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ClinICAL AND TRANSLATIONAL MEDICINE 2024年第3期14卷 e1613页

作者： lin, xuwen Xie, Mei Yao, Jie Ma, Xidong Qin, lin Zhang, Xu-Mei Song, Jialin Bao, Xinyu Zhang, Xin Zhang, Yinguang Liu, Yiming Han, Wenya Liang, Yiran Jing, Ying Xue, Xinying Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Resp & Crit Care Beijing Peoples R China Capital Med Univ Beijing Chest Hosp TB & Thorac Tumor Inst Dept Endoscop Diag & Treatment Beijing Peoples R China Weifang Med Univ Dept Pathol Affiliated Hosp Weifang Shandong Peoples R China Weifang Med Coll Dept Resp & Crit Care Weifang Shandong Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Thorac Surg Beijing Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Thorac Surg Beijing Peoples R China Hubei Univ Med Taihe Hosp Dept Resp & Crit Care Shiyan Peoples R China Fudan Univ Ctr Intelligent Med Greater Bay Area Inst Precis Med Guangzhou Sch Life Sci Guangzhou Guangdong Peoples R China Fudan Univ Greater Bay Area Inst Precis Med Guangzhou Ctr Intelligent Med Sch Life Sci Guangzhou 511462 Guangdong Peoples R China Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing 100038 Peoples R China

The emergence of immune checkpoint inhibitors (ICIs) has heralded a transformative era in the therapeutic landscape of non-small cell lung cancer (NSCLC). While ICIs have demonstrated clinical efficacy in a portion of patients with NSCLC, these treatments concurrently precipitate a spectrum of immune-related adverse events (irAEs), encompassing mild to severe manifestations, collectively posing a risk of significant organ damage. Consequently, there exists an imperative to augment our comprehension of the pathophysiological underpinnings of irAEs and to formulate more efficacious preventive and ameliorative strategies. In this comprehensive review, we delineate the clinical presentation of organ-specific irAEs in patients with NSCLC and provide an in-depth analysis of recent advancements in understanding the mechanisms driving ICI-induced toxicity. Furthermore, we discuss potential strategies and targets for ameliorating these irAEs. Ultimately, this review aims to furnish valuable insights to guide further research endeavours in the context of irAEs in NSCLC patients. Immunotherapy not only revolutionises lung cancer treatment but also poses serious toxicity risks. Elucidating irAE mechanisms in NSCLC: T/B-cell dysregulation, cytokine imbalances, autoantibody production, genetic predispositions and gut microbiome alterations. Highlighting precise irAE interventions in NSCLC: corticosteroids, targeted immunosuppressants, monoclonal antibodies targeting lymphocytes, cytokine inhibitors and signalling pathway modulators. image

关键词： immune checkpoint inhibitors immune-related adverse events mechanism non-small cell lung cancer

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Tertiary lymphoid structures as potential biomarkers for cancer prediction and prognosis

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INTERNATIONAL IMMUNOPHARMACOLOGY 2024年 140卷 112790页

作者： Zhang, Xin Yao, Jie Xie, Mei Liang, Yiran lin, xuwen Song, Jialin Bao, Xinyu Ma, Xidong Wang, Yuanyong Zhang, Yinguang Liu, Yiming Han, Wenya Pan, Lei Xue, Xinying Shandong Second Med Univ Sch Clin Med Weifang 261000 Shandong Peoples R China Capital Med Univ Beijing Shijitan Hosp Emergency & Crit Care Med Ctr Dept Resp & Crit Care Beijing 100038 Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Resp & Crit Care Beijing 100835 Peoples R China Air Force Mil Med Univ Tangdu Hosp Dept Thorac Surg Xian 710038 Shanxi Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Thorac Surg Beijing 100070 Peoples R China Hubei Univ Med Taihe Hosp Dept Resp & Crit Care Med Shiyan 442000 Peoples R China

Tertiary lymphoid structures (TLSs) are ectopic lymphocyte aggregates formed in non-lymphoid tissues, including cancers, and are loci for the generation of in situ anti-tumor immune responses, which play a crucial role in cancer control. The state of TLS presence in cancer and its composition can significantly impact the treatment response and prognosis of patients. TLSs have the potential to serve as predictive and prognostic biomarkers for cancer. However, the mechanisms underlying TLS formation in cancer and how the essential components of TLSs affect cancer are not fully understood. In this review, we summarized TLS formation in cancer, the value of the TLS in different states of existence, and its key constituents for cancer prediction and prognosis. Finally, we discussed the impact of cancer treatment on TLSs.

