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Improving identification ability of adulterants in powdered Panax notoginseng using particle swarm optimization and data fusion

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INFRARED PHYSICS & TECHNOLOGY 2019年 103卷 103101-000页

作者： Yang, Xiaodong Song, Jie Peng, lin Gao, Lutao Liu, xuwen Xie, lin Li, Guanglin Southwest Univ Coll Engn & Technol Chongqing 400715 Peoples R China Yunnan Agr Univ Coll Big Data Kunming 650201 Yunnan Peoples R China

Panax notoginseng (P. notoginseng) is frequently targeted for adulteration with lower-grade P. notoginseng because of its high price. This paper presents a novel method to improve the identification ability of adulterants using spectroscopic techniques and chemometrics. P. notoginseng powder of different grades were blended at different percentages (0-100%), in which the minimum blend ratio was 0.5%. NIR (12,497-4000 cm(-1)) and FT-MIR (4000-400 cm(-1)) spectra of samples were acquired. The wavenumbers of 7099-4200 cm(-1), 3600-2750 cm(-1), and 1750-400 cm(-1) were selected manually as characteristic spectra, which included 3706 variables. Then principal component analysis (PCA) was used to further reduce the data dimension of characteristic spectra, and the first nine principal components (PCs) were applied to build classification models of 14 (the ratio of 0.5% excluded) and 15 kinds of blend ratios. Finally, Support vector machine (SVM) was built for classification of adulterants of different blend ratio. The accuracy of prediction set is 92.46% and 91.79%, respectively. On this basis, particle swarm optimization (PSO) was applied to optimize the parameters of SVM, and the accuracy of prediction set increased to 96.65% and 96.97%, respectively. The results demonstrate that the application of data fusion of NIR and FT-MIR spectra combined with SVM optimized by PSO can improve the identification ability of adulterants in powdered P. notoginseng.

关键词： Panax notoginseng Adulteration PCA PSO SVM

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An Algorithm for the Noninvasive and Personalized Measurement of Microvascular Blood Viscosity Using Physiological Parameters

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BIOMED RESEARCH INTERNATIONAL 2020年第0期2020卷 000-000页

作者： Sun, Ge Yang, lin Wang, Weiwei Zhang, Song Luo, Zhichang Wu, Guanghui Liu, Xiaohong Hao, Dongmei Yang, Yimin Li, xuwen Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Chinese Acad Med Sci Fuwai Hosp Beijing 100037 Peoples R China Capital Med Univ Beijing Inst Heart Lung & Blood Vessel Dis Beijing Anzhen Hosp Beijing 100029 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

Blood viscosity is one of the important parameters to characterize hemorheological properties of the human body. Its real-time and dynamic measurement has important physiological significance for studying the development and prevention of chronic diseases. This study researched noninvasive and personalized measurement of microvascular blood viscosity. In the microcirculation capillary network blood flow model, combined with pulse wave parameters, multiple regression analysis was used to fit the simulated radius of personalized physiological blood vessels to calculate the microvascular blood viscosity. The fitted value related to the simulated radius of the physiological blood vessel had a high correlation with the corresponding theoretically derived value (correlation coefficient: 0.904,P <= 0.001). The calculated value of the microvascular blood viscosity had a certain correlation with the clinical whole blood viscosity at a low shear rate (correlation coefficient: 0.443,P<0.05). This algorithm could provide effective means for noninvasive and long-term individual monitoring and family health care.

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Identification of unhealthy Panax notoginseng from different geographical origins by means of multi-label classification

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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 2019年 222卷 117243-000页

作者： Yang, Xiaodong Song, Jie Wu, Xin Xie, lin Liu, xuwen Li, Guanglin Southwest Univ Coll Engn & Technol Chongqing 400715 Peoples R China

Root-knot nematode is a common plant-parasitic pest with a highly destructive that infects more than 2000 plant species. Panax notoginseng (P. notoginseng) is one of the most susceptible traditional medicine. More importantly, it is difficult to distinguish the powders of P. notoginseng infected with root-knot nematode from those of healthy P. notoginseng due to the color and shape are same after being ground into powder. In this paper, Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) was used to identify P. notoginseng samples. Multiplicative scatter correction (MSC) was applied to preprocess the spectral data. Competitive adaptive reweighted sampling (CARS) and successive projection algorithm (SPA) were employed to select feature variables. Density-based spatial clustering of application with noise (DBSCAN) was adopted to discover groups within the data. Also, we found that the geographical origin is a pivotal factor to consider when identifying unhealthy P. notoginseng. Therefore, we introduced a novel multi-label classification (MLC) method to identify healthy and unhealthy P. notoginseng powders from three different geographical origins. In addition, binary relevance method (BR), classifier chain (CC), ensembles of classifier chains (ECC), and multilayer perceptron classifier (MLPC) were applied to create classification models, ECC exhibits superior performance in particular. (C) 2019 Elsevier B.V. All rights reserved.

