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Fabrication of CoNPs-embedded porous carbon composites based on morphochemical imprinting strategy for detection of H2O2 released from living cells

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ELECTROCHIMICA ACTA 2019年 321卷 134717-000页

作者： Lu, Nannan Zheng, Bo Gu, Yue Yan, Xiaoyi Zhang, Tingting liu, He Xu, Haixin Xu, Zhiqian li, xuwen Zhang, Zhiquan Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China Weinan Normal Univ Coll Chem & Mat Weinan City 714099 Peoples R China

Rational construction of biosensor to determine reactive oxygen species (ROS) generated from living cells is one of the great challenges in physiological and pathological fields. Herein, for the first time, a novel Co nanoparticles (CoNPs) embedded walnut-like N-doped porous carbon microsphere (Co@NCS) can be synthesized using dual imprinting strategy by pyrolysis and acid leaching. The distinct morphology and chemical characteristic of melamine cyanurate (MC) aggregates can be imprinted in the carbon source derived from glucose during the pyrolysis process. According to our research, with synergistic effect of CoHPs and NCS, the Co@NCS shows an excellent electrochemical activity toward the reduction of hydrogen peroxide (H2O2). The Co@NCS modified electrode exhibits a wider linear detection response with the range from 0.5 mu M to 7500 mu M and a low detection limit of 88 nM (S/N = 3). Moreover, with desirable selectivity, decent reproducibility and satisfied anti-interference performance, the fabricated biosensor can be applied to determine H2O2 in human serum samples and that released from living cell, indicating the potential applications in the fields of pathological and physiological sensing. (C) 2019 Elsevier Ltd. All rights reserved.

关键词： Co nanoparticles Porous carbon microspheres Biosensor Hydrogen peroxide living cells

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太湖浮游植物群落结构及其与水质指标间的关系

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生态环境学报 2014年第11期23卷 1814-1820页

作者：李娣李旭文牛志春王霞师伟于红霞南京大学环境学院污染控制与资源化研究国家重点实验室江苏南京210046 江苏省环境监测中心江苏南京210036 空军勤务学院江苏徐州221000

为了探讨太湖浮游植物群落结构时空分布特征、以及太湖浮游植物群落指标与水质指标间的关系,于2013年1月─2013年12月对太湖7个点位浮游植物群落结构和水质指标(水温、透明度、p H、溶解氧、电导率、总氮、总磷、氨氮、高锰酸盐指数、... 详细信息

为了探讨太湖浮游植物群落结构时空分布特征、以及太湖浮游植物群落指标与水质指标间的关系,于2013年1月─2013年12月对太湖7个点位浮游植物群落结构和水质指标(水温、透明度、p H、溶解氧、电导率、总氮、总磷、氨氮、高锰酸盐指数、化学需氧量、氟化物、生化需氧量、硝酸盐氮、亚硝酸盐氮、溶解性磷酸盐和叶绿素a)进行月度调查,研究其浮游植物群落结构和湖泊水质的时空分布;并利用Pearson相关性分析浮游植物密度、浮游植物多样性与水质指标间的关系;找出影响太湖浮游植物群落结构的主要水质指标。结果表明:太湖7个点位共获得124种浮游植物物种,其中蓝藻门(Cyanophyta)30种、绿藻门(Bacillariophyta)47种、硅藻门(Chlorophyta)34种、隐藻门(Cryptophyta)3种、裸藻门(Euglenophyta)6种和甲藻门(Dinoflagellate)4种;其中蓝藻门的微囊藻属(Microcystis spp.)为绝对优势种群,优势度为80.8%;太湖浮游植物总密度与蓝藻门密度呈极显著正相关(r=1.000,P<0.000 1);绿藻门和硅藻门占浮游植物总密度百分比分别和蓝藻门占浮游植物总密度百分比呈极显著负相关(r=-0.497,P<0.000 1;r=-0.814,P<0.000 1)。太湖7个点位水质首要污染物为总氮,其次是总磷和化学需氧量;西太湖污染物浓度最高。从空间上看,太湖浮游植物总密度最高值出现在贡湖湾(远离其入湖口处),且贡湖湾浮游植物群落多样性相对低于太湖其他点位,同时贡湖湾微囊藻属密度百分比达90.1%,远高于太湖其他点位;从时间上看,太湖浮游植物总密度最高值出现在12月份、其次是6月份;通过浮游植物群落指标与水质指标相关性分析,水温、透明度、总氮、化学需氧量、叶绿素a是影响太湖浮游植物群落结构的主要水质指标。控制太湖入湖口水质污染物浓度排放和修复水生态环境是太湖蓝藻治理的有效方法,同时加强太湖入冬藻类监测以预防冬季太湖蓝藻爆发。

