检索结果-内蒙古大学图书馆

Coacervate-Based Instant and Repeatable Underwater Adhesive with Anticancer and Antibacterial Properties

ACS APPLIED MATERIALS & INTERFACES 2021年第40期13卷 48239-48251页

作者： peng, Qiongyao Wu, Qiuqiu Chen, Jingsi Wang, Tao Wu, Meng Yang, Diling peng, xuwen Liu, Jifang Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Guangzhou Med Univ Affiliated Hosp 6 Qingyuan Peoples Hosp Qingyuan 511500 Guangdong Peoples R China

Underwater adhesion is a great challenge for the development of adhesives as the attractive interfacial intermolecular interactions are usually weakened by the surface hydration layer. The coacervation process of sessile organisms like marine mussels and sandcastle worms has inspired substantial research interest in the fabrication of long-lasting underwater adhesives, but they generally suffer from time-consuming curing triggered by surrounding environmental changes and cannot reserve the adhesiveness once damaged. Herein, an instant and repeatable underwater adhesive was developed based on the coacervation of tannic acid (TA) and poly(ethylene glycol)(77)-b-poly(propylene glycol)(29)-b-poly(ethylene glycol)(77) (PEG-PPG-PEG, F68), which was driven by hydrogen-bonding interaction, and the hydrophobic cores of F68 micelles offered an additional cross-linking to enhance the mechanical properties. The TA-F68 coacervates could be facilely painted on different substrates, exhibiting robust and instant underwater adhesion (with adhesion strength up to 1.1 MPa on porcine skin) and excellent repeatability (at least 1000 cycles), superior to the previously reported coacervates. Due to the biological activities of TA, the underwater adhesive displayed innate anticancer and antibacterial properties against different types of cancer cells and bacteria, showing great potential for diverse biomedical applications, such as injectable drug carriers, tissue glues, and wound dressings.

关键词： instant and repeatable underwater adhesive coacervation hydrogen-bonding interaction hydrophobic interaction anticancer antibacterial

来源：评论

学校读者我要写书评

暂无评论

Surface interaction mechanisms of air bubbles, asphaltenes and oil drops in aqueous solutions with implications for interfacial engineering processes

引用

JOURNAL OF COLLOID AND INTERFACE SCIENCE 2023年第1期647卷 264-276页

作者： Yang, Diling Zhao, Ziqian Gong, Lu Sun, Yongxiang peng, xuwen peng, Qiongyao Wang, Tao Liu, Qi Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada

Hypothesis: Surface interactions of bubbles and oil with interface-active species like asphaltenes influence many interfacial phenomena in various engineering processes. It holds both fundamental and practical significance to quantitatively characterize these ***: The surface forces of air bubbles, asphaltenes and asphaltenes-toluene droplets in various aqueous solutions have been quantified using an integrated thin film drainage apparatus and an atomic force microscope coupled with bubble probe. The effects of asphaltenes concentration, pH, salinity, Ca2+ ions and surfactants have been ***: Hydrophobic interaction drives attachment of bubbles and asphaltenes surfaces or oil droplets under high salinity condition. Increasing asphaltenes concentration in oil droplets enhances their hydrophobic attraction with bubbles due to strengthened asphaltenes adsorption and aggregation at oil-water interface. Increasing pH weakens the hydrophobic interaction as oil surfaces become more negatively charged and less hydrophobic. Under low salinity condition, strong electrical double layer and van der Waals repulsion inhibits the bubble-oil droplet contact. Introducing Ca2+ ions and surfactants leads to strong steric repulsion, preventing bubble-oil contact. This research has advanced our mechanistic understanding of how bubbles and oil droplets interact in aqueous systems and offers useful insights to modulate such interactions in oil production, water treatment and other interfacial processes.

