kang'ai injection

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MICROCHEMICAL JOURNAL 2018年 142卷 313-320页

作者： li, Peng Ye, Junfeng Zhang, Yue Wang, Ziqi Ren, Sujuan li, xuwen Jin, Yongri Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China Jilin Univ Hosp 1 Changchun 130012 Jilin Peoples R China

A simple, effective and convenient enrichment method coupled with high performance liquid chromatography (HPLC) was established for the analysis of rare ginsenosides in Kang'ai (KA) injection. Air assisted liquid-liquid microextraction was used in this work for the first time to determine the rare ginsenosides in KA injection. Deep eutectic solvent (DES) and tetrahydrofuran (THF) were specially selected as a novel green extraction solvent and an emulsified solvent, respectively. To remove the DES droplets, Fe3O4 nanoparticles were used. Therefore, centrifugation was free in this work, which can increase the efficiency of analysis procedure. Moreover, Fe3O4 nanoparticles were reusable. To achieve better extraction efficiency and enrichment factor, the experimental conditions have been optimized, including type and volume of DES and emulsified solvent, amount of Fe3O4 nanoparticles and inorganic salt, and pH value. Under the optimum extraction condition, the validation parameters show the limits of detection (LODs) are in the range from 10.2 ng/mL to 137.8 ng/mL and the limits of quantity (LOQs) are in the range from 55.5 ng/mL to 428.5 ng/mL. The recoveries of analytes range from 91.3% to 106.7% with the relative standard deviations (RSDs) ranging from 1.2% to 4.5%. The recommended approach was utilized to acquire the information of constituents in KA injection. Moreover, the results in this research could provide a study basis for further study of KA injection.

关键词： Deep eutectic solvent liquid-liquid microextraction Rare ginsenosides Kang'ai injection HPLC

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基于Sentinel-2数据的苏州消夏湾生态安全缓冲区植被生长状况遥感监测评估

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环境监控与预警 2024年第1期16卷 24-30页

作者：单阳钱晓瑾姜晟王甜甜张悦余悠然纪轩禹郭金金魏玉强王茹李旭文江苏省环境监测中心江苏南京210019 南京邮电大学地理与生物信息学院江苏南京210023

利用2021—2022年Sentinel-2卫星搭载的多光谱成像仪(MSI)遥感数据,通过SNAP遥感软件提供的植被生物物理参数处理模块(Biophysical Processor),反演了苏州消夏湾生态安全缓冲区的5种植被生物物理参数,包括植被吸收光合有效辐射比例(FAP... 详细信息

利用2021—2022年Sentinel-2卫星搭载的多光谱成像仪(MSI)遥感数据,通过SNAP遥感软件提供的植被生物物理参数处理模块(Biophysical Processor),反演了苏州消夏湾生态安全缓冲区的5种植被生物物理参数,包括植被吸收光合有效辐射比例(FAPAR)、植被覆盖度(FVC)、叶面积指数(LAI)、冠层叶绿素含量(CCC)和冠层含水量(CWC),开展植被生态环境监测评估研究。结果表明,该生态安全缓冲区2021年建成并投入运行后,植被覆盖度和生物量有所增加,区域植被冠层结构有所改善,植被生物物理参数从一定的角度反映了消夏湾生态安全缓冲区发挥了生态涵养成效。该研究方法能在大尺度上快捷、高效地反演植被生物物理参数,可为通过植被遥感动态监测评估生态安全缓冲区的生态功能提供有益的借鉴。

关键词：生态安全缓冲区 Sentinel-2 植被生物物理量遥感反演苏州消夏湾

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Pilot-Scale Application of Red Mud-Based Slag Pellets in Steelmaking: Process Optimization, Mechanism, and life Cycle Assessment

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ACS OMEGA 2025年第16期10卷 16762-16776页

作者： Qin, Yihe Yuan, Run li, Han He, xuwen Chen, Jingjing Chen, Xingtong Huang, Suran Huang, Haiming Dongguan Univ Technol Sch Environm & Civil Engn Dongguan 523808 Peoples R China China Univ Min & Technol Sch Chem & Environm Engn Beijing Peoples R China

The resource utilization of red mud (RM) is crucial for the aluminum industry and for addressing environmental concerns. In this study, RM-based slag pellets were prepared through a cold pressing process and used for converter steelmaking. In the pellet preparation experiment, the effects of binder starch and carboxymethyl cellulose sodium (CMC) dosage, moisture content, drying temperature, particle size, and forming pressure on the strength of RM-based pellets were studied. The formation mechanism of RM particles was determined by analyzing the changes in the crystal structure, functional groups, elemental valence state information, and density functional theory calculations. Finally, the environmental benefits of the pellet production process were analyzed. Under the optimal reaction conditions, the compressive strength of RM pellets prepared based on starch and CMC can reach 1162.06 and 1345.6 N/P, which can meet the production needs of the converter. Mechanism analysis shows that organic adhesives adsorb and solidify particles through chemical or hydrogen bonding, resulting in a denser particle structure. RM particles have an excellent slag and phosphorus removal performance. The results of the life cycle assessment clarify the potential contributions of each stage of particle production. The raw materials and transportation distance have significant impacts on the particle production system. The experimental results provide theoretical guidance and a sustainable evaluation for the production of RM slag aggregates.

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