关键词： Panax notoginseng Root-knot nematode Geographical origin Multi-label classification

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重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用对深Ⅱ度烧伤的影响

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中国美容整形外科杂志 2022年第7期33卷 413-416,434页

作者：李亮王旭文何丽彩李双蔺利剑赵龙刚李雯河北中石油中心医院整形手外烧伤科河北廊坊065000 廊坊永清康定精神病医院河北廊坊065600

目的观察重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用对深Ⅱ度烧伤患者的影响。方法选取2019年6月至2020年5月河北中石油中心医院整形手外烧伤科治疗的120例深Ⅱ度烧伤患者为研究对象,采用随机数字表法对患者分组:对照组1... 详细信息

目的观察重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用对深Ⅱ度烧伤患者的影响。方法选取2019年6月至2020年5月河北中石油中心医院整形手外烧伤科治疗的120例深Ⅱ度烧伤患者为研究对象,采用随机数字表法对患者分组:对照组1、对照组2、观察组,每组40例患者。对照组1采用削痂术联合重组人酸性成纤维细胞生长因子治疗,对照组2采用削痂术联合夫西地酸乳膏治疗,观察组采用削痂术联合重组人酸性成纤维细胞生长因子和夫西地酸乳膏治疗,3组患者均连续治疗至创面愈合。治疗前、治疗第20天测量白细胞介素-2(interleukin-2, IL-2)、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素-10(Interleukin-10, IL-10)、白细胞介素-6(interleukin-6, IL-6)、血管内皮生长因子(vascular endothelial growth factor, VEGF)、表皮细胞生长因子(epidermal cell growth factor, EGF)、金属蛋白酶组织抑制因子1(tissue inhibitor of metalloproteinase 1, TIMP-1)、转化生长因子β1(transforming growth factor β1, TGF-β1)水平,观察患者创面愈合时间,采用温哥华瘢痕量表(vancouver scar scale, VSS)评价3组患者瘢痕增生程度,记录患者不良反应情况。结果观察组TNF-α、IL-6水平低于对照组1和对照组2(P<0.05),观察组IL-2、IL-10水平高于对照组1和对照组2(P<0.05),观察组VEGF、EGF、TIMP-1、TGF-β1水平高于对照组1和对照组2(P<0.05),治疗第10、15、20天,3组创面愈合率升高(P<0.05),观察组创面愈合率高于对照组1和对照组2(P<0.05),观察组创面愈合平均时间低于对照组1和对照组2(P<0.05),观察组瘢痕血管分布、颜色、厚度和柔软度评分低于对照组1和对照组2(P<0.05),3组均无明显不良反应发生。结论重组人酸性成纤维细胞生长因子联合夫西地酸乳膏局部应用治疗深Ⅱ度烧伤患者,可降低促炎因子TNF-α、IL-6水平,提升抑炎因子IL-2、IL-10水平,抑制炎症,提升VEGF、EGF、TIMP-1、TGF-β1水平,提升创面愈合率,降低瘢痕增生,安全性较高。

关键词：重组人酸性成纤维细胞生长因子夫西地酸乳膏深Ⅱ度烧伤创面愈合瘢痕增生

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质量基础设施"一站式"服务平台现状、关键技术及发展趋势研究

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中国科技纵横 2025年第2期 128-130页

作者：陈旭文魏春梅曹伟马琳朱明浙江省质量科学研究院浙江杭州 310018

质量基础设施(NQI)作为国家质量发展的基石,对于提升产品和服务质量、促进产业升级和经济发展具有重要意义.随着全球化和信息化的加速发展,企业和消费者对质量的要求越来越高,传统的质量服务模式已难以满足多样化需求.基于此,本文通过... 详细信息

质量基础设施(NQI)作为国家质量发展的基石,对于提升产品和服务质量、促进产业升级和经济发展具有重要意义.随着全球化和信息化的加速发展,企业和消费者对质量的要求越来越高,传统的质量服务模式已难以满足多样化需求.基于此,本文通过研究国内外质量基础设施"一站式"服务的现状,分析国内"一站式"服务平台发展存在的主要问题,揭示了平台关键技术及发展趋势,以期为相关工作提供有益参考和借鉴.

