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中国医学影像技术 2024年第9期40卷 1449-1450页

作者：李翔付旭文寸新华昆明市第三人民医院云南省传染性疾病医学中心医学影像科云南昆明650041 昆明市第三人民医院云南省传染性疾病医学中心骨科云南昆明650041

患者男,21岁,2年前右膝关节肿胀,经关节镜病理证实为“右膝关节结核”,未规律接受抗结核治疗;近半个月间断右膝关节疼痛;否认其他特殊病史。查体:右膝关节明显肿胀,活动受限,皮温正常,浮髌试验(+)。实验室检查:右膝关节穿刺抽液培养示... 详细信息

患者男,21岁,2年前右膝关节肿胀,经关节镜病理证实为“右膝关节结核”,未规律接受抗结核治疗;近半个月间断右膝关节疼痛;否认其他特殊病史。查体:右膝关节明显肿胀,活动受限,皮温正常,浮髌试验(+)。实验室检查:右膝关节穿刺抽液培养示结核分枝杆菌(+)。

关键词：结核,骨关节体层摄影术,X线计算机磁共振成像

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Fuzzy Multilevel Image Thresholding Based on Improved Coyote Optimization Algorithm

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IEEE ACCESS 2021年 9卷 33595-33607页

作者： li, linguo Sun, lijuan Xue, Yu li, Shujing Huang, xuwen Mansour, Romany Fouad Nanjing Univ Posts & Telecommun Sch Comp Nanjing 210003 Peoples R China Fuyang Normal Univ Coll Informat Engn Fuyang 236041 Peoples R China Nanjing Univ Informat Sci & Technol Sch Comp & Software Nanjing 210044 Peoples R China Fuyang Normal Univ Coll Comp & Informat Engn Fuyang 236041 Peoples R China New Valley Univ Fac Sci Dept Math El Kharga 72511 Egypt

Due to the computational complexity of multilevel image thresholding, Swarm Intelligence Optimization Algorithm (SIOA) has been widely applied to improve the calculation efficiency. Therefore, more and more attention has been paid to exploring the application of the latest SIOA in multilevel segmentation. This article takes Otsu and fuzzy entropy as the objective functions, using Coyote Optimization Algorithm (COA) for multilevel thresholds optimization selection, through fuzzy median aggregation of local neighborhood information and then forms the Fuzzy Coyote Optimization Algorithm (FCOA), so that the thresholding image segmentation can be achieved in the end. To prevent the COA algorithm from falling into the local optimum, this article follows the differential evolution strategy adopted by the standard COA, using the number of iterations to construct the differential scaling factor to form the Improved Coyote Optimization Algorithm (ICOA). The experimental results show that fuzzy Kapur entropy and fuzzy median value aggregation-based ICOA(FICOA) achieves better image segmentation quality. Compared with Grey Wolf Optimizer (GWO), Fuzzy Modified Quick Artificial Bee Colony and Aggregation Algorithm (FMQABCA) and Fuzzy Modified Discrete Grey Wolf Optimizer and Aggregation Algorithm (FMDGWOA), FCOA and FICOA have certain advantages in visual effects of image segmentation and PSNR, FSIM evaluation indices. Particularly compared with GWO (also a wolf evolutionary algorithm), FICOA shows significant advantages.

关键词： Image segmentation Optimization linear programming Entropy Particle swarm optimization Histograms Heuristic algorithms Coyote optimization algorithm information entropy image segmentation multilevel thresholding

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Identification of circadian rhythm-related gene classification patterns and immune infiltration analysis in heart failure based on machine learning

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HEliYON 2024年第6期10卷 e27049页

作者： Wang, Xuefu Rao, Jin Zhang, li liu, xuwen Zhang, Yufeng Univ Shanghai Sci & Technol Sch Hlth Sci & Engn Shanghai Peoples R China Naval Med Univ Shanghai Changzheng Hosp Dept Cardiothorac Surg Shanghai Peoples R China Guangxi Univ Nanning Peoples R China

