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Bio-inspired inorganic-protein coating on Mg-based biomaterials for bioengineering applications

Science China Materials 2024年第5期67卷 1678-1680页

作者： xuwen peng Haolan Xu Department of Chemistry Engineering Tsinghua UniversityBeijing100084China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada Future Industries Institute UniSA STEMUniversity of South AustraliaMawson Lakes CampusAdelaideSouth Australia5095Australia

Developing smart and advanced functional materials inspired by the unparalleled complexity and efficiency of biological tissues has received much attention across various *** alloys,particularly pure magnesium,have emerged as notable candidates in orthopedics and dentistry due to their exceptional biocompatibility,degradability,and ability to promote bone regeneration[1].However,the highly reactive chemical nature of magnesium and its rapid degradation upon exposure to water.

关键词： coating alloys magnesium

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Covalent organic framework materials with advanced topologies for efficient methane adsorption

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Science China Materials 2025年第4期68卷 1298-1299页

作者： xuwen peng Hao Zhang Hongbo Zeng Department of Chemical and Materials Engineering Tsinghua UniversityBeijing 100084Chin a 2 Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G IH9Canada

Methane,as the main component of natural gas,is a key transitional fuel resource due to its abundance and relatively low carbon emissions,aligning with global carbon neutrality objectives[1].Traditional natural gas storage methods,such as liquefied and compressed natural gas,require costly infrastructure and high-pressure ***,adsorbed natural gas offers a safer,more cost-effective,and environmentally friendly solution by enhancing storage capacity at reduced pressures through the use of methane adsorbents[2].

关键词： natural gas carbon neutrality natural gasis covalent organic frameworks transitional fuel resource liquefied compressed natural gasrequire enhancing storage capacity reduced pressures methane adsorption

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Multifunctional Hydrogels Integrated with Reversible Noncovalent Interactions for Bioengineering and Sensing Applications

Multifunctional Hydrogels Integrated with Reversible Noncova...

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作者： xuwen peng University of Alberta

学位级别：博士

Hydrogels bear a close resemblance to human tissues and thus have been extensively employed for a broad range of applications in recent years. Intelligent hydrogels that can respond to diverse stimuli, such as pH, temperature, ionic strength, strain and stress, hold great promise for a variety of biological engineering and sensing applications. Nevertheless, weak mechanical properties and narrow functionality have limited the application of traditional hydrogels generally based on permanent covalent bonds. Incorporating reversible noncovalent interactions within hydrogel networks is an effective approach that lifts those restrictions. In the context of the growing demand for bioengineering and sensing applications, it is of great significance yet remains a challenge to integrate multifunctionalities such as mechanical robustness, self-healing properties, stimuli-responsiveness and conductivity into one hydrogel through the introduction of reversible interactions, functional components and well-designed structures. In this thesis, a review of multifunctional hydrogels, non-covalent interactions and corresponding hydrogels, and bioengineering and sensing applications of hydrogels is presented first, followed by three original research projects investigating the integrated multifunctional hydrogels for different potential biomedical and electrical sensing applications. Hydrogels with good stretchability, high adhesiveness, sensitive electrical responsiveness, biocompatible and antibacterial features are exceptionally desirable materials for various biomedical and sensing applications. In the first project, we fabricated a highly stretchable, moldable, self-healing and antibacterial hydrogel with electrical responsiveness by introducing dynamic noncovalent interactions, i. e., hydrogen-bonding among hydroxyl groups of poly (vinyl alcohol) (PVA), carboxyl moieties of poly (methyl vinyl ether-alt-maleic acid) (PMVEMA), and the catechol groups in tannic acid (TA). The prep

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Probing and Manipulating Noncovalent Interactions in Functional Polymeric Systems

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CHEMICAL REVIEWS 2022年第18期122卷 14594-14678页

作者： Chen, Jingsi peng, Qiongyao peng, xuwen Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada

Noncovalent interactions, which usually feature tunable strength, reversibility, and environmental adaptability, have been recognized as driving forces in a variety of biological and chemical processes, contributing to the recognition between molecules, the formation of molecule clusters, and the establishment of complex structures of macromolecules. The marriage of noncovalent interactions and conventional covalent polymers offers the systems novel mechanical, physicochemical, and biological properties, which are highly dependent on the binding mechanisms of the noncovalent interactions that can be illuminated via quantification. This review systematically discusses the nano mechanical characterization of typical noncovalent interactions in polymeric systems, mainly through direct force measurements at microscopic, nanoscopic, and molecular levels, which provide quantitative information (e.g., ranges, strengths, and dynamics) on the binding behaviors. The fundamental understandings of intermolecular and interfacial interactions are then correlated to the macroscopic performances of a series of noncovalently bonded polymers, whose functions (e.g., stimuli-responsiveness, self-healing capacity, universal adhesiveness) can be customized through the manipulation of the noncovalent interactions, providing insights into the rational design of advanced materials with applications in biomedical, energy, environmental, and other engineering fields.

关键词： Ligands Molecular mechanics Noncovalent interactions Polymers Surface interactions

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Highly Robust,Compressible,Anisotropic,and Fire-Retardant Polyimide/Hydroxyapatite Nanowires/Reduced Graphene Oxide Aerogel for Rapid Adsorption of Viscous Oil Assisted by Sunlight

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Research 2024年第4期7卷 58-70页

作者： Pan Huang Yongxiang Sun Lin Yang Haoyu Yang Ying Hu Jifang Liu xuwen peng Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada Heavy Machinery Engineering Research Center of Education Ministry Taiyuan University of Science and TechnologyTaiyuan 030024China Cancer Center The Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510700China Department of Chemical Engineering Tsinghua UniversityBeijing 10084China

Improving the adsorption efficiency of porous adsorbent materials for organic liquids with high viscosity is crucial for addressing oil spill *** this study,a high-performance aerogel adsorbent composed of polyimide(PI),hydroxyapatite nanowires(HAPnws),and reduced graphene oxide(rGO)has been fabricated,which leverages reduced flow tortuosity through anisotropic structures and solar-assisted viscosity reduction via photothermal *** prepared anisotropic PI/HAP/rGO aerogel,with directional channels,shows unique mechanical properties with high stiffness along the axial direction and compressibility along the radial direction.

关键词： nanowires viscosity adsorbent

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Stratum Corneum-Inspired Zwitterionic Hydrogels with Intrinsic Water Retention and Anti-Freezing Properties for Intelligent Flexible Sensors

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ADVANCED FUNCTIONAL MATERIALS 2025年第0期

作者： Wu, Meng Qiao, Chenyu Sui, peng-Fei Luo, Jing-Li Li, Zuoli Cao, Yi Pei, Renjun peng, xuwen Zeng, Hongbo Chinese Acad Sci Suzhou Inst Nanotech & Nanobion CAS Key Lab Nanobio Interface Suzhou 215123 Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Tsinghua Univ Dept Chem Engn Beijing 10084 Peoples R China

Hydrogels, which mimic the properties of natural tissues, are essential for flexible electronics in human-machine interfaces (HMIs). However, traditional hydrogels suffer from dehydration, compromising stability and functionality. To address this issue, a stratum corneum-inspired, water-retaining hydrogel is developed using hygroscopic polymers and bound water. Three types of hydrophilic monomers (non-ionic, mono-ionic, and zwitterionic) are explored, with polyzwitterions, particularly N,N-dimethyl (acrylamidopropyl) ammonium propane sulfonate (DMAAPS), forming a quasi-hydrogel that retains the softness and flexibility of conventional hydrogels. Water acts as a plasticizer, enhancing polymer chain mobility and reducing stiffness. The DMAAPS hydrogel maintains 100% weight retention under specific humidity conditions and shows skin-like softness across a wide humidity range. The Young's modulus increases from 54 to 118 kPa as relative humidity decreases from 80% to 40%. The absence of free water confers intrinsic anti-freezing properties. A triple crosslinking mechanism and conductive polymers endow the hydrogel with stretchability (> 2000%), toughness, elasticity, self-healing, and stable sensing capabilities. The hydrogel functions as an excellent flexible sensor for real-time, sensitive detection of human motion and physiological signals. An intelligent handwriting recognition platform with high accuracy is also established using double-channel signal collection and machine learning algorithms, offering insights for next-generation durable, biomimetic, and smart HMIs.