关键词： Tertiary lymphoid structure Cancer Prediction Prognosis Biomarker

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Optimization of car-sharing scheduling based on genetic combined with simulated annealing strategy

Optimization of car-sharing scheduling based on genetic comb...

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Science and Technology Innovation (IAECST), International Academic Exchange Conference on

作者： Chao Zhou Danyang Guo Jiaqi Li Aiqiong Rong Sihua Liang xuwen lin College of Mechanical Engineering Guangzhou City University of Technology Guang Zhou

ISBN: (纸本)9781665402682

This paper conducts scientific research on the joint scheduling of vehicles and personnel based on the distribution of car-sharing use [1] , so as to propose an optimal control scheduling scheme that improves car utilization while making customers more satisfied and maximizing corporate profits. To begin with, we used the partitioning method to pre-processing the shared vehicle location data set, and use Excel software to disassemble the coordinate information. We need to divide the data according to the parking points, count the data according to different parking points, make descriptive statistics on the total number of parked vehicles at the parking points, and then analyze the use distribution of car-sharing [2] . Additionally, a joint car-sharing scheduling optimization model is built and the model is improved, which is then transformed into a two-layer mTSP model [3] . The upper model is an mTSP model with uncertain number of vehicles with time windows, while the lower model is an mTSP model with uncertain number of persons with time windows. At the same time, the genetic algorithm is used to solve the model, and after the operation of selection, cross over and variation combined with the simulated annealing strategy [4] to achieve better optimization results and construct the most beneficial scheduling solution for the enterprise.

关键词： Adaptation models Technological innovation Supply and demand Urban areas Optimal scheduling Simulated annealing Scheduling

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他莫昔芬辅助治疗的ER阳性乳腺癌患者miR-122、miR-449a检测的临床价值研究

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现代生物医学进展 2024年第23期24卷 4592-4594页

作者：范丽莉许文林彭金娟李丽陶凯江苏大学医学院江苏镇江212013 江苏大学第四附属医院乳腺科江苏镇江212050 江苏大学第四附属医院中心实验室江苏镇江212050

目的:分析他莫昔芬辅助治疗的雌激素受体(ER)阳性乳腺癌患者微小RNA(mi R)-122、mi R-449a检测的临床价值。方法:选择258例ER阳性乳腺癌患者,均接受他莫昔芬辅助治疗。分析血清外泌体mi R-122、mi R-449a表达与患者临床病理特征的关系... 详细信息

目的:分析他莫昔芬辅助治疗的雌激素受体(ER)阳性乳腺癌患者微小RNA(mi R)-122、mi R-449a检测的临床价值。方法:选择258例ER阳性乳腺癌患者,均接受他莫昔芬辅助治疗。分析血清外泌体mi R-122、mi R-449a表达与患者临床病理特征的关系。随访5年,绘制Kaplan-Meier曲线分析生存率,采用多因素Cox回归分析影响因素。结果:组织学分级3级、TNM分期Ⅲ期、腋窝淋巴结转移、Ki-67高表达的ER阳性乳腺癌患者治疗前血清外泌体mi R-122高于组织学分级1-2级、TNM分期Ⅰ/Ⅱ期、无腋窝淋巴结转移、Ki-67低表达,mi R-449a则更低(P<0.05)。mi R-122高表达组中位总生存期(OS)低于mi R-122低表达组(P<0.05);mi R-449a低表达组中位OS低于mi R-449a高表达组(P<0.05);Cox回归分析显示TNM分期为Ⅲ期、Ki-67高表达(≥14%)、mi R-122高表达、mi R-449a低表达是ER阳性乳腺癌患者他莫昔芬辅助治疗预后不良的独立危险因素(P<0.05)。结论:ER阳性乳腺癌患者血清外泌体mi R-122、mi R-449a表达水平与患者组织学分级、TNM分期、腋窝淋巴结转移情况、Ki-67表达等临床病理特征相关,mi R-122高表达、mi R-449a低表达是影响患者5年生存期的独立危险因素,有望成为预测他莫昔芬辅助治疗预后的重要标志物。