关键词： Surface interactions Bubbles Oil droplets Flotation Interfacial Forces Emulsion

来源：评论

学校读者我要写书评

暂无评论

Coacervation-driven instant paintable underwater adhesives with tunable optical and electrochromic properties

引用

JOURNAL OF MATERIALS CHEMISTRY A 2021年第22期9卷 12988-13000页

作者： peng, Qiongyao Chen, Jingsi Wang, Tao Gong, Lu peng, xuwen Wu, Meng Ma, Yuhao Wu, Feiyi Yang, Diling Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Univ Alberta Dept Biomed Engn Edmonton AB T6G 2V2 Canada

Coacervation generally refers to liquid-liquid phase separation when mixing oppositely charged polyelectrolytes in an aqueous solution, which produces a polyelectrolyte-dense coacervate phase in a dilute solution phase. Coacervation plays a crucial role in many biological processes such as the versatile underwater adhesion of sessile organisms, cellular compartmentalization, and cell replication, which inspires a surge of biomimetic designs of underwater adhesives. However, conventional coacervate-based underwater adhesives are usually weak and lack functionalities, limiting their practical applications in biomedical and engineering fields. Herein, a novel instant underwater adhesive is presented based on coacervation via one-step mixing of aqueous solutions of silicotungstic acid (SiW) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (P123) micelles, driven by hydrogen-bonding and hydrophobic interactions. The as-prepared adhesive possesses instant and excellent underwater adhesion (up to 479.6 kPa on poly(methyl methacrylate)) and can be facilely painted underwater on diverse substrates, showing resistance to water flush as well as repeatable stretching and bending of the substrates, superior to many previously reported coacervates. The adhesive also exhibits outstanding stability in high-salt aqueous solutions up to 3 M for at least 1200 h. The introduction of P123 endows the adhesives with thermo-responsive optical properties, while the innate reduction-related color switch of SiW offers electrochromic properties. The functional adhesives hold great promise in bioengineering applications and for the fabrication of novel flexible electronics such as smart aqueous batteries and low-power electrochromic windows.

关键词： Substrates

来源：评论

学校读者我要写书评

暂无评论

High incidence of spontaneous cataracts in aging laboratory rabbits of an inbred strain

引用

VETERINARY OPHTHALMOLOGY 2015年第3期18卷 186-190页

作者： peng, xuwen Roshwalb, Sara Cooper, Timothy K. Zimmerman, Heather Christensen, Neil D. Penn State Univ Dept Comparat Med Hershey Coll Med Hershey PA 17033 USA Penn State Univ Dept Pathol Hershey Coll Med Hershey PA 17033 USA Penn State Univ Jake Gittlen Canc Res Fdn Hershey Coll Med Hershey PA 17033 USA Penn State Univ Dept Microbiol & Immunol Hershey Coll Med Hershey PA 17033 USA

ObjectiveTo investigate the occurrence of spontaneous cataracts in a breeding colony of the inbred EIII/JC strain of New Zealand White rabbits (Oryctolagus cuniculi) and the congenic strain of EIII/JC-HLA-A2.1transgenic rabbits. ProcedureA retrospective study was conducted by collecting and analyzing data from clinical records for individual rabbits filed between January 2011 and October 2013. ResultsThirteen cases (eight females and five males) of cataract were identified in a group of 51 EIII/JC inbred rabbits with a morbidity of 25.5%. The median age of the rabbits identified with unilateral or bilateral cataracts was 43months in contrast to the median age of 23months of the entire group of 51 rabbits. Additionally, seven cases (five females and two males) of cataracts were identified in a group of 21 EIII/JC-HLA-A2.1 transgenic rabbits. The EIII/JC-HLA-A2.1 transgenic rabbits showed similar morbidity (33.3%) and median age (41months) for the development of cataracts as the EIII/JC rabbits. In both groups, none of the rabbits younger than 37months developed cataracts while 13 (93%) of 14 EIII/JC rabbits aged 37-49months and seven (63.6%) of 11 EIII/JC-HLA-A2.1 transgenic rabbits aged 37-43months developed cataracts. In contrast, none of 78 outbred rabbits with a median age of 26months (10-67months) developed cataracts. ConclusionResults of this study indicate that the occurrence and high incidence of spontaneous cataracts in this inbred strain (EIII/JC) of rabbits were strictly age related and consistently transmitted through inbreeding.