关键词：太湖浮游植物群落物种多样性影响因子

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高校工会体育活动对教师心理健康的影响

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成都航空职业技术学院学报 2015年第2期31卷 81-83页

作者：李英李续稳闫开西藏民族大学陕西咸阳712082

高校教师在不同程度上面临着来自社会、生活及家庭等方面的压力,这些无疑会使高校教师产生紧张、疲劳、焦虑等身心不适应的症状。本研究旨在通过对工会组织高校教师参加体育活动造成心理健康影响的分析,探讨高校教师的心理健康状况及体... 详细信息

高校教师在不同程度上面临着来自社会、生活及家庭等方面的压力,这些无疑会使高校教师产生紧张、疲劳、焦虑等身心不适应的症状。本研究旨在通过对工会组织高校教师参加体育活动造成心理健康影响的分析,探讨高校教师的心理健康状况及体育锻炼对高校教师心理健康的作用,为促进高校教师身心健康水平提供参考。

关键词：高校工会体育活动教师心理健康

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Changes of Arterial Pulse Waveform Characteristics with Gestational Age during Normal Pregnancy

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SCIENTIFIC REPORTS 2018年第1期8卷 1-1页

作者： li, Kunyan Zhang, Song Yang, lin Jiang, Hongqing Chi, Zhenyu Wang, Anran Yang, Yimin li, xuwen Hao, Dongmei Zhang, Lei Zheng, Dingchang Beijing Univ Technol Coll Life Sci & Bioengn Beijing 100124 Peoples R China Haidian Maternal & Child Hlth Hosp Beijing 100026 Peoples R China Anglia Ruskin Univ Fac Med Sci Dept Med Sci & Publ Hlth Chelmsford CM1 1SQ Essex England

Arterial pulse waveform analysis has been widely used to reflect physiological changes in the cardiovascular system. This study aimed to comprehensively investigate the changes of waveform characteristics of both photoplethysmographic (PPG) and radial pulses with gestational age during normal pregnancy. PPG and radial pulses were simultaneously recorded from 130 healthy pregnant women at seven gestational time points. After normalizing the arterial pulse waveforms, the abscissa of notch point, the total pulse area and the reflection index were extracted and compared between different measurement points and between the PPG and radial pulses using post-hoc multiple comparisons with Bonferrioni correction. The results showed that the effect of gestational age on all the three waveform characteristics was significant (all p < 0.001) after adjusting for maternal age, heart rate and blood pressures. All the three waveform characteristics demonstrated similar changing trends with gestational age, and they were all significantly different between the measurements from gestational week 12-15 and the others (all p < 0.05, except for the PPG total pulse area between the first and second measurement points). In conclusion, this study has comprehensively quantified similar changes of both PPG and radial pulse waveform characteristics with gestational age.