Background: Circadian rhythms play a key role in the failing heart, but the exact molecular mechanisms linking changes in the expression of circadian rhythm-related genes to heart failure (HF) remain unclear. Methods: By intersecting differentially expressed genes (DEGs) between normal and HF samples in the Gene Expression Omnibus (GEO) database with circadian rhythm-related genes (CRGs), differentially expressed circadian rhythm-related genes (DE-CRGs) were obtained. Machine learning algorithms were used to screen for feature genes, and diagnostic models were constructed based on these feature genes. Subsequently, consensus clustering algorithms and nonnegative matrix factorization (NMF) algorithms were used for clustering analysis of HF samples. On this basis, immune infiltration analysis was used to score the immune infiltration status between HF and normal samples as well as among different subclusters. Gene Set Variation Analysis (GSVA) evaluated the biological functional differences among subclusters. Results: 13 CRGs showed differential expression between HF patients and normal samples. Nine feature genes were obtained through cross-referencing results from four distinct machine learning algorithms. Multivariate LASSO regression and external dataset validation were performed to select five key genes with diagnostic value, including NAMPT, SERPINA3, MAPK10, NPPA, and SLC2A1. Moreover, consensus clustering analysis could divide HF patients into two distinct clusters, which exhibited different biological functions and immune characteristics. Additionally, two subgroups were distinguished using the NMF algorithm based on circadian rhythm associated differentially expressed genes. Studies on immune infiltration showed marked variances in levels of immune infiltration between these subgroups. Subgroup A had higher immune scores and more widespread immune infiltration. Finally, the Weighted Gene Co -expression Network Analysis (WGCNA) method was utilized to discern

关键词： Heart failure Circadian rhythm Machine learning Immune infiltration Unsupervised clustering Bioinformatics

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Surface-Defect-Induced and Synergetic-Effect-Enhanced NIR-II Electrochemiluminescence of Au-Ag Bimetallic Nanoclusters and Its Spectral Sensing

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ANALYTICAL CHEMISTRY 2021年第11期93卷 4909-4915页

作者： Fu, li Gao, xuwen Dong, Shuangtian Hsu, Hsien-Yi Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China City Univ Hong Kong Sch Energy & Environm Kowloon Hong Kong 999077 Peoples R China City Univ Hong Kong Dept Mat Sci & Engn Kowloon Hong Kong 999077 Peoples R China

Aqueous electrochemiluminescence (ECL) in the second near-infrared biowindow (NIR-II, 900-1700 nm) was anticipated for ECL evolution and spectral multiplexing. Herein, aqueous and monochromatic ECL with a single emission peak beyond 900 nm was achieved by employing methionine (Met)-capped Au-Ag bimetallic nanoclusters (BNCs) as luminophores and triethanolamine (TEOA) as a coreactant. The Met-capped Au-Ag BNCs with surface-defect-induced PL around 756 nm were water-soluble and synthesized via doping Met-capped Au NCs with Ag in a doping-in-growth way. By extensively exploiting the red-shifting nature of surface-defect-induced ECL to PL and the synergetic-effect-enhanced ECL of BNCs, physically surface-confined Au-Ag BNCs exhibited efficient NIR-II ECL around 906 nm in aqueous medium. A spectrum-based NIR-II ECL immunoassay around 915 nm was also achieved by immobilizing the Au-Ag BNCs onto an electrode surface via forming a sandwich immunocomplex, which could selectively determine CA125 from 5 x 10(-4) to 1 U/mL with a detection limit of 5 x 10(-5) U/mL (S/N = 3). The combined strategy of surface-defect-induced ECL and synergetic-effect-enhanced ECL would enable promising biorelated application of NIR-II ECL.

关键词： Electrochemiluminescence

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Research on the Development Strategy of Rural Cooperative Economy in the Post‐Epidemic Era ‐‐ Take the Rural Areas in Northern Anhui Province as an Example

Frontiers in Economics and Management

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Frontiers in Economics and Management 2023年第2期4卷 50-54页

作者： xuwen Zhang Han Han Senao li Jing Yan

In recent years, the development of the rural cooperative economy, the government and how to develop. At present, the coordinated development of rural revitalization and urbanization cannot be separated from the revitalization of the rural economy, which means that how to develop the rural cooperative economy has become an important issue of the current rural revitalization. This project is based on discussing how to develop the rural cooperative economy in northern Anhui. Through literature collection, field investigation and research, data analysis and sorting, combined with the advantages of rural areas in northern Anhui, it analyzes the current bottleneck of development and the factors restricting the development of rural cooperative economy in northern Anhui. Based on the basic situation of the rural cooperative economic development, the country and the Anhui province introduced support of rural cooperative economic development policy with the north of rural cooperative economic development actual situation, on the basis of a series of north of rural cooperative economy development quality countermeasures and Suggestions, innovative to develop two village mutual learning evaluation mechanism, promote land adoption agriculture, construction live help farmers base countermeasures, such as policy support, resources as a whole, innovation consciousness gives the specific path of rural cooperative economic development.