关键词： aging cataracts EIII JC inbred strain high incidence inheritance New Zealand White rabbits

来源：评论

学校读者我要写书评

暂无评论

Fluorescence imaging analysis of the glioma microenvironment

引用

Journal of Innovative Optical Health Sciences 2023年第1期16卷 55-66页

作者： xuwen peng Yuzhou Chen Yuke Wang Shuhong Qi Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology Wuhan Hubei 430074P.R.China

Glioma is the most malignant brain *** neurons,macrophages,T cells and other immune ellls constitute the glioma immunosuppressive *** accurate spatial distri-bution of these cells in the glioma microenvironment and its relationship with glioma metastasis is *** constructed a mouse gliomna cell line stably expressing the large Stokes shifted yellow fluorescent protein and applied it to the multicolor immunofluorescence *** inaging data revealed that the neurons were sparsely distributed in the glioma core and the mumber of neurons decreased by 90%compared with normal brain *** spatial distribution of monocyte-macrophages and microglia is *** monocyte macrophages and T cells were heavily recrnuited into the glioma core and *** was no significant difference in the distribution of microglia amnong glioma core,margin,and normal brain *** results provided new perspectives for targeting immune regulation cells and developing new immuno-therapy strategies for glioma.

关键词： Glioma microenvironment spatial distribution heterogeneity multicolor immuno-fluorescence large Stokes-shifted fluorescent protein.

来源：评论

学校读者我要写书评

暂无评论

Hydrogen-Bonding-Driven Multifunctional Polymer Hydrogel Networks Based on Tannic Acid br

引用

ACS APPLIED POLYMER MATERIALS 2022年第3期4卷 1836-1845页

作者： Gao, Yongfeng peng, xuwen Wu, Qiuqiu Yang, Diling Wang, Wenda peng, Qiongyao Wang, Tao Wang, Jianmei Liu, Jifang Zhang, Hao Zeng, Hongbo Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China Univ Alberta Dept Chem & Mat Engn Edmonton AB T6G 1H9 Canada Taiyuan Univ Sci & Technol Heavy Machinery Engn Res Ctr Educ Minist Taiyuan 030024 Shanxi Peoples R China

A hydrogel network based on noncovalent inter-molecular interactions via mixing of poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA), poly(vinyl alcohol) (PVA), andtannic acid (TA) aqueous solutions was developed. Thecoacervation and hydrogel formation process is driven by hydro-gen-bonding interactions between catechol moieties of TA,hydroxide groups of PVA, and carboxylic acid groups of *** formation of the PMVEMA-PVA-TA (PPTA) gel occurs inseconds and can be readily obtained and scaled up in both ionic andnonionic systems. It is noteworthy that this PPTA gel can bestretched more than 135 times its original size and for potentialpreparation of mechanically strongfibers. The gel can be alsoremodeled on diverse substrates and into different shapes. The electrical response sensing behavior promotes the PPTA gel materialas a great candidate for fabricating strain sensors. The as-prepared PPTA gel exhibits excellent adhesion to different substrates andshows antibacterial properties against bothEscherichia coli(Gram-negative) bacteria and methicillin-resistantStaphylococcus aureus(MRSA) bacteria, which provides a promising candidate for the design of biocompatible drug carriers with facile fabrication and flexible modification for various biomedical applications.

关键词： hydrogen bond hydrogel adhesive mechanical properties self-healing antibacterial

来源：评论

学校读者我要写书评

暂无评论

A pH and Temperature Dual-Responsive Microgel-Embedded, Adhesive, and Tough Hydrogel for Drug Delivery and Wound Healing

引用

ACS APPLIED MATERIALS & INTERFACES 2023年第15期15卷 19560-19573页

作者： peng, xuwen peng, Qian Wu, Meng Wang, Wenda Gao, Yongfeng Liu, Xiong Sun, Yongxiang Yang, Diling peng, Qiongyao Wang, Tao Chen, Xing-Zhen Liu, Jifang Zhang, Hao Zeng, Hongbo Univ Alberta Dept Chem & Mat Engn Edmonton AB 619 Canada Guangzhou Med Univ Affiliated Hosp 5 Guangzhou 510700 Guangdong Peoples R China Univ Alberta Fac Med & Dent Dept Physiol Edmonton AB 627 Canada

