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SSRN 2022年

作者： lin, Yongsheng Qiu, Ziwen lin, Xiaojie Wu, Yingxiang Niu, Xianqian Yin, Guanwen Shao, Dandan Xiang, xuwen Li, Yongyu Yang, Chao College of Horticulture Fujian Agriculture and Forestry University Fuzhou350002 China Institute of Natural Products of Horticultural Plants Fujian Agriculture and Forestry University Fuzhou350002 China Qingyuan Agricultural Science and Technology Extension Service Center Qingyuan511518 China Fujian Institute of Tropical Crops Zhangzhou363001 China

Many aromatic plant volatile compounds contain methyleugenol, which is an attractant for insect pollination and has antibacterial, antioxidant, and other properties. The essential oil of Melaleuca bracteata leaves contains 90.46% methyleugenol, which is an ideal material for studying the biosynthetic pathway of methyleugenol, where eugenol synthase (EGS) is one of the key enzymes involved in the synthesis of methyleugenol. We recently reported two eugenol synthase genes (MbEGS1 and MbEGS2) present in M. bracteata, where MbEGS1 and MbEGS2 were mainly expressed in flowers, followed by leaves, and had the lowest expression levels in stems. In this study, the functions of MbEGS1 and MbEGS2 in the biosynthesis of methyleugenol were investigated using transient gene expression technology and virus-induced gene silencing (VIGS) technology in M. bracteata. Here, in the MbEGSs genes overexpression group, the transcription levels of the MbEGS1 gene and MbEGS2 gene were increased 13.46 times and 12.47 times, respectively, while the methyleugenol levels increased 18.68% and 16.48%. We further verified the function of the MbEGSs genes by using VIGS, as the transcript levels of the MbEGS1 and MbEGS2 genes were downregulated by 79.48% and 90.35%, respectively, and the methyleugenol content in M. bracteata decreased by 28.04% and 19.45%, respectively. The results indicated that the MbEGS1 and MbEGS2 genes were involved in the biosynthesis of methyleugenol, and the transcript levels of the MbEGS1 and MbEGS2 genes correlated with the methyleugenol content in M. bracteata. © 2022, The Authors. All rights reserved.

关键词： Biosynthesis

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A study of a fetal heart rate calculation system based on R-R interval

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TECHNOLOGY AND HEALTH CARE 2020年第S1期28卷 S187-S195页

作者： Zhang, Yisong Zhang, Song Yang, lin Yang, Yimin Li, xuwen Hao, Dongmei Xu, Mingzhou Shao, Jing Beijing Univ Technol Coll Life Sci & Bioengn Intelligent Physiol Measurement & Clin Translat Beijing Int Base Sci & Technol Cooperat Beijing 100024 Peoples R China Beijing Aerosp ChangFeng Co Ltd Beijing 100071 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Fetal electrocardiogram (FECG) can be obtained in a non-invasive manner to monitor fetal growth status. OBJECTIVE: In this study, a fetal heart rate (FHR) calculation system was proposed, which consists of the FECG recorder (MF-HOLTER) and the FECG monitoring software (FECG-MS). The abdomen electrocardiogram (AECG) of pregnant woman is acquired through the MF-HOLTER. The FECG-MS packs the AECG data and calls the FECG separation algorithm to obtain the separated FECG and the fetal QRS (FQRS) position. The FHR is further obtained by calculating the R-R interval value. At the same time, this study proposed a FQRS position correction algorithm to calculate the correct FHR values. METHOD: In order to verify the accuracy of the FHR calculation, the ECG signal of FLUKE's PS320 FETAL SIMULATOR and clinical data were simultaneously tested. RESULTS: The accuracy rate is over 98% in processing the simulator's data. In processing clinical data, the FHR values obtained by both the system proposed in this study and Monica AN24 are very close, and the difference is less than 1 bpm. CONCLUSION: The results show that the FHR calculation system is accurate and stable, and has a positive application value and prospect.