关键词： Rural Revitalization Cooperative Economy Urbanization Development Farmers' Income Increase Production Union

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Research on Flower Pattern and Roll Positioning Optimization for Roll Forming Process of TA4 Coiled Tubing

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MATERIALS 2024年第24期17卷 6164页

作者： Deng, xuwen Hui, Songxiao Ye, Xiongyue Ye, Wenjun Yu, Yang li, Yunbo GRINM Guangdong Inst Adv Mat & Technol Foshan 528051 Peoples R China GRIMAT Engn Inst Co Ltd Beijing 101407 Peoples R China Guangdong ForeWeld Corp Ltd Guangzhou 510700 Peoples R China China GRINM Grp Co LTD State Key Lab Nonferrous Met & Proc Beijing 100088 Peoples R China Univ Sci & Technol Beijing Inst Adv Mat & Technol Key Lab Adv Mat Proc MOE Beijing 100083 Peoples R China Gen Res Inst Nonferrous Met Beijing 100088 Peoples R China

Titanium alloy coiled tubing (CT) has great superiority while operating in deep wells with severe conditions, but it faces serious challenges during roll forming like high springback, edge cracking and surface wearing. In order to utilize the high precision and high efficiency production of titanium alloy CT, it is urgently necessary to develop a detailed process design. Based on the W-forming strategy and the cubic curve of the strip edge projection, the flower pattern and roll design for the 21-pass roll forming process were completed. Different tube dimensions and roll positionings were researched regarding the aspects of contact state, stress-strain distribution and geometry ovality using numerical simulation. The thickness/diameter ratio of the tube that can be formed should be within an effective range: exceeding the range leads to edge cracking, and an insufficient ratio leads to high springback. Roll positioning significantly affects the contact state and stress distribution, but leads to no major differences in the tube geometry. Finally, the trial production of the TA4 titanium CT with a size of Phi 50.8 x 4 mm was completed successfully and was consistent with the simulation results.

关键词： TA4 titanium coiled tubing roll forming flower pattern roll positioning

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Biosynthesis and signal transduction of plant growth regulators and their effects on bioactive compound production in Salvia miltiorrhiza (Danshen)

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CHINESE MEDICINE 2024年第1期19卷 102页

作者： li, Heqin Jiang, xuwen Mashiguchi, Kiyoshi Yamaguchi, Shinjiro Lu, Shanfa Qingdao Agr Univ Coll Agron 700 Changcheng Rd Qingdao 266109 Shandong Peoples R China Kyoto Univ Inst Chem Res Uji Kyoto 6110011 Japan Chinese Acad Med Sci & Peking Union Med Coll Inst Med Plant Dev 151 Malianwa North Rd Beijing 100193 Peoples R China Shandong Bairuijia Food Co Ltd 8008 Yi Rd Yantai 261400 Shandong Peoples R China

Plant growth regulators (PGRs) are involved in multiple aspects of plant life, including plant growth, development, and response to environmental stimuli. They are also vital for the formation of secondary metabolites in various plants. Salvia miltiorrhiza is a famous herbal medicine and has been used commonly for > 2000 years in China, as well as widely used in many other countries. S. miltiorrhiza is extensively used to treat cardiovascular and cerebrovascular diseases in clinical practices and has specific merit against various diseases. Owing to its outstanding medicinal and commercial potential, S. miltiorrhiza has been extensively investigated as an ideal model system for medicinal plant biology. Tanshinones and phenolic acids are primary pharmacological constituents of S. miltiorrhiza. As the growing market for S. miltiorrhiza, the enhancement of its bioactive compounds has become a research hotspot. S. miltiorrhiza exhibits a significant response to various PGRs in the production of phenolic acids and tanshinones. Here, we briefly review the biosynthesis and signal transduction of PGRs in plants. The effects and mechanisms of PGRs on bioactive compound production in S. miltiorrhiza are systematically summarized and future research is discussed. This article provides a scientific basis for further research, cultivation, and metabolic engineering in S. miltiorrhiza.