关键词： anti-freezing flexible sensors self-healing stratum corneum-inspired materials water retention wearable electronics Zwitterionic hydrogels

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Fluorescence imaging analysis of the glioma microenvironment

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Journal of Innovative Optical Health Sciences 2023年第1期16卷 55-66页

作者： xuwen peng Yuzhou Chen Yuke Wang Shuhong Qi Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China

Glioma is the most malignant brain *** neurons,macrophages,T cells and other immune ellls constitute the glioma immunosuppressive *** accurate spatial distri-bution of these cells in the glioma microenvironment and its relationship with glioma metastasis is *** constructed a mouse gliomna cell line stably expressing the large Stokes shifted yellow fluorescent protein and applied it to the multicolor immunofluorescence *** inaging data revealed that the neurons were sparsely distributed in the glioma core and the mumber of neurons decreased by 90%compared with normal brain *** spatial distribution of monocyte-macrophages and microglia is *** monocyte macrophages and T cells were heavily recrnuited into the glioma core and *** was no significant difference in the distribution of microglia amnong glioma core,margin,and normal brain *** results provided new perspectives for targeting immune regulation cells and developing new immuno-therapy strategies for glioma.

关键词： Glioma microenvironment spatial distribution heterogeneity multicolor immuno-fluorescence large Stokes-shifted fluorescent protein.

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Surface interaction mechanisms of air bubbles, asphaltenes and oil drops in aqueous solutions with implications for interfacial engineering processes

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JOURNAL OF COLLOID AND INTERFACE SCIENCE 2023年第1期647卷 264-276页

作者： Yang, Diling Zhao, Ziqian Gong, Lu Sun, Yongxiang peng, xuwen peng, Qiongyao Wang, Tao Liu, Qi Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada

Hypothesis: Surface interactions of bubbles and oil with interface-active species like asphaltenes influence many interfacial phenomena in various engineering processes. It holds both fundamental and practical significance to quantitatively characterize these ***: The surface forces of air bubbles, asphaltenes and asphaltenes-toluene droplets in various aqueous solutions have been quantified using an integrated thin film drainage apparatus and an atomic force microscope coupled with bubble probe. The effects of asphaltenes concentration, pH, salinity, Ca2+ ions and surfactants have been ***: Hydrophobic interaction drives attachment of bubbles and asphaltenes surfaces or oil droplets under high salinity condition. Increasing asphaltenes concentration in oil droplets enhances their hydrophobic attraction with bubbles due to strengthened asphaltenes adsorption and aggregation at oil-water interface. Increasing pH weakens the hydrophobic interaction as oil surfaces become more negatively charged and less hydrophobic. Under low salinity condition, strong electrical double layer and van der Waals repulsion inhibits the bubble-oil droplet contact. Introducing Ca2+ ions and surfactants leads to strong steric repulsion, preventing bubble-oil contact. This research has advanced our mechanistic understanding of how bubbles and oil droplets interact in aqueous systems and offers useful insights to modulate such interactions in oil production, water treatment and other interfacial processes.