关键词：质量基础设施"一站式"服务现状关键技术发展趋势

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赞比亚医疗器械现状及挑战

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中国医疗设备 2022年第5期37卷 146-149,165页

作者： Taizya Kapenda 廉翠婷杨琳郝冬梅杨益民李旭雯张松北京工业大学环境与生命学部智能化生理测量与临床转化北京市国际科研合作基地北京100124

赞比亚共和国(下称赞比亚)医疗卫生事业发展不平衡十分显著,缺少医疗设备相关的国家政策,使得负责医疗技术政策实施的医疗设备部门面临很大挑战。本文通过分析赞比亚的卫生与医疗器械现状,以期为赞比亚医疗器械的采购、捐赠和设备报废... 详细信息

赞比亚共和国(下称赞比亚)医疗卫生事业发展不平衡十分显著,缺少医疗设备相关的国家政策,使得负责医疗技术政策实施的医疗设备部门面临很大挑战。本文通过分析赞比亚的卫生与医疗器械现状,以期为赞比亚医疗器械的采购、捐赠和设备报废更新提供参考。赞比亚卫生部通过赞比亚药品监督管理局制定的医疗设备相关政策、计划、资源、规范和指南,明确了在医疗器械部署过程中各环节应遵循的规定制度。本文分析了赞比亚医疗器械管理所面临的挑战:医疗设备缺乏、人力资源缺乏、规划与预算不足,以及设备采购、安装、调试、维护的难题,并提出相应解决办法,如建立医疗设备委员会,采用临床工程人员对医疗设备进行统一管理的方式,以保障临床医护人员以及患者的安全。赞比亚管理和维护医疗设备的能力仍然有限,导致管理和维修能力的增长大大落后于医疗设备的部署,这些既是赞比亚与他国合作的方向,也是自身需要改进的部分。本研究可为提高赞比亚医疗设备服务水平、缓解医疗压力提供参考。

关键词：赞比亚医疗器械政策法规器械管理挑战

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Metabolomic study of natrin-induced apoptosis in SMMC-7721 hepatocellular carcinoma cells by ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2019年第0期124卷 1264-1273页

作者： Lu, Shiyin Lu, Rigang Song, Hui Wu, Jinxia Liu, xuwen Zhou, Xiaoling Yang, Jianqing Zhang, Hongye Tang, Chaoling Guo, Hongwei Hu, Jian Mao, Guifu lin, Hanmei Su, Zhiheng Zheng, Hua Guangxi Med Univ Pharmaceut Coll Nanning Peoples R China Liuzhou Tradit Chinese Med Hosp Dept Pharm Liuzhou Peoples R China Guangxi Inst Food & Drug Control Nanning Peoples R China Liuzhou Tradit Chinese Med Hosp Dept Gastroenterol Liuzhou Peoples R China Guangxi Tradit Chinese Med Univ Affiliated Hosp 1 Gynaecol Nanning Peoples R China Guangxi Med Univ Med Sci Res Ctr Nanning Peoples R China

Natrin, a new member of the cysteine-rich secretory protein (CRISP) family purified from the snake venom of Naja naja atra, has been demonstrated to have anticancer activity. However, the underlying molecular mechanisms need further elucidation. In this study, MU was used to evaluate cell viability. Apoptotic cells were analyzed by employing a transmission electron microscope (TEM). Metabolomic study of the metabolic perturbations caused by natrin-induced apoptosis in differentiated SMMC-7721 cells was performed for the first time by using integrative ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/IDF MS). To investigate the possible mechanism in the mitochondria] pathway of natrin-induced apoptosis, we measured apoptosis-related mRNA changes using real-time fluorescent quantitative PCR (FQ-PCR). Cell proliferation was significantly inhibited after treatment with natrin in a dose dependent manner. Principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA) clearly demonstrated that metabolic profiles were affected by natrin. The results of multivariate statistical analysis showed that a total of 13 metabolites were characterized as potential biomarkers highly implicated in natrin-induced apoptosis, which corresponded to fluctuations of five pathways, including sphingolipid metabolism, fatty acid biosynthesis, fatty acid metabolism, glycerophospholipid metabolism and glycosphingolipid biosynthesis. Furthermore, natrin-induced apoptosis showed an increase in the Bax/Bcl-2 ratio in the mitochondrial pathway compared with controls. This study illustrated that rapid and holistic cell metabolomics combining molecular biological approaches might be a powerful tool for evaluating the underlying mechanisms of natrin-induced apoptosis, which would help to deepen specific insights into the anti-hepatoma mechanisms of natrin and facilitate the clinical application of natrin in the future.