关键词： Plant growth regulators Phenolic acids Tanshinones Salvia miltiorrhiza Danshen

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Surface-Engineering Enhanced Charge Injection and Recombination of Silver Nanoclusters in an Aqueous Medium

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JOURNAL OF PHYSICAL CHEMISTRY C 2021年第40期125卷 22078-22083页

作者： Gao, xuwen Dong, Shuangtian Fu, li Xu, Yuqi Jia, Jingna Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

An effective way to enhance the charge injection and the radiative recombination within atomically precise nanoclusters (NCs) is proposed with Ag-29(BDT)(12) (BDT = 1,3-benzenedithiol) and Ag-29(BDT)(12)(TPP)(4) (TPP = triphenylphosphine) as models. Surface-engineering Ag-29(BDT)(12) with phosphine ligands can passivate the four naked Ag atom sites on the surface of Ag-29(BDT)(12) and circumvent the geometric packing limitation induced by the wide footprint of BDT, which endows Ag-29(BDT)(12)(TPP)(4) with enhanced electrochemical redox for improved charge injection as well as boosted photoluminescence (PL) and electrochemiluminescence (ECL) for enhanced radiative charge recombination. The surface-engineering process demonstrates a negligible effect on the charge-injection potentials as well as the excited state emission for PL and ECL. Ag-29(BDT)(12) and Ag-29(BDT)(12)(TPP)(4) can be injected with holes and electrons via similar electrochemical redox processes;both annihilation ECL and co-reactant ECL of Ag-29(BDT)(12) and Ag-29(BDT)(12)(TPP)(4) match well with their valence (VB) hole/conduction (CB) electron injection-related oxidative/reductive processes and are of similar wavebands with a maximum emission wavelength around 795 nm.

关键词： Elements Redox reactions Quantum mechanics Charge recombination Recombination

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Multifunctional ORF3 protein of hepatitis E virus

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JOURNAL OF MEDICAL VIROLOGY 2024年第6期96卷 e29691-e29691页

作者： li, Xiaoxuan Sun, xuwen Pinpin, Ji Zhao, Qin Sun, Yani Northwest Agr & Forestry Univ Coll Vet Med Dept Prevent Vet Med Yangling Shaanxi Peoples R China

Hepatitis E virus (HEV) is an emerging zoonotic pathogen that is transmitted primarily through the fecal-oral route and can cause acute hepatitis in humans. Since HEV was identified as a zoonotic pathogen, different species of HEV strains have been globally identified from various hosts, leading to an expanding range of hosts. The HEV genome consists of a 5' noncoding region, three open reading frames (ORFs), and a 3' noncoding region. The ORF3 protein is the smallest but has many functions in HEV release and pathogenesis. In this review, we systematically summarize recent progress in understanding the functions of the HEV ORF3 protein in virion release, biogenesis of quasi-enveloped viruses, antigenicity, and host environmental regulation. This review will help us to understand HEV replication and pathogenesis mechanisms better.

关键词： hepatitis E innate immunity ORF3 protein quasi-enveloped virion

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A Mannich-base imidazoline quaternary ammonium salt for corrosion inhibition of mild steel in HCl solution

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MATERIALS CHEMISTRY AND PHYSICS 2023年 293卷

作者： Wang, Ge li, Wentao Wang, Xuan Yuan, xuwen Yang, Huaiyu Chinese Acad Sci Inst Met Res Shenyang 110016 Peoples R China Univ Sci & Technol China Sch Mat Sci & Engn Hefei 230026 Peoples R China Hubei Univ Automot Technol Dept Mat Sci & Engn Shiyan 442002 Peoples R China

The inhibition performance of a novel Mannich base-type imidazoline quaternary salt, namely [N, N-bis(pro-piophenone), N(-1-polyethyleneployamine-2-stearic-imidazole)] benzyl ammonium chloride (PPLC) for mild steel in 0.5 M HCl was investigated. The experimental results show that PPLC is an excellent corrosion inhibitor, which can retard both the anodic and cathodic reactions through strong chemisorption on the surface. The theoretical results from DFT and MD simulations imply that the active site of PPLC was concentrated on the imidazole ring, carbonyl group and benzene ring, and the PPLC could spontaneously adsorb on the surface of metal in a manner parallel.

关键词： Mild steel Polarization EIS DFT MD

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