Stimuli-responsive hydrogels have attracted much attention over the past decade for potential bioengineering applications such as wound dressing and drug delivery. In this work, a pH and temperature dual-responsive microgel-embedded hydrogel has been fabricated by incorporating poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAAm-co-AAc) based microgel particles into polyacrylamide (PAAm)/chitosan (CS) semi-interpenetrating polymer network (semi-IPN), denoted as microgel@PAM/ CS. The resultant hydrogel possesses excellent mechanical properties including stretchability, compressibility, and elasticity. In addition, the microgel@PAM/CS hydrogels can tightly adhere to the surfaces of a variety of tissues such as porcine skin, kidney, intestine, liver, and heart. Moreover, it shows controlled dual-drug release profile of both bovine serum albumin (BSA) (as a model protein) and sulfamethoxazole (SMZ), an antibiotic. Excellent antimicrobial properties are obtained for SMZ-loaded microgel@ PAM/CS hydrogels. Compared with traditional drug administration methods such as by mouth, injection, and inhalation, the microgel@PAM/CS hydrogels possess advantages such as higher drug loading efficiency (by more than 80%) and controllable and sustained (over 48 h) release. The microgel@PAM/ CS hydrogels can significantly enhance the wound healing process. This work provides a facile approach for the fabrication of multifunctional stimuli-responsive microparticle-embedded hydrogels with semi-IPN structures, and the as-prepared microgel@ PAM/CS hydrogels have great potential for applications as smart wound dressing materials in biomedical engineering.

关键词： stimuli-responsive hydrogel multifunctional hydrogel interfacial interaction drug delivery wound dressing

来源：评论

学校读者我要写书评

暂无评论

A novel, minimally invasive, segmental myocardial infarction with a clear healed infarct borderzone in rabbits

引用

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2012年第11期302卷 H2321-H2330页

作者： Ziv, Ohad Schofield, Lorraine Lau, Emily Chaves, Lenny Patel, Divyang Jeng, Paul peng, xuwen Choi, Bum-Rak Koren, Gideon Brown Univ Cardiovasc Res Ctr Rhode Isl Hosp Warren Alpert Med Sch Providence RI 02912 USA Penn State Hershey Coll Med Hershey PA USA

Ziv O, Schofield L, Lau E, Chaves L, Patel D, Jeng P, peng X, Choi BR, Koren G. A novel, minimally invasive, segmental myocardial infarction with a clear healed infarct borderzone in rabbits. Am J Physiol Heart Circ Physiol 302: H2321-H2330, 2012. First published March 23, 2012;doi:10.1152/ajpheart.00031.2012.-Ventricular arrhythmias in the setting of a healed myocardial infarction have been studied to a much lesser degree than acute and subacute infarction, due to the pericardial scarring, which results from the traditional open-chest techniques used for myocardial infarction (MI) induction. We sought to develop a segmental MI with low perioperative mortality in the rabbit that allows optimal visualization and therefore improved study of the infarction borderzone. Rabbits underwent MI using endovascular coil occlusion of the first obtuse marginal artery. Three weeks postprocedure, we evaluated our model by echocardiography and electrophysiology studies, optical mapping of isolated hearts, and histological studies. Seventeen rabbits underwent the protocol (12 MI and 5 sham) with a 92% survival to completion of the study (11 MI and 5 sham). MI rabbits demonstrated wall motion abnormalities on echocardiography while shams did not. At electrophysiological study, two MI rabbits had inducible ventricular tachycardia and one had inducible ventricular fibrillation. Isolated hearts demonstrated no pericardial scarring with a smooth, easily identifiable infarct borderzone. Optical mapping of the borderzone region showed successful mapping of peri-infarct reentry formation, with ventricular fibrillation inducible in 11 of 11 MI hearts and 1 of 5 sham hearts. We demonstrate successful high resolution mapping in the borderzone, showing delayed conduction in this region corresponding to late deflections in the QRS on ECG. We report the successful development of a minimally invasive MI via targeted coil delivery to the obtuse marginal artery with an exceptionally high rate of pro

关键词： arrhythmia optical mapping ventricular tachycardia

来源：评论

学校读者我要写书评

暂无评论

Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization

引用

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2008年第6期295卷 H2264-H2272页

作者： Odening, Katja E. Hyder, Omar Chaves, Leonard Schofield, Lorraine Brunner, Michael Kirk, Malcolm Zehender, Manfred peng, xuwen Koren, Gideon Brown Univ Warren Alpert Med Sch Rhode Isl Hosp Cardiovasc Res CtrDiv Cardiol Providence RI 02903 USA Univ Freiburg Innere Med 3 D-7800 Freiburg Germany Penn State Univ Coll Med Dept Comparat Med Hershey PA USA