关键词： Pulse Waveform Characteristics Peripheral Arterial Pulses Total Pulse Area Notch Point Radial Pulse

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窄蒂鼻唇沟皮下蒂皮瓣在鼻部及鼻旁恶性肿瘤切除后创面修复中的应用

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中华解剖与临床杂志 2023年第8期28卷 527-532页

作者：李旭文葛秀玉宋培军徐静蚌埠医学院第一附属医院整形外科蚌埠233004

目的探讨窄蒂鼻唇沟皮下蒂皮瓣在鼻部及鼻旁恶性肿瘤切除术后修复面部缺损的效果。方法回顾性队列研究。纳入蚌埠医学院第一附属医院整形外科2018年6月—2022年6月收治的鼻部及鼻旁体表恶性肿瘤患者40例,其中男13例、女27例,年龄52~93(6... 详细信息

目的探讨窄蒂鼻唇沟皮下蒂皮瓣在鼻部及鼻旁恶性肿瘤切除术后修复面部缺损的效果。方法回顾性队列研究。纳入蚌埠医学院第一附属医院整形外科2018年6月—2022年6月收治的鼻部及鼻旁体表恶性肿瘤患者40例,其中男13例、女27例,年龄52~93(69±12)岁。患者均行肿瘤扩大切除术,根据肿瘤切除后创面修复方法不同分为2组:对照组20例,采用传统的局部转位皮瓣修复;观察组20例,采用窄蒂鼻唇沟皮下蒂推进皮瓣修复。观察并比较2组患者的临床基线资料,皮瓣面积、皮瓣蒂部宽度、皮瓣面积与蒂部宽度比值、手术时间、术中出血量、皮瓣存活率、供瓣区直接缝合率等围术期指标,术后6个月温哥华瘢痕量表(VSS)评分,以及术后创面感染、皮瓣下积液、创面出血、皮瓣对周围组织牵拉、蒂部“猫耳”形成等并发症发生情况。结果2组患者年龄、性别、住院时间以及肿瘤性质、大小、部位等基线资料比较,差异均无统计学意义(P值均>0.05)。观察组皮瓣面积为(6.90±1.94)cm^(2),对照组为(7.80±2.24)cm^(2),差异无统计学意义(t=1.36,P=0.182)。观察组皮瓣蒂部宽度(0.98±0.29)cm、皮瓣面积与蒂宽比值7.35±2.75、手术时间(70.5±16.7)min、术中出血量(47.5±8.5)mL,对照组依次为(2.93±0.65)cm、2.75±0.82、(83.5±19.9)min、(60.5±15.0)mL,组间比较差异均有统计学意义(t=12.25、7.17、2.24、3.36,P值均<0.05)。观察组与对照组皮瓣存活率分别为95.0%(19/20)和90.0%(18/20),差异无统计学意义(χ^(2)=0.00,P=1.000)。观察组供瓣区直接缝合率为95.0%(19/20),高于对照组的60.0%(12/20),差异有统计学意义(χ^(2)=5.16,P=0.023)。术后6个月观察组血管循环VSS评分为(1.40±0.99)分,对照组为(1.65±0.81)分,差异无统计学意义(t=0.87,P=0.388);观察组皮瓣色泽、柔软度、厚度VSS评分及VSS总分分别为(0.90±0.64)、(2.00±1.03)、(1.30±0.92)、(5.60±3.27)分,对照组依次为(1.45±0.76)、(2.65±0.81)、(1.95±0.89)、(7.70±2.66)分,差异均有统计学意义(t=2.48、2.22、2.27、2.23,P值均<0.05)。观察组与对照组术后发生皮瓣对周围组织牵拉分别为7例和14例、蒂部猫耳形成分别为5例和16例,组间比较差异均有统计学意义(χ^(2)=4.91、12.13,P值均<0.05)。2组患者术后切口感染、出血、皮瓣下积液发生率比较,差异均无统计学意义(P值均>0.05)。结论采用窄蒂鼻唇沟皮下蒂皮瓣修复鼻部及鼻旁恶性肿瘤切除后的软组织缺损创面,对蒂部及供瓣区的处理优于传统的局部邻近皮瓣,且有效缩短手术时间、减少出血量、提高术后皮瓣美观度、减少并发症发生。