关键词： Fetal ECG fetal heart rate R-R interval fetal QRS position correction

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Al/HMX复合含能材料的制备及其燃烧特征参数研究

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固体火箭技术 2023年第2期46卷 213-223页

作者：扈颖慧王旭文张健梁家燕杨玉林林凯峰帅永哈尔滨工业大学化工与化学学院哈尔滨150001 哈尔滨工业大学能源科学与工程学院哈尔滨150001

奥克托今(HMX)包覆铝粉(Al)能够有效降低Al的团聚烧结现象并改善其能量释放效率。采用物理混合法、溶剂-反溶剂法和溶剂蒸发诱导自组装法分别制备了三种不同结构的Al/HMX-1、Al/HMX-2和Al/HMX-3复合含能材料。相较于Al/HMX-1和Al/HMX-2,... 详细信息

奥克托今(HMX)包覆铝粉(Al)能够有效降低Al的团聚烧结现象并改善其能量释放效率。采用物理混合法、溶剂-反溶剂法和溶剂蒸发诱导自组装法分别制备了三种不同结构的Al/HMX-1、Al/HMX-2和Al/HMX-3复合含能材料。相较于Al/HMX-1和Al/HMX-2,Al/HMX-3复合材料为球形包覆结构,D_(50)为6.651μm,各组分均匀分布。Al/HMX-3复合材料具备最优的热分解性能,其HMX的分解峰温降低到264.3℃,比Al/HMX-1和Al/HMX-2分别降低了~20.0℃和~19.2℃。燃烧性能分析表明,Al/HMX-3复合样品的燃烧更剧烈,团聚烧结现象降低,具有最高的燃烧热和燃烧温度。通过HMX均匀的包覆,HMX分解及时为Al燃烧提供氧化性气体“牢笼”促进Al氧化,并减少Al颗粒之间的相互碰撞导致的团聚。因此,燃烧性能和能量释放效率得到大幅度提升。

关键词：铝粉奥克托今包覆结构热分解性能燃烧温度

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Predicting hypertensive disorders in pregnancy using multiple methods: Models with the placental growth factor parameter

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S427-S432页

作者： Sun, Ge Xu, Qi Zhang, Song Yang, lin Liu, Guoli Meng, Yu Chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei Liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Placental growth factor (PlGF), one of the biomarkers, has a certain predictive effect on hypertensive disorders in pregnancy (HDP). OBJECTIVE: To study the HDP prediction effect of different methods for variable selection and modeling for models containing PlGF. METHODS: For the model containing PlGF, the appropriate range of PlGF parameters needed to be selected. Step-logistic regression and lasso were used to compare the model effect of twice range selection. The PlGF model with good predictive effect and appropriate detecting gestational age was selected for the final prediction. RESULTS: The effect of the model containing PlGF tested at 15-16 weeks was better than the PlGF value without comprehensive screening. The sensitivity of both methods was over 92%. By comprehensive comparison, the final model of lasso method in this study was more effective. CONCLUSIONS: In this study, a variety of methods were used to screen models containing PlGF parameters. According to clinical needs and model effects, the optimal HDP prediction model with PlGF parameters in the second trimester of 15-26 weeks of pregnancy was finally selected.

关键词： Placental growth factor model parameters variable selection

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中国-东盟信息港南宁核心基地高质量发展路径研究

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东南亚纵横 2023年第4期 80-89页

作者：林智荣刘曙华黄旭文广西社会科学院院刊编辑部广西社会科学院越南研究所

“数字丝绸之路”注重营造一个更加开放、和平、安全和创新的网络空间,在政治维度重塑全球数字治理价值共识,在经济维度构筑全球数字经济发展新模式,在安全维度提出全球跨境数据流动规制新路径,已经成为“一带一路”倡议的重要组成部分... 详细信息

“数字丝绸之路”注重营造一个更加开放、和平、安全和创新的网络空间,在政治维度重塑全球数字治理价值共识,在经济维度构筑全球数字经济发展新模式,在安全维度提出全球跨境数据流动规制新路径,已经成为“一带一路”倡议的重要组成部分。广西明确建设面向东盟的“数字丝绸之路”,并将中国—东盟信息港作为主要支撑平台。中国-东盟信息港南宁核心基地是南宁建设面向东盟的“数字丝绸之路”的核心载体,其成为“数字丝绸之路”建设的地方实践。基于以上背景和目标,文章分析了中国-东盟信息港南宁核心基地的建设成效、现存问题、发展机遇和面临挑战,并从基础设施、信息共享、技术合作、经贸服务、人文交流五大平台的角度,提出高质量推进中国-东盟信息港南宁核心基地的具体路径及对策措施,以期为深化中国—东盟数字领域合作提供助力。

关键词：信息港中国-东盟数字丝绸之路南宁核心基地数字经济合作

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FETAL MOVEMENT SIGNAL DETECTION METHOD BASED ON MULTIPLE PRESSURE SENSORS

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JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2021年第5期21卷 2140024-2140024页

作者： Liu, Jianli Li, xuwen Zhang, Song Zhang, Qiang Yang, lin Yang, Yimin Hao, Dongmei Beijing Univ Technol Fac Environm & Life Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100024 Peoples R China