关键词： ER阳性乳腺癌他莫昔芬 miR-122 miR-449a 预后

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浅析国内度假型精品酒店建筑空间组合方式

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建筑与文化 2021年第4期 236-238页

作者：陆俊衡林旭文华南理工大学建筑学院华南理工大学建筑设计研究院有限公司

随着社会经济的发展以及人们对旅行诉求的变化,近年来民众对于度假型精品酒店的消费也在不断提升,度假型精品酒店的设计也越发受到关注。对于度假型酒店设计而言,前期布局设计是重要的环节,文章通过对国内部分优秀案例进行研究,分析度... 详细信息

随着社会经济的发展以及人们对旅行诉求的变化,近年来民众对于度假型精品酒店的消费也在不断提升,度假型精品酒店的设计也越发受到关注。对于度假型酒店设计而言,前期布局设计是重要的环节,文章通过对国内部分优秀案例进行研究,分析度假型精品酒店的建筑空间组合方式,以期为度假型精品酒店布局设计提供思考方向。

关键词：度假型精品酒店建筑布局空间组合酒店设计

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Threshold Huffman-Based Covert Timing Channel Detection

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International Journal of Network Security 2025年第1期27卷 61-71页

作者： lin, Yuwei Chen, Yonghong Zhuang, Xiaolong Huang, xuwen School of Computer Science and Technology Huaqiao University Fujian Xiamen361000 China Xiamen Key Laboratory of Data Security and Blockchain Technology Huaqiao University Fujian Xiamen361000 China

Network covert timing channels in computer networks evade effective detection by traditional security mechanisms such as firewalls, posing a significant threat to network security. However, most existing methods struggle to detect such channels when the window size is small. Additionally, the emergence of the new ϵ-κlibur channel has resulted in a decline in performance for detection methods such as GAS, SnapCatch, and DNN when detecting this particular channel. In this paper, we investigate a Huffman tree-based approach for detecting anomalous nodes in traffic and achieving the classification of channels through the design of weight intervals. Our method achieves an average detection rate of over 95% for each channel. Additionally, compared to GAS, SnapCatch, and DNN, our method improves the detection rates for the ϵ-κlibur channel by 11.75%, 8.46%, and 4.81%, respectively. The experimental results demonstrate that our proposed approach successfully detects ϵ-κlibur and achieves detection in a small window. © (2025), (Femto Technique Co., Ltd.). All rights reserved.

关键词： Computer system firewalls

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Semi-interpenetrating network membranes based on poly(phenylene oxide) and poly(acrylonitrile-vinylimidazole) for high-temperature proton exchange membrane fuel cell applications

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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY 2025年 116卷 1-7页

作者： Han, Yuyang Xu, Fei Huang, Kai Li, Yanting Yang, Qinwu Bao, xuwen lin, Bencai Changzhou Univ Jiangsu Collaborat Innovat Ctr Photovolat Sci & En Sch Mat Sci & Engn Changzhou 213164 Jiangsu Peoples R China

In this study, a series of semi-interpenetrating network (semi-IPN) structure proton exchange membranes (PEMs) based on linear polyolefins and cross-linked poly(phenylene oxide) (cPPO) was fabricated for fuel cell applications. The newly synthesized membranes exhibit better flexibility and higher chemical and thermal stability than cPPO membrane owing to a semi-IPN structure. After treatment with Fenton's reagent at 80 degrees C for 240 h, all the synthesized semi-IPN membranes (cPPO-[AN-VBIm]x) show a remaining mass of >90%, indicating good oxidation stability. The proton conductivity and fuel cell performance of cPPO-[AN-VBIm](50) membranes (91 mS cm(-1) at 160 degrees C and 514 mW cm(-2) at 140 degrees C, respectively) are better than those of cPPO membranes (51 mS cm(-1) and 87 mW cm(-2), respectively under the same conditions). This study contributes significantly toward membrane research, reporting a facile and efficient method for fabricating high-performance phosphoric acid-doped membranes for high-temperature fuel cell applications that could guide future studies on efficient and practicable high-temperature PEMs.