关键词：外科皮瓣窄蒂鼻唇沟皮下蒂皮瓣鼻部及鼻旁恶性肿瘤创面修复

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染料防尘剂的制备与研究

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印染助剂 2024年第10期41卷 28-31页

作者：李旭文王金剑传化智联股份有限公司浙江杭州311215

提升防尘剂中高沸点、高黏度组分含量,引入合适HLB值生物基乳化剂和双子型表面活性剂,可以降低防尘剂在高温下的挥发度,提高其防尘性能、耐电解质性能、储存稳定性和乳化性能,且对染料色光没有影响,具有良好的应用推广前景和市场竞争力。

关键词：防尘剂生物基乳化剂双子型表面活性剂乳化

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Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b] pyridazine derivatives as potent PI3K/mTOR dual inhibitors

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2023年第1期247卷 115030页

作者： li, Chuchu Han, Yuqiao Wang, Zhengyang Yu, Yanan Wang, Chen Ren, Ziwei Guo, Yanzhi Zhu, Tong li, xuwen Dong, Suzhen Ma, Mingliang East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China Shanghai Inst Mat Med Chinese Acad Sci State Key Lab Drug Res 555 Zu Chong Zhi RdZhangjiang Hitech Pk Shanghai 201203 Peoples R China Shanghai Univ Engn Sci Sch Math Phys & Stat Shanghai 201620 Peoples R China Bohai Rim Adv Res Inst Drug Discovery Shandong Lab Yantai Drug Discovery Yantai 264117 Peoples R China East China Normal Univ Key Lab Brain Funct Genom Minist Educ Shanghai 200062 Peoples R China

The PI3K-Akt-mTOR signaling pathway is a highly frequently activated signal transduction pathway in human malignancies, which has been a hot target for anti-tumoral drug discovery. Based on our previous research, a function-oriented synthesis (FOS) of imidazo[1,2-a]pyrazines and imidazo[1,2-b]pyridazines was conducted, and their anticancer activities in vitro and in vivo were evaluated. Among them, compound 42 exhibited excellent dual PI3K/mTOR inhibitory activity, with IC50 values on PI3K alpha and mTOR of 0.06 nM and 3.12 nM, respectively, much better than our previous reported compound 15a. Furthermore, compound 42 exhibited significant in vitro and in vivo anti-tumoral activities, great kinase selectivity, low hepatotoxicity, modest plasma clearance and acceptable oral bioavailability, which is a promising PI3K/mTOR targeted anti-cancer drug candidate.

关键词： PI3K mTOR dual inhibitors Cancer Antitumor activity Hepatotoxicity

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基于微型无人机遥感数据的城市水环境信息提取初探

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中国环境监测 2018年第3期34卷 141-147页

作者：侍昊李旭文牛志春李卫正王甜甜张悦江苏省环境监测中心江苏南京210036 南京林业大学现代分析测试中心江苏南京210037

近年来,黑臭水体整治已经成为各级政府的重要工作内容。为更好地开展黑臭水体筛查和监管工作,提出基于多旋翼无人机搭载多光谱相机的遥感监测方案,尝试采用影像特征变换结合面向对象分类方法提取黑臭水体的遥感信息。结果表明:(1)无人... 详细信息

近年来,黑臭水体整治已经成为各级政府的重要工作内容。为更好地开展黑臭水体筛查和监管工作,提出基于多旋翼无人机搭载多光谱相机的遥感监测方案,尝试采用影像特征变换结合面向对象分类方法提取黑臭水体的遥感信息。结果表明:(1)无人机影像上地物具有更加丰富的色彩和纹理;(2)与主成分变换和纹理分析方法相比,光谱指数对典型地物具有较好的判别能力;(3)采用标准最邻近分类法提取城市水环境信息,能够获得较高分类精度。

关键词：黑臭水体无人机多光谱影像特征变换信息提取

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Comparison of electrohysterogram signal measured by surface electrodes with different designs: A computational study with dipole band and abdomen models