Objective: Fetal movement (FM) is one of the objective phenomena of fetal life. The decrease of FM is a clinical indicator of fetal hypoxia. A fetal motion detection method is based on multiple pressure sensors and multi features. Methods: Collecting the abdominal data of pregnant women using multi-pressure sensors, preprocessing the signal with a digital filter, extracting the time-frequency characteristics of FM signal. The designed classifier is used for recognition of the extracted features. Results: The detection system used for FM time series can provide reliable results with a detection rate of 93.0% and a positive rate is 75.9%. Conclusion: The portable detection system proposed in this paper is a good alternative that will optimize medical use, professionals and hospital resources and has potential application prospects in the field of home electronic medical treatment.

关键词： Fetal movement detection pressure sensor classifier

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不同鼻胃管喂养模式对食管闭锁术后恢复的影响

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中华小儿外科杂志 2023年第11期44卷 968-974页

作者：杨福江胡博戴春娟马林赵绪稳王金虎杜晓斌天津市儿童医院(天津大学儿童医院)新生儿外科天津300074

目的探讨食管闭锁术后经鼻胃管进行高能量密度的早期肠内营养模式对术后恢复的影响。方法收集2016年1月至2022年12月在天津市儿童医院一期食管吻合手术治疗的Ⅲb型先天性食管闭锁36例患儿的资料,所有患儿均于术后早期经鼻胃管进行肠内营... 详细信息

目的探讨食管闭锁术后经鼻胃管进行高能量密度的早期肠内营养模式对术后恢复的影响。方法收集2016年1月至2022年12月在天津市儿童医院一期食管吻合手术治疗的Ⅲb型先天性食管闭锁36例患儿的资料,所有患儿均于术后早期经鼻胃管进行肠内营养(enteral nutrition,EN)。根据所使用配方奶能量密度分为两组:一组为早期微量EN组17例,其中男11例,女6例,胎龄为(38.8±1.3)周,出生体重为(2.6±0.3)kg,术后早期给予深度水解配方奶微量喂养;另一组早期强化EN组19例,其中男13例,女6例,胎龄为(38.5±1.8)周,出生体重为(2.8±0.4)kg,术后早期给予高能量密度深度水解配方奶喂养。两组均根据胃肠道耐受情况,逐步增加肠内营养量,最终过渡至完全经口喂养。采用IBM SPSS Statistics 26软件处理所有数据,符合正态分布的定量资料用独立样本t检验,非正态分布用非参数检验。结果两组在术前一般指标、手术方式、喂养不耐受、术后首次排便时间、术后14 d血清前白蛋白水平及术后1个月年龄别体重Z值(weight for age z score,WAZ)方面差异无统计学意义(P>0.05);早期强化EN组术后7 d血清前白蛋白水平、日均体重增长、达到全肠内营养时间、住院时长、住院总费用方面明显优于早期微量EN组,差异均有统计学意义(P<0.05)。结论新生儿食管闭锁术后早期高能量密度的肠内营养有助于改善围手术期营养状态,缩短住院时间及减少医疗花费,值得临床推广。

关键词：食管闭锁肠内营养高能量密度奶

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Comparative transcriptome analysis of gene expression patterns on B16F10 melanoma cells under Photobiomodulation of different light modes

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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 2021年第0期216卷 112127-112127页

作者： Chen, Zeqing Qin, Haokuan lin, Shangfei Lu, Zhicheng Fan, Xuewei Liu, xuwen Liu, Muqing Fudan Univ Acad Engn & Technol Inst Future Lighting 220th Handan Rd Shanghai 200433 Peoples R China Zhongshan Fudan Joint Innovat Ctr 6th Xiangxing Rd Zhongshan City 528403 Peoples R China Fudan Univ Inst Elect Light Sources 220th Handan Rd Shanghai 200433 Peoples R China

Cutaneous melanoma is one of the aggressive cancers. Recent studies have shown that Photobiomodulation (PBM) can inhibit the proliferation of melanoma cells. However, it is not clear that the effect of PBM light mode on the inhibition of melanoma cells. Herein, we investigated the difference of influence between continuous wave (CW) and Pulse PBM on B16F10 melanoma cells. Our results suggested that Pulse mode had a more sig-nificant inhibition on the viability of B16F10 melanoma cells than CW mode under the PBM light parameter of wavelength, dose, and average irradiance at 457 nm, 1.14 J/cm(2), and 0.19 mW/cm(2). Besides, we revealed the differentially expressed genes of B16F10 melanoma cells under the various treatments of PBM light mode (not PBM treatment, CW mode, and Pulse mode) by RNA sequencing. Together, our data suggested that Pulse-PBM can improve the effect of PBM on cells significantly and there may be different molecular mechanisms be-tween Pulse and CW mode including anti-proliferative and cell necrosis. The study shed new light on investi-gating the molecular mechanisms of various PBM light modes on B16F10 melanoma cells.