关键词： Poly(phenylene oxide) Semi-interpenetrating network Proton exchange membrane Fuel cells Proton conductivity Phosphoric acid-doped membranes

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新时代公立医院党建文化建设路径探讨

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中国卫生标准管理 2020年第13期11卷 11-14页

作者：林序文张曲涛广东省东莞市滨海湾中心医院党委办公室广东东莞523900

进入新时代,随着健康中国战略的实施,公立医院改革不断深化、行业竞争日趋激烈,党建文化建设在医院发展中发挥着越来越重要的作用。文章从坚定政治文化,提升医院核心领导力;倡导学习文化,强化党建工作渗透力;弘扬大爱文化,提高基层党建... 详细信息

进入新时代,随着健康中国战略的实施,公立医院改革不断深化、行业竞争日趋激烈,党建文化建设在医院发展中发挥着越来越重要的作用。文章从坚定政治文化,提升医院核心领导力;倡导学习文化,强化党建工作渗透力;弘扬大爱文化,提高基层党建有效力;注重群体文化,增强党员群众凝聚力;涵养廉洁文化,扩大党风廉政辐射力等五个角度出发,研究探讨新时代公立医院党建文化建设路径创新策略,着力打造效能型、学习型、服务型、战斗型、廉洁型“五型”党组织,以期为加强公立医院党建文化建设提供有益参考,共同繁荣社会主义公立医院的党建文化。

关键词：新时代公立医院党建文化建设路径

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Highly Robust,Compressible,Anisotropic,and Fire-Retardant Polyimide/Hydroxyapatite Nanowires/Reduced Graphene Oxide Aerogel for Rapid Adsorption of Viscous Oil Assisted by Sunlight

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Research 2024年第4期7卷 58-70页

作者： Pan Huang Yongxiang Sun lin Yang Haoyu Yang Ying Hu Jifang Liu xuwen Peng Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada Heavy Machinery Engineering Research Center of Education Ministry Taiyuan University of Science and TechnologyTaiyuan 030024China Cancer Center The Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510700China Department of Chemical Engineering Tsinghua UniversityBeijing 10084China

Improving the adsorption efficiency of porous adsorbent materials for organic liquids with high viscosity is crucial for addressing oil spill *** this study,a high-performance aerogel adsorbent composed of polyimide(PI),hydroxyapatite nanowires(HAPnws),and reduced graphene oxide(rGO)has been fabricated,which leverages reduced flow tortuosity through anisotropic structures and solar-assisted viscosity reduction via photothermal *** prepared anisotropic PI/HAP/rGO aerogel,with directional channels,shows unique mechanical properties with high stiffness along the axial direction and compressibility along the radial direction.

关键词： nanowires viscosity adsorbent

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功能复合下城市公共图书馆的空间设计研究——以镇江市图书馆新馆项目为例

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城市建筑 2020年第8期17卷 49-52页

作者：汪燎宇林旭文华南理工大学建筑学院广东广州510640 华南理工大学建筑设计研究院有限公司广东广州510640

城市图书馆是兼具使用功能与文化载体的场所。随着社会的发展,图书馆的功能愈发多元化。文章通过对城市图书馆功能复合背景下公共空间设计进行探讨,以华南理工大学建筑设计研究院镇江市图书馆新馆项目的中标方案(以下简称"镇图新馆... 详细信息

城市图书馆是兼具使用功能与文化载体的场所。随着社会的发展,图书馆的功能愈发多元化。文章通过对城市图书馆功能复合背景下公共空间设计进行探讨,以华南理工大学建筑设计研究院镇江市图书馆新馆项目的中标方案(以下简称"镇图新馆")作为工程实践对象,分析探讨"复合功能"下的图书馆公共空间设计,提出"空间整合"与"可持续运营"策略,从而达到充分激活城市图书馆的公共性与图书馆高效运营的目的。

关键词：功能复合城市图书馆空间整合可持续运营

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