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SCIENTIFIC REPORTS 2017年第1期7卷 17282-17282页

作者： Gao, Pei Hao, Dongmei An, Yang Wang, Ying Qiu, Qian Yang, lin Yang, Yimin Zhang, Song li, xuwen Zheng, Dingchang Beijing Univ Technol Coll Life Sci & Bioengn Beijing 100124 Peoples R China Anglia Ruskin Univ Hlth & Wellbeing Acad Fac Med Sci Chelmsford CM1 1SQ Essex England

Non-invasive measurement of uterine activity using electrohysterogram (EHG) surface electrodes has been attempted to monitor uterine contraction. This study aimed to computationally compare the performance of acquiring EHG signals using monopolar electrode and three types of Laplacian concentric ring electrodes (bipolar, quasi-bipolar and tri-polar). With the implementation of dipole band model and abdomen model, the performances of four electrodes in terms of the local sensitivity were quantified by potential attenuation. Furthermore, the effects of fat and muscle thickness on potential attenuation were evaluated using the bipolar and tri-polar electrodes with different radius. The results showed that all the four types of electrodes detected the simulated EHG signals with consistency. That the bipolar and tri-polar electrodes had greater attenuations than the others, and the shorter distance between the origin and location of dipole band at 20 dB attenuation, indicating that they had relatively better local sensitivity. In addition, ANOVA analysis showed that, for all the electrodes with different outer ring radius, the effects of fat and muscle on potential attenuation were significant (all p < 0.01). It is therefore concluded that the bipolar and tri-polar electrodes had higher local sensitivity than the others, indicating that they can be applied to detect EHG effectively.

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Cobalt-decorated 3D hybrid nanozyme: A catalytic amplification platform with intrinsic oxidase-like activity

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ELECTROCHIMICA ACTA 2021年 395卷 139197-139197页

作者： Lu, Nannan Yan, Xiaoyi Gu, Yue Zhang, Tingting liu, Yu Song, Yu Xu, Zhiqian Xing, Yue li, xuwen Zhang, Zhiquan Zhai, Shengyong Jilin Univ Coll Chem Changchun 130012 Peoples R China Anhui Univ Chinese Med Sch Pharm Hefei 230013 Peoples R China Qingdao Univ Qingdao Canc Inst Qingdao 266071 Peoples R China Changchun Univ Chinese Med Jilin Ginseng Acad Changchun 130117 Peoples R China

Research about constructing multi-dimensional carbon nanomaterials is of great significance in electrocatalytic and sensing fields in order to integrate structural merits of each individual unit. Also, nano-materials with enzyme-like activities are prospective candidates for artificial enzyme design and electrochemical application. Herein, we fabricate Co, N co-doped hierarchical hybrid (Co@NCNTs/NC) nanozyme, which integrates of both N-doped carbon nanotubes (NCNTs) and N-doped carbon sheets (NC). The three-dimensional (3D) porous carbon composite is prepared by thermal treatment of metal-organic framework (MOF) which was synthesized by growing of ZIF-67 on ZIF-L at room temperature. The obtained nanomaterial not only possesses an improved oxidase-like activity that can catalyze 3,3',5,5'-tetramethylbenzidine (TMB) in the absence of hydrogen peroxide (H2O2), but also constructs a signal amplification platform towards dopamine (DA) due to the synergistic catalysis of Co species and N-doped porous carbon architecture. The electrocatalytic performance for DA detection shows a broad linear range from 30 nM to 710 mu M and a detection limit of 9 nM. The Co@NCNTs/NC/GCE is employed to practically detect DA in human serum and artificial cerebrospinal fluid (aCSF) samples with satisfactory results. The present work exhibits a great promising in colorimetric and electrochemical sensing fields and presents a new sight for the fabrication of MOF-derived nanozyme. (C) 2021 Elsevier Ltd. All rights reserved.

关键词： Metal-organic frameworks Oxidase-like activity Nanozyme Electrochemical sensing Dopamine

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