Odening KE, Hyder O, Chaves L, Schofield L, Brunner M, Kirk M, Zehender M, peng X, Koren G. Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization. Am J Physiol Heart Circ Physiol 295: H2264-H2272, 2008. First published October 3, 2008;doi: 10.1152/ajpheart. 00680.2008. Anesthetic agents prolong cardiac repolarization by blocking ion currents. However, the clinical relevance of this blockade in subjects with reduced repolarization reserve is unknown. We have generated transgenic long QT syndromes type 1 (LQT1) and type 2 (LQT2) rabbits that lack slow delayed rectifier K+ currents (I-Ks) or rapidly activating K+ currents (I-Kr) and used them as a model system to detect the channel-blocking properties of anesthetic agents. Therefore, LQT1, LQT2, and littermate control (LMC) rabbits were administered isoflurane, thiopental, midazolam, propofol, or ketamine, and surface ECGs were analyzed. Genotype-specific heart rate correction formulas were used to determine the expected QT interval at a given heart rate. The QT index (QTi) was calculated as percentage of the observed QT/expected QT. Isoflurane, a drug that blocks I-Ks, prolonged the QTi only in LQT2 and LMC but not in LQT1 rabbits. Midazolam, which blocks inward rectifier K+ current (I-Ks), prolonged the QTi in both LQT1 and LQT2 but not in LMC. Thiopental, which blocks both I-Ks and I-K1, increased the QTi in LQT2 and LMC more than in LQT1. By contrast, ketamine, which does not block I-Kr, I-Ks, or I-K1, did not alter the QTi in any group. Finally, anesthesia with isoflurane or propofol resulted in lethal polymorphic ventricular tachycardia (pVT) in three out of nine LQT2 rabbits. Transgenic LQT1 and LQT2 rabbits could serve as an in vivo model in which to examine the pharmacogenomics of drug-induced QT prolongation of anesthetic agents and their proarrhythmic potential. Transgenic LQT2 rabbits developed pVT under isoflurane an

关键词： repolarization reserve long QT syndrome types 1 and 2 sudden cardiac death ventricular fibrillation

来源：评论

学校读者我要写书评

暂无评论

Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo

引用

EUROPEAN JOURNAL OF PHARMACOLOGY 2011年第1期650卷 309-316页

作者： Biermann, Jurgen Wu, Kezhong Odening, Katja E. Asbach, Stefan Koren, Gideon peng, xuwen Zehender, Manfred Bode, Christoph Brunner, Michael Univ Hosp Freiburg Dept Cardiol & Angiol D-79106 Freiburg Germany Brown Univ Rhode Isl Hosp Warren Alpert Med Sch Cardiovasc Res Ctr Providence RI 02903 USA Penn State Univ Coll Med Dept Comparat Med Hershey PA USA

Transgenic rabbits expressing loss-of-function pore mutants of the human gene KCHQ1 (K(v)LQT1-Y315S) have a Long QT-Syndrome 1 (LQT1) phenotype We evaluated for the first time the effect of nicorandil an opener of ATP sensitive potassium channels and of isoproterenol on cardiac action potential duration and heart rate dependent dispersion of repolarisation in transgenic LQT1 rabbits In vivo LQT1 and littermate control were subjected to transvenous electrophysiological studies in vitro monophasic action potentials were recorded from explanted Langendorff-perfused hearts In vivo ventricular effective refractory periods (VERP) at the right ventricular base were significantly prolonged in LQT1 as compared to litterrnate control resulting in a more pronounced VERP dispersion in LQT1 This difference in VI RP dispersion between LQT1 and littermate control disappeared after infusion of nicorandil In vitro mean action potential durations (APD(75) and APD(90)) of LQT1 were significantly prolonged compared to littermate control at baseline Nicorandil decreased APD(75) and APD(90) in LQT1 and littermate control at all stimulated heart rates After adding nicorandil the APD90 it all hearts rates and the APD75 at high heart rates were no longer different Dispersion of repolarisation (AAPD(75) and Delta APD(90)) was heart rate dependently decreased after nicorandil at all tested stimulation cycle lengths only in LQT1 We demonstrated phenotypic differences of LQT1 and littermate control in vivo and in vitro Nicorandil 20 mu mol/1 improved repolarisation abnormalities and heterogeneities in transgenic LQT1 rabbits (C) 2010 Elsevier B V All rights reserved

关键词： Long QT Syndrome Polymorphic ventricular tachycardia Transgenic rabbit model Electrophysiological studies Nicorandil Dispersion of repolarisation

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：