关键词： Metabolomics Natrin Hepatocellular carcinoma (HCC) Apoptosis UPLC-QtrOF MS

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The complete chloroplast genome of the lipstick tree,Bixa Orellana(Bixaceae)

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Mitochondrial DNA Part B 2019年第1期4卷 17-18页

作者： Seping Dai xuwen Li Jianzhong Ni lin Ruan Renchao Zhou Wei Lun Ng Guangzhou Institute of Forestry and Landscape Architecture Guangzhou China State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life Science Sun Yat-sen University Guangzhou China

Bixa orellanais a small tree known for its red, oil-soluble pigment contained in the seed coat that is used as a natural dye and food coloring. In this study, we assembled and characterized the complete chloroplast genome ofB. orellanaas a resource for future genetic studies. With a total length of 159,825 bp, the chloroplast genome comprised of a large single-copy (LSC) region of 89,476 bp, a small single-copy (SSC) region of 19,617 bp, and two inverted repeat (IR) regions of 25,356 bp each. A total of 127 genes were predicted, consisting of 83 protein-coding genes, 36 tRNA genes, and 8 rRNA genes. Phylogenetic analysis confirmed the position ofB. orellanawithin the order Malvales.

关键词： Bixa achiote natural dye complete chloroplast genome automated assembly

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医学数据挖掘在线教学平台的设计与实现

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中国医学教育技术 2021年第6期35卷 698-702页

作者：徐晓巍杨林郑思孙月萍王序文李姣中国医学科学院医学信息研究所北京100020

为了培养医学生掌握医学数据挖掘方法并应用于临床科研工作,提高医学生的信息素养,该研究设计实现了医学数据挖掘在线教学平台,并于2020年春季学期面向协和研究生的“医学数据挖掘实用技术”教学实践中投入使用,该平台有效弥补实践类课... 详细信息

为了培养医学生掌握医学数据挖掘方法并应用于临床科研工作,提高医学生的信息素养,该研究设计实现了医学数据挖掘在线教学平台,并于2020年春季学期面向协和研究生的“医学数据挖掘实用技术”教学实践中投入使用,该平台有效弥补实践类课程短板,能够满足不同学科背景的学生需求。学生课后反馈结果表明,该平台的应用降低了技术类课程的学习门槛,激发了医学生对于数据挖掘类课程的学习积极性,有助于其实践能力的提升。

关键词：医学数据挖掘平台建设医学教育

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环境温度和驱动电流对LED的峰值波长的影响

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照明工程学报 2020年第1期31卷 16-21页

作者：刘旭文林上飞刘木清复旦大学光源与照明工程系上海200433 复旦大学先进照明技术教育部工程研究中心上海200433 复旦大学工程与应用技术研究院上海200433

LED作为一种节能高效的发光器件,其光学特性受驱动电流、环境温度等因素的影响。本文主要研究不同的环境温度和驱动电流模式对不同波长LED峰值波长的影响,选取了可见光波段内的13种不同的波长的LED、3种不同的环境温度、10种不同的驱动... 详细信息

LED作为一种节能高效的发光器件,其光学特性受驱动电流、环境温度等因素的影响。本文主要研究不同的环境温度和驱动电流模式对不同波长LED峰值波长的影响,选取了可见光波段内的13种不同的波长的LED、3种不同的环境温度、10种不同的驱动电流进行实验,并得出以下实验结论:①在相同温度情况下,415~531 nm波长区间内的LED的峰值波长随着驱动电流占空比的增加而增加,在591~740 nm波长区间的LED的峰值波长随着驱动电流占空比的增加而减小。②在相同模式电流驱动下,随着环境温度的升高,所有不同波长类型的LED的峰值波长都增加,即发生红移,且LED峰值波长的移动量与温差之间具有很好的线性关系。③环境温度的升高可以使得LED波长增大,且这种波长增大量与LED本身波长有关,温度使红光LED波长增大量Δλ红明显比蓝光LED波长增大量Δλ蓝要高。④环境温度与驱动电流共同作用下,可以使得LED峰值波长出现更大的偏移量,两种因素对LED峰值波长的影响效果可以叠加。实验结果希望可为改变LED光学特性提供参考。

关键词： LED 峰值波长驱动电流环境温度

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