关键词： Photobiomodulation B16F10 melanoma cells Continuous wave Pulse light mode Transcriptomic study

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CHANGES IN GAUSSIAN MODElinG PARAMETERS OF PPG PULSE DURING HEALTHY PREGNANCY

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JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 2021年第5期21卷 2140001-2140001页

作者： Meng, Yu Yang, lin Zhang, Song Wu, Guanghui Liu, Xiaohong Hao, Dongmei Yang, Yimin Li, xuwen Beijing Univ Technol Fac Environm & Life Beijing 100024 Peoples R China Capital Med Univ Beijing Anzhen Hosp Beijing Inst Heart Lung & Blood Vessel Dis Beijing 100029 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

We used Gaussian modeling to depict the changes in finger photoplethysmographic (PPG) pulse during pregnancy in healthy women. We enrolled 70 healthy pregnant women and recorded their PPG pulses in 11-13 gestational weeks, 20-22 gestational weeks, and 37-39 gestational weeks. Three independent positive Gaussian functions were utilized to decompose the pulses, and each Gaussian function extracted three key parameters: the peak amplitude (H), the peak position (T), and the half-width (W). The method of ANOVA and post-hoc multiple comparisons of mathematical statistics were utilized to study the differences of these parameters between the three trimesters. We found that in the first trimester H-1 increased significantly (H-1 : 49.7 +/- 10.3 versus 52.9 +/- 6.9, p < 0.05). T-2 and T-3 increased in the first trimester (T-2 : 28.1 +/- 2.8 versus 28.4 +/- 2.2, p > 0.05;T-3: 54.3 +/- 4.2 versus 56.3 +/- 4.3, p < 0.01), then decreased significantly (T-2 : 28.4 +/- 2.2 versus 27.3 +/- 2.2, T-3: 56.3 +/- 4.3 versus 54.7 +/- 5.2, p < 0.05). H-1 is associated with cardiac output, and T-2 and T-3 are associated with peripheral vascular resistance. The results of this study were consistent with the conclusion that healthy pregnant women exhibited high flow state of the cardiovascular system and their peripheral vascular resistance decreased first and then gradually recovered during pregnancy. This study indicated that PPG pulse could also reflect the changes in the maternal cardiovascular system during pregnancy.

关键词： PPG pulse healthy pregnant women Gaussian modeling parameters

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Room temperature ferromagnetism in D-D neutron irradiated rutile TiO2 single crystals

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RSC ADVANCES 2020年第32期10卷 18687-18693页

作者： Liu, Huan Li, Gongping Dejun, E. Xu, Nannan lin, Qiaolu Gao, Xudong Lan, Changlin Chen, Jingsheng Wang, Canglong Zhan, xuwen Zhang, Kai Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Gansu Peoples R China Chinese Acad Sci Inst Modern Phys Lanzhou 730000 Gansu Peoples R China Natl Univ Singapore Dept Mat Sci & Engn Singapore 117608 Singapore China Inst Atom Energy Beijing 102413 Peoples R China

Room temperature ferromagnetism (RTFM) was observed in unirradiated rutile TiO2 single crystals prepared by the floating zone method due to oxygen vacancy (V-O) defects. D-D neutrons mainly collide elastically with TiO2, producing V-O, titanium vacancies (V-Ti) and other point defects;the density and kind of defect is related to the neutron irradiation fluence. D-D neutron irradiation is used to regulate the concentration and type of defect, avoiding impurity elements. As the irradiation fluence increases, the saturation magnetization (M-s) first increases, then decreases and then increases. To verify the origin of RTFM, the CASTEP module was used to calculate the magnetic and structural properties of point defects in TiO2. V-O induces a 2.39 mu(B) magnetic moment, Ti3+ and F+ induce 1.28 mu(B) and 1.70 mu(B) magnetic moments, respectively, while V-Ti induces a magnetic moment of similar to 4 mu(B). Combining experimental and theoretical results, increases in V-O concentration lead to M-s increases;more V-O combine with electrons to form F+, inducing a smaller magnetic moment. V-O and V-Ti play a key role and M-s changes accordingly with larger fluence. V-O, F+ and V-Ti are the most likely origins of RTFM.

关键词： Magnetic moments

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