关键词： Surface interactions Bubbles Oil droplets Flotation Interfacial Forces Emulsion

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A pH and Temperature Dual-Responsive Microgel-Embedded, Adhesive, and Tough Hydrogel for Drug Delivery and Wound Healing

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ACS APPLIED MATERIALS & INTERFACES 2023年第15期15卷 19560-19573页

作者： peng, xuwen peng, Qian Wu, Meng Wang, Wenda Gao, Yongfeng Liu, Xiong Sun, Yongxiang Yang, Diling peng, Qiongyao Wang, Tao Chen, Xing-Zhen Liu, Jifang Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB 619 Canada Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China Univ Alberta Fac Med & Dent Dept Physiol Edmonton AB 627 Canada

Stimuli-responsive hydrogels have attracted much attention over the past decade for potential bioengineering applications such as wound dressing and drug delivery. In this work, a pH and temperature dual-responsive microgel-embedded hydrogel has been fabricated by incorporating poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAAm-co-AAc) based microgel particles into polyacrylamide (PAAm)/chitosan (CS) semi-interpenetrating polymer network (semi-IPN), denoted as microgel@PAM/ CS. The resultant hydrogel possesses excellent mechanical properties including stretchability, compressibility, and elasticity. In addition, the microgel@PAM/CS hydrogels can tightly adhere to the surfaces of a variety of tissues such as porcine skin, kidney, intestine, liver, and heart. Moreover, it shows controlled dual-drug release profile of both bovine serum albumin (BSA) (as a model protein) and sulfamethoxazole (SMZ), an antibiotic. Excellent antimicrobial properties are obtained for SMZ-loaded microgel@ PAM/CS hydrogels. Compared with traditional drug administration methods such as by mouth, injection, and inhalation, the microgel@PAM/CS hydrogels possess advantages such as higher drug loading efficiency (by more than 80%) and controllable and sustained (over 48 h) release. The microgel@PAM/ CS hydrogels can significantly enhance the wound healing process. This work provides a facile approach for the fabrication of multifunctional stimuli-responsive microparticle-embedded hydrogels with semi-IPN structures, and the as-prepared microgel@ PAM/CS hydrogels have great potential for applications as smart wound dressing materials in biomedical engineering.

关键词： stimuli-responsive hydrogel multifunctional hydrogel interfacial interaction drug delivery wound dressing

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Recent advances in coacervation and underlying noncovalent molecular interaction mechanisms

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PROGRESS IN POLYMER SCIENCE 2024年 153卷

作者： peng, Qiongyao Wang, Tao Yang, Diling peng, xuwen Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G1H9 Canada

Coacervation is a liquid-liquid phase separation phenomenon. It involves the formation of a dense coacervate phase, rich in concentrated materials, and a co-existing immiscible dilute supernatant. This phenomenon can occur either from a homogeneous aqueous solution (simple coacervation) or when two different macromolecular aqueous solutions (proteins, polymers, and colloids) are brought into contact (complex coacervation). Coacervation has historical significance as it may have played a role in the origin of life, concentrating nutritious materials through liquid-liquid phase separation. It also reveals the underlying mechanisms of many biological phenomena such as intracellular biomolecular condensates, extracellular matrices, squid beak's gradient properties, sessile organism's wet adhesion, Alzheimer's diseases, and more. Coacervation provides insights and inspires promising solutions in areas like artificial cells/tissues, gradient materials, gene/drug delivery, underwater adhesives, and beyond. The driving forces of coacervation are noncovalent molecular interactions, often referred to as 'chemistry beyond the molecule', including hydrophobic interaction, electrostatic interaction, hydrogen-bonding interaction, cation- zr interaction, zr - zr interaction, multivalency, etc. In this work, we have systematically reviewed the underlying noncovalent molecular interactions of simple coacervation and complex coacervation, respectively. We summarize commonly used materials and their corresponding molecular structures, dis cussing their applications. Some remaining challenge issues and perspectives for future studies are also presented. Understanding the underlying noncovalent molecular interactions of coacervation, alongside insights into molecular compositions and structures, can better guide the design of novel materials, elucidate various biological phenomena, and contribute to the development and optimization of relevant engineering technologies. (c) 2024 The Auth

关键词： Simple coacervation Complex coacervation Noncovalent molecular interactions Liquid-liquid phase separation LLPS

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